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Discoid Rash

MedGen UID:
812051
•Concept ID:
C3805721
•
Finding
Synonym: Discoid rash

Definition

A disc-shaped patch(es) of skin inflammation that is red, raised, and scaly; it typically develops on the face, scalp, and neck, and often leaves scars and dyspigmentation as a result of postinflammatory hyperpigmentation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiscoid Rash

Professional guidelines

PubMed

Elderly-onset systemic lupus erythematosus: prevalence, clinical course and treatment.
Lazaro D
Drugs Aging 2007;24(9):701-15. doi: 10.2165/00002512-200724090-00001. PMID: 17727302
Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms.
Heinlen LD, McClain MT, Merrill J, Akbarali YW, Edgerton CC, Harley JB, James JA
Arthritis Rheum 2007 Jul;56(7):2344-51. doi: 10.1002/art.22665. PMID: 17599763
Glutathione S-transferase genotype and risk of systemic lupus erythematosus in Koreans.
Kang TY, El-Sohemy A, Comelis MC, Eny KM, Bae SC
Lupus 2005;14(5):381-4. doi: 10.1191/0961203305lu2100oa. PMID: 15934438

Recent clinical studies

Etiology

Anti-Toxoplasma gondii antibodies as a risk factor for the prevalence and severity of systemic lupus erythematosus.
Li Z, Lei Z, Yang W, Jing C, Sun X, Yang G, Zhao X, Zhang M, Xu M, Tang Y, Wang Q, Zhao J, Zhou Z, Wen Z, Chen X, Peng Q, Wang G, Zhang P, Sun E, Shen N, Xu W, Li Z, Yang H, Yin Z
Parasit Vectors 2024 Jan 30;17(1):44. doi: 10.1186/s13071-024-06141-8. PMID: 38291478Free PMC Article
Timing and Predictors of Incident Cardiovascular Disease in Systemic Lupus Erythematosus: Risk Occurs Early and Highlights Racial Disparities.
Garg S, Bartels CM, Bao G, Helmick CG, Drenkard C, Lim SS
J Rheumatol 2023 Jan;50(1):84-92. Epub 2022 Aug 1 doi: 10.3899/jrheum.220279. PMID: 35914786Free PMC Article
Association between IL-37 and Systemic Lupus Erythematosus Risk.
Wu Q, Zhou J, Yuan ZC, Lan YY, Xu WD, Huang AF
Immunol Invest 2022 May;51(4):727-738. Epub 2021 Jan 17 doi: 10.1080/08820139.2020.1869254. PMID: 33459098
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article
Cutaneous vasculitis in SLE.
Kallas R, Goldman D, Petri MA
Lupus Sci Med 2020 Sep;7(1) doi: 10.1136/lupus-2020-000411. PMID: 32963114Free PMC Article

Diagnosis

Interrelation of T cell cytokines and autoantibodies in systemic lupus erythematosus: A cross-sectional study.
Alduraibi FK, Sullivan KA, Chatham WW, Hsu HC, Mountz JD
Clin Immunol 2023 Feb;247:109239. Epub 2023 Jan 20 doi: 10.1016/j.clim.2023.109239. PMID: 36682593Free PMC Article
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article
Cutaneous vasculitis in SLE.
Kallas R, Goldman D, Petri MA
Lupus Sci Med 2020 Sep;7(1) doi: 10.1136/lupus-2020-000411. PMID: 32963114Free PMC Article
Clinical presentation of human C1q deficiency: How much of a lupus?
Stegert M, Bock M, Trendelenburg M
Mol Immunol 2015 Sep;67(1):3-11. Epub 2015 Apr 3 doi: 10.1016/j.molimm.2015.03.007. PMID: 25846716
Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature.
Chiewchengchol D, Murphy R, Edwards SW, Beresford MW
Pediatr Rheumatol Online J 2015;13:1. Epub 2015 Jan 5 doi: 10.1186/1546-0096-13-1. PMID: 25587243Free PMC Article

Therapy

Acute acalculous cholecystitis as the initial manifestation of systemic lupus erythematous: A case report.
Lee J, Lee YJ, Kim Y
Medicine (Baltimore) 2021 Jun 4;100(22):e26238. doi: 10.1097/MD.0000000000026238. PMID: 34087909Free PMC Article
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article
Predictors of predominant Lupus Low Disease Activity State (LLDAS-50).
Babaoglu H, Li J, Goldman D, Magder LS, Petri M
Lupus 2019 Dec;28(14):1648-1655. Epub 2019 Nov 6 doi: 10.1177/0961203319886028. PMID: 31694446Free PMC Article
Early Lupus Project - A multicentre Italian study on systemic lupus erythematosus of recent onset.
Sebastiani GD, Prevete I, Piga M, Iuliano A, Bettio S, Bortoluzzi A, Coladonato L, Tani C, Spinelli FR, Fineschi I, Mathieu A
Lupus 2015 Oct;24(12):1276-82. Epub 2015 May 15 doi: 10.1177/0961203315585817. PMID: 25979916
Association of smoking with cutaneous manifestations in systemic lupus erythematosus.
Bourré-Tessier J, Peschken CA, Bernatsky S, Joseph L, Clarke AE, Fortin PR, Hitchon C, Mittoo S, Smith CD, Zummer M, Pope J, Tucker L, Hudson M, Arbillaga H, Esdaile J, Silverman E, Chédeville G, Huber AM, Belisle P; Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus 1000 Canadian Faces of Lupus Investigators, Pineau CA
Arthritis Care Res (Hoboken) 2013 Aug;65(8):1275-80. doi: 10.1002/acr.21966. PMID: 23401335

Prognosis

Similarities and differences between younger and older disease onset patients with newly diagnosed systemic lupus erythematosus.
Prevete I, Iuliano A, Cauli A, Piga M, Iannone F, Coladonato L, Bortoluzzi A, Silvagni E, Tani C, Elefante E, Doria A, Iaccarino L, Franceschini F, Fredi M, Conti F, Spinelli FR, Frediani B, Gonzales Garcìa E, Scirè CA, Zanetti A, Rozza D, Carrara G, Sebastiani GD; Early Lupus project
Clin Exp Rheumatol 2023 Jan;41(1):145-150. Epub 2022 Jul 26 doi: 10.55563/clinexprheumatol/oo5ymg. PMID: 35894063
Cutaneous vasculitis in SLE.
Kallas R, Goldman D, Petri MA
Lupus Sci Med 2020 Sep;7(1) doi: 10.1136/lupus-2020-000411. PMID: 32963114Free PMC Article
Predictors of predominant Lupus Low Disease Activity State (LLDAS-50).
Babaoglu H, Li J, Goldman D, Magder LS, Petri M
Lupus 2019 Dec;28(14):1648-1655. Epub 2019 Nov 6 doi: 10.1177/0961203319886028. PMID: 31694446Free PMC Article
Clinical presentation of human C1q deficiency: How much of a lupus?
Stegert M, Bock M, Trendelenburg M
Mol Immunol 2015 Sep;67(1):3-11. Epub 2015 Apr 3 doi: 10.1016/j.molimm.2015.03.007. PMID: 25846716
Systemic symptoms in the progression of cutaneous to systemic lupus erythematosus.
Wieczorek IT, Propert KJ, Okawa J, Werth VP
JAMA Dermatol 2014 Mar;150(3):291-6. doi: 10.1001/jamadermatol.2013.9026. PMID: 24477339

Clinical prediction guides

Timing and Predictors of Incident Cardiovascular Disease in Systemic Lupus Erythematosus: Risk Occurs Early and Highlights Racial Disparities.
Garg S, Bartels CM, Bao G, Helmick CG, Drenkard C, Lim SS
J Rheumatol 2023 Jan;50(1):84-92. Epub 2022 Aug 1 doi: 10.3899/jrheum.220279. PMID: 35914786Free PMC Article
Acute acalculous cholecystitis as the initial manifestation of systemic lupus erythematous: A case report.
Lee J, Lee YJ, Kim Y
Medicine (Baltimore) 2021 Jun 4;100(22):e26238. doi: 10.1097/MD.0000000000026238. PMID: 34087909Free PMC Article
Cutaneous vasculitis in SLE.
Kallas R, Goldman D, Petri MA
Lupus Sci Med 2020 Sep;7(1) doi: 10.1136/lupus-2020-000411. PMID: 32963114Free PMC Article
Changes of NADH Fluorescence from the Skin of Patients with Systemic Lupus Erythematosus.
Bogaczewicz J, Tokarska K, Wozniacka A
Biomed Res Int 2019;2019:5897487. Epub 2019 Dec 24 doi: 10.1155/2019/5897487. PMID: 31930128Free PMC Article
Predictors of predominant Lupus Low Disease Activity State (LLDAS-50).
Babaoglu H, Li J, Goldman D, Magder LS, Petri M
Lupus 2019 Dec;28(14):1648-1655. Epub 2019 Nov 6 doi: 10.1177/0961203319886028. PMID: 31694446Free PMC Article

Recent systematic reviews

Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article

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