U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Inappropriate crying

MedGen UID:
810697
Concept ID:
C0860609
Finding; Sign or Symptom
Synonyms: Cry frequently for no reason; Cry frequently without apparent cause; Cry frequently without cause; Cry frequently without reason; Frequently cries for no reason; Frequently cries without apparent cause; Frequently cries without cause; Frequently cries without reason
 
HPO: HP:0030215

Definition

Uncontrolled episodes of crying occur without any apparent motivating stimuli. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInappropriate crying

Conditions with this feature

Rett syndrome, congenital variant
MedGen UID:
462055
Concept ID:
C3150705
Disease or Syndrome
The congenital variant of Rett syndrome is a severe neurodevelopmental disorder with features of classic Rett syndrome (RTT; 312750), but earlier onset in the first months of life. Classic Rett syndrome shows later onset and is caused by mutation in the MECP2 gene (300005).
Neurodevelopmental disorder with poor language and loss of hand skills
MedGen UID:
1637031
Concept ID:
C4693546
Disease or Syndrome
NDPLHS is an autosomal dominant disorder characterized by developmental stagnation or regression apparent in the first years of life and manifest as loss of purposeful hand movements, loss of language, and intellectual disability. Additional features may include stereotypic movements, dystonia, gait abnormalities, sleep disturbances, and small hands and feet. The phenotype is reminiscent of Rett syndrome (RTT; 312750) (summary by Yoo et al., 2017).
Glycosylphosphatidylinositol biosynthesis defect 18
MedGen UID:
1648478
Concept ID:
C4748357
Disease or Syndrome
Developmental and epileptic encephalopathy-95 (DEE95) is a severe autosomal recessive disorder characterized by severely impaired global development, hypotonia, weakness, ataxia, coarse facial features, and intractable seizures. More variable features may include abnormalities of the hands and feet, inguinal hernia, and feeding difficulties. The disorder is part of a group of similar neurologic disorders resulting from biochemical defects in the glycosylphosphatidylinositol (GPI) biosynthetic pathway (summary by Nguyen et al., 2018). For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350. For a discussion of genetic heterogeneity of GPI biosynthesis defects, see GPIBD1 (610293).
Neurodevelopmental disorder with seizures and gingival overgrowth
MedGen UID:
1784299
Concept ID:
C5543395
Disease or Syndrome
Neurodevelopmental disorder with seizures and gingival overgrowth (NEDSGO) is an autosomal recessive disorder with a highly variable phenotype. Some patients have early normal development with developmental regression apparent in the first years of life, whereas others present with hypotonia or delayed development. Most patients develop significant gingival hypertrophy associated with a prominent mandible or cherubism in the first years of life. Other more variable features may include coarse facial features, optic atrophy, sensorineural hearing loss, ataxia, and seizures. Brain imaging may show cerebellar or cerebral atrophy and enlarged ventricles. There is a wide phenotypic spectrum with features that may develop with age; the disorder appears to comprise a continuum of evolving neurologic manifestations (Harms et al., 2020).
Liver disease, severe congenital
MedGen UID:
1823968
Concept ID:
C5774195
Disease or Syndrome
Severe congenital liver disease (SCOLIV) is an autosomal recessive disorder characterized by the onset of progressive hepatic dysfunction usually in the first years of life. Affected individuals show feeding difficulties with failure to thrive and features such as jaundice, hepatomegaly, and abdominal distension. Laboratory workup is consistent with hepatic insufficiency and may also show coagulation defects, anemia, or metabolic disturbances. Cirrhosis and hypernodularity are commonly observed on liver biopsy. Many patients die of liver failure in early childhood (Moreno Traspas et al., 2022).

Professional guidelines

PubMed

Masemola HC, Moodley SV, Shirinde J
S Afr Fam Pract (2004) 2022 Jul 28;64(1):e1-e9. doi: 10.4102/safp.v64i1.5557. PMID: 35924620Free PMC Article
Zarowitz BJ, O'Shea T
Consult Pharm 2013 Nov;28(11):713-22. doi: 10.4140/TCP.n.2013.713. PMID: 24217191
Parvizi J, Arciniegas DB, Bernardini GL, Hoffmann MW, Mohr JP, Rapoport MJ, Schmahmann JD, Silver JM, Tuhrim S
Mayo Clin Proc 2006 Nov;81(11):1482-6. doi: 10.4065/81.11.1482. PMID: 17120404

Recent clinical studies

Etiology

Basheer S, Nagappa M, Mahadevan A, Bindu PS, Taly AB, Girimaji SC
Prim Care Companion CNS Disord 2017 Aug 17;19(4) doi: 10.4088/PCC.17m02110. PMID: 28841275
Strowd RE, Cartwright MS, Okun MS, Haq I, Siddiqui MS
J Neurol 2010 Aug;257(8):1382-7. Epub 2010 Apr 8 doi: 10.1007/s00415-010-5550-3. PMID: 20376475
Siddiqui MS, Fernandez HH, Garvan CW, Kirsch-Darrow L, Bowers D, Rodriguez RL, Jacobson CE 4th, Rosado C, Vaidyanathan S, Foote KD, Okun MS
World J Biol Psychiatry 2009;10(3):234-40. doi: 10.1080/15622970701639445. PMID: 18609421

Diagnosis

Basheer S, Nagappa M, Mahadevan A, Bindu PS, Taly AB, Girimaji SC
Prim Care Companion CNS Disord 2017 Aug 17;19(4) doi: 10.4088/PCC.17m02110. PMID: 28841275
Strowd RE, Cartwright MS, Okun MS, Haq I, Siddiqui MS
J Neurol 2010 Aug;257(8):1382-7. Epub 2010 Apr 8 doi: 10.1007/s00415-010-5550-3. PMID: 20376475
Siddiqui MS, Fernandez HH, Garvan CW, Kirsch-Darrow L, Bowers D, Rodriguez RL, Jacobson CE 4th, Rosado C, Vaidyanathan S, Foote KD, Okun MS
World J Biol Psychiatry 2009;10(3):234-40. doi: 10.1080/15622970701639445. PMID: 18609421
Sheikh BY, Coates R, Siqueira EB
Neuroradiology 1993;35(7):537-8. doi: 10.1007/BF00588716. PMID: 8232884

Therapy

Strowd RE, Cartwright MS, Okun MS, Haq I, Siddiqui MS
J Neurol 2010 Aug;257(8):1382-7. Epub 2010 Apr 8 doi: 10.1007/s00415-010-5550-3. PMID: 20376475

Prognosis

Basheer S, Nagappa M, Mahadevan A, Bindu PS, Taly AB, Girimaji SC
Prim Care Companion CNS Disord 2017 Aug 17;19(4) doi: 10.4088/PCC.17m02110. PMID: 28841275
Strowd RE, Cartwright MS, Okun MS, Haq I, Siddiqui MS
J Neurol 2010 Aug;257(8):1382-7. Epub 2010 Apr 8 doi: 10.1007/s00415-010-5550-3. PMID: 20376475

Clinical prediction guides

Basheer S, Nagappa M, Mahadevan A, Bindu PS, Taly AB, Girimaji SC
Prim Care Companion CNS Disord 2017 Aug 17;19(4) doi: 10.4088/PCC.17m02110. PMID: 28841275
Strowd RE, Cartwright MS, Okun MS, Haq I, Siddiqui MS
J Neurol 2010 Aug;257(8):1382-7. Epub 2010 Apr 8 doi: 10.1007/s00415-010-5550-3. PMID: 20376475
Siddiqui MS, Fernandez HH, Garvan CW, Kirsch-Darrow L, Bowers D, Rodriguez RL, Jacobson CE 4th, Rosado C, Vaidyanathan S, Foote KD, Okun MS
World J Biol Psychiatry 2009;10(3):234-40. doi: 10.1080/15622970701639445. PMID: 18609421

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...