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Esophageal leukoplakia

MedGen UID:
75628
•Concept ID:
C0267095
•
Neoplastic Process
Synonyms: Esophageal Epidermoid Metaplasia; Esophageal epidermoid metaplasia; esophageal epidermoid metaplasia; Esophageal Leukoplakia; esophageal leukoplakia; esophageal leukoplakia (disease); Esophagus Leukoplakia; esophagus leukoplakia; Leukoplakia of esophagus; Leukoplakia of Esophagus; leukoplakia of esophagus; leukoplakia of oesophagus; Leukoplakia of the Esophagus; leukoplakia of the esophagus; leukoplakia of the oesophagus; oesophagus leukoplakia
SNOMED CT: Leukoplakia of esophagus (89057003)
 
HPO: HP:0012859
Monarch Initiative: MONDO:0004697

Definition

A white patch or plaque occurring on the surface of the esophageal mucous membranes that cannot be rubbed off and cannot be characterized clinically as any other disease. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal leukoplakia

Professional guidelines

PubMed

A survey study with assessment of esophageal screening and genetic counseling in patients with Howel-Evans syndrome.
Jenkins LE, Abner S, Schadt C
Dermatol Online J 2018 Jun 15;24(6) PMID: 30142717
Retinoids in the management of head and neck cancer. An update.
Fountzilas G
J Chemother 1994 Apr;6(2):127-38. doi: 10.1080/1120009x.1994.11741142. PMID: 8077988
Endoscopic and biopsy criteria for the diagnosis of esophagitis with a fiberoptic esophagoscope.
Kobayashi S, Kasugai T
Am J Dig Dis 1974 Apr;19(4):345-52. doi: 10.1007/BF01072525. PMID: 4821309

Recent clinical studies

Etiology

The Significance of a Pale Area Via Flexible Spectral Imaging Color Enhancement in the Diagnosis of Esophageal Precancerous Lesions and Early-stage Squamous Cancer.
Li Y, Yangjin C, Shi Y, Wen Y, Jin Z, Cui R, Zhang H, Ding S
J Clin Gastroenterol 2019 Oct;53(9):e400-e404. doi: 10.1097/MCG.0000000000001191. PMID: 30829906Free PMC Article
Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges.
Johncilla ME, Srivastava A
Virchows Arch 2018 Jan;472(1):29-41. Epub 2017 Oct 15 doi: 10.1007/s00428-017-2238-4. PMID: 29034419
Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients.
Singhi AD, Arnold CA, Crowder CD, Lam-Himlin DM, Voltaggio L, Montgomery EA
Mod Pathol 2014 Jan;27(1):38-43. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.100. PMID: 23765246

Diagnosis

The Significance of a Pale Area Via Flexible Spectral Imaging Color Enhancement in the Diagnosis of Esophageal Precancerous Lesions and Early-stage Squamous Cancer.
Li Y, Yangjin C, Shi Y, Wen Y, Jin Z, Cui R, Zhang H, Ding S
J Clin Gastroenterol 2019 Oct;53(9):e400-e404. doi: 10.1097/MCG.0000000000001191. PMID: 30829906Free PMC Article
Esophagitis unrelated to reflux disease: current status and emerging diagnostic challenges.
Johncilla ME, Srivastava A
Virchows Arch 2018 Jan;472(1):29-41. Epub 2017 Oct 15 doi: 10.1007/s00428-017-2238-4. PMID: 29034419
An Elderly Woman With an Uncommon Cause of Dysphagia. Esophageal Leukoplakia.
Al-Bawardy B, Said SM, Iyer P
Gastroenterology 2015 Sep;149(3):e9-10. Epub 2015 Jul 29 doi: 10.1053/j.gastro.2014.12.052. PMID: 26226586
Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients.
Singhi AD, Arnold CA, Crowder CD, Lam-Himlin DM, Voltaggio L, Montgomery EA
Mod Pathol 2014 Jan;27(1):38-43. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.100. PMID: 23765246

Therapy

An Elderly Woman With an Uncommon Cause of Dysphagia. Esophageal Leukoplakia.
Al-Bawardy B, Said SM, Iyer P
Gastroenterology 2015 Sep;149(3):e9-10. Epub 2015 Jul 29 doi: 10.1053/j.gastro.2014.12.052. PMID: 26226586
Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients.
Singhi AD, Arnold CA, Crowder CD, Lam-Himlin DM, Voltaggio L, Montgomery EA
Mod Pathol 2014 Jan;27(1):38-43. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.100. PMID: 23765246

Prognosis

Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients.
Singhi AD, Arnold CA, Crowder CD, Lam-Himlin DM, Voltaggio L, Montgomery EA
Mod Pathol 2014 Jan;27(1):38-43. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.100. PMID: 23765246

Clinical prediction guides

Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients.
Singhi AD, Arnold CA, Crowder CD, Lam-Himlin DM, Voltaggio L, Montgomery EA
Mod Pathol 2014 Jan;27(1):38-43. Epub 2013 Jun 14 doi: 10.1038/modpathol.2013.100. PMID: 23765246

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