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Eosinophilic colitis

MedGen UID:
75633
Concept ID:
C0267448
Disease or Syndrome
Synonyms: Colonic eosinophilia; Eosinophilic Colitis; eosinophilic colitis; Eosinophilic infiltration in the colon
SNOMED CT: Eosinophilic colitis (29120000)
 
HPO: HP:0031813
Monarch Initiative: MONDO:0018439
Orphanet: ORPHA402035

Definition

An excess of eosinophilic cells in colonic tissue, i.e., eosinophilic infiltration in the colon. [from HPO]

Term Hierarchy

Conditions with this feature

Immunodeficiency 11b with atopic dermatitis
MedGen UID:
1627819
Concept ID:
C4539957
Disease or Syndrome
IMD11B is an autosomal dominant disorder of immune dysfunction characterized by onset of moderate to severe atopic dermatitis in early childhood. Some patients may have recurrent infections and other variable immune abnormalities. Laboratory studies show defects in T-cell activation, increased IgE, and eosinophilia (summary by Ma et al., 2017).
Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease
MedGen UID:
1618052
Concept ID:
C4540232
Disease or Syndrome
Immunodeficiency-71 with inflammatory disease and congenital thrombocytopenia (IMD71) is an autosomal recessive immunologic disorder characterized by the onset of recurrent infections and inflammatory features such as vasculitis and eczema in infancy or early childhood. Infectious agents include bacteria and viruses. Laboratory findings are variable, but usually show thrombocytopenia, sometimes with abnormal platelet morphology, increased serum IgE, IgA, or IgM, leukocytosis, decreased or increased T lymphocytes, and increased eosinophils. Detailed studies show impaired neutrophil and T-cell chemotaxis, as well as impaired T-cell activation due to defects in F-actin (see 102610) polymerization (summary by Brigida et al., 2018).
Autoinflammation, immune dysregulation, and eosinophilia
MedGen UID:
1750270
Concept ID:
C5436572
Disease or Syndrome
Autoinflammation, immune dysregulation, and eosinophilia (AIIDE) is an autosomal dominant disorder characterized by onset of severe atopic dermatitis and chronic gastrointestinal inflammation, mainly involving the colon, in infancy or early childhood. Affected individuals tend to have asthma and food or environmental allergies, as well as poor overall growth with short stature. Severe liver involvement has also been reported (Takeichi et al., 2021). Laboratory studies show increased eosinophils with normal or increased IgE levels, as well as evidence of a hyperactive immune state, including increased erythrocyte sedimentation rate and C-reactive protein. Treatment with JAK inhibitors, such as ruxolitinib and tofacitinib, results in dramatic clinical improvement (summary by Gruber et al., 2020).

Professional guidelines

PubMed

Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, Attwood SE, Auth MKH, Bailey DD, Biederman L, Blanchard C, Bonis PA, Bose P, Bredenoord AJ, Chang JW, Chehade M, Collins MH, Di Lorenzo C, Dias JA, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox AT, Genta RM, Greuter T, Gupta SK, Hirano I, Hiremath GS, Horsley-Silva JL, Ishihara S, Ishimura N, Jensen ET, Gutiérrez-Junquera C, Katzka DA, Khoury P, Kinoshita Y, Kliewer KL, Koletzko S, Leung J, Liacouras CA, Lucendo AJ, Martin LJ, McGowan EC, Menard-Katcher C, Metz DC, Miller TL, Moawad FJ, Muir AB, Mukkada VA, Murch S, Nhu QM, Nomura I, Nurko S, Ohtsuka Y, Oliva S, Orel R, Papadopoulou A, Patel DA, Pesek RD, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Ruffner MA, Safroneeva E, Schreiner P, Schoepfer A, Schroeder SR, Shah N, Souza RF, Spechler SJ, Spergel JM, Straumann A, Talley NJ, Thapar N, Vandenplas Y, Venkatesh RD, Vieira MC, von Arnim U, Walker MM, Wechsler JB, Wershil BK, Wright BL, Yamada Y, Yang GY, Zevit N, Rothenberg ME, Furuta GT, Aceves SS
Clin Gastroenterol Hepatol 2022 Nov;20(11):2474-2484.e3. Epub 2022 Feb 16 doi: 10.1016/j.cgh.2022.02.017. PMID: 35181570Free PMC Article
Hua S, Cook D, Walker MM, Talley NJ
Expert Rev Clin Pharmacol 2016 Sep;9(9):1195-209. Epub 2016 Jun 6 doi: 10.1080/17512433.2016.1190268. PMID: 27191032
Alfadda AA, Storr MA, Shaffer EA
Br Med Bull 2011;100:59-72. Epub 2011 Oct 19 doi: 10.1093/bmb/ldr045. PMID: 22012125

Recent clinical studies

Etiology

Shoda T, Taylor RJ, Sakai N, Rothenberg ME
J Allergy Clin Immunol 2024 Jun;153(6):1472-1484. Epub 2024 Mar 28 doi: 10.1016/j.jaci.2024.03.013. PMID: 38555071Free PMC Article
Papadopoulou A, Amil-Dias J, Auth MK, Chehade M, Collins MH, Gupta SK, Gutiérrez-Junquera C, Orel R, Vieira MC, Zevit N, Atkins D, Bredenoord AJ, Carneiro F, Dellon ES, Gonsalves N, Menard-Katcher C, Koletzko S, Liacouras C, Marderfeld L, Oliva S, Ohtsuka Y, Rothenberg ME, Strauman A, Thapar N, Yang GY, Furuta GT
J Pediatr Gastroenterol Nutr 2024 Jan;78(1):122-152. Epub 2023 Jul 4 doi: 10.1097/MPG.0000000000003877. PMID: 38291684
Marasco G, Visaggi P, Vassallo M, Fiocca M, Cremon C, Barbaro MR, De Bortoli N, Bellini M, Stanghellini V, Savarino EV, Barbara G
Int J Mol Sci 2023 Oct 13;24(20) doi: 10.3390/ijms242015165. PMID: 37894846Free PMC Article
Licari A, Votto M, D'Auria E, Castagnoli R, Caimmi SME, Marseglia GL
Curr Pediatr Rev 2020;16(2):106-114. doi: 10.2174/1573396315666191022154432. PMID: 31642786
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439

Diagnosis

Dellon ES, Gonsalves N, Abonia JP, Alexander JA, Arva NC, Atkins D, Attwood SE, Auth MKH, Bailey DD, Biederman L, Blanchard C, Bonis PA, Bose P, Bredenoord AJ, Chang JW, Chehade M, Collins MH, Di Lorenzo C, Dias JA, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox AT, Genta RM, Greuter T, Gupta SK, Hirano I, Hiremath GS, Horsley-Silva JL, Ishihara S, Ishimura N, Jensen ET, Gutiérrez-Junquera C, Katzka DA, Khoury P, Kinoshita Y, Kliewer KL, Koletzko S, Leung J, Liacouras CA, Lucendo AJ, Martin LJ, McGowan EC, Menard-Katcher C, Metz DC, Miller TL, Moawad FJ, Muir AB, Mukkada VA, Murch S, Nhu QM, Nomura I, Nurko S, Ohtsuka Y, Oliva S, Orel R, Papadopoulou A, Patel DA, Pesek RD, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Ruffner MA, Safroneeva E, Schreiner P, Schoepfer A, Schroeder SR, Shah N, Souza RF, Spechler SJ, Spergel JM, Straumann A, Talley NJ, Thapar N, Vandenplas Y, Venkatesh RD, Vieira MC, von Arnim U, Walker MM, Wechsler JB, Wershil BK, Wright BL, Yamada Y, Yang GY, Zevit N, Rothenberg ME, Furuta GT, Aceves SS
Clin Gastroenterol Hepatol 2022 Nov;20(11):2474-2484.e3. Epub 2022 Feb 16 doi: 10.1016/j.cgh.2022.02.017. PMID: 35181570Free PMC Article
Chen PH, Anderson L, Zhang K, Weiss GA
Curr Gastroenterol Rep 2021 Jul 30;23(8):13. doi: 10.1007/s11894-021-00809-2. PMID: 34331146
Giudici G, Ribaldone DG, Astegiano M, Saracco GM, Pellicano R
Minerva Gastroenterol Dietol 2020 Jun;66(2):157-163. Epub 2020 Jan 28 doi: 10.23736/S1121-421X.20.02656-2. PMID: 31994372
Impellizzeri G, Marasco G, Eusebi LH, Salfi N, Bazzoli F, Zagari RM
Dig Liver Dis 2019 Jun;51(6):769-773. Epub 2019 May 20 doi: 10.1016/j.dld.2019.04.011. PMID: 31122823
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439

Therapy

Marasco G, Visaggi P, Vassallo M, Fiocca M, Cremon C, Barbaro MR, De Bortoli N, Bellini M, Stanghellini V, Savarino EV, Barbara G
Int J Mol Sci 2023 Oct 13;24(20) doi: 10.3390/ijms242015165. PMID: 37894846Free PMC Article
Dellon ES, Spergel JM
Ann Allergy Asthma Immunol 2023 Jan;130(1):21-27. Epub 2022 Jun 20 doi: 10.1016/j.anai.2022.06.015. PMID: 35738437Free PMC Article
Chen PH, Anderson L, Zhang K, Weiss GA
Curr Gastroenterol Rep 2021 Jul 30;23(8):13. doi: 10.1007/s11894-021-00809-2. PMID: 34331146
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439
Zhang M, Li Y
J Gastroenterol Hepatol 2017 Jan;32(1):64-72. doi: 10.1111/jgh.13463. PMID: 27253425

Prognosis

Licari A, Votto M, D'Auria E, Castagnoli R, Caimmi SME, Marseglia GL
Curr Pediatr Rev 2020;16(2):106-114. doi: 10.2174/1573396315666191022154432. PMID: 31642786
Walker MM, Potter MD, Talley NJ
Curr Opin Gastroenterol 2019 Jan;35(1):42-50. doi: 10.1097/MOG.0000000000000492. PMID: 30480590
Dionísio de Sousa IJ, Bonito N, Pais A, Gervásio H
BMJ Case Rep 2016 Mar 8;2016 doi: 10.1136/bcr-2016-214496. PMID: 26957036Free PMC Article
Mogilevski T, Nickless D, Hume S
BMJ Case Rep 2015 Jun 23;2015 doi: 10.1136/bcr-2014-206964. PMID: 26106168Free PMC Article
Yen EF, Pardi DS
Best Pract Res Clin Gastroenterol 2012 Oct;26(5):611-22. doi: 10.1016/j.bpg.2012.11.012. PMID: 23384806

Clinical prediction guides

Allen-Brady K, Colletier KJ, Woller S, Eliason K, Uchida AM, Ro G, Newman M, Peterson KA
Am J Gastroenterol 2023 Feb 1;118(2):263-268. Epub 2022 Sep 21 doi: 10.14309/ajg.0000000000002021. PMID: 36148824Free PMC Article
Shoda T, Collins MH, Rochman M, Wen T, Caldwell JM, Mack LE, Osswald GA, Besse JA, Haberman Y, Aceves SS, Arva NC, Capocelli KE, Chehade M, Davis CM, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Khoury P, Klion A, Menard-Katcher C, Leung J, Mukkada VA, Putnam PE, Spergel JM, Wechsler JB, Yang GY, Furuta GT, Denson LA, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Diseases Researchers (CEGIR)
Gastroenterology 2022 May;162(6):1635-1649. Epub 2022 Jan 25 doi: 10.1053/j.gastro.2022.01.022. PMID: 35085569Free PMC Article
Raffaele A, Vatta F, Votto M, Licari A, Ruffoli M, Brunero M, Marseglia G, Riccipetitoni G
Pediatr Surg Int 2021 Apr;37(4):485-490. Epub 2021 Jan 7 doi: 10.1007/s00383-020-04832-8. PMID: 33409540
Caviglia GP, Ribaldone DG, Rosso C, Saracco GM, Astegiano M, Pellicano R
Panminerva Med 2018 Mar;60(1):29-34. Epub 2018 Jan 25 doi: 10.23736/S0031-0808.18.03405-5. PMID: 29370679
Liszka Ł, Woszczyk D, Pajak J
J Gastroenterol Hepatol 2006 May;21(5):792-7. doi: 10.1111/j.1440-1746.2006.04332.x. PMID: 16704525

Recent systematic reviews

Lima RV, Muniz MCR, Barroso LL, Pinheiro MCA, Matos YMT, Nogueira SBR, Nogueira HBR
Pediatr Allergy Immunol 2024 Apr;35(4):e14122. doi: 10.1111/pai.14122. PMID: 38581140
Bel Imam M, Stikas CV, Guha P, Chawes BL, Chu D, Greenhawt M, Khaleva E, Munblit D, Nekliudov N, van de Veen W, Schoos AM; Core Outcome Measures for Food Allergy (COMFA) consortium
Clin Exp Allergy 2023 May;53(5):526-535. Epub 2023 Mar 7 doi: 10.1111/cea.14304. PMID: 36880564
Lecouffe-Desprets M, Groh M, Bour B, Le Jeunne C, Puéchal X
Joint Bone Spine 2016 Oct;83(5):479-84. Epub 2015 Dec 19 doi: 10.1016/j.jbspin.2015.11.006. PMID: 26709253

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