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Laryngeal obstruction

MedGen UID:
82677
•Concept ID:
C0264306
•
Finding; Pathologic Function
Synonyms: Laryngeal Obstruction; Obstruction of larynx
SNOMED CT: Obstruction of larynx (61169001)
 
HPO: HP:0005945

Definition

Blockage of the upper airway at the level of the larynx often accompanied by respiratory distress. [from HPO]

Conditions with this feature

Larynx, congenital partial atresia of
MedGen UID:
372073
•Concept ID:
C1835555
•
Congenital Abnormality
See: Condition Record
Larynx, congenital partial atresia of

Professional guidelines

PubMed

Acute subglottic laryngitis. Etiology, epidemiology, pathogenesis and clinical picture.
Mazurek H, Bręborowicz A, Doniec Z, Emeryk A, Krenke K, Kulus M, Zielnik-Jurkiewicz B
Adv Respir Med 2019;87(5):308-316. doi: 10.5603/ARM.2019.0056. PMID: 31680234
Neonatal Stridor: Diagnosis and Management.
Bhatt J, Prager JD
Clin Perinatol 2018 Dec;45(4):817-831. Epub 2018 Sep 24 doi: 10.1016/j.clp.2018.07.015. PMID: 30396420
Exercise inducible laryngeal obstruction: diagnostics and management.
Røksund OD, Heimdal JH, Clemm H, Vollsæter M, Halvorsen T
Paediatr Respir Rev 2017 Jan;21:86-94. Epub 2016 Jul 18 doi: 10.1016/j.prrv.2016.07.003. PMID: 27492717

Recent clinical studies

Etiology

Development and validation of the Exercise-Induced Laryngeal Obstruction Dyspnea Index (EILODI).
Olin JT, Shaffer M, Nauman E, Durso CS, Fan EM, Staudenmayer H, Christopher KL, Gartner-Schmidt J
J Allergy Clin Immunol 2022 Apr;149(4):1437-1444. Epub 2021 Oct 4 doi: 10.1016/j.jaci.2021.09.027. PMID: 34619181
Respiratory manifestations in the Ehlers-Danlos syndromes.
Bascom R, Dhingra R, Francomano CA
Am J Med Genet C Semin Med Genet 2021 Dec;187(4):533-548. Epub 2021 Nov 22 doi: 10.1002/ajmg.c.31953. PMID: 34811894
Triggers of breathlessness in inducible laryngeal obstruction and asthma.
Haines J, Chua SHK, Smith J, Slinger C, Simpson AJ, Fowler SJ
Clin Exp Allergy 2020 Nov;50(11):1230-1237. Epub 2020 Sep 6 doi: 10.1111/cea.13715. PMID: 32713022
Surgical Intervention for Exercise-Induced Laryngeal Obstruction.
Heimdal JH, Maat R, Nordang L
Immunol Allergy Clin North Am 2018 May;38(2):317-324. Epub 2018 Mar 2 doi: 10.1016/j.iac.2018.01.005. PMID: 29631739
Exercise inducible laryngeal obstruction: diagnostics and management.
Røksund OD, Heimdal JH, Clemm H, Vollsæter M, Halvorsen T
Paediatr Respir Rev 2017 Jan;21:86-94. Epub 2016 Jul 18 doi: 10.1016/j.prrv.2016.07.003. PMID: 27492717

Diagnosis

Drug Allergy Mimics.
Waldron JL, Glennon CM, Kroshinsky DA, Khan DA, Wolfson AR
J Allergy Clin Immunol Pract 2024 May;12(5):1122-1129.e1. Epub 2024 Feb 5 doi: 10.1016/j.jaip.2024.01.047. PMID: 38325764
Respiratory manifestations in the Ehlers-Danlos syndromes.
Bascom R, Dhingra R, Francomano CA
Am J Med Genet C Semin Med Genet 2021 Dec;187(4):533-548. Epub 2021 Nov 22 doi: 10.1002/ajmg.c.31953. PMID: 34811894
Acute subglottic laryngitis. Etiology, epidemiology, pathogenesis and clinical picture.
Mazurek H, Bręborowicz A, Doniec Z, Emeryk A, Krenke K, Kulus M, Zielnik-Jurkiewicz B
Adv Respir Med 2019;87(5):308-316. doi: 10.5603/ARM.2019.0056. PMID: 31680234
Exercise-induced Laryngeal Obstruction.
Fan E, Olin JT
Am J Respir Crit Care Med 2019 Jun 15;199(12):P23-P24. doi: 10.1164/rccm.19912P23. PMID: 31199188
Exercise-Induced Laryngeal Obstruction-An Overview.
Nordang L, Norlander K, Walsted ES
Immunol Allergy Clin North Am 2018 May;38(2):271-280. Epub 2018 Feb 19 doi: 10.1016/j.iac.2018.01.001. PMID: 29631735

Therapy

Vocal cord dysfunction/inducible laryngeal obstruction: novel diagnostics and therapeutics.
Koh J, Phyland D, Baxter M, Leong P, Bardin PG
Expert Rev Respir Med 2023 Jan-Jun;17(6):429-445. Epub 2023 May 22 doi: 10.1080/17476348.2023.2215434. PMID: 37194252
Occupational aspects of irritable larynx syndrome.
Denton E, Hoy R
Curr Opin Allergy Clin Immunol 2020 Apr;20(2):90-95. doi: 10.1097/ACI.0000000000000619. PMID: 31913163
Surgical Intervention for Exercise-Induced Laryngeal Obstruction.
Heimdal JH, Maat R, Nordang L
Immunol Allergy Clin North Am 2018 May;38(2):317-324. Epub 2018 Mar 2 doi: 10.1016/j.iac.2018.01.005. PMID: 29631739
Severe asthma in children.
Bush A, Fleming L, Saglani S
Respirology 2017 Jul;22(5):886-897. Epub 2017 May 25 doi: 10.1111/resp.13085. PMID: 28543931
Exercise inducible laryngeal obstruction: diagnostics and management.
Røksund OD, Heimdal JH, Clemm H, Vollsæter M, Halvorsen T
Paediatr Respir Rev 2017 Jan;21:86-94. Epub 2016 Jul 18 doi: 10.1016/j.prrv.2016.07.003. PMID: 27492717

Prognosis

Triggers of breathlessness in inducible laryngeal obstruction and asthma.
Haines J, Chua SHK, Smith J, Slinger C, Simpson AJ, Fowler SJ
Clin Exp Allergy 2020 Nov;50(11):1230-1237. Epub 2020 Sep 6 doi: 10.1111/cea.13715. PMID: 32713022
Occupational aspects of irritable larynx syndrome.
Denton E, Hoy R
Curr Opin Allergy Clin Immunol 2020 Apr;20(2):90-95. doi: 10.1097/ACI.0000000000000619. PMID: 31913163
Exercise-induced laryngeal obstruction: Quality initiative to improve assessment and management.
Campisi ES, Schneiderman JE, Owen B, Moraes TJ, Campisi P
Int J Pediatr Otorhinolaryngol 2019 Dec;127:109677. Epub 2019 Sep 11 doi: 10.1016/j.ijporl.2019.109677. PMID: 31526937
Neonatal Stridor: Diagnosis and Management.
Bhatt J, Prager JD
Clin Perinatol 2018 Dec;45(4):817-831. Epub 2018 Sep 24 doi: 10.1016/j.clp.2018.07.015. PMID: 30396420
Episodic Laryngeal Breathing Disorders: Literature Review and Proposal of Preliminary Theoretical Framework.
Shembel AC, Sandage MJ, Verdolini Abbott K
J Voice 2017 Jan;31(1):125.e7-125.e16. Epub 2016 Feb 24 doi: 10.1016/j.jvoice.2015.11.027. PMID: 26922093

Clinical prediction guides

Diagnostic work-up of exercise-induced laryngeal obstruction.
Giraud L, Destors M, Clin R, Fabre C, Doutreleau S, Atallah I
Eur Arch Otorhinolaryngol 2023 Mar;280(3):1273-1281. Epub 2022 Sep 22 doi: 10.1007/s00405-022-07654-7. PMID: 36136148
Exercise-induced laryngeal obstruction in children and adolescents: are we listening?
Welsh L, Giannini A, Massie J
Arch Dis Child Educ Pract Ed 2021 Apr;106(2):66-70. Epub 2020 Oct 19 doi: 10.1136/archdischild-2020-319454. PMID: 33077532
Cough in exercise and athletes.
Boulet LP, Turmel J
Pulm Pharmacol Ther 2019 Apr;55:67-74. Epub 2019 Feb 13 doi: 10.1016/j.pupt.2019.02.003. PMID: 30771475
Surgical Intervention for Exercise-Induced Laryngeal Obstruction.
Heimdal JH, Maat R, Nordang L
Immunol Allergy Clin North Am 2018 May;38(2):317-324. Epub 2018 Mar 2 doi: 10.1016/j.iac.2018.01.005. PMID: 29631739
Exercise induced laryngeal obstruction: a review of diagnosis and management.
Liyanagedera S, McLeod R, Elhassan HA
Eur Arch Otorhinolaryngol 2017 Apr;274(4):1781-1789. Epub 2016 Oct 11 doi: 10.1007/s00405-016-4338-1. PMID: 27730324Free PMC Article

Recent systematic reviews

Adult Laryngomalacia: A Scoping Review.
Mills JF, Monaghan NP, Nguyen SA, O'Rourke AK, Halstead LA, Meyer TA
Otolaryngol Head Neck Surg 2024 Apr;170(4):1020-1031. Epub 2024 Jan 14 doi: 10.1002/ohn.639. PMID: 38219735
Systematic review of the effectiveness of non-pharmacological interventions used to treat adults with inducible laryngeal obstruction.
Haines J, Smith JA, Wingfield-Digby J, King J, Yorke J, Fowler SJ
BMJ Open Respir Res 2022 Jun;9(1) doi: 10.1136/bmjresp-2022-001199. PMID: 35705262Free PMC Article
The impact of identifying laryngeal obstruction syndromes on reducing treatment of pediatric asthma: A systematic review.
Zhang C, Hicks M, Ospina MB, Martha V, Alnouri G, Dennett L, Sataloff R, Hicks A
Pediatr Pulmonol 2022 Jun;57(6):1401-1415. Epub 2022 Apr 22 doi: 10.1002/ppul.25910. PMID: 35355450Free PMC Article
Prevalence and impact of comorbid laryngeal dysfunction in asthma: A systematic review and meta-analysis.
Lee JH, An J, Won HK, Kang Y, Kwon HS, Kim TB, Cho YS, Moon HB, Song WJ, Hull JH
J Allergy Clin Immunol 2020 Apr;145(4):1165-1173. Epub 2020 Jan 12 doi: 10.1016/j.jaci.2019.12.906. PMID: 31940470
Exercise induced laryngeal obstruction: a review of diagnosis and management.
Liyanagedera S, McLeod R, Elhassan HA
Eur Arch Otorhinolaryngol 2017 Apr;274(4):1781-1789. Epub 2016 Oct 11 doi: 10.1007/s00405-016-4338-1. PMID: 27730324Free PMC Article

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