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Malignant Type B1 Thymoma

MedGen UID:
76019
•Concept ID:
C0279704
•
Neoplastic Process
Synonyms: Thymoma, lymphocyte-rich, malignant; Thymoma, lymphocytic, malignant; Thymoma, organoid, malignant; Thymoma, predominantly cortical, malignant; Thymoma, type B1, malignant
SNOMED CT: Thymoma, predominantly cortical, malignant (128712002); Thymoma, organoid, malignant (128712002); Thymoma, lymphocytic, malignant (128712002); Thymoma, lymphocyte-rich, malignant (128712002); Thymoma, type B1, malignant (128712002)

Definition

A type B1 thymoma which is characterized by an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Type B1 Thymoma

Professional guidelines

PubMed

A Recurrence Predictive Model for Thymic Tumors and Its Implication for Postoperative Management: a Chinese Alliance for Research in Thymomas Database Study.
Liu H, Gu Z, Qiu B, Detterbeck FC, Roden AC, Ruffini E, Okumura M, Girard N, Xiang Y, Liu Y, Du Z, Hao Y, Fu J, Zhang P, Pang L, Chen K, Wang Y, Yu Z, Mao T, Fang W; AME Thoracic Surgery Cooperative Group
J Thorac Oncol 2020 Mar;15(3):448-456. Epub 2019 Nov 11 doi: 10.1016/j.jtho.2019.10.018. PMID: 31726106
Systemic treatment of advanced thymic malignancies.
Kelly RJ
Am Soc Clin Oncol Educ Book 2014:e367-73. doi: 10.14694/EdBook_AM.2014.34.e367. PMID: 24857125
ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting.
Marx A, Ströbel P, Badve SS, Chalabreysse L, Chan JK, Chen G, de Leval L, Detterbeck F, Girard N, Huang J, Kurrer MO, Lauriola L, Marino M, Matsuno Y, Molina TJ, Mukai K, Nicholson AG, Nonaka D, Rieker R, Rosai J, Ruffini E, Travis WD
J Thorac Oncol 2014 May;9(5):596-611. doi: 10.1097/JTO.0000000000000154. PMID: 24722150

Recent clinical studies

Etiology

Histological Classification and Invasion Prediction of Thymoma by Machine Learning-Based Computed Tomography Imaging.
Wang D, Zhang Y, Li B, Zhuang Q, Zhang X, Lin D
Contrast Media Mol Imaging 2022;2022:4594757. Epub 2022 Aug 5 doi: 10.1155/2022/4594757. PMID: 36051922Free PMC Article
Right Epipericardial Fat Necrosis After Thymectomy.
Utsumi T, Saito T, Honda O, Ishida M, Maru N, Matsui H, Taniguchi Y, Hino H, Murakawa T
Ann Thorac Surg 2022 Apr;113(4):e259-e261. Epub 2021 Jun 29 doi: 10.1016/j.athoracsur.2021.06.013. PMID: 34214546
Systemic treatment of advanced thymic malignancies.
Kelly RJ
Am Soc Clin Oncol Educ Book 2014:e367-73. doi: 10.14694/EdBook_AM.2014.34.e367. PMID: 24857125
Ossifying thymoma clinically presenting with peripheral T-cell lymphocytosis.
Chen HK, Huang WT, Eng HL, Lu HI, Huang HY
Ann Thorac Surg 2009 Jul;88(1):e5-7. doi: 10.1016/j.athoracsur.2009.03.093. PMID: 19559177
Polymorphic markers in MHC class II/III region: a study on Italian patients with myasthenia gravis.
Franciotta D, Cuccia M, Dondi E, Piccolo G, Cosi V
J Neurol Sci 2001 Sep 15;190(1-2):11-6. doi: 10.1016/s0022-510x(01)00573-1. PMID: 11574100

Diagnosis

Initial Evaluation of [(18)F]FAPI-74 PET for Various Histopathologically Confirmed Cancers and Benign Lesions.
Watabe T, Naka S, Tatsumi M, Kamiya T, Kimura T, Shintani Y, Abe K, Miyake T, Shimazu K, Kobayashi S, Kurokawa Y, Eguchi H, Doki Y, Inohara H, Kato H, Mori Y, Cardinale J, Giesel FL
J Nucl Med 2023 Aug;64(8):1225-1231. Epub 2023 Jun 2 doi: 10.2967/jnumed.123.265486. PMID: 37268427Free PMC Article
Thymic Parenchymal Hyperplasia.
Suster D, Ronen N, Pierce DC, Suster S
Mod Pathol 2023 Aug;36(8):100207. Epub 2023 May 5 doi: 10.1016/j.modpat.2023.100207. PMID: 37149223
Right Epipericardial Fat Necrosis After Thymectomy.
Utsumi T, Saito T, Honda O, Ishida M, Maru N, Matsui H, Taniguchi Y, Hino H, Murakawa T
Ann Thorac Surg 2022 Apr;113(4):e259-e261. Epub 2021 Jun 29 doi: 10.1016/j.athoracsur.2021.06.013. PMID: 34214546
Ovarian Metastasis of a Thymoma: Report of a Case and Literature Review.
Martín-Hernández R, Villanueva MM, Sánchez MN, López EC
Int J Gynecol Pathol 2015 Jul;34(4):374-8. doi: 10.1097/PGP.0000000000000168. PMID: 26061071
Giant ossifying malignant thymoma in a child.
Bikhchandani J, Valusek PA, Juang D, E O'Brien J Jr, Hetherington M, St Peter SD
J Pediatr Surg 2010 Sep;45(9):e31-4. doi: 10.1016/j.jpedsurg.2010.06.021. PMID: 20850614

Therapy

A Phase 2 Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumors (KCSG LU17-21).
Jung HA, Kim M, Kim HS, Kim JH, Choi YH, Cho J, Park JH, Park KU, Ku BM, Park S, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ
J Thorac Oncol 2023 Feb;18(2):223-231. Epub 2022 Oct 25 doi: 10.1016/j.jtho.2022.10.008. PMID: 36307042
Right Epipericardial Fat Necrosis After Thymectomy.
Utsumi T, Saito T, Honda O, Ishida M, Maru N, Matsui H, Taniguchi Y, Hino H, Murakawa T
Ann Thorac Surg 2022 Apr;113(4):e259-e261. Epub 2021 Jun 29 doi: 10.1016/j.athoracsur.2021.06.013. PMID: 34214546
Systemic treatment of advanced thymic malignancies.
Kelly RJ
Am Soc Clin Oncol Educ Book 2014:e367-73. doi: 10.14694/EdBook_AM.2014.34.e367. PMID: 24857125
Giant ossifying malignant thymoma in a child.
Bikhchandani J, Valusek PA, Juang D, E O'Brien J Jr, Hetherington M, St Peter SD
J Pediatr Surg 2010 Sep;45(9):e31-4. doi: 10.1016/j.jpedsurg.2010.06.021. PMID: 20850614
Complete regression of a thymoma to glucocorticoids, commenced for palliation of symptoms.
Barratt S, Puthucheary ZA, Plummeridge M
Eur J Cardiothorac Surg 2007 Jun;31(6):1142-3. Epub 2007 Apr 3 doi: 10.1016/j.ejcts.2007.02.032. PMID: 17408959

Prognosis

Initial Evaluation of [(18)F]FAPI-74 PET for Various Histopathologically Confirmed Cancers and Benign Lesions.
Watabe T, Naka S, Tatsumi M, Kamiya T, Kimura T, Shintani Y, Abe K, Miyake T, Shimazu K, Kobayashi S, Kurokawa Y, Eguchi H, Doki Y, Inohara H, Kato H, Mori Y, Cardinale J, Giesel FL
J Nucl Med 2023 Aug;64(8):1225-1231. Epub 2023 Jun 2 doi: 10.2967/jnumed.123.265486. PMID: 37268427Free PMC Article
Unique correlation between GTF2I mutation and spindle cell morphology in thymomas (type A and AB thymomas).
Wells K, Lamrca A, Papaxoinis G, Wallace A, Quinn AM, Summers Y, Nonaka D
J Clin Pathol 2023 Jul;76(7):463-466. Epub 2022 Jan 17 doi: 10.1136/jclinpath-2021-207837. PMID: 35039450
Histological Classification and Invasion Prediction of Thymoma by Machine Learning-Based Computed Tomography Imaging.
Wang D, Zhang Y, Li B, Zhuang Q, Zhang X, Lin D
Contrast Media Mol Imaging 2022;2022:4594757. Epub 2022 Aug 5 doi: 10.1155/2022/4594757. PMID: 36051922Free PMC Article
Ossifying thymoma clinically presenting with peripheral T-cell lymphocytosis.
Chen HK, Huang WT, Eng HL, Lu HI, Huang HY
Ann Thorac Surg 2009 Jul;88(1):e5-7. doi: 10.1016/j.athoracsur.2009.03.093. PMID: 19559177
Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy.
de Jong WK, Blaauwgeers JL, Schaapveld M, Timens W, Klinkenberg TJ, Groen HJ
Eur J Cancer 2008 Jan;44(1):123-30. doi: 10.1016/j.ejca.2007.11.004. PMID: 18068351

Clinical prediction guides

A Phase 2 Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumors (KCSG LU17-21).
Jung HA, Kim M, Kim HS, Kim JH, Choi YH, Cho J, Park JH, Park KU, Ku BM, Park S, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ
J Thorac Oncol 2023 Feb;18(2):223-231. Epub 2022 Oct 25 doi: 10.1016/j.jtho.2022.10.008. PMID: 36307042
Histological Classification and Invasion Prediction of Thymoma by Machine Learning-Based Computed Tomography Imaging.
Wang D, Zhang Y, Li B, Zhuang Q, Zhang X, Lin D
Contrast Media Mol Imaging 2022;2022:4594757. Epub 2022 Aug 5 doi: 10.1155/2022/4594757. PMID: 36051922Free PMC Article
Characterization of molecular genetics and clinicopathology in thymic MALT lymphoma.
Wang X, Miao Y, Cao Z, Zheng S, Xue X, Feng X
Ann Hematol 2022 Jan;101(1):91-97. Epub 2021 Oct 4 doi: 10.1007/s00277-021-04671-0. PMID: 34605949
New onset of myasthenia gravis 10 years after proton beam therapy for thymoma.
Karasaki T, Murakawa T, Nagayama K, Nitadori J, Anraku M, Kikuchi Y, Shinozaki-Ushiku A, Igaki H, Nakajima J
Gen Thorac Cardiovasc Surg 2016 May;64(5):290-3. Epub 2014 Oct 10 doi: 10.1007/s11748-014-0484-9. PMID: 25301055
Thymic epithelial tumours: a population-based study of the incidence, diagnostic procedures and therapy.
de Jong WK, Blaauwgeers JL, Schaapveld M, Timens W, Klinkenberg TJ, Groen HJ
Eur J Cancer 2008 Jan;44(1):123-30. doi: 10.1016/j.ejca.2007.11.004. PMID: 18068351

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