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Recurrent Cervical Carcinoma

MedGen UID:
78845
•Concept ID:
C0278579
•
Neoplastic Process
Synonyms: Cervical Carcinoma Recurrent; Recurrent Carcinoma of Cervix; Recurrent Carcinoma of Cervix Uteri; Recurrent Carcinoma of the Cervix; Recurrent Carcinoma of the Cervix Uteri; Recurrent Carcinoma of the Uterine Cervix; Recurrent Carcinoma of Uterine Cervix; Recurrent Cervical Cancer; Recurrent Cervix Uteri Carcinoma; Recurrent Uterine Cervix Carcinoma; Relapsed Carcinoma of Cervix; Relapsed Carcinoma of Cervix Uteri; Relapsed Carcinoma of the Cervix; Relapsed Carcinoma of the Cervix Uteri; Relapsed Carcinoma of the Uterine Cervix; Relapsed Carcinoma of Uterine Cervix; Relapsed Cervical Carcinoma; Relapsed Cervix Carcinoma; Relapsed Cervix Uteri Carcinoma; Relapsed Uterine Cervix Carcinoma

Definition

The reemergence of cervical carcinoma after a period of remission. [from NCI]

Professional guidelines

PubMed

Safety and efficacy of 3D-printed templates assisted CT-guided radioactive iodine-125 seed implantation for the treatment of recurrent cervical carcinoma after external beam radiotherapy.
Liu Y, Jiang P, Zhang H, Wang J
J Gynecol Oncol 2021 Mar;32(2):e15. Epub 2020 Nov 25 doi: 10.3802/jgo.2021.32.e15. PMID: 33300313Free PMC Article
Exenteration as a primary treatment for locally advanced cervical cancer: long-term results and prognostic factors.
Forner DM, Lampe B
Am J Obstet Gynecol 2011 Aug;205(2):148.e1-6. Epub 2011 Apr 7 doi: 10.1016/j.ajog.2011.03.057. PMID: 21640963
Long-term results of salvage radiotherapy for the treatment of recurrent cervical carcinoma after prior surgery.
Haasbeek CJ, Uitterhoeve AL, van der Velden J, González DG, Stalpers LJ
Radiother Oncol 2008 Nov;89(2):197-204. Epub 2008 Jan 30 doi: 10.1016/j.radonc.2008.01.004. PMID: 18237803

Recent clinical studies

Etiology

Final analysis of a randomized phase II/III trial of conventional paclitaxel and carboplatin with or without bevacizumab versus dose-dense paclitaxel and carboplatin with or without bevacizumab, in stage IVB, recurrent, or persistent cervical carcinoma (JCOG1311).
Ishikawa M, Shibata T, Kataoka T, Takekuma M, Kobayashi H, Yaegashi N, Satoh T; Gynecologic Cancer Study Group in Japan Clinical Oncology Group
Int J Gynecol Cancer 2023 May 1;33(5):692-700. doi: 10.1136/ijgc-2022-004214. PMID: 36997229
Computed Tomography-Based Interstitial Brachytherapy for Recurrent Cervical Carcinoma in the Vaginal Apex.
Engineer R, Chopra S, Shukla R, Mahantshetty U, Phurailatpam R, Ghadi Y, Gupta S, Shrivastava SK
Clin Oncol (R Coll Radiol) 2022 Jan;34(1):e1-e6. Epub 2021 Oct 26 doi: 10.1016/j.clon.2021.09.012. PMID: 34716084
Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240).
Tewari KS, Sill MW, Penson RT, Huang H, Ramondetta LM, Landrum LM, Oaknin A, Reid TJ, Leitao MM, Michael HE, DiSaia PJ, Copeland LJ, Creasman WT, Stehman FB, Brady MF, Burger RA, Thigpen JT, Birrer MJ, Waggoner SE, Moore DH, Look KY, Koh WJ, Monk BJ
Lancet 2017 Oct 7;390(10103):1654-1663. Epub 2017 Jul 27 doi: 10.1016/S0140-6736(17)31607-0. PMID: 28756902Free PMC Article
Chemotherapy for advanced and recurrent cervical carcinoma: results from cooperative group trials.
Leath CA 3rd, Straughn JM Jr
Gynecol Oncol 2013 Apr;129(1):251-7. Epub 2012 Dec 30 doi: 10.1016/j.ygyno.2012.12.035. PMID: 23280089
Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study.
Monk BJ, Sill MW, McMeekin DS, Cohn DE, Ramondetta LM, Boardman CH, Benda J, Cella D
J Clin Oncol 2009 Oct 1;27(28):4649-55. Epub 2009 Aug 31 doi: 10.1200/JCO.2009.21.8909. PMID: 19720909Free PMC Article

Diagnosis

Computed Tomography-Based Interstitial Brachytherapy for Recurrent Cervical Carcinoma in the Vaginal Apex.
Engineer R, Chopra S, Shukla R, Mahantshetty U, Phurailatpam R, Ghadi Y, Gupta S, Shrivastava SK
Clin Oncol (R Coll Radiol) 2022 Jan;34(1):e1-e6. Epub 2021 Oct 26 doi: 10.1016/j.clon.2021.09.012. PMID: 34716084
Chemotherapy for advanced and recurrent cervical carcinoma: results from cooperative group trials.
Leath CA 3rd, Straughn JM Jr
Gynecol Oncol 2013 Apr;129(1):251-7. Epub 2012 Dec 30 doi: 10.1016/j.ygyno.2012.12.035. PMID: 23280089
Recurrent uterine cervical carcinoma: spectrum of imaging findings.
Choi JI, Kim SH, Seong CK, Sim JS, Lee HJ, Do KH
Korean J Radiol 2000 Oct-Dec;1(4):198-207. doi: 10.3348/kjr.2000.1.4.198. PMID: 11752955Free PMC Article
Recurrent cervical carcinoma: typical and atypical manifestations.
Fulcher AS, O'Sullivan SG, Segreti EM, Kavanagh BD
Radiographics 1999 Oct;19 Spec No:S103-16; quiz S264-5. doi: 10.1148/radiographics.19.suppl_1.g99oc19s103. PMID: 10517448
Diagnosis of recurrent cervical carcinoma after radical hysterectomy.
Larson DM, Copeland LJ, Malone JM Jr, Stringer CA, Gershenson DM, Edwards CL
Obstet Gynecol 1988 Jan;71(1):6-9. PMID: 3336543

Therapy

Final analysis of a randomized phase II/III trial of conventional paclitaxel and carboplatin with or without bevacizumab versus dose-dense paclitaxel and carboplatin with or without bevacizumab, in stage IVB, recurrent, or persistent cervical carcinoma (JCOG1311).
Ishikawa M, Shibata T, Kataoka T, Takekuma M, Kobayashi H, Yaegashi N, Satoh T; Gynecologic Cancer Study Group in Japan Clinical Oncology Group
Int J Gynecol Cancer 2023 May 1;33(5):692-700. doi: 10.1136/ijgc-2022-004214. PMID: 36997229
Comments on: Safety and efficacy of 3D-printed templates assisted CT-guided radioactive iodine-125 seed implantation for the treatment of recurrent cervical carcinoma after external beam radiotherapy.
Shin HS
J Gynecol Oncol 2021 Mar;32(2):e50. doi: 10.3802/jgo.2021.32.e50. PMID: 33650344Free PMC Article
Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240).
Tewari KS, Sill MW, Penson RT, Huang H, Ramondetta LM, Landrum LM, Oaknin A, Reid TJ, Leitao MM, Michael HE, DiSaia PJ, Copeland LJ, Creasman WT, Stehman FB, Brady MF, Burger RA, Thigpen JT, Birrer MJ, Waggoner SE, Moore DH, Look KY, Koh WJ, Monk BJ
Lancet 2017 Oct 7;390(10103):1654-1663. Epub 2017 Jul 27 doi: 10.1016/S0140-6736(17)31607-0. PMID: 28756902Free PMC Article
Chemotherapy for advanced and recurrent cervical carcinoma: results from cooperative group trials.
Leath CA 3rd, Straughn JM Jr
Gynecol Oncol 2013 Apr;129(1):251-7. Epub 2012 Dec 30 doi: 10.1016/j.ygyno.2012.12.035. PMID: 23280089
Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study.
Monk BJ, Sill MW, McMeekin DS, Cohn DE, Ramondetta LM, Boardman CH, Benda J, Cella D
J Clin Oncol 2009 Oct 1;27(28):4649-55. Epub 2009 Aug 31 doi: 10.1200/JCO.2009.21.8909. PMID: 19720909Free PMC Article

Prognosis

Final analysis of a randomized phase II/III trial of conventional paclitaxel and carboplatin with or without bevacizumab versus dose-dense paclitaxel and carboplatin with or without bevacizumab, in stage IVB, recurrent, or persistent cervical carcinoma (JCOG1311).
Ishikawa M, Shibata T, Kataoka T, Takekuma M, Kobayashi H, Yaegashi N, Satoh T; Gynecologic Cancer Study Group in Japan Clinical Oncology Group
Int J Gynecol Cancer 2023 May 1;33(5):692-700. doi: 10.1136/ijgc-2022-004214. PMID: 36997229
Curative pelvic exenteration for recurrent cervical carcinoma in the era of concurrent chemotherapy and radiation therapy. A systematic review.
Sardain H, Lavoue V, Redpath M, Bertheuil N, Foucher F, Levêque J
Eur J Surg Oncol 2015 Aug;41(8):975-85. Epub 2015 Apr 14 doi: 10.1016/j.ejso.2015.03.235. PMID: 25922209
Phase III trial of four cisplatin-containing doublet combinations in stage IVB, recurrent, or persistent cervical carcinoma: a Gynecologic Oncology Group study.
Monk BJ, Sill MW, McMeekin DS, Cohn DE, Ramondetta LM, Boardman CH, Benda J, Cella D
J Clin Oncol 2009 Oct 1;27(28):4649-55. Epub 2009 Aug 31 doi: 10.1200/JCO.2009.21.8909. PMID: 19720909Free PMC Article
Chemotherapy for recurrent cervical carcinoma.
Moore DH
Curr Opin Oncol 2006 Sep;18(5):516-9. doi: 10.1097/01.cco.0000239893.21161.51. PMID: 16894302
Recurrent uterine cervical carcinoma: spectrum of imaging findings.
Choi JI, Kim SH, Seong CK, Sim JS, Lee HJ, Do KH
Korean J Radiol 2000 Oct-Dec;1(4):198-207. doi: 10.3348/kjr.2000.1.4.198. PMID: 11752955Free PMC Article

Clinical prediction guides

FDG PET-CT as an important diagnostic tool and prognostic marker in suspected recurrent cervical carcinoma after radiotherapy: comparison with MRI.
Stojiljkovic M, Sobic Saranovic D, Odalovic S, Popovic M, Petrovic J, Rankovic N, Veljkovic M, Artiko V
Radiol Oncol 2022 Dec 1;56(4):453-460. Epub 2022 Nov 2 doi: 10.2478/raon-2022-0042. PMID: 36317553Free PMC Article
Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240).
Tewari KS, Sill MW, Penson RT, Huang H, Ramondetta LM, Landrum LM, Oaknin A, Reid TJ, Leitao MM, Michael HE, DiSaia PJ, Copeland LJ, Creasman WT, Stehman FB, Brady MF, Burger RA, Thigpen JT, Birrer MJ, Waggoner SE, Moore DH, Look KY, Koh WJ, Monk BJ
Lancet 2017 Oct 7;390(10103):1654-1663. Epub 2017 Jul 27 doi: 10.1016/S0140-6736(17)31607-0. PMID: 28756902Free PMC Article
Curative pelvic exenteration for recurrent cervical carcinoma in the era of concurrent chemotherapy and radiation therapy. A systematic review.
Sardain H, Lavoue V, Redpath M, Bertheuil N, Foucher F, Levêque J
Eur J Surg Oncol 2015 Aug;41(8):975-85. Epub 2015 Apr 14 doi: 10.1016/j.ejso.2015.03.235. PMID: 25922209
Feasibility and outcome of concurrent chemoradiotherapy for recurrent cervical carcinoma after initial surgery.
Lee YS, Kim YS, Kim JH, Ahn SD, Lee SW, Shin SS, Nam JH, Kim YT, Kim YM, Kim JH, Choi EK
Tumori 2010 Jul-Aug;96(4):553-9. doi: 10.1177/030089161009600407. PMID: 20968134
Recurrent cervical carcinoma: typical and atypical manifestations.
Fulcher AS, O'Sullivan SG, Segreti EM, Kavanagh BD
Radiographics 1999 Oct;19 Spec No:S103-16; quiz S264-5. doi: 10.1148/radiographics.19.suppl_1.g99oc19s103. PMID: 10517448

Recent systematic reviews

Treatment of neovaginal prolapse: case report and systematic review of the literature.
Neron M, Ferron G, Vieille P, Letouzey V, Fatton B, de Tayrac R
Int Urogynecol J 2017 Jan;28(1):41-47. Epub 2016 Apr 2 doi: 10.1007/s00192-016-3009-5. PMID: 27038991
Curative pelvic exenteration for recurrent cervical carcinoma in the era of concurrent chemotherapy and radiation therapy. A systematic review.
Sardain H, Lavoue V, Redpath M, Bertheuil N, Foucher F, Levêque J
Eur J Surg Oncol 2015 Aug;41(8):975-85. Epub 2015 Apr 14 doi: 10.1016/j.ejso.2015.03.235. PMID: 25922209

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