U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Giant cell myocarditis

MedGen UID:
82685
•Concept ID:
C0264856
•
Disease or Syndrome
Synonym: Giant Cell Myocarditis
SNOMED CT: Giant cell myocarditis (60812006)

Definition

An often fatal inflammatory disorder that affects the myocardium. Morphologically, it is characterized by the presence of an inflammatory infiltrate in the myocardial tissue that includes multinucleated giant cells. It is often associated with the presence of an autoimmune disorder. Patients present with arrhythmias and/or heart failure. Heart transplantation is the only treatment option available. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant cell myocarditis

Professional guidelines

PubMed

Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week.
Bang V, Ganatra S, Shah SP, Dani SS, Neilan TG, Thavendiranathan P, Resnic FS, Piemonte TC, Barac A, Patel R, Sharma A, Parikh R, Chaudhry GM, Vesely M, Hayek SS, Leja M, Venesy D, Patten R, Lenihan D, Nohria A, Cooper LT
J Am Coll Cardiol 2021 Mar 2;77(8):1122-1134. doi: 10.1016/j.jacc.2020.11.074. PMID: 33632487
Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort.
Montero S, Aissaoui N, Tadié JM, Bizouarn P, Scherrer V, Persichini R, Delmas C, Rolle F, Besnier E, Le Guyader A, Combes A, Schmidt M
Int J Cardiol 2018 Feb 15;253:105-112. doi: 10.1016/j.ijcard.2017.10.053. PMID: 29306448
Acute viral myocarditis: current concepts in diagnosis and treatment.
Shauer A, Gotsman I, Keren A, Zwas DR, Hellman Y, Durst R, Admon D
Isr Med Assoc J 2013 Mar;15(3):180-5. PMID: 23662385

Recent clinical studies

Etiology

Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case Series.
Baumeier C, Aleshcheva G, Harms D, Gross U, Hamm C, Assmus B, Westenfeld R, Kelm M, Rammos S, Wenzel P, Münzel T, Elsässer A, Gailani M, Perings C, Bourakkadi A, Flesch M, Kempf T, Bauersachs J, Escher F, Schultheiss HP
Int J Mol Sci 2022 Jun 22;23(13) doi: 10.3390/ijms23136940. PMID: 35805941Free PMC Article
Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week.
Bang V, Ganatra S, Shah SP, Dani SS, Neilan TG, Thavendiranathan P, Resnic FS, Piemonte TC, Barac A, Patel R, Sharma A, Parikh R, Chaudhry GM, Vesely M, Hayek SS, Leja M, Venesy D, Patten R, Lenihan D, Nohria A, Cooper LT
J Am Coll Cardiol 2021 Mar 2;77(8):1122-1134. doi: 10.1016/j.jacc.2020.11.074. PMID: 33632487
Giant cell myositis and myocarditis revisited.
Oflazer P
Acta Myol 2020 Dec;39(4):302-306. Epub 2020 Dec 1 doi: 10.36185/2532-1900-033. PMID: 33458585Free PMC Article
Inflammatory Cardiomyopathic Syndromes.
Trachtenberg BH, Hare JM
Circ Res 2017 Sep 15;121(7):803-818. doi: 10.1161/CIRCRESAHA.117.310221. PMID: 28912184
Cardiac Autoimmunity: Myocarditis.
Bracamonte-Baran W, Čiháková D
Adv Exp Med Biol 2017;1003:187-221. doi: 10.1007/978-3-319-57613-8_10. PMID: 28667560Free PMC Article

Diagnosis

Transcriptional and Immune Landscape of Cardiac Sarcoidosis.
Liu J, Ma P, Lai L, Villanueva A, Koenig A, Bean GR, Bowles DE, Glass C, Watson M, Lavine KJ, Lin CY
Circ Res 2022 Sep 30;131(8):654-669. Epub 2022 Sep 16 doi: 10.1161/CIRCRESAHA.121.320449. PMID: 36111531Free PMC Article
Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week.
Bang V, Ganatra S, Shah SP, Dani SS, Neilan TG, Thavendiranathan P, Resnic FS, Piemonte TC, Barac A, Patel R, Sharma A, Parikh R, Chaudhry GM, Vesely M, Hayek SS, Leja M, Venesy D, Patten R, Lenihan D, Nohria A, Cooper LT
J Am Coll Cardiol 2021 Mar 2;77(8):1122-1134. doi: 10.1016/j.jacc.2020.11.074. PMID: 33632487
Inflammatory Cardiomyopathic Syndromes.
Trachtenberg BH, Hare JM
Circ Res 2017 Sep 15;121(7):803-818. doi: 10.1161/CIRCRESAHA.117.310221. PMID: 28912184
Cardiac Autoimmunity: Myocarditis.
Bracamonte-Baran W, Čiháková D
Adv Exp Med Biol 2017;1003:187-221. doi: 10.1007/978-3-319-57613-8_10. PMID: 28667560Free PMC Article
Myocarditis.
Cooper LT Jr
N Engl J Med 2009 Apr 9;360(15):1526-38. doi: 10.1056/NEJMra0800028. PMID: 19357408Free PMC Article

Therapy

Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case Series.
Baumeier C, Aleshcheva G, Harms D, Gross U, Hamm C, Assmus B, Westenfeld R, Kelm M, Rammos S, Wenzel P, Münzel T, Elsässer A, Gailani M, Perings C, Bourakkadi A, Flesch M, Kempf T, Bauersachs J, Escher F, Schultheiss HP
Int J Mol Sci 2022 Jun 22;23(13) doi: 10.3390/ijms23136940. PMID: 35805941Free PMC Article
Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week.
Bang V, Ganatra S, Shah SP, Dani SS, Neilan TG, Thavendiranathan P, Resnic FS, Piemonte TC, Barac A, Patel R, Sharma A, Parikh R, Chaudhry GM, Vesely M, Hayek SS, Leja M, Venesy D, Patten R, Lenihan D, Nohria A, Cooper LT
J Am Coll Cardiol 2021 Mar 2;77(8):1122-1134. doi: 10.1016/j.jacc.2020.11.074. PMID: 33632487
Inflammatory Cardiomyopathic Syndromes.
Trachtenberg BH, Hare JM
Circ Res 2017 Sep 15;121(7):803-818. doi: 10.1161/CIRCRESAHA.117.310221. PMID: 28912184
Cardiac Autoimmunity: Myocarditis.
Bracamonte-Baran W, Čiháková D
Adv Exp Med Biol 2017;1003:187-221. doi: 10.1007/978-3-319-57613-8_10. PMID: 28667560Free PMC Article
Giant Cell Myocarditis: A Brief Review.
Xu J, Brooks EG
Arch Pathol Lab Med 2016 Dec;140(12):1429-1434. doi: 10.5858/arpa.2016-0068-RS. PMID: 27922771

Prognosis

Transcriptional and Immune Landscape of Cardiac Sarcoidosis.
Liu J, Ma P, Lai L, Villanueva A, Koenig A, Bean GR, Bowles DE, Glass C, Watson M, Lavine KJ, Lin CY
Circ Res 2022 Sep 30;131(8):654-669. Epub 2022 Sep 16 doi: 10.1161/CIRCRESAHA.121.320449. PMID: 36111531Free PMC Article
Management of Patients With Giant Cell Myocarditis: JACC Review Topic of the Week.
Bang V, Ganatra S, Shah SP, Dani SS, Neilan TG, Thavendiranathan P, Resnic FS, Piemonte TC, Barac A, Patel R, Sharma A, Parikh R, Chaudhry GM, Vesely M, Hayek SS, Leja M, Venesy D, Patten R, Lenihan D, Nohria A, Cooper LT
J Am Coll Cardiol 2021 Mar 2;77(8):1122-1134. doi: 10.1016/j.jacc.2020.11.074. PMID: 33632487
Inflammatory Cardiomyopathic Syndromes.
Trachtenberg BH, Hare JM
Circ Res 2017 Sep 15;121(7):803-818. doi: 10.1161/CIRCRESAHA.117.310221. PMID: 28912184
Cardiac Autoimmunity: Myocarditis.
Bracamonte-Baran W, Čiháková D
Adv Exp Med Biol 2017;1003:187-221. doi: 10.1007/978-3-319-57613-8_10. PMID: 28667560Free PMC Article
Myocarditis.
Cooper LT Jr
N Engl J Med 2009 Apr 9;360(15):1526-38. doi: 10.1056/NEJMra0800028. PMID: 19357408Free PMC Article

Clinical prediction guides

Transcriptional and Immune Landscape of Cardiac Sarcoidosis.
Liu J, Ma P, Lai L, Villanueva A, Koenig A, Bean GR, Bowles DE, Glass C, Watson M, Lavine KJ, Lin CY
Circ Res 2022 Sep 30;131(8):654-669. Epub 2022 Sep 16 doi: 10.1161/CIRCRESAHA.121.320449. PMID: 36111531Free PMC Article
Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort.
Montero S, Aissaoui N, Tadié JM, Bizouarn P, Scherrer V, Persichini R, Delmas C, Rolle F, Besnier E, Le Guyader A, Combes A, Schmidt M
Int J Cardiol 2018 Feb 15;253:105-112. doi: 10.1016/j.ijcard.2017.10.053. PMID: 29306448
Imaging of Inflammation in Unexplained Cardiomyopathy.
Kadkhodayan A, Chareonthaitawee P, Raman SV, Cooper LT
JACC Cardiovasc Imaging 2016 May;9(5):603-17. doi: 10.1016/j.jcmg.2016.01.010. PMID: 27151523
Myocarditis.
Blauwet LA, Cooper LT
Prog Cardiovasc Dis 2010 Jan-Feb;52(4):274-88. doi: 10.1016/j.pcad.2009.11.006. PMID: 20109598Free PMC Article
Giant cell myocarditis: diagnosis and treatment.
Cooper LT Jr
Herz 2000 May;25(3):291-8. doi: 10.1007/s000590050023. PMID: 10904855

Recent systematic reviews

Myocarditis and inflammatory bowel diseases: A single-center experience and a systematic literature review.
Giordani AS, Candelora A, Fiacca M, Cheng C, Barberio B, Baritussio A, Marcolongo R, Iliceto S, Carturan E, De Gaspari M, Rizzo S, Basso C, Tarantini G, Savarino EV, Alp C
Int J Cardiol 2023 Apr 1;376:165-171. Epub 2023 Feb 3 doi: 10.1016/j.ijcard.2023.01.071. PMID: 36738845
Short- and long-term outcomes after heart transplantation in cardiac sarcoidosis and giant-cell myocarditis: a systematic review and meta-analysis.
Bobbio E, Björkenstam M, Nwaru BI, Giallauria F, Hessman E, Bergh N, Polte CL, Lehtonen J, Karason K, Bollano E
Clin Res Cardiol 2022 Feb;111(2):125-140. Epub 2021 Aug 17 doi: 10.1007/s00392-021-01920-0. PMID: 34402927Free PMC Article
Inflammatory cardiomyopathies: short- and long-term outcomes after heart transplantation-a protocol for a systematic review and meta-analysis.
Bobbio E, Lingbrant M, Nwaru BI, Hessman E, Lehtonen J, Karason K, Bollano E
Heart Fail Rev 2020 May;25(3):481-485. doi: 10.1007/s10741-020-09919-x. PMID: 31932994Free PMC Article
Fulminant giant-cell myocarditis on mechanical circulatory support: Management and outcomes of a French multicentre cohort.
Montero S, Aissaoui N, Tadié JM, Bizouarn P, Scherrer V, Persichini R, Delmas C, Rolle F, Besnier E, Le Guyader A, Combes A, Schmidt M
Int J Cardiol 2018 Feb 15;253:105-112. doi: 10.1016/j.ijcard.2017.10.053. PMID: 29306448

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...