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Subclinical infection

MedGen UID:
82906
•Concept ID:
C0275522
•
Disease or Syndrome
Synonyms: Asymptomatic Infection; Asymptomatic Infections; Inapparent Infection; Inapparent Infections; Infection, Asymptomatic; Infection, Inapparent; Infection, Subclinical; Subclinical Infection; Subclinical Infections
SNOMED CT: Subclinical infection (28456004)

Definition

Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubclinical infection

Professional guidelines

PubMed

A guide to the management of hepatitis E infection during pregnancy.
Kar P, Sengupta A
Expert Rev Gastroenterol Hepatol 2019 Mar;13(3):205-211. Epub 2019 Jan 24 doi: 10.1080/17474124.2019.1568869. PMID: 30791760
Treatment of chlamydial infections.
Hammerschlag MR, Kohlhoff SA
Expert Opin Pharmacother 2012 Mar;13(4):545-52. Epub 2012 Feb 9 doi: 10.1517/14656566.2012.658776. PMID: 22316336
Current management strategies for the prevention and treatment of cytomegalovirus infection in pediatric transplant recipients.
Bueno J, Ramil C, Green M
Paediatr Drugs 2002;4(5):279-90. doi: 10.2165/00128072-200204050-00001. PMID: 11994033

Recent clinical studies

Etiology

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Opportunities and challenges for human papillomavirus vaccination in cancer.
Roden RBS, Stern PL
Nat Rev Cancer 2018 Apr;18(4):240-254. Epub 2018 Mar 2 doi: 10.1038/nrc.2018.13. PMID: 29497146Free PMC Article
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Dengue virus pathogenesis: an integrated view.
Martina BE, Koraka P, Osterhaus AD
Clin Microbiol Rev 2009 Oct;22(4):564-81. doi: 10.1128/CMR.00035-09. PMID: 19822889Free PMC Article

Diagnosis

Imaging of COVID-19: CT, MRI, and PET.
Fields BKK, Demirjian NL, Dadgar H, Gholamrezanezhad A
Semin Nucl Med 2021 Jul;51(4):312-320. Epub 2020 Nov 30 doi: 10.1053/j.semnuclmed.2020.11.003. PMID: 33288215Free PMC Article
Recent advances in the diagnosis of leptospirosis.
Verma V, Goyal M, Kala D, Gupta S, Kumar D, Kaushal A
Front Biosci (Landmark Ed) 2020 Mar 1;25(9):1655-1681. doi: 10.2741/4872. PMID: 32114449
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Epidemic sporotrichosis.
Schubach A, Barros MB, Wanke B
Curr Opin Infect Dis 2008 Apr;21(2):129-33. doi: 10.1097/QCO.0b013e3282f44c52. PMID: 18317034

Therapy

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Opportunities and challenges for human papillomavirus vaccination in cancer.
Roden RBS, Stern PL
Nat Rev Cancer 2018 Apr;18(4):240-254. Epub 2018 Mar 2 doi: 10.1038/nrc.2018.13. PMID: 29497146Free PMC Article
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2013 Dec 2;(12):CD001058. doi: 10.1002/14651858.CD001058.pub3. PMID: 24297389

Prognosis

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
EPIDEMIOLOGY OF PARACOCCIDIOIDOMYCOSIS.
Martinez R
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):11-20. doi: 10.1590/S0036-46652015000700004. PMID: 26465364Free PMC Article
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2013 Dec 2;(12):CD001058. doi: 10.1002/14651858.CD001058.pub3. PMID: 24297389

Clinical prediction guides

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Swadling L, Diniz MO, Schmidt NM, Amin OE, Chandran A, Shaw E, Pade C, Gibbons JM, Le Bert N, Tan AT, Jeffery-Smith A, Tan CCS, Tham CYL, Kucykowicz S, Aidoo-Micah G, Rosenheim J, Davies J, Johnson M, Jensen MP, Joy G, McCoy LE, Valdes AM, Chain BM, Goldblatt D, Altmann DM, Boyton RJ, Manisty C, Treibel TA, Moon JC; COVIDsortium Investigators, van Dorp L, Balloux F, McKnight Á, Noursadeghi M, Bertoletti A, Maini MK
Nature 2022 Jan;601(7891):110-117. Epub 2021 Nov 10 doi: 10.1038/s41586-021-04186-8. PMID: 34758478Free PMC Article
Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review.
Leung T, Matrajt L
PLoS Negl Trop Dis 2021 May;15(5):e0009383. Epub 2021 May 20 doi: 10.1371/journal.pntd.0009383. PMID: 34014927Free PMC Article
Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Enteroaggregative Escherichia coli subclinical and clinical infections.
Lima AAM, Medeiros PHQS, Havt A
Curr Opin Infect Dis 2018 Oct;31(5):433-439. doi: 10.1097/QCO.0000000000000477. PMID: 30063473
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651

Recent systematic reviews

Asymptomatic Infection and Transmission of Pertussis in Households: A Systematic Review.
Craig R, Kunkel E, Crowcroft NS, Fitzpatrick MC, de Melker H, Althouse BM, Merkel T, Scarpino SV, Koelle K, Friedman L, Arnold C, Bolotin S
Clin Infect Dis 2020 Jan 1;70(1):152-161. doi: 10.1093/cid/ciz531. PMID: 31257450
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2013 Dec 2;(12):CD001058. doi: 10.1002/14651858.CD001058.pub3. PMID: 24297389
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2010 Aug 4;(8):CD001058. doi: 10.1002/14651858.CD001058.pub2. PMID: 20687063
Of cattle, sand flies and men: a systematic review of risk factor analyses for South Asian visceral leishmaniasis and implications for elimination.
Bern C, Courtenay O, Alvar J
PLoS Negl Trop Dis 2010 Feb 9;4(2):e599. doi: 10.1371/journal.pntd.0000599. PMID: 20161727Free PMC Article
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson J
Cochrane Database Syst Rev 2003;(2):CD001058. doi: 10.1002/14651858.CD001058. PMID: 12804398

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