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Mixed Type Pancreatic Intraductal Papillary-Mucinous Neoplasm

MedGen UID:
821751
•Concept ID:
C3829003
•
Neoplastic Process
Synonym: Mixed Type Pancreatic IPMN

Definition

An intraductal papillary-mucinous neoplasm of the pancreas that arises primarily from the main pancreatic duct and extends to the branch ducts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed Type Pancreatic Intraductal Papillary-Mucinous Neoplasm

Professional guidelines

PubMed

The management of intraductal papillary mucinous neoplasms of the pancreas.
Pollini T, Andrianello S, Caravati A, Perri G, Malleo G, Paiella S, Marchegiani G, Salvia R
Minerva Chir 2019 Oct;74(5):414-421. doi: 10.23736/S0026-4733.19.08145-8. PMID: 31795628
Uptodate in the assessment and management of intraductal papillary mucinous neoplasms of the pancreas.
Pagliari D, Saviano A, Serricchio ML, Dal Lago AA, Brizi MG, Lanza F, Manfredi R, Gasbarrini A, Attili F
Eur Rev Med Pharmacol Sci 2017 Jun;21(12):2858-2874. PMID: 28682431
Management of Mixed-Type Intraductal Papillary Mucinous Neoplasm.
Roch AM, Schmidt CM
Adv Surg 2016 Sep;50(1):1-15. Epub 2016 Jul 9 doi: 10.1016/j.yasu.2016.03.001. PMID: 27520858

Recent clinical studies

Etiology

Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
The management of intraductal papillary mucinous neoplasms of the pancreas.
Pollini T, Andrianello S, Caravati A, Perri G, Malleo G, Paiella S, Marchegiani G, Salvia R
Minerva Chir 2019 Oct;74(5):414-421. doi: 10.23736/S0026-4733.19.08145-8. PMID: 31795628
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Uptodate in the assessment and management of intraductal papillary mucinous neoplasms of the pancreas.
Pagliari D, Saviano A, Serricchio ML, Dal Lago AA, Brizi MG, Lanza F, Manfredi R, Gasbarrini A, Attili F
Eur Rev Med Pharmacol Sci 2017 Jun;21(12):2858-2874. PMID: 28682431
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Diagnosis

Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
The management of intraductal papillary mucinous neoplasms of the pancreas.
Pollini T, Andrianello S, Caravati A, Perri G, Malleo G, Paiella S, Marchegiani G, Salvia R
Minerva Chir 2019 Oct;74(5):414-421. doi: 10.23736/S0026-4733.19.08145-8. PMID: 31795628
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Uptodate in the assessment and management of intraductal papillary mucinous neoplasms of the pancreas.
Pagliari D, Saviano A, Serricchio ML, Dal Lago AA, Brizi MG, Lanza F, Manfredi R, Gasbarrini A, Attili F
Eur Rev Med Pharmacol Sci 2017 Jun;21(12):2858-2874. PMID: 28682431
Management of Mixed-Type Intraductal Papillary Mucinous Neoplasm.
Roch AM, Schmidt CM
Adv Surg 2016 Sep;50(1):1-15. Epub 2016 Jul 9 doi: 10.1016/j.yasu.2016.03.001. PMID: 27520858

Therapy

Impact of preoperative endoscopic procedures on adverse event rates after surgical resection for main-duct and mixed-type intraductal papillary mucinous neoplasms (IPMNs).
Ni P, Mayo H, Fernández-Del Castillo C, Elamin S, Brown DR, Mino-Kenudson M, Krishnan K, Casey B, Lafaro K, Lennon AM, Afghani E, Hernandez-Barco YG
Pancreatology 2024 Feb;24(1):152-159. Epub 2023 Nov 14 doi: 10.1016/j.pan.2023.11.007. PMID: 37981524
Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: An international multicenter study.
Kim HS, Song W, Choo W, Lee S, Han Y, Bassi C, Salvia R, Marchegiani G, Wolfgang CL, He J, Blair AB, Kluger MD, Su GH, Kim SC, Song KB, Yamamoto M, Hatori T, Yang CY, Yamaue H, Hirono S, Satoi S, Fujii T, Hirano S, Lou W, Hashimoto Y, Shimizu Y, Del Chiaro M, Valente R, Lohr M, Choi DW, Choi SH, Heo JS, Motoi F, Matsumoto I, Lee WJ, Kang CM, Shyr YM, Wang SE, Han HS, Yoon YS, Besselink MG, van Huijgevoort NCM, Sho M, Nagano H, Kim SG, Honda G, Yang Y, Yu HC, Yang JD, Chung JC, Nagakawa Y, Seo HI, Lee S, Kim H, Kwon W, Park T, Jang JY
J Hepatobiliary Pancreat Sci 2023 Jan;30(1):133-143. Epub 2021 Apr 20 doi: 10.1002/jhbp.962. PMID: 33811460
Imaging Features for Predicting High-Grade Dysplasia or Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review and Meta-Analysis.
Zhao W, Liu S, Cong L, Zhao Y
Ann Surg Oncol 2022 Feb;29(2):1297-1312. Epub 2021 Sep 23 doi: 10.1245/s10434-021-10662-2. PMID: 34554343
Management and outcomes of intraductal papillary mucinous neoplasms.
Hipp J, Mohamed S, Pott J, Sick O, Makowiec F, Hopt UT, Fichtner-Feigl S, Wittel UA
BJS Open 2019 Aug;3(4):490-499. Epub 2019 Mar 21 doi: 10.1002/bjs5.50156. PMID: 31388641Free PMC Article
Smoking is not associated with severe dysplasia or invasive carcinoma in resected intraductal papillary mucinous neoplasms.
Rezaee N, Khalifian S, Cameron JL, Pawlik TM, Hruban RH, Fishman EK, Makary MA, Lennon AM, Wolfgang CL, Weiss MJ
J Gastrointest Surg 2015 Apr;19(4):656-65. Epub 2014 Dec 5 doi: 10.1007/s11605-014-2714-y. PMID: 25477314Free PMC Article

Prognosis

Malignant potential and specific characteristics of pure main duct type intraductal papillary mucinous neoplasm.
Fujita Y, Hirono S, Kawai M, Okada KI, Miyazawa M, Kitahata Y, Ueno M, Hayami S, Kobayashi R, Yanagisawa A, Yamaue H
Eur J Surg Oncol 2022 May;48(5):1054-1061. Epub 2021 Dec 9 doi: 10.1016/j.ejso.2021.11.137. PMID: 34933794
Intraductal Papillary Mucinous Neoplasm of the Pancreas: Need for a Tailored Approach to a Rare Entity.
Konaktchieva M, Penchev D, Popivanov G, Vladova L, Cirocchi R, Penkov M, Karagyozov P, Mutafchiyski V
Folia Med (Plovdiv) 2021 Dec 31;63(6):970-976. doi: 10.3897/folmed.63.e63071. PMID: 35851243
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Clinical prediction guides

Intraductal Papillary Mucinous Neoplasm of the Pancreas: Need for a Tailored Approach to a Rare Entity.
Konaktchieva M, Penchev D, Popivanov G, Vladova L, Cirocchi R, Penkov M, Karagyozov P, Mutafchiyski V
Folia Med (Plovdiv) 2021 Dec 31;63(6):970-976. doi: 10.3897/folmed.63.e63071. PMID: 35851243
Surgical strategy for intraductal papillary mucinous neoplasms of the pancreas.
Hirono S, Yamaue H
Surg Today 2020 Jan;50(1):50-55. Epub 2019 Dec 5 doi: 10.1007/s00595-019-01931-5. PMID: 31807871Free PMC Article
The management of intraductal papillary mucinous neoplasms of the pancreas.
Pollini T, Andrianello S, Caravati A, Perri G, Malleo G, Paiella S, Marchegiani G, Salvia R
Minerva Chir 2019 Oct;74(5):414-421. doi: 10.23736/S0026-4733.19.08145-8. PMID: 31795628
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
Intraductal papillary mucinous neoplasm.
Shi C, Hruban RH
Hum Pathol 2012 Jan;43(1):1-16. Epub 2011 Jul 20 doi: 10.1016/j.humpath.2011.04.003. PMID: 21777948

Recent systematic reviews

The role of intraoperative pancreatoscopy in the surgical management of intraductal papillary mucinous neoplasms of the pancreas: a systematic scoping review.
Ciprani D, Frampton A, Amar H, Oppong K, Pandanaboyana S, Aroori S
Surg Endosc 2023 Dec;37(12):9043-9051. Epub 2023 Oct 31 doi: 10.1007/s00464-023-10518-8. PMID: 37907657
Imaging Features for Predicting High-Grade Dysplasia or Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review and Meta-Analysis.
Zhao W, Liu S, Cong L, Zhao Y
Ann Surg Oncol 2022 Feb;29(2):1297-1312. Epub 2021 Sep 23 doi: 10.1245/s10434-021-10662-2. PMID: 34554343
Prophylactic total pancreatectomy in individuals at high risk of pancreatic ductal adenocarcinoma (PROPAN): systematic review and shared decision-making programme using decision tables.
Scholten L, Latenstein AE, Aalfs CM, Bruno MJ, Busch OR, Bonsing BA, Koerkamp BG, Molenaar IQ, Ubbink DT, van Hooft JE, Fockens P, Glas J, DeVries JH, Besselink MG; Dutch Pancreatic Cancer Group
United European Gastroenterol J 2020 Oct;8(8):865-877. Epub 2020 Jul 23 doi: 10.1177/2050640620945534. PMID: 32703081Free PMC Article

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