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Adult Acute Myeloid Leukemia with Minimal Differentiation

MedGen UID:
76319
Concept ID:
C0281641
Neoplastic Process
Synonyms: Adult Acute M0 Leukemia; Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Myeloblastic Leukemia with Minimal Differentiation; Adult Acute Myelogenous Leukemia with Minimal Differentiation; Adult Acute Myeloid Leukemia Minimally Differentiated; M0 Adult Acute Leukemia; M0 Adult Acute Myeloblastic Leukemia; M0 Adult Acute Myeloblastic Leukemia with Minimal Differentiation; M0 Adult Acute Myelogenous Leukemia; M0 Adult Acute Myelogenous Leukemia with Minimal Differentiation; M0 Adult Acute Myeloid Leukemia with Minimal Differentiation; M0 Adult AML; M0 Adult ANLL

Definition

An acute myeloid leukemia with minimal differentiation occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Myeloid Leukemia with Minimal Differentiation

Professional guidelines

PubMed

Bai Y, Chen C, Guo X, Ding T, Yang X, Yu J, Yang J, Ruan J, Zheng X, Chen Z
Cancer Biomark 2020;29(1):125-137. doi: 10.3233/CBM-190899. PMID: 32568176
Boyer T, Gonzales F, Plesa A, Peyrouze P, Barthelemy A, Guihard S, Quesnel B, Roumier C, Preudhomme C, Cheok M
J Vis Exp 2018 Mar 26;(133) doi: 10.3791/56976. PMID: 29630051Free PMC Article
Lo-Coco F, Ammatuna E, Montesinos P, Sanz MA
Semin Oncol 2008 Aug;35(4):401-9. doi: 10.1053/j.seminoncol.2008.04.010. PMID: 18692690

Recent clinical studies

Etiology

Riether C
Front Immunol 2022;13:1049301. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.1049301. PMID: 36405718Free PMC Article
Lin P, Falini B
Am J Clin Pathol 2015 Jul;144(1):19-28. doi: 10.1309/AJCP97BJBEVZEUIN. PMID: 26071459
Lee H, Kim M, Lim J, Kim Y, Han K, Cho BS, Kim HJ
Int J Hematol 2013 Jun;97(6):808-12. Epub 2013 Apr 23 doi: 10.1007/s12185-013-1337-5. PMID: 23609419
Iland HJ, Bradstock K, Supple SG, Catalano A, Collins M, Hertzberg M, Browett P, Grigg A, Firkin F, Hugman A, Reynolds J, Di Iulio J, Tiley C, Taylor K, Filshie R, Seldon M, Taper J, Szer J, Moore J, Bashford J, Seymour JF; Australasian Leukaemia and Lymphoma Group
Blood 2012 Aug 23;120(8):1570-80; quiz 1752. Epub 2012 Jun 19 doi: 10.1182/blood-2012-02-410746. PMID: 22715121
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823

Diagnosis

Xie W, Raess PW, Dunlap J, Hoyos CM, Li H, Li P, Swords R, Olson SB, Yang F, Anekpuritanang T, Hu S, Wiszniewska J, Fan G, Press RD, Moore SR
Leuk Lymphoma 2022 Aug;63(8):1907-1916. Epub 2022 Mar 8 doi: 10.1080/10428194.2022.2047672. PMID: 35258401
Brown LE, Zhang D, Cui W
Ann Clin Lab Sci 2020 May;50(3):327-332. PMID: 32581021
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Lee H, Kim M, Lim J, Kim Y, Han K, Cho BS, Kim HJ
Int J Hematol 2013 Jun;97(6):808-12. Epub 2013 Apr 23 doi: 10.1007/s12185-013-1337-5. PMID: 23609419
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823

Therapy

Blombery P, Lew TE, Dengler MA, Thompson ER, Lin VS, Chen X, Nguyen T, Panigrahi A, Handunnetti SM, Carney DA, Westerman DA, Tam CS, Adams JM, Wei AH, Huang DCS, Seymour JF, Roberts AW, Anderson MA
Blood 2022 Feb 24;139(8):1198-1207. doi: 10.1182/blood.2021012775. PMID: 34469514
Bialek-Waldmann JK, Heuser M, Ganser A, Stripecke R
Cancer Immunol Immunother 2019 Nov;68(11):1891-1899. Epub 2019 Oct 18 doi: 10.1007/s00262-019-02406-9. PMID: 31628525Free PMC Article
Iland HJ, Bradstock K, Supple SG, Catalano A, Collins M, Hertzberg M, Browett P, Grigg A, Firkin F, Hugman A, Reynolds J, Di Iulio J, Tiley C, Taylor K, Filshie R, Seldon M, Taper J, Szer J, Moore J, Bashford J, Seymour JF; Australasian Leukaemia and Lymphoma Group
Blood 2012 Aug 23;120(8):1570-80; quiz 1752. Epub 2012 Jun 19 doi: 10.1182/blood-2012-02-410746. PMID: 22715121
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823
Tallman MS
Semin Hematol 2008 Jul;45(3 Suppl 2):S25-9. doi: 10.1053/j.seminhematol.2008.07.008. PMID: 18760708

Prognosis

Weigert N, Rowe JM, Lazarus HM, Salman MY
Blood Rev 2022 Jan;51:100873. Epub 2021 Aug 5 doi: 10.1016/j.blre.2021.100873. PMID: 34483002
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Lin P, Falini B
Am J Clin Pathol 2015 Jul;144(1):19-28. doi: 10.1309/AJCP97BJBEVZEUIN. PMID: 26071459
Lee H, Kim M, Lim J, Kim Y, Han K, Cho BS, Kim HJ
Int J Hematol 2013 Jun;97(6):808-12. Epub 2013 Apr 23 doi: 10.1007/s12185-013-1337-5. PMID: 23609419
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823

Clinical prediction guides

Blombery P, Lew TE, Dengler MA, Thompson ER, Lin VS, Chen X, Nguyen T, Panigrahi A, Handunnetti SM, Carney DA, Westerman DA, Tam CS, Adams JM, Wei AH, Huang DCS, Seymour JF, Roberts AW, Anderson MA
Blood 2022 Feb 24;139(8):1198-1207. doi: 10.1182/blood.2021012775. PMID: 34469514
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Gaidzik VI, Weber D, Paschka P, Kaumanns A, Krieger S, Corbacioglu A, Krönke J, Kapp-Schwoerer S, Krämer D, Horst HA, Schmidt-Wolf I, Held G, Kündgen A, Ringhoffer M, Götze K, Kindler T, Fiedler W, Wattad M, Schlenk RF, Bullinger L, Teleanu V, Schlegelberger B, Thol F, Heuser M, Ganser A, Döhner H, Döhner K; German-Austrian Acute Myeloid Leukemia Study Group (AMLSG)
Leukemia 2018 Jan;32(1):30-37. Epub 2017 Jun 23 doi: 10.1038/leu.2017.200. PMID: 28643785
Lo-Coco F, Ammatuna E, Montesinos P, Sanz MA
Semin Oncol 2008 Aug;35(4):401-9. doi: 10.1053/j.seminoncol.2008.04.010. PMID: 18692690
Miller AA, Kurschel E, Osieka R, Schmidt CG
Eur J Cancer Clin Oncol 1987 Sep;23(9):1283-7. doi: 10.1016/0277-5379(87)90109-x. PMID: 3678322

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