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Recurrent Uterine Corpus Sarcoma

MedGen UID:
771073
•Concept ID:
C3642433
•
Neoplastic Process
Synonyms: Recurrent Sarcoma of the Uterine Corpus; Recurrent Sarcoma of Uterine Corpus; Relapsed Sarcoma of the Uterine Corpus; Relapsed Sarcoma of Uterine Corpus; Relapsed Uterine Corpus Sarcoma

Definition

The reemergence of uterine corpus sarcoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Practice guidelines for management of uterine corpus cancer in Korea: a Korean Society of Gynecologic Oncology Consensus Statement.
Lee SW, Lee TS, Hong DG, No JH, Park DC, Bae JM, Seong SJ, Shin SJ, Ju W, Lee KH, Lee YK, Cho H, Lee C, Paek J, Kim HJ, Lee JW, Kim JW, Bae DS
J Gynecol Oncol 2017 Jan;28(1):e12. Epub 2016 Oct 27 doi: 10.3802/jgo.2017.28.e12. PMID: 27894165Free PMC Article
Advances in the treatment of gynecologic malignancies. Part 2: Cancers of the uterine corpus and ovary.
Kim RY, Omura GA, Alvarez RD
Oncology (Williston Park) 2002 Dec;16(12):1669-78; discussion 1678-80. PMID: 12520642
Treatment, results and prognostic factors in stage I and II sarcomas of the corpus uteri.
Vongtama V, Karlen JR, Piver SM, Tsukada Y, Moore RH
AJR Am J Roentgenol 1976 Jan;126(1):139-47. doi: 10.2214/ajr.126.1.139. PMID: 175673

Recent clinical studies

Etiology

Alveolar soft part sarcoma of the uterine corpus: A 13-year follow-up case report and review of the literature.
Huang SW, Huang HY, Lin H
Taiwan J Obstet Gynecol 2023 Sep;62(5):769-773. doi: 10.1016/j.tjog.2023.07.025. PMID: 37679012
Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Analyses of Clinicopathological, Molecular, and Prognostic Characteristics With Retrospective Review of 237 Endometrial Carcinoma Cases.
Kim HG, Kim H, Yeo MK, Won KY, Kim YS, Han GH, Kim HS, Na K
Cancer Genomics Proteomics 2022 Jul-Aug;19(4):526-539. doi: 10.21873/cgp.20338. PMID: 35732320Free PMC Article
Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations.
Bennett JA, Ordulu Z, Young RH, Pinto A, Van de Vijver K, Burandt E, Wanjari P, Shah R, de Kock L, Foulkes WD, McCluggage WG, Ritterhouse LL, Oliva E
Mod Pathol 2021 Sep;34(9):1750-1762. Epub 2021 May 20 doi: 10.1038/s41379-021-00821-x. PMID: 34017064
Magnetic resonance imaging of uterine malignancies.
Whitten CR, DeSouza NM
Top Magn Reson Imaging 2006 Dec;17(6):365-77. doi: 10.1097/RMR.0b013e3180417d47. PMID: 17417085
Cancer of the endometrium and corpus uteri.
Yamada SD, McGonigle KF
Curr Opin Obstet Gynecol 1998 Feb;10(1):57-60. doi: 10.1097/00001703-199802000-00011. PMID: 9484631

Diagnosis

Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.
Momeni-Boroujeni A, Mullaney K, DiNapoli SE, Leitao MM Jr, Hensley ML, Katabi N, Allison DHR, Park KJ, Antonescu CR, Chiang S
Mod Pathol 2024 May;37(5):100474. Epub 2024 Mar 18 doi: 10.1016/j.modpat.2024.100474. PMID: 38508521
Alveolar soft part sarcoma of the uterine corpus: A 13-year follow-up case report and review of the literature.
Huang SW, Huang HY, Lin H
Taiwan J Obstet Gynecol 2023 Sep;62(5):769-773. doi: 10.1016/j.tjog.2023.07.025. PMID: 37679012
Embryonal rhabdomyosarcoma of the uterine corpus: a clinicopathological and molecular analysis of 21 cases highlighting a frequent association with DICER1 mutations.
Bennett JA, Ordulu Z, Young RH, Pinto A, Van de Vijver K, Burandt E, Wanjari P, Shah R, de Kock L, Foulkes WD, McCluggage WG, Ritterhouse LL, Oliva E
Mod Pathol 2021 Sep;34(9):1750-1762. Epub 2021 May 20 doi: 10.1038/s41379-021-00821-x. PMID: 34017064
Uterine leiomyosarcoma: a review article.
Gockley AA, Rauh-Hain JA, del Carmen MG
Int J Gynecol Cancer 2014 Nov;24(9):1538-42. doi: 10.1097/IGC.0000000000000290. PMID: 25304676
Magnetic resonance imaging of uterine malignancies.
Whitten CR, DeSouza NM
Top Magn Reson Imaging 2006 Dec;17(6):365-77. doi: 10.1097/RMR.0b013e3180417d47. PMID: 17417085

Therapy

Tailored Therapy Based on Molecular Characteristics in Endometrial Cancer.
Lee SY
Biomed Res Int 2021;2021:2068023. Epub 2021 May 5 doi: 10.1155/2021/2068023. PMID: 34036097Free PMC Article
Efficacy and safety of nivolumab in Japanese patients with uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma: Multicenter, open-label phase 2 trial.
Tamura K, Hasegawa K, Katsumata N, Matsumoto K, Mukai H, Takahashi S, Nomura H, Minami H
Cancer Sci 2019 Sep;110(9):2894-2904. Epub 2019 Sep 3 doi: 10.1111/cas.14148. PMID: 31348579Free PMC Article
Localized vaginal/uterine rhabdomyosarcoma-results of a pooled analysis from four international cooperative groups.
Minard-Colin V, Walterhouse D, Bisogno G, Martelli H, Anderson J, Rodeberg DA, Ferrari A, Jenney M, Wolden S, De Salvo G, Arndt C, Merks JHM, Gallego S, Schwob D, Haie-Meder C, Bergeron C, Stevens MCG, Oberlin O, Hawkins D; International Society of Pediatric Oncology Sarcoma Committee, the Children's Oncology Group, the Italian Cooperative Soft Tissue Sarcoma Group, and the European pediatric Soft tissue sarcoma Study Group
Pediatr Blood Cancer 2018 Sep;65(9):e27096. Epub 2018 May 21 doi: 10.1002/pbc.27096. PMID: 29781567Free PMC Article
Cancer of the endometrium and corpus uteri.
Yamada SD, McGonigle KF
Curr Opin Obstet Gynecol 1998 Feb;10(1):57-60. doi: 10.1097/00001703-199802000-00011. PMID: 9484631
Endometrial stromal sarcoma of twenty cases.
Huang KT, Chen CA, Tseng GC, Chen TM, Cheng WF, Hsieh CY
Acta Obstet Gynecol Scand 1996 Jul;75(6):551-5. doi: 10.3109/00016349609054670. PMID: 8693932

Prognosis

Alveolar soft part sarcoma of the uterine corpus: A 13-year follow-up case report and review of the literature.
Huang SW, Huang HY, Lin H
Taiwan J Obstet Gynecol 2023 Sep;62(5):769-773. doi: 10.1016/j.tjog.2023.07.025. PMID: 37679012
Mesonephric-like Carcinosarcoma of the Uterine Corpus: Clinicopathological, Molecular and Prognostic Characteristics in Comparison With Uterine Mesonephric-like Adenocarcinoma and Conventional Endometrial Carcinosarcoma.
Park S, Park E, Kim HS
Cancer Genomics Proteomics 2022 Nov-Dec;19(6):747-760. doi: 10.21873/cgp.20357. PMID: 36316041Free PMC Article
Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Analyses of Clinicopathological, Molecular, and Prognostic Characteristics With Retrospective Review of 237 Endometrial Carcinoma Cases.
Kim HG, Kim H, Yeo MK, Won KY, Kim YS, Han GH, Kim HS, Na K
Cancer Genomics Proteomics 2022 Jul-Aug;19(4):526-539. doi: 10.21873/cgp.20338. PMID: 35732320Free PMC Article
Uterine leiomyosarcoma: a review article.
Gockley AA, Rauh-Hain JA, del Carmen MG
Int J Gynecol Cancer 2014 Nov;24(9):1538-42. doi: 10.1097/IGC.0000000000000290. PMID: 25304676
Mullerian adenosarcoma of the female genital tract.
McCluggage WG
Adv Anat Pathol 2010 Mar;17(2):122-9. doi: 10.1097/PAP.0b013e3181cfe732. PMID: 20179434

Clinical prediction guides

Expanding the Spectrum of NR4A3 Fusion-Positive Gynecologic Leiomyosarcomas.
Momeni-Boroujeni A, Mullaney K, DiNapoli SE, Leitao MM Jr, Hensley ML, Katabi N, Allison DHR, Park KJ, Antonescu CR, Chiang S
Mod Pathol 2024 May;37(5):100474. Epub 2024 Mar 18 doi: 10.1016/j.modpat.2024.100474. PMID: 38508521
Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup.
Kommoss FKF, Stichel D, Mora J, Esteller M, Jones DTW, Pfister SM, Brack E, Wachtel M, Bode PK, Sinn HP, Schmidt D, Mentzel T, Kommoss F, Sahm F, von Deimling A, Koelsche C
Mod Pathol 2021 Aug;34(8):1558-1569. Epub 2021 Apr 12 doi: 10.1038/s41379-021-00804-y. PMID: 33846547Free PMC Article
Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Efficacy and safety of nivolumab in Japanese patients with uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma: Multicenter, open-label phase 2 trial.
Tamura K, Hasegawa K, Katsumata N, Matsumoto K, Mukai H, Takahashi S, Nomura H, Minami H
Cancer Sci 2019 Sep;110(9):2894-2904. Epub 2019 Sep 3 doi: 10.1111/cas.14148. PMID: 31348579Free PMC Article
Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET.
Torizuka T, Kanno T, Futatsubashi M, Okada H, Yoshikawa E, Nakamura F, Takekuma M, Maeda M, Ouchi Y
J Nucl Med 2003 Jul;44(7):1051-6. PMID: 12843219

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