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Adult Acute Myeloid Leukemia with Minimal Differentiation

MedGen UID:
76319
•Concept ID:
C0281641
•
Neoplastic Process
Synonyms: Adult Acute M0 Leukemia; Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Myeloblastic Leukemia with Minimal Differentiation; Adult Acute Myelogenous Leukemia with Minimal Differentiation; Adult Acute Myeloid Leukemia Minimally Differentiated; M0 Adult Acute Leukemia; M0 Adult Acute Myeloblastic Leukemia; M0 Adult Acute Myeloblastic Leukemia with Minimal Differentiation; M0 Adult Acute Myelogenous Leukemia; M0 Adult Acute Myelogenous Leukemia with Minimal Differentiation; M0 Adult Acute Myeloid Leukemia with Minimal Differentiation; M0 Adult AML; M0 Adult ANLL

Definition

An acute myeloid leukemia with minimal differentiation occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Myeloid Leukemia with Minimal Differentiation

Professional guidelines

PubMed

miR-638 in circulating leukaemia cells as a non-invasive biomarker in diagnosis, treatment response and MRD surveillance of acute promyelocytic leukaemia.
Bai Y, Chen C, Guo X, Ding T, Yang X, Yu J, Yang J, Ruan J, Zheng X, Chen Z
Cancer Biomark 2020;29(1):125-137. doi: 10.3233/CBM-190899. PMID: 32568176
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up.
Boyer T, Gonzales F, Plesa A, Peyrouze P, Barthelemy A, Guihard S, Quesnel B, Roumier C, Preudhomme C, Cheok M
J Vis Exp 2018 Mar 26;(133) doi: 10.3791/56976. PMID: 29630051Free PMC Article
Acute promyelocytic leukemia: recent advances in diagnosis and management.
Lo-Coco F, Ammatuna E, Montesinos P, Sanz MA
Semin Oncol 2008 Aug;35(4):401-9. doi: 10.1053/j.seminoncol.2008.04.010. PMID: 18692690

Recent clinical studies

Etiology

Monocytic Differentiation of Human Acute Myeloid Leukemia Cells: A Proteomic and Phosphoproteomic Comparison of FAB-M4/M5 Patients with and without Nucleophosmin 1 Mutations.
Selheim F, Aasebø E, Reikvam H, Bruserud Ø, Hernandez-Valladares M
Int J Mol Sci 2024 May 7;25(10) doi: 10.3390/ijms25105080. PMID: 38791118Free PMC Article
Regulation of hematopoietic and leukemia stem cells by regulatory T cells.
Riether C
Front Immunol 2022;13:1049301. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.1049301. PMID: 36405718Free PMC Article
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Lin P, Falini B
Am J Clin Pathol 2015 Jul;144(1):19-28. doi: 10.1309/AJCP97BJBEVZEUIN. PMID: 26071459
All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4).
Iland HJ, Bradstock K, Supple SG, Catalano A, Collins M, Hertzberg M, Browett P, Grigg A, Firkin F, Hugman A, Reynolds J, Di Iulio J, Tiley C, Taylor K, Filshie R, Seldon M, Taper J, Szer J, Moore J, Bashford J, Seymour JF; Australasian Leukaemia and Lymphoma Group
Blood 2012 Aug 23;120(8):1570-80; quiz 1752. Epub 2012 Jun 19 doi: 10.1182/blood-2012-02-410746. PMID: 22715121
Idiopathic cytopenia of undetermined significance and the minimal criteria for a diagnosis of myelodysplastic syndrome.
Pavlu J, Emmerson J, Marks AJ, Bain BJ
Leuk Lymphoma 2011 Mar;52(3):515-6. Epub 2011 Jan 11 doi: 10.3109/10428194.2010.545464. PMID: 21323527

Diagnosis

Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome.
Xie W, Raess PW, Dunlap J, Hoyos CM, Li H, Li P, Swords R, Olson SB, Yang F, Anekpuritanang T, Hu S, Wiszniewska J, Fan G, Press RD, Moore SR
Leuk Lymphoma 2022 Aug;63(8):1907-1916. Epub 2022 Mar 8 doi: 10.1080/10428194.2022.2047672. PMID: 35258401
Molecular Minimal Residual Disease in Acute Myeloid Leukemia.
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Acute myeloid leukemia associated with FGFR1 abnormalities.
Lee H, Kim M, Lim J, Kim Y, Han K, Cho BS, Kim HJ
Int J Hematol 2013 Jun;97(6):808-12. Epub 2013 Apr 23 doi: 10.1007/s12185-013-1337-5. PMID: 23609419
Acute myeloid leukaemia in the elderly: a review.
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823
Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells.
Becker PS, Wagle M, Matous S, Swanson RS, Pihan G, Lowry PA, Stewart FM, Heard SO
Biol Blood Marrow Transplant 1997 Apr;3(1):45-9. PMID: 9209740

Therapy

Outcomes of older patients aged 60 to 70 years undergoing reduced intensity transplant for acute myeloblastic leukemia: results of the NCRI acute myeloid leukemia 16 trial.
Russell NH, Hills RK, Thomas A, Thomas I, Kjeldsen L, Dennis M, Craddock C, Freeman S, Clark RE, Burnett AK
Haematologica 2022 Jul 1;107(7):1518-1527. doi: 10.3324/haematol.2021.279010. PMID: 34647442Free PMC Article
Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Blombery P, Lew TE, Dengler MA, Thompson ER, Lin VS, Chen X, Nguyen T, Panigrahi A, Handunnetti SM, Carney DA, Westerman DA, Tam CS, Adams JM, Wei AH, Huang DCS, Seymour JF, Roberts AW, Anderson MA
Blood 2022 Feb 24;139(8):1198-1207. doi: 10.1182/blood.2021012775. PMID: 34469514Free PMC Article
Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation.
Bialek-Waldmann JK, Heuser M, Ganser A, Stripecke R
Cancer Immunol Immunother 2019 Nov;68(11):1891-1899. Epub 2019 Oct 18 doi: 10.1007/s00262-019-02406-9. PMID: 31628525Free PMC Article
All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4).
Iland HJ, Bradstock K, Supple SG, Catalano A, Collins M, Hertzberg M, Browett P, Grigg A, Firkin F, Hugman A, Reynolds J, Di Iulio J, Tiley C, Taylor K, Filshie R, Seldon M, Taper J, Szer J, Moore J, Bashford J, Seymour JF; Australasian Leukaemia and Lymphoma Group
Blood 2012 Aug 23;120(8):1570-80; quiz 1752. Epub 2012 Jun 19 doi: 10.1182/blood-2012-02-410746. PMID: 22715121
Acute myeloid leukaemia in the elderly: a review.
Pollyea DA, Kohrt HE, Medeiros BC
Br J Haematol 2011 Mar;152(5):524-42. doi: 10.1111/j.1365-2141.2010.08470.x. PMID: 21314823

Prognosis

Consolidation in AML: Abundant opinion and much unknown.
Weigert N, Rowe JM, Lazarus HM, Salman MY
Blood Rev 2022 Jan;51:100873. Epub 2021 Aug 5 doi: 10.1016/j.blre.2021.100873. PMID: 34483002
Molecular Minimal Residual Disease in Acute Myeloid Leukemia.
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Lin P, Falini B
Am J Clin Pathol 2015 Jul;144(1):19-28. doi: 10.1309/AJCP97BJBEVZEUIN. PMID: 26071459
Idiopathic cytopenia of undetermined significance and the minimal criteria for a diagnosis of myelodysplastic syndrome.
Pavlu J, Emmerson J, Marks AJ, Bain BJ
Leuk Lymphoma 2011 Mar;52(3):515-6. Epub 2011 Jan 11 doi: 10.3109/10428194.2010.545464. PMID: 21323527
Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells.
Becker PS, Wagle M, Matous S, Swanson RS, Pihan G, Lowry PA, Stewart FM, Heard SO
Biol Blood Marrow Transplant 1997 Apr;3(1):45-9. PMID: 9209740

Clinical prediction guides

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Blombery P, Lew TE, Dengler MA, Thompson ER, Lin VS, Chen X, Nguyen T, Panigrahi A, Handunnetti SM, Carney DA, Westerman DA, Tam CS, Adams JM, Wei AH, Huang DCS, Seymour JF, Roberts AW, Anderson MA
Blood 2022 Feb 24;139(8):1198-1207. doi: 10.1182/blood.2021012775. PMID: 34469514Free PMC Article
Molecular Minimal Residual Disease in Acute Myeloid Leukemia.
Jongen-Lavrencic M, Grob T, Hanekamp D, Kavelaars FG, Al Hinai A, Zeilemaker A, Erpelinck-Verschueren CAJ, Gradowska PL, Meijer R, Cloos J, Biemond BJ, Graux C, van Marwijk Kooy M, Manz MG, Pabst T, Passweg JR, Havelange V, Ossenkoppele GJ, Sanders MA, Schuurhuis GJ, Löwenberg B, Valk PJM
N Engl J Med 2018 Mar 29;378(13):1189-1199. doi: 10.1056/NEJMoa1716863. PMID: 29601269
Immunophenotypic findings in acute myeloid leukemia with FLT3 internal tandem duplication.
Muñoz L, Aventín A, Villamor N, Juncà J, Acebedo G, Domingo A, Rozman M, Torres JP, Tormo M, Nomdedéu JF
Haematologica 2003 Jun;88(6):637-45. PMID: 12801839
Acute myeloblastic leukemia with minimal myeloid differentiation: phenotypical and ultrastructural characteristics.
Villamor N, Zarco MA, Rozman M, Ribera JM, Feliu E, Montserrat E
Leukemia 1998 Jul;12(7):1071-5. doi: 10.1038/sj.leu.2401074. PMID: 9665192
Clinical pharmacology of sodium butyrate in patients with acute leukemia.
Miller AA, Kurschel E, Osieka R, Schmidt CG
Eur J Cancer Clin Oncol 1987 Sep;23(9):1283-7. doi: 10.1016/0277-5379(87)90109-x. PMID: 3678322

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