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Small size posterior uveal melanoma

MedGen UID:
75883
•Concept ID:
C0278867
•
Neoplastic Process
Synonyms: Small Size Ciliary Body and Choroid Melanoma; Small Size Posterior Uveal Melanoma; small size posterior uveal melanoma
 
Monarch Initiative: MONDO:0024863

Definition

Ciliary body and choroid melanoma measuring less than 10 mm in greatest diameter. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall size posterior uveal melanoma

Professional guidelines

PubMed

In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal melanoma.
Cimino C, Sánchez López E, Bonaccorso A, Bonilla L, Musumeci T, Badia J, Baldomà L, Pignatello R, Marrazzo A, Barbaraci C, García ML, Carbone C
Int J Pharm 2024 Jul 20;660:124300. Epub 2024 Jun 6 doi: 10.1016/j.ijpharm.2024.124300. PMID: 38851409
Impact of delayed treatment in growing posterior uveal melanomas.
Augsburger JJ, Vrabec TR
Arch Ophthalmol 1993 Oct;111(10):1382-6. doi: 10.1001/archopht.1993.01090100090033. PMID: 8216019

Recent clinical studies

Etiology

Surgical Technique, Indications, and Outcomes of BIOM-Assisted Transvitreal Biopsy for Uveal Melanoma.
Snyder LL, Daniels AB
Retina 2022 Nov 1;42(11):2229-2235. Epub 2019 Dec 5 doi: 10.1097/IAE.0000000000002677. PMID: 31815876Free PMC Article
Ruthenium brachytherapy for uveal melanomas: Factors affecting the development of radiation complications.
Pagliara MM, Tagliaferri L, Azario L, Lenkowicz J, Lanza A, Autorino R, Caputo CG, Gambacorta MA, Valentini V, Blasi MA
Brachytherapy 2018 Mar-Apr;17(2):432-438. Epub 2017 Dec 21 doi: 10.1016/j.brachy.2017.11.004. PMID: 29275868
Comparison of Alternative Tumor Size Classifications for Posterior Uveal Melanomas.
Skinner CC, Augsburger JJ, Augsburger BD, Correa ZM
Invest Ophthalmol Vis Sci 2017 Jul 1;58(9):3335-3342. doi: 10.1167/iovs.16-20465. PMID: 28672400
Posterior uveal melanoma. Distribution of the sites of origin and patterns of tumour extent in the ocular fundus.
Krohn J, Frøystein T, Dahl O
Br J Ophthalmol 2008 Jun;92(6):751-6. doi: 10.1136/bjo.2007.133025. PMID: 18523080
Changes in ultrasound findings in posterior uveal melanoma after Ruthenium 106 brachytherapy.
Kaiserman I, Anteby I, Chowers I, Blumenthal EZ, Kliers I, Pe'er J
Ophthalmology 2002 Jun;109(6):1137-41. doi: 10.1016/s0161-6420(02)01054-0. PMID: 12045056

Diagnosis

Postoperative Echography for Optimization of Radiation Dosimetry in Patients with Uveal Melanoma Treated with Plaque Brachytherapy.
Binkley EM, King BA, Hyer DE, Javed A, Milhem MM, Hinz CJ, Mott SL, Boldt HC
Ophthalmol Retina 2023 Jul;7(7):620-627. Epub 2023 Feb 21 doi: 10.1016/j.oret.2023.02.010. PMID: 36822323
Surgical Technique, Indications, and Outcomes of BIOM-Assisted Transvitreal Biopsy for Uveal Melanoma.
Snyder LL, Daniels AB
Retina 2022 Nov 1;42(11):2229-2235. Epub 2019 Dec 5 doi: 10.1097/IAE.0000000000002677. PMID: 31815876Free PMC Article
Intraocular leiomyoma: Current concepts.
Tomar AS, Finger PT, Iacob CE
Surv Ophthalmol 2020 Jul-Aug;65(4):421-437. Epub 2020 Jan 7 doi: 10.1016/j.survophthal.2019.12.008. PMID: 31923479

Therapy

Efficient inhibition of uveal melanoma via ternary siRNA complexes.
Xie L, Yang Y, Shen J
Int J Pharm 2020 Jan 5;573:118894. Epub 2019 Nov 23 doi: 10.1016/j.ijpharm.2019.118894. PMID: 31765784Free PMC Article
Ruthenium brachytherapy for uveal melanomas: Factors affecting the development of radiation complications.
Pagliara MM, Tagliaferri L, Azario L, Lenkowicz J, Lanza A, Autorino R, Caputo CG, Gambacorta MA, Valentini V, Blasi MA
Brachytherapy 2018 Mar-Apr;17(2):432-438. Epub 2017 Dec 21 doi: 10.1016/j.brachy.2017.11.004. PMID: 29275868
(106)Ru plaque brachytherapy for uveal melanoma: factors associated with local tumor recurrence.
Barker CA, Francis JH, Cohen GN, Marr BP, Wolden SL, McCormick B, Abramson DH
Brachytherapy 2014 Nov-Dec;13(6):584-90. Epub 2014 May 28 doi: 10.1016/j.brachy.2014.04.002. PMID: 24880583Free PMC Article
Ruthenium brachytherapy for uveal melanoma, 1979-2003: survival and functional outcomes in the Swedish population.
Bergman L, Nilsson B, Lundell G, Lundell M, Seregard S
Ophthalmology 2005 May;112(5):834-40. doi: 10.1016/j.ophtha.2004.11.038. PMID: 15878063
Changes in ultrasound findings in posterior uveal melanoma after Ruthenium 106 brachytherapy.
Kaiserman I, Anteby I, Chowers I, Blumenthal EZ, Kliers I, Pe'er J
Ophthalmology 2002 Jun;109(6):1137-41. doi: 10.1016/s0161-6420(02)01054-0. PMID: 12045056

Prognosis

Surgical Technique, Indications, and Outcomes of BIOM-Assisted Transvitreal Biopsy for Uveal Melanoma.
Snyder LL, Daniels AB
Retina 2022 Nov 1;42(11):2229-2235. Epub 2019 Dec 5 doi: 10.1097/IAE.0000000000002677. PMID: 31815876Free PMC Article
Intraocular leiomyoma: Current concepts.
Tomar AS, Finger PT, Iacob CE
Surv Ophthalmol 2020 Jul-Aug;65(4):421-437. Epub 2020 Jan 7 doi: 10.1016/j.survophthal.2019.12.008. PMID: 31923479
Comparison of Alternative Tumor Size Classifications for Posterior Uveal Melanomas.
Skinner CC, Augsburger JJ, Augsburger BD, Correa ZM
Invest Ophthalmol Vis Sci 2017 Jul 1;58(9):3335-3342. doi: 10.1167/iovs.16-20465. PMID: 28672400
Ruthenium brachytherapy for uveal melanoma, 1979-2003: survival and functional outcomes in the Swedish population.
Bergman L, Nilsson B, Lundell G, Lundell M, Seregard S
Ophthalmology 2005 May;112(5):834-40. doi: 10.1016/j.ophtha.2004.11.038. PMID: 15878063
Changes in ultrasound findings in posterior uveal melanoma after Ruthenium 106 brachytherapy.
Kaiserman I, Anteby I, Chowers I, Blumenthal EZ, Kliers I, Pe'er J
Ophthalmology 2002 Jun;109(6):1137-41. doi: 10.1016/s0161-6420(02)01054-0. PMID: 12045056

Clinical prediction guides

Ruthenium brachytherapy for uveal melanomas: Factors affecting the development of radiation complications.
Pagliara MM, Tagliaferri L, Azario L, Lenkowicz J, Lanza A, Autorino R, Caputo CG, Gambacorta MA, Valentini V, Blasi MA
Brachytherapy 2018 Mar-Apr;17(2):432-438. Epub 2017 Dec 21 doi: 10.1016/j.brachy.2017.11.004. PMID: 29275868
(106)Ru plaque brachytherapy for uveal melanoma: factors associated with local tumor recurrence.
Barker CA, Francis JH, Cohen GN, Marr BP, Wolden SL, McCormick B, Abramson DH
Brachytherapy 2014 Nov-Dec;13(6):584-90. Epub 2014 May 28 doi: 10.1016/j.brachy.2014.04.002. PMID: 24880583Free PMC Article
Posterior uveal melanoma. Distribution of the sites of origin and patterns of tumour extent in the ocular fundus.
Krohn J, Frøystein T, Dahl O
Br J Ophthalmol 2008 Jun;92(6):751-6. doi: 10.1136/bjo.2007.133025. PMID: 18523080
Ruthenium brachytherapy for uveal melanoma, 1979-2003: survival and functional outcomes in the Swedish population.
Bergman L, Nilsson B, Lundell G, Lundell M, Seregard S
Ophthalmology 2005 May;112(5):834-40. doi: 10.1016/j.ophtha.2004.11.038. PMID: 15878063
Changes in ultrasound findings in posterior uveal melanoma after Ruthenium 106 brachytherapy.
Kaiserman I, Anteby I, Chowers I, Blumenthal EZ, Kliers I, Pe'er J
Ophthalmology 2002 Jun;109(6):1137-41. doi: 10.1016/s0161-6420(02)01054-0. PMID: 12045056

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