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Recurrent Kidney Wilms Tumor

MedGen UID:
78873
•Concept ID:
C0278716
•
Neoplastic Process
Synonyms: Recurrent Kidney Adenosarcoma; Recurrent Kidney Nephroblastoma; Recurrent Renal Adenosarcoma; Recurrent Renal Wilms Tumor; Recurrent Renal Wilms' Tumor; Relapsed Kidney Adenosarcoma; Relapsed Kidney Nephroblastoma; Relapsed Renal Adenosarcoma; Relapsed Renal Wilms' Tumor

Definition

The reemergence of Wilms tumor of the kidney after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Kidney Wilms Tumor

Professional guidelines

PubMed

Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 May;70 Suppl 2(Suppl 2):e30342. doi: 10.1002/pbc.30342. PMID: 37096797Free PMC Article
Advances in the clinical management of high-risk Wilms tumors.
Ortiz MV, Koenig C, Armstrong AE, Brok J, de Camargo B, Mavinkurve-Groothuis AMC, Herrera TBV, Venkatramani R, Woods AD, Dome JS, Spreafico F
Pediatr Blood Cancer 2023 Mar;70(3):e30153. Epub 2023 Jan 10 doi: 10.1002/pbc.30153. PMID: 36625399
Wilms' tumor management.
Wu HY, Snyder HM 3rd, D'Angio GJ
Curr Opin Urol 2005 Jul;15(4):273-6. doi: 10.1097/01.mou.0000172403.69890.eb. PMID: 15928519

Recent clinical studies

Etiology

New approaches to risk stratification for Wilms tumor.
Nelson MV, van den Heuvel-Eibrink MM, Graf N, Dome JS
Curr Opin Pediatr 2021 Feb 1;33(1):40-48. Epub 2020 Dec 29 doi: 10.1097/MOP.0000000000000988. PMID: 33394739Free PMC Article
T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.
Chapuis AG, Egan DN, Bar M, Schmitt TM, McAfee MS, Paulson KG, Voillet V, Gottardo R, Ragnarsson GB, Bleakley M, Yeung CC, Muhlhauser P, Nguyen HN, Kropp LA, Castelli L, Wagener F, Hunter D, Lindberg M, Cohen K, Seese A, McElrath MJ, Duerkopp N, Gooley TA, Greenberg PD
Nat Med 2019 Jul;25(7):1064-1072. Epub 2019 Jun 24 doi: 10.1038/s41591-019-0472-9. PMID: 31235963Free PMC Article
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia.
McNeer NA, Philip J, Geiger H, Ries RE, Lavallée VP, Walsh M, Shah M, Arora K, Emde AK, Robine N, Alonzo TA, Kolb EA, Gamis AS, Smith M, Gerhard DS, Guidry-Auvil J, Meshinchi S, Kentsis A
Leukemia 2019 Aug;33(8):1934-1943. Epub 2019 Feb 13 doi: 10.1038/s41375-019-0402-3. PMID: 30760869Free PMC Article
A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.
Gadd S, Huff V, Walz AL, Ooms AHAG, Armstrong AE, Gerhard DS, Smith MA, Auvil JMG, Meerzaman D, Chen QR, Hsu CH, Yan C, Nguyen C, Hu Y, Hermida LC, Davidsen T, Gesuwan P, Ma Y, Zong Z, Mungall AJ, Moore RA, Marra MA, Dome JS, Mullighan CG, Ma J, Wheeler DA, Hampton OA, Ross N, Gastier-Foster JM, Arold ST, Perlman EJ
Nat Genet 2017 Oct;49(10):1487-1494. Epub 2017 Aug 21 doi: 10.1038/ng.3940. PMID: 28825729Free PMC Article
Pediatric genitourinary tumors.
Buckley KS
Curr Opin Oncol 2012 May;24(3):291-6. doi: 10.1097/CCO.0b013e32835265c9. PMID: 22476187

Diagnosis

New approaches to risk stratification for Wilms tumor.
Nelson MV, van den Heuvel-Eibrink MM, Graf N, Dome JS
Curr Opin Pediatr 2021 Feb 1;33(1):40-48. Epub 2020 Dec 29 doi: 10.1097/MOP.0000000000000988. PMID: 33394739Free PMC Article
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia.
McNeer NA, Philip J, Geiger H, Ries RE, Lavallée VP, Walsh M, Shah M, Arora K, Emde AK, Robine N, Alonzo TA, Kolb EA, Gamis AS, Smith M, Gerhard DS, Guidry-Auvil J, Meshinchi S, Kentsis A
Leukemia 2019 Aug;33(8):1934-1943. Epub 2019 Feb 13 doi: 10.1038/s41375-019-0402-3. PMID: 30760869Free PMC Article
Wilms' tumor management.
Wu HY, Snyder HM 3rd, D'Angio GJ
Curr Opin Urol 2005 Jul;15(4):273-6. doi: 10.1097/01.mou.0000172403.69890.eb. PMID: 15928519
Pediatric renal tumors.
Shamberger RC
Semin Surg Oncol 1999 Mar;16(2):105-20. doi: 10.1002/(sici)1098-2388(199903)16:2<105::aid-ssu4>3.0.co;2-t. PMID: 9988867
Current issues in the diagnosis and management of Wilms' tumor.
Paulino AC
Oncology (Williston Park) 1996 Oct;10(10):1553-65; discussion 1565-71. PMID: 8905846

Therapy

The Potential Role of Immunotherapy in Wilms' Tumor: Opportunities and Challenges.
Sanatkar SA, Heidari A, Arya S, Ghasemi M, Rezaei N
Curr Pharm Des 2023;29(20):1617-1627. doi: 10.2174/1381612829666230721122011. PMID: 37488763
Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.
Lahman MC, Schmitt TM, Paulson KG, Vigneron N, Buenrostro D, Wagener FD, Voillet V, Martin L, Gottardo R, Bielas J, McElrath JM, Stirewalt DL, Pogosova-Agadjanyan EL, Yeung CC, Pierce RH, Egan DN, Bar M, Hendrie PC, Kinsella S, Vakil A, Butler J, Chaffee M, Linton J, McAfee MS, Hunter DS, Bleakley M, Rongvaux A, Van den Eynde BJ, Chapuis AG, Greenberg PD
Sci Transl Med 2022 Feb 9;14(631):eabg8070. doi: 10.1126/scitranslmed.abg8070. PMID: 35138909Free PMC Article
T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.
Chapuis AG, Egan DN, Bar M, Schmitt TM, McAfee MS, Paulson KG, Voillet V, Gottardo R, Ragnarsson GB, Bleakley M, Yeung CC, Muhlhauser P, Nguyen HN, Kropp LA, Castelli L, Wagener F, Hunter D, Lindberg M, Cohen K, Seese A, McElrath MJ, Duerkopp N, Gooley TA, Greenberg PD
Nat Med 2019 Jul;25(7):1064-1072. Epub 2019 Jun 24 doi: 10.1038/s41591-019-0472-9. PMID: 31235963Free PMC Article
Pharmacotherapeutic Management of Wilms Tumor: An Update.
Oostveen RM, Pritchard-Jones K
Paediatr Drugs 2019 Feb;21(1):1-13. doi: 10.1007/s40272-018-0323-z. PMID: 30604241
Wilms' tumor management.
Wu HY, Snyder HM 3rd, D'Angio GJ
Curr Opin Urol 2005 Jul;15(4):273-6. doi: 10.1097/01.mou.0000172403.69890.eb. PMID: 15928519

Prognosis

New approaches to risk stratification for Wilms tumor.
Nelson MV, van den Heuvel-Eibrink MM, Graf N, Dome JS
Curr Opin Pediatr 2021 Feb 1;33(1):40-48. Epub 2020 Dec 29 doi: 10.1097/MOP.0000000000000988. PMID: 33394739Free PMC Article
Pediatric genitourinary tumors.
Buckley KS
Curr Opin Oncol 2012 May;24(3):291-6. doi: 10.1097/CCO.0b013e32835265c9. PMID: 22476187
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Wilms' tumor management.
Wu HY, Snyder HM 3rd, D'Angio GJ
Curr Opin Urol 2005 Jul;15(4):273-6. doi: 10.1097/01.mou.0000172403.69890.eb. PMID: 15928519
Pediatric renal tumors.
Shamberger RC
Semin Surg Oncol 1999 Mar;16(2):105-20. doi: 10.1002/(sici)1098-2388(199903)16:2<105::aid-ssu4>3.0.co;2-t. PMID: 9988867

Clinical prediction guides

Bioinformatical analysis of the key differentially expressed genes for screening potential biomarkers in Wilms tumor.
Cai L, Shi B, Zhu K, Zhong X, Lai D, Wang J, Tou J
Sci Rep 2023 Sep 16;13(1):15404. doi: 10.1038/s41598-023-42730-w. PMID: 37717078Free PMC Article
Postchemotherapy tumor volume as a prognostic indicator in Wilms tumor: A single-center experience from South India.
Joseph LL, Boddu D, Srinivasan HN, Regi SS, Antonisamy B, John R, Mathew LG, Totadri S
Pediatr Blood Cancer 2022 Feb;69(2):e29454. Epub 2021 Nov 22 doi: 10.1002/pbc.29454. PMID: 34811921
CD8+ T-cell lymphocytes infiltration predict clinical outcomes in Wilms' tumor.
Mardanpour K, Rahbar M, Mardanpour S, Mardanpour N, Rezaei M
Tumour Biol 2020 Dec;42(12):1010428320975976. doi: 10.1177/1010428320975976. PMID: 33283684
Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.
Qi XW, Zhang F, Wu H, Liu JL, Zong BG, Xu C, Jiang J
Sci Rep 2015 Mar 9;5:8924. doi: 10.1038/srep08924. PMID: 25748047Free PMC Article
Risk stratification for wilms tumor: current approach and future directions.
Dome JS, Perlman EJ, Graf N
Am Soc Clin Oncol Educ Book 2014:215-23. doi: 10.14694/EdBook_AM.2014.34.215. PMID: 24857079

Recent systematic reviews

Efficacy and late kidney effects of nephron-sparing surgery in the management of unilateral Wilms tumor: a systematic review and meta-analysis.
Li S, Wang J, Li M, Zhang Z, Mi T, Wu X, Wang Z, Jin L, He D
Pediatr Surg Int 2023 Dec 27;40(1):29. doi: 10.1007/s00383-023-05611-x. PMID: 38150145
Clinical features, treatment, and outcomes of bilateral Wilms' tumor: A systematic review and meta-analysis.
Han Q, Li K, Dong K, Xiao X, Yao W, Liu G
J Pediatr Surg 2018 Dec;53(12):2465-2469. Epub 2018 Sep 1 doi: 10.1016/j.jpedsurg.2018.08.022. PMID: 30274708
Biomarkers for Wilms Tumor: A Systematic Review.
Cone EB, Dalton SS, Van Noord M, Tracy ET, Rice HE, Routh JC
J Urol 2016 Nov;196(5):1530-1535. Epub 2016 May 31 doi: 10.1016/j.juro.2016.05.100. PMID: 27259655Free PMC Article
Nephron-sparing surgery for Wilms tumor: A systematic review.
Vanden Berg RN, Bierman EN, Noord MV, Rice HE, Routh JC
Urol Oncol 2016 Jan;34(1):24-32. Epub 2015 Aug 5 doi: 10.1016/j.urolonc.2015.07.003. PMID: 26254695Free PMC Article
Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.
Qi XW, Zhang F, Wu H, Liu JL, Zong BG, Xu C, Jiang J
Sci Rep 2015 Mar 9;5:8924. doi: 10.1038/srep08924. PMID: 25748047Free PMC Article

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