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Aortic rupture

MedGen UID:
Concept ID:
Disease or Syndrome
Synonyms: Aortic Rupture; Aortic Ruptures; Rupture, Aortic; Ruptures, Aortic
HPO: HP:0031649


Tearing of the aortic wall generally associated with profuse internal bleeding. [from HPO]

Conditions with this feature

Aortic aneurysm, familial thoracic 7
MedGen UID:
Concept ID:
Disease or Syndrome
Ehlers-Danlos syndrome, kyphoscoliotic type, 2
MedGen UID:
Concept ID:
Disease or Syndrome
FKBP14 kyphoscoliotic Ehlers-Danlos syndrome (FKBP14-kEDS) is characterized by congenital muscle hypotonia and weakness (typically improving during childhood), progressive scoliosis, joint hypermobility, hyperelastic skin, gross motor developmental delay, myopathy, and hearing impairment. Most affected children achieve independent walking between ages two and four years. A decline of motor function in adulthood may be seen, but affected individuals are likely to be able to participate in activities of daily living in adulthood and maintain independent walking. Occasional features underlying systemic connective tissue involvement include aortic rupture and arterial dissection, subdural hygroma, insufficiency of cardiac valves, bluish sclerae, bladder diverticula, inguinal or umbilical herniae, and premature rupture of membranes during pregnancy. Rarer findings may include bifid uvula with submucous or frank cleft palate, speech/language delay without true cognitive impairment, and rectal prolapse.

Professional guidelines


Jen JP, Malik A, Lewis G, Holloway B
Br J Hosp Med (Lond) 2020 Oct 2;81(10):1-12. Epub 2020 Oct 23 doi: 10.12968/hmed.2020.0344. PMID: 33135923
Alfson DB, Ham SW
Cardiol Clin 2017 Aug;35(3):387-410. Epub 2017 May 26 doi: 10.1016/j.ccl.2017.03.007. PMID: 28683909
Nauta FJ, Trimarchi S, Kamman AV, Moll FL, van Herwaarden JA, Patel HJ, Figueroa CA, Eagle KA, Froehlich JB
Vasc Med 2016 Jun;21(3):251-63. Epub 2016 Apr 11 doi: 10.1177/1358863X16642318. PMID: 27067136

Recent clinical studies


De Freitas S, D'Ambrosio N, Fatima J
Surg Clin North Am 2023 Aug;103(4):595-614. Epub 2023 Jun 9 doi: 10.1016/j.suc.2023.05.001. PMID: 37455027
Calgi MP, McNeil JS
Anesthesiol Clin 2022 Dec;40(4):657-669. Epub 2022 Sep 28 doi: 10.1016/j.anclin.2022.08.010. PMID: 36328621
Blusztein D, Agrawal H
J Invasive Cardiol 2021 Jul;33(7):E575. PMID: 34224386
Poniedzialek-Czajkowska E, Sadowska A, Mierzynski R, Leszczynska-Gorzelak B
Ginekol Pol 2019;90(6):346-350. doi: 10.5603/GP.2019.0052. PMID: 31276187
Sakalihasan N, Limet R, Defawe OD
Lancet 2005 Apr 30-May 6;365(9470):1577-89. doi: 10.1016/S0140-6736(05)66459-8. PMID: 15866312


Blusztein D, Agrawal H
J Invasive Cardiol 2021 Jul;33(7):E575. PMID: 34224386
White A, Broder J, Mando-Vandrick J, Wendell J, Crowe J
Adv Emerg Nurs J 2013 Jan-Mar;35(1):28-52. doi: 10.1097/TME.0b013e31827145d0. PMID: 23364404
Thrumurthy SG, Karthikesalingam A, Patterson BO, Holt PJ, Thompson MM
BMJ 2011 Jan 11;344:d8290. doi: 10.1136/bmj.d8290. PMID: 22236596
Feldman DN, Roman MJ
Cardiology 2006;106(2):73-81. Epub 2006 Apr 12 doi: 10.1159/000092635. PMID: 16612073
Balm R, Hoornweg LL
J Cardiovasc Surg (Torino) 2005 Apr;46(2):101-5. PMID: 15793488


Blusztein D, Agrawal H
J Invasive Cardiol 2021 Jul;33(7):E575. PMID: 34224386
Dalman RL, Wanhainen A, Mani K, Modarai B
J Intern Med 2020 Jul;288(1):23-37. Epub 2020 Mar 18 doi: 10.1111/joim.13042. PMID: 32187752
Golledge J
Nat Rev Cardiol 2019 Apr;16(4):225-242. doi: 10.1038/s41569-018-0114-9. PMID: 30443031
Yoshimura K, Morikage N, Nishino-Fujimoto S, Furutani A, Shirasawa B, Hamano K
Curr Drug Targets 2018;19(11):1265-1275. doi: 10.2174/1389450119666171227223331. PMID: 29284386Free PMC Article
Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, Hiratzka LF, Murphy WR, Olin JW, Puschett JB, Rosenfield KA, Sacks D, Stanley JC, Taylor LM Jr, White CJ, White J, White RA, Antman EM, Smith SC Jr, Adams CD, Anderson JL, Faxon DP, Fuster V, Gibbons RJ, Hunt SA, Jacobs AK, Nishimura R, Ornato JP, Page RL, Riegel B; American Association for Vascular Surgery; Society for Vascular Surgery; Society for Cardiovascular Angiography and Interventions; Society for Vascular Medicine and Biology; Society of Interventional Radiology; ACC/AHA Task Force on Practice Guidelines Writing Committee to Develop Guidelines for the Management of Patients With Peripheral Arterial Disease; American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; Vascular Disease Foundation
Circulation 2006 Mar 21;113(11):e463-654. doi: 10.1161/CIRCULATIONAHA.106.174526. PMID: 16549646


Mordi IR, Forsythe RO, Gellatly C, Iskandar Z, McBride OM, Saratzis A, Chalmers R, Chin C, Bown MJ, Newby DE, Lang CC, Huang JTJ, Choy AM
J Am Heart Assoc 2019 Oct 15;8(20):e013743. Epub 2019 Oct 9 doi: 10.1161/JAHA.119.013743. PMID: 31595818Free PMC Article
Patel K, Zafar MA, Ziganshin BA, Elefteriades JA
Cardiology 2018;141(2):107-122. Epub 2018 Nov 19 doi: 10.1159/000490373. PMID: 30453299
Ahmed R, Ghoorah K, Kunadian V
Cardiol Rev 2016 Mar-Apr;24(2):88-93. doi: 10.1097/CRD.0000000000000052. PMID: 25580705
Booher AM, Eagle KA, Bossone E
Herz 2011 Sep;36(6):480-7. doi: 10.1007/s00059-011-3504-x. PMID: 21912914
Ayling J
Emerg Med Serv 2003 Nov;32(11):37. PMID: 14658209

Clinical prediction guides

Fletcher AJ, Syed MBJ, Aitman TJ, Newby DE, Walker NL
Circulation 2020 May 12;141(19):1570-1587. Epub 2020 May 11 doi: 10.1161/CIRCULATIONAHA.119.043756. PMID: 32392100Free PMC Article
Nazerian P, Mueller C, Soeiro AM, Leidel BA, Salvadeo SAT, Giachino F, Vanni S, Grimm K, Oliveira MT Jr, Pivetta E, Lupia E, Grifoni S, Morello F; ADvISED Investigators
Circulation 2018 Jan 16;137(3):250-258. Epub 2017 Oct 13 doi: 10.1161/CIRCULATIONAHA.117.029457. PMID: 29030346
Lilja F, Wanhainen A, Mani K
J Cardiovasc Surg (Torino) 2017 Dec;58(6):848-853. Epub 2017 Jun 20 doi: 10.23736/S0021-9509.17.10064-9. PMID: 28633519
Wanhainen A, Mani K, Golledge J
Arterioscler Thromb Vasc Biol 2016 Feb;36(2):236-44. Epub 2015 Dec 29 doi: 10.1161/ATVBAHA.115.306538. PMID: 26715680
Raman SV, Aneja A, Jarjour WN
J Cardiovasc Magn Reson 2012 Nov 30;14(1):82. doi: 10.1186/1532-429X-14-82. PMID: 23199343Free PMC Article

Recent systematic reviews

Yu X, Jiang D, Wang J, Wang R, Chen T, Wang K, Durgahee MSA, Wei X, Cao S
Heart 2019 Sep;105(17):1351-1357. Epub 2019 Apr 1 doi: 10.1136/heartjnl-2018-314639. PMID: 30936409
Choong AMTL, Marjot J, Wee IJY, Syn N, Marjot T, Brightwell RE, Walker PJ
J Vasc Surg 2019 May;69(5):1615-1632.e17. Epub 2019 Feb 18 doi: 10.1016/j.jvs.2018.09.030. PMID: 30792059
Zaiem F, Almasri J, Tello M, Prokop LJ, Chaikof EL, Murad MH
J Vasc Surg 2018 Jan;67(1):320-331.e37. Epub 2017 Jun 26 doi: 10.1016/j.jvs.2017.04.058. PMID: 28662928
Harris DG, Rabin J, Bhardwaj A, June AS, Oates CP, Garrido D, Toursavadkohi S, Khoynezhad A, Crawford RS
Ann Vasc Surg 2016 Aug;35:75-81. Epub 2016 Jun 3 doi: 10.1016/j.avsg.2016.02.021. PMID: 27263820
Vitale J, Manfredini R, Gallerani M, Mumoli N, Eagle KA, Ageno W, Dentali F
Chronobiol Int 2015 Apr;32(3):385-94. Epub 2014 Nov 21 doi: 10.3109/07420528.2014.983604. PMID: 25414043

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