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Adult Acute Monoblastic Leukemia

MedGen UID:
76004
•Concept ID:
C0279629
•
Neoplastic Process
Synonyms: Adult Acute M5a Leukemia; M5a Adult Acute Leukemia; M5a Adult Acute Poorly Differentiated Monoblastic Leukemia

Definition

An acute monoblastic leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Monoblastic Leukemia

Professional guidelines

PubMed

Myelomonocytic and monocytic acute myeloid leukemia demonstrate comparable poor outcomes with venetoclax-based treatment: a monocentric real-world study.
Zhao L, Yang J, Chen M, Xiang X, Ma H, Niu T, Gong Y, Chen X, Liu J, Wu Y
Ann Hematol 2024 Apr;103(4):1197-1209. Epub 2024 Feb 8 doi: 10.1007/s00277-024-05646-7. PMID: 38329487
Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions.
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Treatment of acute granulocytic leukemias.
Bernard J, Weil M, Jacquillat C
Annu Rev Med 1974;25:39-51. doi: 10.1146/annurev.me.25.020174.000351. PMID: 4596234

Recent clinical studies

Etiology

Expression of ERV3-1 in leukocytes of acute myelogenous leukemia patients.
Nakagawa S, Kawashima M, Miyatake Y, Kudo K, Kotaki R, Ando K, Kotani A
Gene 2021 Mar 20;773:145363. Epub 2020 Dec 16 doi: 10.1016/j.gene.2020.145363. PMID: 33338509
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Early mortality in acute myeloid leukemia.
Hahn A, Giri S, Yaghmour G, Martin MG
Leuk Res 2015 May;39(5):505-9. Epub 2015 Feb 9 doi: 10.1016/j.leukres.2015.02.003. PMID: 25726083
Immunophenotypic and molecular features of 'cuplike' acute myeloid leukemias.
Carluccio P, Mestice A, Pastore D, Delia M, Ricco A, Russo-Rossi A, Casieri P, Liso A, Martelli MP, Albano F, Specchia G
Eur J Haematol 2014 Feb;92(2):121-6. doi: 10.1111/ejh.12217. PMID: 24138595
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Gingival Infiltration in Acute Monocytic Leukemia.
Rogers E, Cusnir M
N Engl J Med 2022 Jan 6;386(1):79. doi: 10.1056/NEJMicm2113297. PMID: 34986288
Neutrophilic Eccrine Hidradenitis.
Beatty CJ, Ghareeb ER
N Engl J Med 2021 Aug 5;385(6):e19. doi: 10.1056/NEJMicm2101571. PMID: 34347955
Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.
Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT
Cancer Discov 2020 Apr;10(4):536-551. Epub 2020 Jan 23 doi: 10.1158/2159-8290.CD-19-0710. PMID: 31974170Free PMC Article
Fever.
Kysia RF, Brown DF, Nadel ES
J Emerg Med 2004 Nov;27(4):407-10. doi: 10.1016/j.jemermed.2004.08.001. PMID: 15498623
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Therapy

Neutrophilic Eccrine Hidradenitis.
Beatty CJ, Ghareeb ER
N Engl J Med 2021 Aug 5;385(6):e19. doi: 10.1056/NEJMicm2101571. PMID: 34347955
Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.
Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT
Cancer Discov 2020 Apr;10(4):536-551. Epub 2020 Jan 23 doi: 10.1158/2159-8290.CD-19-0710. PMID: 31974170Free PMC Article
Aleukemic monocytic leukemia cutis.
Barzilai A, Lyakhovitsky A, Goldberg I, Meytes D, Trau H
Cutis 2002 Apr;69(4):301-4. PMID: 12080951
Aleukemic leukemia cutis.
Ohno S, Yokoo T, Ohta M, Yamamoto M, Danno K, Hamato N, Tomii K, Ohno Y, Kobashi Y
J Am Acad Dermatol 1990 Feb;22(2 Pt 2):374-7. doi: 10.1016/0190-9622(90)70052-j. PMID: 2406302
Tn polyagglutination preceding acute leukemia.
Ness PM, Garratty G, Morel PA, Perkins HA
Blood 1979 Jul;54(1):30-4. PMID: 286607

Prognosis

Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Early mortality in acute myeloid leukemia.
Hahn A, Giri S, Yaghmour G, Martin MG
Leuk Res 2015 May;39(5):505-9. Epub 2015 Feb 9 doi: 10.1016/j.leukres.2015.02.003. PMID: 25726083
Leukemia cutis.
Miyoshi I, Uemura Y, Sonobe H, Taguchi H
Intern Med 2007;46(1):65-6. Epub 2007 Jan 1 doi: 10.2169/internalmedicine.46.6232. PMID: 17202740
Polysomy 8 defines a clinico-cytogenetic entity representing a subset of myeloid hematologic malignancies associated with a poor prognosis: report on a cohort of 12 patients and review of 105 published cases.
Beyer V, Mühlematter D, Parlier V, Cabrol C, Bougeon-Mamin S, Solenthaler M, Tobler A, Pugin P, Gregor M, Hitz F, Hess U, Chapuis B, Laurencet F, Schanz U, Schmidt PM, van Melle G, Jotterand M
Cancer Genet Cytogenet 2005 Jul 15;160(2):97-119. doi: 10.1016/j.cancergencyto.2004.12.003. PMID: 15993266
Aleukemic monocytic leukemia cutis.
Barzilai A, Lyakhovitsky A, Goldberg I, Meytes D, Trau H
Cutis 2002 Apr;69(4):301-4. PMID: 12080951

Clinical prediction guides

Expression of ERV3-1 in leukocytes of acute myelogenous leukemia patients.
Nakagawa S, Kawashima M, Miyatake Y, Kudo K, Kotaki R, Ando K, Kotani A
Gene 2021 Mar 20;773:145363. Epub 2020 Dec 16 doi: 10.1016/j.gene.2020.145363. PMID: 33338509
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts.
Harrison JS, Wang X, Studzinski GP
Oncotarget 2016 Jun 14;7(24):36447-36460. doi: 10.18632/oncotarget.8998. PMID: 27144333Free PMC Article
Early mortality in acute myeloid leukemia.
Hahn A, Giri S, Yaghmour G, Martin MG
Leuk Res 2015 May;39(5):505-9. Epub 2015 Feb 9 doi: 10.1016/j.leukres.2015.02.003. PMID: 25726083
Leukaemia in benzene workers.
Infante PF, Rinsky RA, Wagoner JK, Young RJ
Lancet 1977 Jul 9;2(8028):76-8. doi: 10.1016/s0140-6736(77)90074-5. PMID: 69157

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