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Thyroid Gland Undifferentiated Small Cell Carcinoma

MedGen UID:
75882
•Concept ID:
C0278860
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Undifferentiated Small Cell Carcinoma

Professional guidelines

PubMed

Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas.
Bishop JA, Alaggio R, Zhang L, Seethala RR, Antonescu CR
Am J Surg Pathol 2015 Sep;39(9):1267-74. doi: 10.1097/PAS.0000000000000460. PMID: 26034869Free PMC Article

Recent clinical studies

Etiology

Primary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa).
Zhang L, Lubin D, Sinard JH, Dickson BC, Antonescu CR, Wu H, Panni RZ, Dogan S, Untch BR, Ghossein RA, Xu B
Head Neck Pathol 2022 Sep;16(3):716-727. Epub 2022 Feb 26 doi: 10.1007/s12105-022-01428-7. PMID: 35218514Free PMC Article
Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the united states during 1996. U.S. and German Thyroid Cancer Study Group. An American College of Surgeons Commission on Cancer Patient Care Evaluation study.
Hundahl SA, Cady B, Cunningham MP, Mazzaferri E, McKee RF, Rosai J, Shah JP, Fremgen AM, Stewart AK, Hölzer S
Cancer 2000 Jul 1;89(1):202-17. doi: 10.1002/1097-0142(20000701)89:1<202::aid-cncr27>3.0.co;2-a. PMID: 10897019
Clinical significance of cytogenetic findings in solid tumors.
Mitelman F, Johansson B, Mandahl N, Mertens F
Cancer Genet Cytogenet 1997 May;95(1):1-8. doi: 10.1016/s0165-4608(96)00252-x. PMID: 9140447
Small cell undifferentiated carcinoma of the larynx. Report of two patients and review of 13 additional cases.
Mills SE, Cooper PH, Garland TA, Johns ME
Cancer 1983 Jan 1;51(1):116-20. doi: 10.1002/1097-0142(19830101)51:1<116::aid-cncr2820510123>3.0.co;2-a. PMID: 6295589

Diagnosis

Primary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa).
Zhang L, Lubin D, Sinard JH, Dickson BC, Antonescu CR, Wu H, Panni RZ, Dogan S, Untch BR, Ghossein RA, Xu B
Head Neck Pathol 2022 Sep;16(3):716-727. Epub 2022 Feb 26 doi: 10.1007/s12105-022-01428-7. PMID: 35218514Free PMC Article
Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas.
Bishop JA, Alaggio R, Zhang L, Seethala RR, Antonescu CR
Am J Surg Pathol 2015 Sep;39(9):1267-74. doi: 10.1097/PAS.0000000000000460. PMID: 26034869Free PMC Article
Clinical significance of cytogenetic findings in solid tumors.
Mitelman F, Johansson B, Mandahl N, Mertens F
Cancer Genet Cytogenet 1997 May;95(1):1-8. doi: 10.1016/s0165-4608(96)00252-x. PMID: 9140447
Small cell carcinoma of the thyroid. A reclassification of cases originally diagnosed as small cell carcinomas of the thyroid.
Schmid KW, Kröll M, Hofstädter F, Ladurner D
Pathol Res Pract 1986 Oct;181(5):540-3. doi: 10.1016/S0344-0338(86)80146-7. PMID: 3024138
Small cell undifferentiated carcinoma of the larynx. Report of two patients and review of 13 additional cases.
Mills SE, Cooper PH, Garland TA, Johns ME
Cancer 1983 Jan 1;51(1):116-20. doi: 10.1002/1097-0142(19830101)51:1<116::aid-cncr2820510123>3.0.co;2-a. PMID: 6295589

Therapy

Reversine, a 2,6-disubstituted purine, as an anti-cancer agent in differentiated and undifferentiated thyroid cancer cells.
Hua SC, Chang TC, Chen HR, Lu CH, Liu YW, Chen SH, Yu HI, Chang YP, Lee YR
Pharm Res 2012 Jul;29(7):1990-2005. Epub 2012 Apr 4 doi: 10.1007/s11095-012-0727-3. PMID: 22477067

Prognosis

Usefulness of S100A9 for diagnosis of intrathyroid epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE).
Ito Y, Miyauchi A, Arai K, Nozawa R, Miya A, Kobayashi K, Nakamura Y, Kakudo K
Pathology 2006 Dec;38(6):541-4. doi: 10.1080/00313020601024086. PMID: 17393982
Use of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens.
Chhieng DC, Cangiarella JF, Zakowski MF, Goswami S, Cohen JM, Yee HT
Cancer 2001 Oct 25;93(5):330-6. doi: 10.1002/cncr.9048. PMID: 11668468
Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the united states during 1996. U.S. and German Thyroid Cancer Study Group. An American College of Surgeons Commission on Cancer Patient Care Evaluation study.
Hundahl SA, Cady B, Cunningham MP, Mazzaferri E, McKee RF, Rosai J, Shah JP, Fremgen AM, Stewart AK, Hölzer S
Cancer 2000 Jul 1;89(1):202-17. doi: 10.1002/1097-0142(20000701)89:1<202::aid-cncr27>3.0.co;2-a. PMID: 10897019
Clinical significance of cytogenetic findings in solid tumors.
Mitelman F, Johansson B, Mandahl N, Mertens F
Cancer Genet Cytogenet 1997 May;95(1):1-8. doi: 10.1016/s0165-4608(96)00252-x. PMID: 9140447
Small cell undifferentiated carcinoma of the larynx. Report of two patients and review of 13 additional cases.
Mills SE, Cooper PH, Garland TA, Johns ME
Cancer 1983 Jan 1;51(1):116-20. doi: 10.1002/1097-0142(19830101)51:1<116::aid-cncr2820510123>3.0.co;2-a. PMID: 6295589

Clinical prediction guides

Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas.
Bishop JA, Alaggio R, Zhang L, Seethala RR, Antonescu CR
Am J Surg Pathol 2015 Sep;39(9):1267-74. doi: 10.1097/PAS.0000000000000460. PMID: 26034869Free PMC Article
Usefulness of S100A9 for diagnosis of intrathyroid epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE).
Ito Y, Miyauchi A, Arai K, Nozawa R, Miya A, Kobayashi K, Nakamura Y, Kakudo K
Pathology 2006 Dec;38(6):541-4. doi: 10.1080/00313020601024086. PMID: 17393982
Use of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens.
Chhieng DC, Cangiarella JF, Zakowski MF, Goswami S, Cohen JM, Yee HT
Cancer 2001 Oct 25;93(5):330-6. doi: 10.1002/cncr.9048. PMID: 11668468
Neuroendocrine carcinoma of the paranasal sinus: a morphological and endocrinological study.
Kameya T, Shimosato Y, Adachi I, Abe K, Ebihara S, Ono I
Cancer 1980 Jan 15;45(2):330-9. doi: 10.1002/1097-0142(19800115)45:2<330::aid-cncr2820450222>3.0.co;2-s. PMID: 6243246

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