U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Postnatal Drug Withdrawal

MedGen UID:
769745
•Concept ID:
C3641105
•
Mental or Behavioral Dysfunction

Definition

Withdrawal signs and symptoms that present during the postnatal period and are caused by drug use by the pregnant mother. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPostnatal Drug Withdrawal

Professional guidelines

PubMed

A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome.
van Hoogdalem MW, Wexelblatt SL, Akinbi HT, Vinks AA, Mizuno T
Pharmacol Ther 2022 Jun;234:108045. Epub 2021 Nov 20 doi: 10.1016/j.pharmthera.2021.108045. PMID: 34813863
Management of the newborn infant affected by maternal opiates and other drugs of dependency.
Oei J, Lui K
J Paediatr Child Health 2007 Jan-Feb;43(1-2):9-18. doi: 10.1111/j.1440-1754.2007.00994.x. PMID: 17207049
Fluoxetine: a suitable long-term treatment.
Calil HM
J Clin Psychiatry 2001;62 Suppl 22:24-9. PMID: 11599644

Recent clinical studies

Etiology

Surveillance, Epidemiology, and Estimated Burden of Neonatal Abstinence Syndrome, Tennessee, 2013-2016.
Brennan J, Wiedeman C, Dunn JR, Schaffner W, Jones TF
Public Health Rep 2019 Sep/Oct;134(5):537-541. Epub 2019 Aug 7 doi: 10.1177/0033354919867718. PMID: 31390300Free PMC Article
Educational Disabilities Among Children Born With Neonatal Abstinence Syndrome.
Fill MA, Miller AM, Wilkinson RH, Warren MD, Dunn JR, Schaffner W, Jones TF
Pediatrics 2018 Sep;142(3) doi: 10.1542/peds.2018-0562. PMID: 30166364Free PMC Article
Improving Care for Neonatal Abstinence Syndrome.
Patrick SW, Schumacher RE, Horbar JD, Buus-Frank ME, Edwards EM, Morrow KA, Ferrelli KR, Picarillo AP, Gupta M, Soll RF
Pediatrics 2016 May;137(5) Epub 2016 Apr 15 doi: 10.1542/peds.2015-3835. PMID: 27244809Free PMC Article
Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.
Patrick SW, Burke JF, Biel TJ, Auger KA, Goyal NK, Cooper WO
Hosp Pediatr 2015 Oct;5(10):513-9. doi: 10.1542/hpeds.2015-0024. PMID: 26427919Free PMC Article
Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.
Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM
JAMA 2012 May 9;307(18):1934-40. Epub 2012 Apr 30 doi: 10.1001/jama.2012.3951. PMID: 22546608

Diagnosis

Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.
Patrick SW, Burke JF, Biel TJ, Auger KA, Goyal NK, Cooper WO
Hosp Pediatr 2015 Oct;5(10):513-9. doi: 10.1542/hpeds.2015-0024. PMID: 26427919Free PMC Article
Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.
Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM
JAMA 2012 May 9;307(18):1934-40. Epub 2012 Apr 30 doi: 10.1001/jama.2012.3951. PMID: 22546608

Prognosis

Born Into Addiction: Neonatal Abstinence Syndrome and Pediatric Dentistry.
Cully JL
Pediatr Dent 2017 Sep 15;39(5):358-360. PMID: 29070156
Incidence of Neonatal Abstinence Syndrome - 28 States, 1999-2013.
Ko JY, Patrick SW, Tong VT, Patel R, Lind JN, Barfield WD
MMWR Morb Mortal Wkly Rep 2016 Aug 12;65(31):799-802. doi: 10.15585/mmwr.mm6531a2. PMID: 27513154
Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.
Patrick SW, Burke JF, Biel TJ, Auger KA, Goyal NK, Cooper WO
Hosp Pediatr 2015 Oct;5(10):513-9. doi: 10.1542/hpeds.2015-0024. PMID: 26427919Free PMC Article
Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.
Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM
JAMA 2012 May 9;307(18):1934-40. Epub 2012 Apr 30 doi: 10.1001/jama.2012.3951. PMID: 22546608

Clinical prediction guides

Risk of Hospital Readmission Among Infants With Neonatal Abstinence Syndrome.
Patrick SW, Burke JF, Biel TJ, Auger KA, Goyal NK, Cooper WO
Hosp Pediatr 2015 Oct;5(10):513-9. doi: 10.1542/hpeds.2015-0024. PMID: 26427919Free PMC Article
Neonatal abstinence syndrome and associated health care expenditures: United States, 2000-2009.
Patrick SW, Schumacher RE, Benneyworth BD, Krans EE, McAllister JM, Davis MM
JAMA 2012 May 9;307(18):1934-40. Epub 2012 Apr 30 doi: 10.1001/jama.2012.3951. PMID: 22546608

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...