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Histologic Chorioamnionitis

MedGen UID:
822440
•Concept ID:
C3829692
•
Finding
Synonym: Microscopic Chorioamnionitis

Definition

Inflammation of the fetal sac membranes that is characterized by neutrophilic infiltration of the amnion and chorion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHistologic Chorioamnionitis

Professional guidelines

PubMed

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Management of Preterm Premature Rupture of Membranes in the Late Preterm Period.
Freeman SW, Denoble A, Kuller JA, Ellestad S, Dotters-Katz S
Obstet Gynecol Surv 2022 May;77(5):283-292. doi: 10.1097/OGX.0000000000001024. PMID: 35522430
Should the diagnostic criteria for suspected clinical chorioamnionitis be changed?
Sung JH, Choi SJ, Oh SY, Roh CR
J Matern Fetal Neonatal Med 2021 Mar;34(5):824-833. Epub 2019 Jun 3 doi: 10.1080/14767058.2019.1618822. PMID: 31084245

Recent clinical studies

Etiology

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes.
Greenberg V, Vazquez-Benitez G, Kharbanda EO, Daley MF, Fu Tseng H, Klein NP, Naleway AL, Williams JTB, Donahue J, Jackson L, Weintraub E, Lipkind H, DeSilva MB
Vaccine 2023 May 22;41(22):3429-3435. Epub 2023 Apr 26 doi: 10.1016/j.vaccine.2023.04.043. PMID: 37117057Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Histologic chorioamnionitis concomitant placental abruption and its effects on pregnancy outcome.
Kovo M, Gonen N, Schreiber L, Hochman R, Noy LK, Levy M, Bar J, Weiner E
Placenta 2020 May;94:39-43. Epub 2020 Mar 27 doi: 10.1016/j.placenta.2020.03.012. PMID: 32421533
Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis.
Park HW, Choi YS, Kim KS, Kim SN
PLoS One 2015;10(9):e0138114. Epub 2015 Sep 16 doi: 10.1371/journal.pone.0138114. PMID: 26375582Free PMC Article

Diagnosis

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes.
Greenberg V, Vazquez-Benitez G, Kharbanda EO, Daley MF, Fu Tseng H, Klein NP, Naleway AL, Williams JTB, Donahue J, Jackson L, Weintraub E, Lipkind H, DeSilva MB
Vaccine 2023 May 22;41(22):3429-3435. Epub 2023 Apr 26 doi: 10.1016/j.vaccine.2023.04.043. PMID: 37117057Free PMC Article
Ureaplasma species and preterm birth: current perspectives.
Sprong KE, Mabenge M, Wright CA, Govender S
Crit Rev Microbiol 2020 Mar;46(2):169-181. Epub 2020 Mar 6 doi: 10.1080/1040841X.2020.1736986. PMID: 32141797
Validation of diagnostic tests for histologic chorioamnionitis: Systematic review and meta-analysis.
Cataño Sabogal CP, Fonseca J, García-Perdomo HA
Eur J Obstet Gynecol Reprod Biol 2018 Sep;228:13-26. Epub 2018 Jun 9 doi: 10.1016/j.ejogrb.2018.05.043. PMID: 29908373
Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis.
Park HW, Choi YS, Kim KS, Kim SN
PLoS One 2015;10(9):e0138114. Epub 2015 Sep 16 doi: 10.1371/journal.pone.0138114. PMID: 26375582Free PMC Article

Therapy

Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment.
Jung E, Romero R, Suksai M, Gotsch F, Chaemsaithong P, Erez O, Conde-Agudelo A, Gomez-Lopez N, Berry SM, Meyyazhagan A, Yoon BH
Am J Obstet Gynecol 2024 Mar;230(3S):S807-S840. Epub 2023 Mar 21 doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317Free PMC Article
Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes.
Greenberg V, Vazquez-Benitez G, Kharbanda EO, Daley MF, Fu Tseng H, Klein NP, Naleway AL, Williams JTB, Donahue J, Jackson L, Weintraub E, Lipkind H, DeSilva MB
Vaccine 2023 May 22;41(22):3429-3435. Epub 2023 Apr 26 doi: 10.1016/j.vaccine.2023.04.043. PMID: 37117057Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Ureaplasma species and preterm birth: current perspectives.
Sprong KE, Mabenge M, Wright CA, Govender S
Crit Rev Microbiol 2020 Mar;46(2):169-181. Epub 2020 Mar 6 doi: 10.1080/1040841X.2020.1736986. PMID: 32141797
Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis.
Park HW, Choi YS, Kim KS, Kim SN
PLoS One 2015;10(9):e0138114. Epub 2015 Sep 16 doi: 10.1371/journal.pone.0138114. PMID: 26375582Free PMC Article

Prognosis

Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes.
Greenberg V, Vazquez-Benitez G, Kharbanda EO, Daley MF, Fu Tseng H, Klein NP, Naleway AL, Williams JTB, Donahue J, Jackson L, Weintraub E, Lipkind H, DeSilva MB
Vaccine 2023 May 22;41(22):3429-3435. Epub 2023 Apr 26 doi: 10.1016/j.vaccine.2023.04.043. PMID: 37117057Free PMC Article
Acute histologic chorioamnionitis independently and directly increases the risk for brain abnormalities seen on magnetic resonance imaging in very preterm infants.
Jain VG, Kline JE, He L, Kline-Fath BM, Altaye M, Muglia LJ, DeFranco EA, Ambalavanan N, Parikh NA; Cincinnati Infant Neurodevelopment Early Prediction Study Investigators
Am J Obstet Gynecol 2022 Oct;227(4):623.e1-623.e13. Epub 2022 May 26 doi: 10.1016/j.ajog.2022.05.042. PMID: 35644247Free PMC Article
Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Should the diagnostic criteria for suspected clinical chorioamnionitis be changed?
Sung JH, Choi SJ, Oh SY, Roh CR
J Matern Fetal Neonatal Med 2021 Mar;34(5):824-833. Epub 2019 Jun 3 doi: 10.1080/14767058.2019.1618822. PMID: 31084245
Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis.
Park HW, Choi YS, Kim KS, Kim SN
PLoS One 2015;10(9):e0138114. Epub 2015 Sep 16 doi: 10.1371/journal.pone.0138114. PMID: 26375582Free PMC Article

Clinical prediction guides

Validation of diagnosis codes for chorioamnionitis in medical encounter data, 2013-2018.
Hall C, Magallon SM, Snell KJ, Romano CJ, Bukowinski AT, Gumbs GR, Conlin AMS
Pharmacoepidemiol Drug Saf 2023 Nov;32(11):1280-1289. Epub 2023 Jul 3 doi: 10.1002/pds.5659. PMID: 37345511
Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes.
Greenberg V, Vazquez-Benitez G, Kharbanda EO, Daley MF, Fu Tseng H, Klein NP, Naleway AL, Williams JTB, Donahue J, Jackson L, Weintraub E, Lipkind H, DeSilva MB
Vaccine 2023 May 22;41(22):3429-3435. Epub 2023 Apr 26 doi: 10.1016/j.vaccine.2023.04.043. PMID: 37117057Free PMC Article
Histologic chorioamnionitis in extremely preterm births, microbiological findings and infant outcome.
Budal EB, Bentsen MHL, Kessler J, Ebbing C, Lindemann PC, Haugen OH, Aukland SM, Eide GE, Halvorsen T, Collett K
J Matern Fetal Neonatal Med 2023 Dec;36(1):2196599. doi: 10.1080/14767058.2023.2196599. PMID: 37031964
Validation of diagnostic tests for histologic chorioamnionitis: Systematic review and meta-analysis.
Cataño Sabogal CP, Fonseca J, García-Perdomo HA
Eur J Obstet Gynecol Reprod Biol 2018 Sep;228:13-26. Epub 2018 Jun 9 doi: 10.1016/j.ejogrb.2018.05.043. PMID: 29908373
Impact of clinical and/or histological chorioamnionitis on neurodevelopmental outcomes in preterm infants: A literature review.
Maisonneuve E, Ancel PY, Foix-L'Hélias L, Marret S, Kayem G
J Gynecol Obstet Hum Reprod 2017 Apr;46(4):307-316. Epub 2017 Feb 11 doi: 10.1016/j.jogoh.2017.02.007. PMID: 28643657

Recent systematic reviews

Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.
Beck C, Gallagher K, Taylor LA, Goldstein JA, Mithal LB, Gernand AD
Obstet Gynecol 2021 Jun 1;137(6):1007-1022. doi: 10.1097/AOG.0000000000004377. PMID: 33957655Free PMC Article
Validation of diagnostic tests for histologic chorioamnionitis: Systematic review and meta-analysis.
Cataño Sabogal CP, Fonseca J, García-Perdomo HA
Eur J Obstet Gynecol Reprod Biol 2018 Sep;228:13-26. Epub 2018 Jun 9 doi: 10.1016/j.ejogrb.2018.05.043. PMID: 29908373
Chorioamnionitis in the Development of Cerebral Palsy: A Meta-analysis and Systematic Review.
Shi Z, Ma L, Luo K, Bajaj M, Chawla S, Natarajan G, Hagberg H, Tan S
Pediatrics 2017 Jun;139(6) doi: 10.1542/peds.2016-3781. PMID: 28814548Free PMC Article
Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis.
Park HW, Choi YS, Kim KS, Kim SN
PLoS One 2015;10(9):e0138114. Epub 2015 Sep 16 doi: 10.1371/journal.pone.0138114. PMID: 26375582Free PMC Article
Antibiotic regimens for management of intra-amniotic infection.
Chapman E, Reveiz L, Illanes E, Bonfill Cosp X
Cochrane Database Syst Rev 2014 Dec 19;2014(12):CD010976. doi: 10.1002/14651858.CD010976.pub2. PMID: 25526426Free PMC Article

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