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Chronic hepatitis due to cryptosporidium infection

MedGen UID:
815150
•Concept ID:
C3808820
•
Disease or Syndrome; Finding
Synonym: Chronic hepatitis due to cryptospridium infection
 
HPO: HP:0200124

Definition

Chronic hepatitis associated with infection by cryptosporidia, as demonstrated (for example) by immunohistochemistry of liver tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic hepatitis due to cryptosporidium infection

Conditions with this feature

Cryptosporidiosis-chronic cholangitis-liver disease syndrome
MedGen UID:
767601
•Concept ID:
C3554687
•
Disease or Syndrome
Immunodeficiency-56 is an autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens (summary by Kotlarz et al., 2013).
See: Condition Record
Cryptosporidiosis-chronic cholangitis-liver disease syndrome

Professional guidelines

PubMed

Thiazolides: a new class of drugs for the treatment of chronic hepatitis B and C.
Rossignol JF, Keeffe EB
Future Microbiol 2008 Oct;3(5):539-45. doi: 10.2217/17460913.3.5.539. PMID: 18811238

Recent clinical studies

Etiology

Prevalence and clinical significance of Cryptosporidium infection in patients with hepatitis B virus-associated acute-on-chronic liver failure.
Yu Z, Li F, Zeng Z, Huang Z, Fan Z, Jin Y, Luo W, Xiang X, Deng Q
Int J Infect Dis 2011 Dec;15(12):e845-8. Epub 2011 Oct 12 doi: 10.1016/j.ijid.2011.08.006. PMID: 21992928
Pancreatic abnormalities and AIDS related sclerosing cholangitis.
Teare JP, Daly CA, Rodgers C, Padley SP, Coker RJ, Main J, Harris JR, Scullion D, Bray GP, Summerfield JA
Genitourin Med 1997 Aug;73(4):271-3. doi: 10.1136/sti.73.4.271. PMID: 9389948Free PMC Article

Diagnosis

Pancreatic abnormalities and AIDS related sclerosing cholangitis.
Teare JP, Daly CA, Rodgers C, Padley SP, Coker RJ, Main J, Harris JR, Scullion D, Bray GP, Summerfield JA
Genitourin Med 1997 Aug;73(4):271-3. doi: 10.1136/sti.73.4.271. PMID: 9389948Free PMC Article
The pathology of AIDS.
Macher AM
Public Health Rep 1988 May-Jun;103(3):246-54. PMID: 2836878Free PMC Article
Human immunodeficiency virus infection in childhood.
Blokzijl ML
Ann Trop Paediatr 1988 Mar;8(1):1-17. doi: 10.1080/02724936.1988.11748530. PMID: 2456715

Therapy

Thiazolides: a new class of drugs for the treatment of chronic hepatitis B and C.
Rossignol JF, Keeffe EB
Future Microbiol 2008 Oct;3(5):539-45. doi: 10.2217/17460913.3.5.539. PMID: 18811238

Prognosis

Prevalence and clinical significance of Cryptosporidium infection in patients with hepatitis B virus-associated acute-on-chronic liver failure.
Yu Z, Li F, Zeng Z, Huang Z, Fan Z, Jin Y, Luo W, Xiang X, Deng Q
Int J Infect Dis 2011 Dec;15(12):e845-8. Epub 2011 Oct 12 doi: 10.1016/j.ijid.2011.08.006. PMID: 21992928
Liver transplantation for endstage hepatitis C cirrhosis in a patient with primary hypogammaglobulinaemia.
Bjøro K, Schrumpf E, Bergan A, Haaland T, Skaug K, Frøland SS
Scand J Infect Dis 1998;30(5):520-2. doi: 10.1080/00365549850161575. PMID: 10066058

Clinical prediction guides

The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation.
Elazar M, Liu M, McKenna SA, Liu P, Gehrig EA, Puglisi JD, Rossignol JF, Glenn JS
Gastroenterology 2009 Nov;137(5):1827-35. Epub 2009 Aug 4 doi: 10.1053/j.gastro.2009.07.056. PMID: 19664635

Supplemental Content

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