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Noninvasive malignant thymoma

MedGen UID:
78893
•Concept ID:
C0278847
•
Neoplastic Process
Synonyms: Malignant Thymoma, Noninvasive; malignant thymoma, noninvasive; Noninvasive Malignant Thymoma; noninvasive malignant thymoma; Thymoma Malignant Noninvasive; thymoma malignant noninvasive
 
Monarch Initiative: MONDO:0004147

Definition

A morphologically malignant thymoma that is entirely confined within the capsule. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNoninvasive malignant thymoma

Professional guidelines

PubMed

Differential diagnosis of thymic tumors using a combination of 11C-methionine PET and FDG PET.
Sasaki M, Kuwabara Y, Ichiya Y, Akashi Y, Yoshida T, Nakagawa M, Murayama S, Masuda K
J Nucl Med 1999 Oct;40(10):1595-601. PMID: 10520697
Thymoma: a clinico-pathologic study based on newly developed morphologic criteria.
Rendina EA, Pescarmona EO, Venuta F, Nardi S, De Rosa G, Martelli M, Ricci C
Tumori 1988 Feb 29;74(1):79-84. doi: 10.1177/030089168807400114. PMID: 3354066

Recent clinical studies

Etiology

Myasthenic crisis.
Claytor B, Cho SM, Li Y
Muscle Nerve 2023 Jul;68(1):8-19. Epub 2023 Apr 28 doi: 10.1002/mus.27832. PMID: 37114503
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Type AB thymoma with brain metastasis: Report of a case.
Ohata N, Usami N, Kawaguchi K, Tateyama H, Yokoi K
Surg Today 2011 Oct;41(10):1436-8. Epub 2011 Sep 16 doi: 10.1007/s00595-010-4442-6. PMID: 21922373
Thymomas in patients with myasthenia gravis.
Slater G, Papatestas AE, Genkins G, Kornfeld P, Horowitz SH, Bender A
Ann Surg 1978 Aug;188(2):171-4. doi: 10.1097/00000658-197808000-00008. PMID: 686883Free PMC Article
Thymoma: a clinical and pathological study of 65 cases.
Salyer WR, Eggleston JC
Cancer 1976 Jan;37(1):229-49. doi: 10.1002/1097-0142(197601)37:1<229::aid-cncr2820370133>3.0.co;2-2. PMID: 1247958

Diagnosis

Myasthenic crisis.
Claytor B, Cho SM, Li Y
Muscle Nerve 2023 Jul;68(1):8-19. Epub 2023 Apr 28 doi: 10.1002/mus.27832. PMID: 37114503
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.
Bellissimo T, Russo E, Ganci F, Vico C, Sacconi A, Longo F, Vitolo D, Anile M, Disio D, Marino M, Blandino G, Venuta F, Fazi F
Cancer Biol Ther 2016;17(1):79-82. doi: 10.1080/15384047.2015.1108493. PMID: 26575977Free PMC Article
Imaging of the thymus.
Mendelson DS
Chest Surg Clin N Am 2001 May;11(2):269-93, x. PMID: 11413756
Thymomas in patients with myasthenia gravis.
Slater G, Papatestas AE, Genkins G, Kornfeld P, Horowitz SH, Bender A
Ann Surg 1978 Aug;188(2):171-4. doi: 10.1097/00000658-197808000-00008. PMID: 686883Free PMC Article

Therapy

Lupus Nephritis with Thymoma Managed by Thoracoscopic Surgery and Prednisolone.
Iijima T, Hoshino J, Takaichi K, Kohno T, Fujii T, Ohashi K, Ubara Y
Intern Med 2017;56(24):3311-3316. Epub 2017 Dec 15 doi: 10.2169/internalmedicine.8966-17. PMID: 29249764Free PMC Article
First experience of robotic extended thymectomy in Japan for myasthenia gravis with thymoma.
Nakamura H, Taniguchi Y, Fujioka S, Miwa K, Haruki T, Takagi Y, Yurugi Y, Kubouchi Y
Gen Thorac Cardiovasc Surg 2012 Mar;60(3):183-7. Epub 2012 Mar 15 doi: 10.1007/s11748-011-0817-x. PMID: 22419192
Incidental discovery of an anterior mediastinal angiomyolipoma.
Watts KA, Watts JR Jr
J Thorac Imaging 2007 May;22(2):180-1. doi: 10.1097/01.rti.0000213571.09280.f8. PMID: 17527125
Ifosfamide in thymic neoplasms.
Daniele O, Fornasiero A
Oncology 2003;65 Suppl 2:44-5. doi: 10.1159/000073357. PMID: 14586146
Acetylcholine receptor autoantibody secretion by thymocytes: relationship to myasthenia gravis.
Yoshikawa H, Lennon VA
Neurology 1997 Aug;49(2):562-7. doi: 10.1212/wnl.49.2.562. PMID: 9270597

Prognosis

Myasthenic crisis.
Claytor B, Cho SM, Li Y
Muscle Nerve 2023 Jul;68(1):8-19. Epub 2023 Apr 28 doi: 10.1002/mus.27832. PMID: 37114503
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.
Bellissimo T, Russo E, Ganci F, Vico C, Sacconi A, Longo F, Vitolo D, Anile M, Disio D, Marino M, Blandino G, Venuta F, Fazi F
Cancer Biol Ther 2016;17(1):79-82. doi: 10.1080/15384047.2015.1108493. PMID: 26575977Free PMC Article
A thymoma associated with hyperparathyroidism.
Suzuki T, Suzuki S, Kitami A, Hori G, Inoue T, Suzuki S, Kubota T
Thorac Cardiovasc Surg 1997 Aug;45(4):211-2. doi: 10.1055/s-2007-1013728. PMID: 9323828
Thymomas in patients with myasthenia gravis.
Slater G, Papatestas AE, Genkins G, Kornfeld P, Horowitz SH, Bender A
Ann Surg 1978 Aug;188(2):171-4. doi: 10.1097/00000658-197808000-00008. PMID: 686883Free PMC Article

Clinical prediction guides

Advanced biomedical imaging for accurate discrimination and prognostication of mediastinal masses.
Mahmoudi S, Gruenewald LD, Eichler K, Martin SS, Booz C, Bernatz S, Lahrsow M, Yel I, Gotta J, Biciusca T, Mohammed H, Ziegengeist NS, Torgashov K, Hammerstingl RM, Sommer CM, Weber C, Almansour H, Bucolo G, D'Angelo T, Scholtz JE, Gruber-Rouh T, Vogl TJ, Koch V
Eur J Clin Invest 2023 Dec;53(12):e14075. Epub 2023 Aug 12 doi: 10.1111/eci.14075. PMID: 37571983
Development and Validation of Multi-Omics Thymoma Risk Classification Model Based on Transfer Learning.
Liu W, Wang W, Zhang H, Guo M, Xu Y, Liu X
J Digit Imaging 2023 Oct;36(5):2015-2024. Epub 2023 Jun 2 doi: 10.1007/s10278-023-00855-4. PMID: 37268842Free PMC Article
Predictors of outcome in patients with myasthenic crisis undergoing non-invasive mechanical ventilation: A retrospective 20 year longitudinal cohort study from a single Italian center.
Iori E, Mazzoli M, Ariatti A, Bastia E, Agnoletto V, Gozzi M, Marchioni A, Galassi G
Neuromuscul Disord 2021 Dec;31(12):1241-1250. Epub 2021 Aug 20 doi: 10.1016/j.nmd.2021.08.008. PMID: 34782245
Acetylcholine receptor autoantibody secretion by thymocytes: relationship to myasthenia gravis.
Yoshikawa H, Lennon VA
Neurology 1997 Aug;49(2):562-7. doi: 10.1212/wnl.49.2.562. PMID: 9270597
p53 expression and proliferative activity predict survival in non-invasive thymomas.
Pich A, Chiarle R, Chiusa L, Ponti R, Geuna M, Palestro G
Int J Cancer 1996 Jun 21;69(3):180-3. doi: 10.1002/(SICI)1097-0215(19960621)69:3<180::AID-IJC5>3.0.CO;2-W. PMID: 8682584

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