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Increased risk for hematologic cancer, particularly acute myeloid leukemia

MedGen UID:
766533
•Concept ID:
C3553619
•
Finding

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased risk for hematologic cancer, particularly acute myeloid leukemia

Professional guidelines

PubMed

Current Concepts of Pathogenesis and Treatment of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.
Zeeh FC, Meyer SC
Hamostaseologie 2021 Jun;41(3):197-205. Epub 2021 Jun 30 doi: 10.1055/a-1447-6667. PMID: 34192778
Treatment decisions for elderly patients with haematological malignancies: a dilemma.
Peyrade F, Gastaud L, Ré D, Pacquelet-Cheli S, Thyss A
Lancet Oncol 2012 Aug;13(8):e344-52. doi: 10.1016/S1470-2045(12)70234-6. PMID: 22846839
Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.
Leone G, Voso MT, Teofili L, Lübbert M
Clin Immunol 2003 Oct;109(1):89-102. doi: 10.1016/s1521-6616(03)00207-9. PMID: 14585280

Recent clinical studies

Etiology

Human Immunodeficiency Virus and Clonal Hematopoiesis.
Vorri SC, Christodoulou I, Karanika S, Karantanos T
Cells 2023 Feb 22;12(5) doi: 10.3390/cells12050686. PMID: 36899822Free PMC Article
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Huang YH, Chen CW, Sundaramurthy V, Słabicki M, Hao D, Watson CJ, Tovy A, Reyes JM, Dakhova O, Crovetti BR, Galonska C, Lee M, Brunetti L, Zhou Y, Tatton-Brown K, Huang Y, Cheng X, Meissner A, Valk PJM, Van Maldergem L, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell MA
Cancer Discov 2022 Jan;12(1):220-235. Epub 2021 Aug 24 doi: 10.1158/2159-8290.CD-21-0560. PMID: 34429321Free PMC Article
Therapy-related myeloid neoplasms in lymphoma survivors: Reducing risks.
Al-Juhaishi T, Khurana A, Shafer D
Best Pract Res Clin Haematol 2019 Mar;32(1):47-53. Epub 2019 Feb 16 doi: 10.1016/j.beha.2019.02.008. PMID: 30927975
Genetic and epigenetic determinants of AML pathogenesis.
Cai SF, Levine RL
Semin Hematol 2019 Apr;56(2):84-89. Epub 2018 Aug 22 doi: 10.1053/j.seminhematol.2018.08.001. PMID: 30926095Free PMC Article
Therapy-related myeloid neoplasms.
Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440

Diagnosis

Myelodysplastic neoplasms evolving from inherited bone marrow failure syndromes / germline predisposition syndromes: Back under the microscope.
Elghetany MT, Patnaik MM, Khoury JD
Leuk Res 2024 Feb;137:107441. Epub 2024 Jan 23 doi: 10.1016/j.leukres.2024.107441. PMID: 38301422
Defining clonal hematopoiesis of indeterminate potential: evolutionary dynamics and detection under aging and inflammation.
Goldman EA, Spellman PT, Agarwal A
Cold Spring Harb Mol Case Stud 2023 Apr;9(2) Epub 2023 May 9 doi: 10.1101/mcs.a006251. PMID: 36889927Free PMC Article
Risk of primary haematologic cancers following incident non-metastatic breast cancer: A Danish population-based cohort study.
Hjorth CF, Farkas DK, Schapira L, Cullen MR, Sørensen HT, Cronin-Fenton D
Cancer Epidemiol 2023 Feb;82:102311. Epub 2022 Dec 9 doi: 10.1016/j.canep.2022.102311. PMID: 36508968
Current Concepts of Pathogenesis and Treatment of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.
Zeeh FC, Meyer SC
Hamostaseologie 2021 Jun;41(3):197-205. Epub 2021 Jun 30 doi: 10.1055/a-1447-6667. PMID: 34192778
Revisiting use of growth factors in myelodysplastic syndromes.
Newman K, Maness-Harris L, El-Hemaidi I, Akhtari M
Asian Pac J Cancer Prev 2012;13(4):1081-91. doi: 10.7314/apjcp.2012.13.4.1081. PMID: 22799286

Therapy

Current Concepts of Pathogenesis and Treatment of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.
Zeeh FC, Meyer SC
Hamostaseologie 2021 Jun;41(3):197-205. Epub 2021 Jun 30 doi: 10.1055/a-1447-6667. PMID: 34192778
Therapy-related myeloid neoplasms in lymphoma survivors: Reducing risks.
Al-Juhaishi T, Khurana A, Shafer D
Best Pract Res Clin Haematol 2019 Mar;32(1):47-53. Epub 2019 Feb 16 doi: 10.1016/j.beha.2019.02.008. PMID: 30927975
Revisiting use of growth factors in myelodysplastic syndromes.
Newman K, Maness-Harris L, El-Hemaidi I, Akhtari M
Asian Pac J Cancer Prev 2012;13(4):1081-91. doi: 10.7314/apjcp.2012.13.4.1081. PMID: 22799286
Acute myeloid leukemia developing in patients with autoimmune diseases.
Ramadan SM, Fouad TM, Summa V, Hasan SKh, Lo-Coco F
Haematologica 2012 Jun;97(6):805-17. Epub 2011 Dec 16 doi: 10.3324/haematol.2011.056283. PMID: 22180424Free PMC Article
Benzene and lymphohematopoietic malignancies in humans.
Hayes RB, Songnian Y, Dosemeci M, Linet M
Am J Ind Med 2001 Aug;40(2):117-26. doi: 10.1002/ajim.1078. PMID: 11494338

Prognosis

Mutational landscape of blast phase myeloproliferative neoplasms (MPN-BP) and antecedent MPN.
Pasca S, Chifotides HT, Verstovsek S, Bose P
Int Rev Cell Mol Biol 2022;366:83-124. Epub 2021 Dec 14 doi: 10.1016/bs.ircmb.2021.02.008. PMID: 35153007
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.
Huang YH, Chen CW, Sundaramurthy V, Słabicki M, Hao D, Watson CJ, Tovy A, Reyes JM, Dakhova O, Crovetti BR, Galonska C, Lee M, Brunetti L, Zhou Y, Tatton-Brown K, Huang Y, Cheng X, Meissner A, Valk PJM, Van Maldergem L, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell MA
Cancer Discov 2022 Jan;12(1):220-235. Epub 2021 Aug 24 doi: 10.1158/2159-8290.CD-21-0560. PMID: 34429321Free PMC Article
Current Concepts of Pathogenesis and Treatment of Philadelphia Chromosome-Negative Myeloproliferative Neoplasms.
Zeeh FC, Meyer SC
Hamostaseologie 2021 Jun;41(3):197-205. Epub 2021 Jun 30 doi: 10.1055/a-1447-6667. PMID: 34192778
Therapy-related myeloid neoplasms in lymphoma survivors: Reducing risks.
Al-Juhaishi T, Khurana A, Shafer D
Best Pract Res Clin Haematol 2019 Mar;32(1):47-53. Epub 2019 Feb 16 doi: 10.1016/j.beha.2019.02.008. PMID: 30927975
Genetic and epigenetic determinants of AML pathogenesis.
Cai SF, Levine RL
Semin Hematol 2019 Apr;56(2):84-89. Epub 2018 Aug 22 doi: 10.1053/j.seminhematol.2018.08.001. PMID: 30926095Free PMC Article

Clinical prediction guides

Risk of primary haematologic cancers following incident non-metastatic breast cancer: A Danish population-based cohort study.
Hjorth CF, Farkas DK, Schapira L, Cullen MR, Sørensen HT, Cronin-Fenton D
Cancer Epidemiol 2023 Feb;82:102311. Epub 2022 Dec 9 doi: 10.1016/j.canep.2022.102311. PMID: 36508968
Mutational landscape of blast phase myeloproliferative neoplasms (MPN-BP) and antecedent MPN.
Pasca S, Chifotides HT, Verstovsek S, Bose P
Int Rev Cell Mol Biol 2022;366:83-124. Epub 2021 Dec 14 doi: 10.1016/bs.ircmb.2021.02.008. PMID: 35153007
Acute myeloid leukemia following exposure to benzene more closely resembles de novo than therapy related-disease.
Irons RD, Chen Y, Wang X, Ryder J, Kerzic PJ
Genes Chromosomes Cancer 2013 Oct;52(10):887-94. Epub 2013 Jul 10 doi: 10.1002/gcc.22084. PMID: 23840003
Revisiting use of growth factors in myelodysplastic syndromes.
Newman K, Maness-Harris L, El-Hemaidi I, Akhtari M
Asian Pac J Cancer Prev 2012;13(4):1081-91. doi: 10.7314/apjcp.2012.13.4.1081. PMID: 22799286
Therapy-related myeloid neoplasms.
Leone G, Fianchi L, Voso MT
Curr Opin Oncol 2011 Nov;23(6):672-80. doi: 10.1097/CCO.0b013e32834bcc2a. PMID: 21918440

Supplemental Content

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