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Subclinical infection

MedGen UID:
82906
•Concept ID:
C0275522
•
Disease or Syndrome
Synonyms: Asymptomatic Infection; Asymptomatic Infections; Inapparent Infection; Inapparent Infections; Infection, Asymptomatic; Infection, Inapparent; Infection, Subclinical; Subclinical Infection; Subclinical Infections
SNOMED CT: Subclinical infection (28456004)

Definition

Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubclinical infection

Professional guidelines

PubMed

A guide to the management of hepatitis E infection during pregnancy.
Kar P, Sengupta A
Expert Rev Gastroenterol Hepatol 2019 Mar;13(3):205-211. Epub 2019 Jan 24 doi: 10.1080/17474124.2019.1568869. PMID: 30791760
Treatment of Chlamydial infections: 2014 update.
Kohlhoff SA, Hammerschlag MR
Expert Opin Pharmacother 2015 Feb;16(2):205-12. doi: 10.1517/14656566.2015.999041. PMID: 25579069
Treatment of chlamydial infections.
Hammerschlag MR, Kohlhoff SA
Expert Opin Pharmacother 2012 Mar;13(4):545-52. Epub 2012 Feb 9 doi: 10.1517/14656566.2012.658776. PMID: 22316336

Recent clinical studies

Etiology

Emerging Zoonotic Diseases in Ferrets.
Wyre NR
Vet Clin North Am Exot Anim Pract 2020 May;23(2):299-308. doi: 10.1016/j.cvex.2020.01.012. PMID: 32327037
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
The impact of malnutrition on childhood infections.
Walson JL, Berkley JA
Curr Opin Infect Dis 2018 Jun;31(3):231-236. doi: 10.1097/QCO.0000000000000448. PMID: 29570495Free PMC Article
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Dengue virus pathogenesis: an integrated view.
Martina BE, Koraka P, Osterhaus AD
Clin Microbiol Rev 2009 Oct;22(4):564-81. doi: 10.1128/CMR.00035-09. PMID: 19822889Free PMC Article

Diagnosis

Histologic features of colonic infections.
Westerhoff M
Pathologe 2022 Feb;43(1):16-30. Epub 2021 Nov 12 doi: 10.1007/s00292-021-01015-7. PMID: 34767063Free PMC Article
Emerging Zoonotic Diseases in Ferrets.
Wyre NR
Vet Clin North Am Exot Anim Pract 2020 May;23(2):299-308. doi: 10.1016/j.cvex.2020.01.012. PMID: 32327037
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Epidemic sporotrichosis.
Schubach A, Barros MB, Wanke B
Curr Opin Infect Dis 2008 Apr;21(2):129-33. doi: 10.1097/QCO.0b013e3282f44c52. PMID: 18317034

Therapy

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
A guide to the management of hepatitis E infection during pregnancy.
Kar P, Sengupta A
Expert Rev Gastroenterol Hepatol 2019 Mar;13(3):205-211. Epub 2019 Jan 24 doi: 10.1080/17474124.2019.1568869. PMID: 30791760
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Epidemic sporotrichosis.
Schubach A, Barros MB, Wanke B
Curr Opin Infect Dis 2008 Apr;21(2):129-33. doi: 10.1097/QCO.0b013e3282f44c52. PMID: 18317034

Prognosis

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
The impact of malnutrition on childhood infections.
Walson JL, Berkley JA
Curr Opin Infect Dis 2018 Jun;31(3):231-236. doi: 10.1097/QCO.0000000000000448. PMID: 29570495Free PMC Article
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
EPIDEMIOLOGY OF PARACOCCIDIOIDOMYCOSIS.
Martinez R
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):11-20. doi: 10.1590/S0036-46652015000700004. PMID: 26465364Free PMC Article

Clinical prediction guides

Refractory neutrophilic asthma and ciliary genes.
Guntur VP, Manka LA, Moore CM, Wynn E, Vladar EK, Alam R, Pham TH, Fingerlin TE, Martin RJ
J Allergy Clin Immunol 2022 Jun;149(6):1970-1980. Epub 2022 Jan 13 doi: 10.1016/j.jaci.2021.12.761. PMID: 35034774
Protection afforded by previous Vibrio cholerae infection against subsequent disease and infection: A review.
Leung T, Matrajt L
PLoS Negl Trop Dis 2021 May;15(5):e0009383. Epub 2021 May 20 doi: 10.1371/journal.pntd.0009383. PMID: 34014927Free PMC Article
Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Enteroaggregative Escherichia coli subclinical and clinical infections.
Lima AAM, Medeiros PHQS, Havt A
Curr Opin Infect Dis 2018 Oct;31(5):433-439. doi: 10.1097/QCO.0000000000000477. PMID: 30063473
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651

Recent systematic reviews

Asymptomatic Infection and Transmission of Pertussis in Households: A Systematic Review.
Craig R, Kunkel E, Crowcroft NS, Fitzpatrick MC, de Melker H, Althouse BM, Merkel T, Scarpino SV, Koelle K, Friedman L, Arnold C, Bolotin S
Clin Infect Dis 2020 Jan 1;70(1):152-161. doi: 10.1093/cid/ciz531. PMID: 31257450
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2013 Dec 2;(12):CD001058. doi: 10.1002/14651858.CD001058.pub3. PMID: 24297389
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2010 Aug 4;(8):CD001058. doi: 10.1002/14651858.CD001058.pub2. PMID: 20687063
Of cattle, sand flies and men: a systematic review of risk factor analyses for South Asian visceral leishmaniasis and implications for elimination.
Bern C, Courtenay O, Alvar J
PLoS Negl Trop Dis 2010 Feb 9;4(2):e599. doi: 10.1371/journal.pntd.0000599. PMID: 20161727Free PMC Article
Prophylactic antibiotics for inhibiting preterm labour with intact membranes.
King J, Flenady V
Cochrane Database Syst Rev 2002;(4):CD000246. doi: 10.1002/14651858.CD000246. PMID: 12519538

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