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Proliferative Verrucous Leukoplakia

MedGen UID:
785040
Concept ID:
C3697776
Neoplastic Process
Synonyms: Papillary Leukoplakia; Proliferative verrucous leukoplakia; Proliferative verrucous oral leukoplakia; Verrucous Oral Leukoplakia
SNOMED CT: Proliferative verrucous leukoplakia (698010001); Proliferative verrucous oral leukoplakia (698010001)

Definition

Warty leukoplakia on the oral mucosa. It is associated with a high risk for malignant transformation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProliferative Verrucous Leukoplakia

Professional guidelines

PubMed

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article

Recent clinical studies

Etiology

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325

Diagnosis

Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV, González-Moles MÁ, Kerr AR, Lodi G, Mello FW, Monteiro L, Ogden GR, Sloan P, Johnson NW
Oral Dis 2021 Nov;27(8):1862-1880. Epub 2020 Nov 26 doi: 10.1111/odi.13704. PMID: 33128420
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Capella DL, Gonçalves JM, Abrantes AAA, Grando LJ, Daniel FI
Braz J Otorhinolaryngol 2017 Sep-Oct;83(5):585-593. Epub 2017 Jan 24 doi: 10.1016/j.bjorl.2016.12.005. PMID: 28209441Free PMC Article

Therapy

Yan Y, Li Z, Tian X, Zeng X, Chen Q, Wang J
Photodiagnosis Photodyn Ther 2022 Sep;39:103002. Epub 2022 Jul 6 doi: 10.1016/j.pdpdt.2022.103002. PMID: 35809828
Lafuente Ibáñez de Mendoza I, Lorenzo Pouso AI, Aguirre Urízar JM, Barba Montero C, Blanco Carrión A, Gándara Vila P, Pérez Sayáns M
J Oral Pathol Med 2022 Jan;51(1):30-38. Epub 2021 Oct 13 doi: 10.1111/jop.13246. PMID: 34558734
Proaño-Haro A, Bagan L, Bagan JV
J Oral Pathol Med 2021 Sep;50(8):820-828. Epub 2021 Apr 13 doi: 10.1111/jop.13178. PMID: 33765364
Keshavarz-Fathi M, Rezaei N
Arch Immunol Ther Exp (Warsz) 2021 Feb 27;69(1):3. doi: 10.1007/s00005-021-00604-x. PMID: 33638703
Cabay RJ, Morton TH Jr, Epstein JB
J Oral Pathol Med 2007 May;36(5):255-61. doi: 10.1111/j.1600-0714.2007.00506.x. PMID: 17448134

Prognosis

Arroyo E, Pérez Sayáns M, Bravo SB, de Oliveira Barbeiro C, Paravani Palaçon M, Chamorro Petronacci CM, García Vence M, Chantada Vázquez MDP, Blanco Carrión A, Suárez Peñaranda JM, García García A, Gándara Vila P, Días Almeida J, Veríssimo da Costa GC, Sousa Nogueira FC, Medeiros Evaristo JA, de Abreu Pereira D, Rintala M, Salo T, Rautava J, Padín Iruegas E, Oliveira Alves MG, Morandin Ferrisse T, Albergoni da Silveira H, Esquiche León J, Vilela Silva E, Flores IL, Bufalino A
Lab Invest 2023 Oct;103(10):100222. Epub 2023 Jul 26 doi: 10.1016/j.labinv.2023.100222. PMID: 37507024
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Maymone MBC, Greer RO, Kesecker J, Sahitya PC, Burdine LK, Cheng AD, Maymone AC, Vashi NA
J Am Acad Dermatol 2019 Jul;81(1):59-71. Epub 2018 Nov 14 doi: 10.1016/j.jaad.2018.09.060. PMID: 30447325
Munde A, Karle R
J Cancer Res Ther 2016 Apr-Jun;12(2):469-73. doi: 10.4103/0973-1482.151443. PMID: 27461595

Clinical prediction guides

Arroyo E, Pérez Sayáns M, Bravo SB, de Oliveira Barbeiro C, Paravani Palaçon M, Chamorro Petronacci CM, García Vence M, Chantada Vázquez MDP, Blanco Carrión A, Suárez Peñaranda JM, García García A, Gándara Vila P, Días Almeida J, Veríssimo da Costa GC, Sousa Nogueira FC, Medeiros Evaristo JA, de Abreu Pereira D, Rintala M, Salo T, Rautava J, Padín Iruegas E, Oliveira Alves MG, Morandin Ferrisse T, Albergoni da Silveira H, Esquiche León J, Vilela Silva E, Flores IL, Bufalino A
Lab Invest 2023 Oct;103(10):100222. Epub 2023 Jul 26 doi: 10.1016/j.labinv.2023.100222. PMID: 37507024
Novack R, Zhang L, Hoang LN, Kadhim M, Ng TL, Poh CF, Kevin Ko YC
Mod Pathol 2023 Jul;36(7):100153. Epub 2023 Mar 9 doi: 10.1016/j.modpat.2023.100153. PMID: 36906072
Kerr AR, Lodi G
Oral Dis 2021 Nov;27(8):2008-2025. Epub 2021 Oct 9 doi: 10.1111/odi.13980. PMID: 34324758
Thompson LDR, Fitzpatrick SG, Müller S, Eisenberg E, Upadhyaya JD, Lingen MW, Vigneswaran N, Woo SB, Bhattacharyya I, Bilodeau EA, Carlos R, Islam MN, Leon ME, Lewis JS Jr, Magliocca KR, Mani H, Mehrad M, Purgina B, Richardson M, Wenig BM, Cohen DM
Head Neck Pathol 2021 Jun;15(2):572-587. Epub 2021 Jan 7 doi: 10.1007/s12105-020-01262-9. PMID: 33415517Free PMC Article
Munde A, Karle R
J Cancer Res Ther 2016 Apr-Jun;12(2):469-73. doi: 10.4103/0973-1482.151443. PMID: 27461595

Recent systematic reviews

Nissanka-Jayasuriya EH, Fenton TR, Rose-Zerilli MJJ
Br J Oral Maxillofac Surg 2024 Feb;62(2):118-127. Epub 2023 Dec 5 doi: 10.1016/j.bjoms.2023.11.012. PMID: 38296711
Torrejon-Moya A, Jané-Salas E, López-López J
J Oral Pathol Med 2020 May;49(5):404-408. Epub 2020 Feb 9 doi: 10.1111/jop.12999. PMID: 31990082
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Okoturo EM, Risk JM, Schache AG, Shaw RJ, Boyd MT
Br J Oral Maxillofac Surg 2018 Nov;56(9):780-785. Epub 2018 Sep 3 doi: 10.1016/j.bjoms.2018.08.010. PMID: 30190088
Abadie WM, Partington EJ, Fowler CB, Schmalbach CE
Otolaryngol Head Neck Surg 2015 Oct;153(4):504-11. Epub 2015 Jun 4 doi: 10.1177/0194599815586779. PMID: 26044786

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      Nucleic Acid Probes
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