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Diabetic autonomic neuropathy

MedGen UID:
82887
•Concept ID:
C0271686
•
Disease or Syndrome
Synonyms: Autonomic Neuropathies, Diabetic; Autonomic Neuropathy, Diabetic; Diabetic Autonomic Neuropathies; Diabetic Autonomic Neuropathy; Neuropathies, Diabetic Autonomic; Neuropathy, Diabetic Autonomic
SNOMED CT: Autonomic neuropathy due to diabetes (50620007); Autonomic neuropathy with diabetes mellitus (50620007); Autonomic neuropathy due to diabetes mellitus (50620007); Diabetic autonomic neuropathy (50620007)
 
Monarch Initiative: MONDO:0001299

Definition

Autonomic neuropathy that is caused by diabetes mellitus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiabetic autonomic neuropathy

Professional guidelines

PubMed

Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.
Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W
Clin Neurophysiol 2021 Feb;132(2):666-682. Epub 2020 Dec 22 doi: 10.1016/j.clinph.2020.11.024. PMID: 33419664
Treatment of gastrointestinal autonomic neuropathy.
Törnblom H
Diabetologia 2016 Mar;59(3):409-13. Epub 2015 Dec 3 doi: 10.1007/s00125-015-3828-9. PMID: 26634570

Recent clinical studies

Etiology

Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Diabetic autonomic neuropathy: a clinical update.
Sharma JK, Rohatgi A, Sharma D
J R Coll Physicians Edinb 2020 Sep;50(3):269-273. doi: 10.4997/JRCPE.2020.310. PMID: 32936100
Diabetic autonomic neuropathy.
Vinik AI, Erbas T
Handb Clin Neurol 2013;117:279-94. doi: 10.1016/B978-0-444-53491-0.00022-5. PMID: 24095132
Diabetic autonomic neuropathy.
Vinik AI, Maser RE, Mitchell BD, Freeman R
Diabetes Care 2003 May;26(5):1553-79. doi: 10.2337/diacare.26.5.1553. PMID: 12716821
Diabetic autonomic neuropathy.
Ahmed AM, Hussein A, Ahmed NH
Saudi Med J 2000 Nov;21(11):1034-7. PMID: 11360064

Diagnosis

Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.
Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W
Clin Neurophysiol 2021 Feb;132(2):666-682. Epub 2020 Dec 22 doi: 10.1016/j.clinph.2020.11.024. PMID: 33419664
Diabetic neuropathies.
Patel K, Horak H, Tiryaki E
Muscle Nerve 2021 Jan;63(1):22-30. Epub 2020 Jul 28 doi: 10.1002/mus.27014. PMID: 32589300
Autonomic Peripheral Neuropathy.
Freeman R
Continuum (Minneap Minn) 2020 Feb;26(1):58-71. doi: 10.1212/CON.0000000000000825. PMID: 31996622
Diabetic autonomic neuropathy.
Freeman R
Handb Clin Neurol 2014;126:63-79. doi: 10.1016/B978-0-444-53480-4.00006-0. PMID: 25410215
Diabetic autonomic neuropathy.
Vinik AI, Maser RE, Mitchell BD, Freeman R
Diabetes Care 2003 May;26(5):1553-79. doi: 10.2337/diacare.26.5.1553. PMID: 12716821

Therapy

Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Treatment of Diabetic Autonomic Neuropathy in Older Adults with Diabetes Mellitus.
Scheinberg N, Salbu RL, Goswami G, Cohen K
Consult Pharm 2016 Nov 1;31(11):633-645. doi: 10.4140/TCP.n.2016.633. PMID: 28107120
Diabetic autonomic neuropathy.
Vinik AI, Maser RE, Mitchell BD, Freeman R
Diabetes Care 2003 May;26(5):1553-79. doi: 10.2337/diacare.26.5.1553. PMID: 12716821
Hypoglycaemia unawareness.
Meijer E, Hoekstra JB, Erkelens DW
Presse Med 1994 Apr 2;23(13):623-7. PMID: 8029194
Hypoglycemia unawareness.
Gerich JE, Mokan M, Veneman T, Korytkowski M, Mitrakou A
Endocr Rev 1991 Nov;12(4):356-71. doi: 10.1210/edrv-12-4-356. PMID: 1760993

Prognosis

Management of diabetic neuropathy.
Cernea S, Raz I
Metabolism 2021 Oct;123:154867. Epub 2021 Aug 17 doi: 10.1016/j.metabol.2021.154867. PMID: 34411554
Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.
Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W
Clin Neurophysiol 2021 Feb;132(2):666-682. Epub 2020 Dec 22 doi: 10.1016/j.clinph.2020.11.024. PMID: 33419664
Diabetic autonomic neuropathy.
Vinik AI, Erbas T
Handb Clin Neurol 2013;117:279-94. doi: 10.1016/B978-0-444-53491-0.00022-5. PMID: 24095132
Diabetic autonomic neuropathy.
Ahmed AM, Hussein A, Ahmed NH
Saudi Med J 2000 Nov;21(11):1034-7. PMID: 11360064
Diabetic autonomic neuropathy.
Low PA
Semin Neurol 1996 Jun;16(2):143-51. doi: 10.1055/s-2008-1040970. PMID: 8987128

Clinical prediction guides

Pure autonomic failure and the differential diagnosis of autonomic peripheral neuropathies.
González-Duarte A, Varma-Doyle A, Freeman R
Curr Opin Neurol 2021 Oct 1;34(5):675-682. doi: 10.1097/WCO.0000000000000985. PMID: 34392300
Electrodiagnostic assessment of the autonomic nervous system: A consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.
Cheshire WP, Freeman R, Gibbons CH, Cortelli P, Wenning GK, Hilz MJ, Spies JM, Lipp A, Sandroni P, Wada N, Mano A, Ah Kim H, Kimpinski K, Iodice V, Idiáquez J, Thaisetthawatkul P, Coon EA, Low PA, Singer W
Clin Neurophysiol 2021 Feb;132(2):666-682. Epub 2020 Dec 22 doi: 10.1016/j.clinph.2020.11.024. PMID: 33419664
Autonomic neuropathy and urologic complications in diabetes.
Agochukwu-Mmonu N, Pop-Busui R, Wessells H, Sarma AV
Auton Neurosci 2020 Dec;229:102736. Epub 2020 Oct 16 doi: 10.1016/j.autneu.2020.102736. PMID: 33197694Free PMC Article
Diabetic autonomic neuropathy.
Vinik AI, Erbas T
Handb Clin Neurol 2013;117:279-94. doi: 10.1016/B978-0-444-53491-0.00022-5. PMID: 24095132
Diabetic autonomic neuropathy.
Clarke BF, Ewing DJ, Campbell IW
Diabetologia 1979 Oct;17(4):195-212. doi: 10.1007/BF01235856. PMID: 387501

Recent systematic reviews

Reactive Hyperemia and Cardiovascular Autonomic Neuropathy in Type 2 Diabetic Patients: A Systematic Review of Randomized and Nonrandomized Clinical Trials.
López-Galán E, Montoya-Pedrón A, Barrio-Deler R, Sánchez-Hechavarría ME, Muñoz-Bustos ME, Muñoz-Bustos GA
Medicina (Kaunas) 2023 Apr 16;59(4) doi: 10.3390/medicina59040770. PMID: 37109728Free PMC Article

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