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Nodding Syndrome

MedGen UID:
772552
•Concept ID:
C3658353
•
Disease or Syndrome
Synonyms: Nodding Syndromes; Syndrome, Nodding; Syndromes, Nodding

Definition

Unexplained neurologic condition characterized by episodes of atonic seizures, convulsions or staring spells with further cognitive decline. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNodding Syndrome

Professional guidelines

PubMed

Doxycycline, a role in the treatment of onchocerciasis-associated epilepsy?
Pierella E, Siewe Fodjo JN, Colebunders R
Trends Parasitol 2024 Aug;40(8):667-669. Epub 2024 Jul 25 doi: 10.1016/j.pt.2024.06.005. PMID: 39060121
Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed.
Colebunders R, Siewe Fodjo JN, Kamoen O, Amaral LJ, Hadermann A, Trevisan C, Taylor MJ, Gauglitz J, Hoerauf A, Sato Y, Polman K, Basáñez MG, Bhwana D, Lakwo T, Abd-Elfarag G, Pion SD
Infect Dis Poverty 2024 Jan 12;13(1):5. doi: 10.1186/s40249-024-01174-8. PMID: 38212805Free PMC Article
Onchocerca volvulus and epilepsy: A comprehensive review using the Bradford Hill criteria for causation.
Colebunders R, Njamnshi AK, Menon S, Newton CR, Hotterbeekx A, Preux PM, Hopkins A, Vaillant M, Siewe Fodjo JN
PLoS Negl Trop Dis 2021 Jan;15(1):e0008965. Epub 2021 Jan 7 doi: 10.1371/journal.pntd.0008965. PMID: 33411705Free PMC Article

Recent clinical studies

Etiology

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed.
Colebunders R, Siewe Fodjo JN, Kamoen O, Amaral LJ, Hadermann A, Trevisan C, Taylor MJ, Gauglitz J, Hoerauf A, Sato Y, Polman K, Basáñez MG, Bhwana D, Lakwo T, Abd-Elfarag G, Pion SD
Infect Dis Poverty 2024 Jan 12;13(1):5. doi: 10.1186/s40249-024-01174-8. PMID: 38212805Free PMC Article
Onchocerciasis-associated epilepsy: an update and future perspectives.
Hadermann A, Amaral LJ, Van Cutsem G, Siewe Fodjo JN, Colebunders R
Trends Parasitol 2023 Feb;39(2):126-138. Epub 2022 Dec 15 doi: 10.1016/j.pt.2022.11.010. PMID: 36528471
Reducing onchocerciasis-associated morbidity in onchocerciasis-endemic foci with high ongoing transmission: a focus on the children.
Colebunders R, Kaiser C, Basáñez MG, Olliaro P, Lakwo T, Siewe Fodjo JN
Int J Infect Dis 2022 Mar;116:302-305. Epub 2022 Jan 21 doi: 10.1016/j.ijid.2022.01.042. PMID: 35074518Free PMC Article
High prevalence of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan: A community-based survey.
Colebunders R, Y Carter J, Olore PC, Puok K, Bhattacharyya S, Menon S, Abd-Elfarag G, Ojok M, Ensoy-Musoro C, Lako R, Logora MY
Seizure 2018 Dec;63:93-101. Epub 2018 Nov 13 doi: 10.1016/j.seizure.2018.11.004. PMID: 30468964Free PMC Article
Financing and collaboration on research and development for nodding syndrome.
Årdal C, Røttingen JA
Health Res Policy Syst 2016 Mar 17;14:19. doi: 10.1186/s12961-016-0091-6. PMID: 26983551Free PMC Article

Diagnosis

Epidemiology of epilepsy and relationship with onchocerciasis prevalence in villages of the Ntui Health District of Cameroon.
Ngarka L, Siewe Fodjo JN, Ambomatei C, Njamnshi WY, Taryunyu Njamnshi JN, Nfor LN, Mengnjo MK, Njamnshi AK
Epilepsy Behav 2023 May;142:109184. Epub 2023 Mar 25 doi: 10.1016/j.yebeh.2023.109184. PMID: 36972641Free PMC Article
Nodding syndrome phenotypes.
Spencer PS, Mazumder R, Palmer VS, Pollanen MS
Rev Neurol (Paris) 2019 Dec;175(10):679-685. Epub 2019 Nov 18 doi: 10.1016/j.neurol.2019.09.005. PMID: 31753452
Nodding Syndrome in the Spotlight - Placing Recent Findings in Perspective.
Spencer PS, Schmutzhard E, Winkler AS
Trends Parasitol 2017 Jul;33(7):490-492. Epub 2017 Jun 6 doi: 10.1016/j.pt.2017.05.001. PMID: 28596064Free PMC Article
Uganda: how goes the nodding syndrome war?
Burton A
Lancet Neurol 2016 Jan;15(1):30-1. Epub 2015 Dec 8 doi: 10.1016/S1474-4422(15)00350-6. PMID: 26700904
Nodding syndrome, western Uganda, 1994.
Kaiser C, Rubaale T, Tukesiga E, Kipp W, Asaba G
Am J Trop Med Hyg 2015 Jul;93(1):198-202. Epub 2015 Apr 27 doi: 10.4269/ajtmh.14-0838. PMID: 25918208Free PMC Article

Therapy

Doxycycline, a role in the treatment of onchocerciasis-associated epilepsy?
Pierella E, Siewe Fodjo JN, Colebunders R
Trends Parasitol 2024 Aug;40(8):667-669. Epub 2024 Jul 25 doi: 10.1016/j.pt.2024.06.005. PMID: 39060121
Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed.
Colebunders R, Siewe Fodjo JN, Kamoen O, Amaral LJ, Hadermann A, Trevisan C, Taylor MJ, Gauglitz J, Hoerauf A, Sato Y, Polman K, Basáñez MG, Bhwana D, Lakwo T, Abd-Elfarag G, Pion SD
Infect Dis Poverty 2024 Jan 12;13(1):5. doi: 10.1186/s40249-024-01174-8. PMID: 38212805Free PMC Article
Epidemiology of epilepsy and relationship with onchocerciasis prevalence in villages of the Ntui Health District of Cameroon.
Ngarka L, Siewe Fodjo JN, Ambomatei C, Njamnshi WY, Taryunyu Njamnshi JN, Nfor LN, Mengnjo MK, Njamnshi AK
Epilepsy Behav 2023 May;142:109184. Epub 2023 Mar 25 doi: 10.1016/j.yebeh.2023.109184. PMID: 36972641Free PMC Article
Onchocerciasis-associated epilepsy: an update and future perspectives.
Hadermann A, Amaral LJ, Van Cutsem G, Siewe Fodjo JN, Colebunders R
Trends Parasitol 2023 Feb;39(2):126-138. Epub 2022 Dec 15 doi: 10.1016/j.pt.2022.11.010. PMID: 36528471
Reducing onchocerciasis-associated morbidity in onchocerciasis-endemic foci with high ongoing transmission: a focus on the children.
Colebunders R, Kaiser C, Basáñez MG, Olliaro P, Lakwo T, Siewe Fodjo JN
Int J Infect Dis 2022 Mar;116:302-305. Epub 2022 Jan 21 doi: 10.1016/j.ijid.2022.01.042. PMID: 35074518Free PMC Article

Prognosis

The spectrum of disease and tau pathology of nodding syndrome in Uganda.
Pollanen MS, Onzivua S, McKeever PM, Robertson J, Mackenzie IR, Kovacs GG, Olwa F, Kitara DL, Fong A
Brain 2023 Mar 1;146(3):954-967. doi: 10.1093/brain/awac137. PMID: 35411378Free PMC Article
High prevalence of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan: A community-based survey.
Colebunders R, Y Carter J, Olore PC, Puok K, Bhattacharyya S, Menon S, Abd-Elfarag G, Ojok M, Ensoy-Musoro C, Lako R, Logora MY
Seizure 2018 Dec;63:93-101. Epub 2018 Nov 13 doi: 10.1016/j.seizure.2018.11.004. PMID: 30468964Free PMC Article
Financing and collaboration on research and development for nodding syndrome.
Årdal C, Røttingen JA
Health Res Policy Syst 2016 Mar 17;14:19. doi: 10.1186/s12961-016-0091-6. PMID: 26983551Free PMC Article
Neurophysiological and clinical findings on Nodding Syndrome in 21 South Sudanese children and a review of the literature.
de Polo G, Romaniello R, Otim A, Benjamin K, Bonanni P, Borgatti R
Seizure 2015 Sep;31:64-71. Epub 2015 Jul 20 doi: 10.1016/j.seizure.2015.07.006. PMID: 26362379
Nodding syndrome.
Dowell SF, Sejvar JJ, Riek L, Vandemaele KA, Lamunu M, Kuesel AC, Schmutzhard E, Matuja W, Bunga S, Foltz J, Nutman TB, Winkler AS, Mbonye AK
Emerg Infect Dis 2013;19(9):1374-84. doi: 10.3201/eid1909.130401. PMID: 23965548Free PMC Article

Clinical prediction guides

Epidemiology of epilepsy and relationship with onchocerciasis prevalence in villages of the Ntui Health District of Cameroon.
Ngarka L, Siewe Fodjo JN, Ambomatei C, Njamnshi WY, Taryunyu Njamnshi JN, Nfor LN, Mengnjo MK, Njamnshi AK
Epilepsy Behav 2023 May;142:109184. Epub 2023 Mar 25 doi: 10.1016/j.yebeh.2023.109184. PMID: 36972641Free PMC Article
The spectrum of disease and tau pathology of nodding syndrome in Uganda.
Pollanen MS, Onzivua S, McKeever PM, Robertson J, Mackenzie IR, Kovacs GG, Olwa F, Kitara DL, Fong A
Brain 2023 Mar 1;146(3):954-967. doi: 10.1093/brain/awac137. PMID: 35411378Free PMC Article
High prevalence of onchocerciasis-associated epilepsy in villages in Maridi County, Republic of South Sudan: A community-based survey.
Colebunders R, Y Carter J, Olore PC, Puok K, Bhattacharyya S, Menon S, Abd-Elfarag G, Ojok M, Ensoy-Musoro C, Lako R, Logora MY
Seizure 2018 Dec;63:93-101. Epub 2018 Nov 13 doi: 10.1016/j.seizure.2018.11.004. PMID: 30468964Free PMC Article
Onchocerciasis-Associated Epilepsy, an Additional Reason for Strengthening Onchocerciasis Elimination Programs.
Colebunders R, Nelson Siewe FJ, Hotterbeekx A
Trends Parasitol 2018 Mar;34(3):208-216. Epub 2017 Dec 26 doi: 10.1016/j.pt.2017.11.009. PMID: 29288080
Nodding syndrome, western Uganda, 1994.
Kaiser C, Rubaale T, Tukesiga E, Kipp W, Asaba G
Am J Trop Med Hyg 2015 Jul;93(1):198-202. Epub 2015 Apr 27 doi: 10.4269/ajtmh.14-0838. PMID: 25918208Free PMC Article

Recent systematic reviews

Mapping, Associated Factors, and Pathophysiology of Nodding Syndrome in Africa: A Systematic Review.
Metanmo S, Dossa D, Ahmat DN, Winkler AS, Boumediene F
Neuroepidemiology 2024;58(2):92-119. Epub 2024 Jan 15 doi: 10.1159/000536013. PMID: 38171341
Mortality among persons with epilepsy in onchocerciasis-endemic and non-endemic areas of sub-Saharan Africa: A systematic review and meta-analysis.
Siewe Fodjo JN, Van Cutsem G, Amaral LJ, Colebunders R
Seizure 2023 Aug;110:253-261. Epub 2023 Jul 10 doi: 10.1016/j.seizure.2023.07.006. PMID: 37451075
Onchocerciasis in tropical neurology: A scoping review.
Luna J, Metanmo S, Boumediene F, Mbelesso P, Auditeau E, Ajzenberg D, Preux PM
J Neurol Sci 2021 Feb 15;421:117314. Epub 2021 Jan 9 doi: 10.1016/j.jns.2021.117314. PMID: 33493958

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