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Congenital Phrenic Nerve Palsy

MedGen UID:
768671
•Concept ID:
C3640031
•
Disease or Syndrome

Definition

Damage to the phrenic nerve that results in paralysis of the hemidiaphragm at birth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCongenital Phrenic Nerve Palsy

Professional guidelines

PubMed

Diaphragmatic nerve palsy after cardiac surgery in children in Egypt: outcome and debate in management.
El Tantawy AE, Imam S, Shawky H, Salah T
World J Pediatr Congenit Heart Surg 2013 Jan;4(1):19-23. doi: 10.1177/2150135112454444. PMID: 23799750
Postoperative phrenic nerve palsy: early clinical implications and management.
Lemmer J, Stiller B, Heise G, Hübler M, Alexi-Meskishvili V, Weng Y, Redlin M, Amann V, Ovroutski S, Berger F
Intensive Care Med 2006 Aug;32(8):1227-33. Epub 2006 Jun 2 doi: 10.1007/s00134-006-0208-4. PMID: 16741696
Central hypoventilation and diaphragmatic eventration: diagnosis and management.
Flageole H
Semin Pediatr Surg 2003 Feb;12(1):38-45. doi: 10.1053/spsu.2003.50004. PMID: 12520471

Recent clinical studies

Etiology

Outcome analysis of a conservative approach to diaphragmatic paralysis following congenital cardiac surgery in neonates and infants: a bicentric retrospective study.
Denamur S, Chenouard A, Lefort B, Baron O, Neville P, Baruteau A, Joram N, Chantreuil J, Bourgoin P
Interact Cardiovasc Thorac Surg 2021 Oct 4;33(4):597-604. doi: 10.1093/icvts/ivab123. PMID: 34000037Free PMC Article
Diaphragmatic paralysis after phrenic nerve injury in newborns.
Rizeq YK, Many BT, Vacek JC, Reiter AJ, Raval MV, Abdullah F, Goldstein SD
J Pediatr Surg 2020 Feb;55(2):240-244. Epub 2019 Nov 5 doi: 10.1016/j.jpedsurg.2019.10.038. PMID: 31757507
Impact of Phrenic Nerve Palsy on Late Fontan Circulation.
Komori M, Hoashi T, Shimada M, Kitano M, Ohuchi H, Kurosaki K, Ichikawa H
Ann Thorac Surg 2020 Jun;109(6):1897-1902. Epub 2019 Nov 13 doi: 10.1016/j.athoracsur.2019.09.064. PMID: 31733188
Employing bioabsorbable grafts in two-stage laryngotracheal reconstruction of pediatric patient with severe subglottic stenosis and history of airway surgery.
Le E, Tran L
Int J Pediatr Otorhinolaryngol 2018 Dec;115:58-60. Epub 2018 Sep 19 doi: 10.1016/j.ijporl.2018.09.013. PMID: 30368394
Unusual varieties of diaphragmatic herniae.
Stokes KB
Prog Pediatr Surg 1991;27:127-47. doi: 10.1007/978-3-642-87767-4_8. PMID: 1907381

Diagnosis

Fontan Failure Secondary to Charcot-Marie-Tooth-Induced Phrenic Neuropathy.
Abdul TY, Schneider AE, Cetta F, Driscoll DJ
Tex Heart Inst J 2018 Aug;45(4):270-272. Epub 2018 Aug 1 doi: 10.14503/THIJ-17-6337. PMID: 30374244Free PMC Article
Employing bioabsorbable grafts in two-stage laryngotracheal reconstruction of pediatric patient with severe subglottic stenosis and history of airway surgery.
Le E, Tran L
Int J Pediatr Otorhinolaryngol 2018 Dec;115:58-60. Epub 2018 Sep 19 doi: 10.1016/j.ijporl.2018.09.013. PMID: 30368394
Imaging of the diaphragm: anatomy and function.
Nason LK, Walker CM, McNeeley MF, Burivong W, Fligner CL, Godwin JD
Radiographics 2012 Mar-Apr;32(2):E51-70. doi: 10.1148/rg.322115127. PMID: 22411950
Radiologic evaluation of the diaphragm.
Oh KS, Newman B, Bender TM, Bowen A
Radiol Clin North Am 1988 Mar;26(2):355-64. PMID: 3277228
Brachial plexus palsy: intrauterine onset.
Dunn DW, Engle WA
Pediatr Neurol 1985 Nov-Dec;1(6):367-9. doi: 10.1016/0887-8994(85)90074-8. PMID: 3880422

Therapy

A Case of Incidentally Discovered Congenital Complete Pericardial Defect during Lobectomy for Lung Cancer: A Case Report and Literature Review.
Setogawa T, Kato T, Watanabe H, Nakamura S, Mizuno T, Chen-Yoshikawa TF
Ann Thorac Cardiovasc Surg 2024;30(1) doi: 10.5761/atcs.cr.24-00041. PMID: 38749719Free PMC Article
Outcome analysis of a conservative approach to diaphragmatic paralysis following congenital cardiac surgery in neonates and infants: a bicentric retrospective study.
Denamur S, Chenouard A, Lefort B, Baron O, Neville P, Baruteau A, Joram N, Chantreuil J, Bourgoin P
Interact Cardiovasc Thorac Surg 2021 Oct 4;33(4):597-604. doi: 10.1093/icvts/ivab123. PMID: 34000037Free PMC Article
Fontan Failure Secondary to Charcot-Marie-Tooth-Induced Phrenic Neuropathy.
Abdul TY, Schneider AE, Cetta F, Driscoll DJ
Tex Heart Inst J 2018 Aug;45(4):270-272. Epub 2018 Aug 1 doi: 10.14503/THIJ-17-6337. PMID: 30374244Free PMC Article
Employing bioabsorbable grafts in two-stage laryngotracheal reconstruction of pediatric patient with severe subglottic stenosis and history of airway surgery.
Le E, Tran L
Int J Pediatr Otorhinolaryngol 2018 Dec;115:58-60. Epub 2018 Sep 19 doi: 10.1016/j.ijporl.2018.09.013. PMID: 30368394
Clinical implications of postoperative unilateral phrenic nerve paralysis.
Mickell JJ, Oh KS, Siewers RD, Galvis AG, Fricker FJ, Mathews RA
J Thorac Cardiovasc Surg 1978 Sep;76(3):297-304. PMID: 682661

Prognosis

Impact of Phrenic Nerve Palsy on Late Fontan Circulation.
Komori M, Hoashi T, Shimada M, Kitano M, Ohuchi H, Kurosaki K, Ichikawa H
Ann Thorac Surg 2020 Jun;109(6):1897-1902. Epub 2019 Nov 13 doi: 10.1016/j.athoracsur.2019.09.064. PMID: 31733188
Congenital cervical kyphosis in a child associated with tetraparesis: case report.
Van Gorp V, Dricot F, van Berlaer G, Van Rompaey K, Hachimi-Idrissi S
Pediatr Neurosurg 2009;45(6):422-4. Epub 2009 Dec 24 doi: 10.1159/000270158. PMID: 20051702
Technical considerations for myocardial revascularization in congenital bilateral hypoplasia of the pericardium.
Firstenberg MS, Sai-Sudhakar CB, Raman SV, Michler RE
Ann Thorac Surg 2006 Jan;81(1):352-4. doi: 10.1016/j.athoracsur.2004.08.085. PMID: 16368404
Central hypoventilation and diaphragmatic eventration: diagnosis and management.
Flageole H
Semin Pediatr Surg 2003 Feb;12(1):38-45. doi: 10.1053/spsu.2003.50004. PMID: 12520471
Clinical implications of postoperative unilateral phrenic nerve paralysis.
Mickell JJ, Oh KS, Siewers RD, Galvis AG, Fricker FJ, Mathews RA
J Thorac Cardiovasc Surg 1978 Sep;76(3):297-304. PMID: 682661

Clinical prediction guides

A Case of Incidentally Discovered Congenital Complete Pericardial Defect during Lobectomy for Lung Cancer: A Case Report and Literature Review.
Setogawa T, Kato T, Watanabe H, Nakamura S, Mizuno T, Chen-Yoshikawa TF
Ann Thorac Cardiovasc Surg 2024;30(1) doi: 10.5761/atcs.cr.24-00041. PMID: 38749719Free PMC Article
Diaphragmatic paralysis after phrenic nerve injury in newborns.
Rizeq YK, Many BT, Vacek JC, Reiter AJ, Raval MV, Abdullah F, Goldstein SD
J Pediatr Surg 2020 Feb;55(2):240-244. Epub 2019 Nov 5 doi: 10.1016/j.jpedsurg.2019.10.038. PMID: 31757507
Impact of Phrenic Nerve Palsy on Late Fontan Circulation.
Komori M, Hoashi T, Shimada M, Kitano M, Ohuchi H, Kurosaki K, Ichikawa H
Ann Thorac Surg 2020 Jun;109(6):1897-1902. Epub 2019 Nov 13 doi: 10.1016/j.athoracsur.2019.09.064. PMID: 31733188
Intrathoracic phrenic pacing: a 10-year experience in France.
Le Pimpec-Barthes F, Gonzalez-Bermejo J, Hubsch JP, Duguet A, Morélot-Panzini C, Riquet M, Similowski T
J Thorac Cardiovasc Surg 2011 Aug;142(2):378-83. Epub 2011 May 26 doi: 10.1016/j.jtcvs.2011.04.033. PMID: 21620417
Postoperative phrenic nerve palsy: early clinical implications and management.
Lemmer J, Stiller B, Heise G, Hübler M, Alexi-Meskishvili V, Weng Y, Redlin M, Amann V, Ovroutski S, Berger F
Intensive Care Med 2006 Aug;32(8):1227-33. Epub 2006 Jun 2 doi: 10.1007/s00134-006-0208-4. PMID: 16741696

Recent systematic reviews

Perioperative Complications of Video-Assisted Thoracoscopic Pulmonary Procedures in Neonates and Infants.
Zoeller C, Ure BM, Dingemann J
Eur J Pediatr Surg 2018 Apr;28(2):163-170. Epub 2018 Mar 6 doi: 10.1055/s-0038-1636917. PMID: 29510429

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