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t(9;11)

MedGen UID:
820618
•Concept ID:
C3827870
•
Cell or Molecular Dysfunction

Definition

A translocation between chromosome 9 and chromosome 11. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(9;11)

Professional guidelines

PubMed

Emergence of translocation t(9;11)-positive leukemia during treatment of childhood acute lymphoblastic leukemia.
Metzler M, Strissel PL, Strick R, Niemeyer C, Roettgers S, Borkhardt A, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Reinhardt D, Creutzig U, Beck JD, Rascher W, Repp R, Langer T
Genes Chromosomes Cancer 2004 Nov;41(3):291-6. doi: 10.1002/gcc.20083. PMID: 15334554
Therapy related leukemias: susceptibility, prevention and treatment.
Leone G, Voso MT, Sica S, Morosetti R, Pagano L
Leuk Lymphoma 2001 Apr;41(3-4):255-76. doi: 10.3109/10428190109057981. PMID: 11378539
All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders.
Rowley JD, Reshmi S, Sobulo O, Musvee T, Anastasi J, Raimondi S, Schneider NR, Barredo JC, Cantu ES, Schlegelberger B, Behm F, Doggett NA, Borrow J, Zeleznik-Le N
Blood 1997 Jul 15;90(2):535-41. PMID: 9226152

Recent clinical studies

Etiology

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Polycomb complexes in MLL-AF9-related leukemias.
Sparavier A, Di Croce L
Curr Opin Genet Dev 2022 Aug;75:101920. Epub 2022 May 21 doi: 10.1016/j.gde.2022.101920. PMID: 35609423
Distinct pathologic feature of myeloid neoplasm with t(v;11p15); NUP98 rearrangement.
Lauw MIS, Qi Z, Eversmeyer L, Prakash S, Wen KW, Yu J, Monaghan SA, Aggarwal N, Wang L
Hum Pathol 2022 May;123:11-19. Epub 2022 Feb 12 doi: 10.1016/j.humpath.2022.02.004. PMID: 35167894
Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A.
Bill M, Mrózek K, Kohlschmidt J, Eisfeld AK, Walker CJ, Nicolet D, Papaioannou D, Blachly JS, Orwick S, Carroll AJ, Kolitz JE, Powell BL, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD
Proc Natl Acad Sci U S A 2020 Oct 20;117(42):26340-26346. Epub 2020 Oct 5 doi: 10.1073/pnas.2014732117. PMID: 33020282Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Diagnosis

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Emergence of translocation t(9;11)-positive leukemia during treatment of childhood acute lymphoblastic leukemia.
Metzler M, Strissel PL, Strick R, Niemeyer C, Roettgers S, Borkhardt A, Harbott J, Ludwig WD, Stanulla M, Schrappe M, Reinhardt D, Creutzig U, Beck JD, Rascher W, Repp R, Langer T
Genes Chromosomes Cancer 2004 Nov;41(3):291-6. doi: 10.1002/gcc.20083. PMID: 15334554
Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints.
Atlas M, Head D, Behm F, Schmidt E, Zeleznik-Le NH, Roe BA, Burian D, Domer PH
Leukemia 1998 Dec;12(12):1895-902. doi: 10.1038/sj.leu.2401223. PMID: 9844920
Quantitative acute leukemia cytogenetics.
Mitelman F, Heim S
Genes Chromosomes Cancer 1992 Jul;5(1):57-66. doi: 10.1002/gcc.2870050109. PMID: 1384663

Therapy

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Favorable impact of the t(9;11) in childhood acute myeloid leukemia.
Rubnitz JE, Raimondi SC, Tong X, Srivastava DK, Razzouk BI, Shurtleff SA, Downing JR, Pui CH, Ribeiro RC, Behm FG
J Clin Oncol 2002 May 1;20(9):2302-9. doi: 10.1200/JCO.2002.08.023. PMID: 11981001
Therapy related leukemias: susceptibility, prevention and treatment.
Leone G, Voso MT, Sica S, Morosetti R, Pagano L
Leuk Lymphoma 2001 Apr;41(3-4):255-76. doi: 10.3109/10428190109057981. PMID: 11378539
All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders.
Rowley JD, Reshmi S, Sobulo O, Musvee T, Anastasi J, Raimondi S, Schneider NR, Barredo JC, Cantu ES, Schlegelberger B, Behm F, Doggett NA, Borrow J, Zeleznik-Le N
Blood 1997 Jul 15;90(2):535-41. PMID: 9226152
Syndromes of acute nonlymphocytic leukemia.
Koeffler HP
Ann Intern Med 1987 Nov;107(5):748-58. doi: 10.7326/0003-4819-107-5-748. PMID: 3310797

Prognosis

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
Polycomb complexes in MLL-AF9-related leukemias.
Sparavier A, Di Croce L
Curr Opin Genet Dev 2022 Aug;75:101920. Epub 2022 May 21 doi: 10.1016/j.gde.2022.101920. PMID: 35609423
Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A.
Bill M, Mrózek K, Kohlschmidt J, Eisfeld AK, Walker CJ, Nicolet D, Papaioannou D, Blachly JS, Orwick S, Carroll AJ, Kolitz JE, Powell BL, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD
Proc Natl Acad Sci U S A 2020 Oct 20;117(42):26340-26346. Epub 2020 Oct 5 doi: 10.1073/pnas.2014732117. PMID: 33020282Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
Krivtsov AV, Twomey D, Feng Z, Stubbs MC, Wang Y, Faber J, Levine JE, Wang J, Hahn WC, Gilliland DG, Golub TR, Armstrong SA
Nature 2006 Aug 17;442(7104):818-22. Epub 2006 Jul 16 doi: 10.1038/nature04980. PMID: 16862118

Clinical prediction guides

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study.
Attarbaschi A, Möricke A, Harrison CJ, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger SP, Horibe K, Manabe A, Loh ML, Pieters R, Schmiegelow K, Silverman LB, Stary J, Vora A, Pui CH, Schrappe M, Zimmermann M; Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
J Clin Oncol 2023 Mar 1;41(7):1404-1422. Epub 2022 Oct 18 doi: 10.1200/JCO.22.01297. PMID: 36256911Free PMC Article
High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells.
Jeong J, Jager A, Domizi P, Pavel-Dinu M, Gojenola L, Iwasaki M, Wei MC, Pan F, Zehnder JL, Porteus MH, Davis KL, Cleary ML
Blood Adv 2019 Oct 8;3(19):2825-2835. doi: 10.1182/bloodadvances.2019000450. PMID: 31582391Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Hematological malignancies with t(9;11)(p21-22;q23)--a laboratory and clinical study of 125 cases. European 11q23 Workshop participants.
Swansbury GJ, Slater R, Bain BJ, Moorman AV, Secker-Walker LM
Leukemia 1998 May;12(5):792-800. doi: 10.1038/sj.leu.2401014. PMID: 9593283
Quantitative acute leukemia cytogenetics.
Mitelman F, Heim S
Genes Chromosomes Cancer 1992 Jul;5(1):57-66. doi: 10.1002/gcc.2870050109. PMID: 1384663

Recent systematic reviews

Is acute lymphoblastic leukemia with mature B-cell phenotype and KMT2A rearrangements a new entity? A systematic review and meta-analysis.
Hidalgo-Gómez G, Palacio-Garcia C, Gallur L, Blanco A, Tazón-Vega B, Saumell S, Martínez N, Murillo L, Murciano T, Velasco P, Bosch F, Diaz-Heredia C, Ortega M
Leuk Lymphoma 2021 Sep;62(9):2202-2210. Epub 2021 Apr 7 doi: 10.1080/10428194.2021.1907375. PMID: 33827367

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