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Subclinical infection

MedGen UID:
82906
•Concept ID:
C0275522
•
Disease or Syndrome
Synonyms: Asymptomatic Infection; Asymptomatic Infections; Inapparent Infection; Inapparent Infections; Infection, Asymptomatic; Infection, Inapparent; Infection, Subclinical; Subclinical Infection; Subclinical Infections
SNOMED CT: Subclinical infection (28456004)

Definition

Infection associated with no detectable symptoms but caused by microorganisms capable of producing easily recognizable diseases, such a poliomyelitis or mumps. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubclinical infection

Professional guidelines

PubMed

A guide to the management of hepatitis E infection during pregnancy.
Kar P, Sengupta A
Expert Rev Gastroenterol Hepatol 2019 Mar;13(3):205-211. Epub 2019 Jan 24 doi: 10.1080/17474124.2019.1568869. PMID: 30791760
Treatment of Chlamydial infections: 2014 update.
Kohlhoff SA, Hammerschlag MR
Expert Opin Pharmacother 2015 Feb;16(2):205-12. doi: 10.1517/14656566.2015.999041. PMID: 25579069
Treatment of chlamydial infections.
Hammerschlag MR, Kohlhoff SA
Expert Opin Pharmacother 2012 Mar;13(4):545-52. Epub 2012 Feb 9 doi: 10.1517/14656566.2012.658776. PMID: 22316336

Recent clinical studies

Etiology

Varicella in the 21st Century.
Obi OA
Neoreviews 2024 May 1;25(5):e274-e281. doi: 10.1542/neo.25-5-e274. PMID: 38688890
Emerging Zoonotic Diseases in Ferrets.
Wyre NR
Vet Clin North Am Exot Anim Pract 2020 May;23(2):299-308. doi: 10.1016/j.cvex.2020.01.012. PMID: 32327037
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Dengue virus pathogenesis: an integrated view.
Martina BE, Koraka P, Osterhaus AD
Clin Microbiol Rev 2009 Oct;22(4):564-81. doi: 10.1128/CMR.00035-09. PMID: 19822889Free PMC Article

Diagnosis

Varicella in the 21st Century.
Obi OA
Neoreviews 2024 May 1;25(5):e274-e281. doi: 10.1542/neo.25-5-e274. PMID: 38688890
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Laryngeal histoplasmosis.
Ansari HA, Saeed N, Khan N, Hasan N
BMJ Case Rep 2016 Aug 17;2016 doi: 10.1136/bcr-2016-216423. PMID: 27535733Free PMC Article
Epidemic sporotrichosis.
Schubach A, Barros MB, Wanke B
Curr Opin Infect Dis 2008 Apr;21(2):129-33. doi: 10.1097/QCO.0b013e3282f44c52. PMID: 18317034

Therapy

Varicella in the 21st Century.
Obi OA
Neoreviews 2024 May 1;25(5):e274-e281. doi: 10.1542/neo.25-5-e274. PMID: 38688890
Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
Epidemic sporotrichosis.
Schubach A, Barros MB, Wanke B
Curr Opin Infect Dis 2008 Apr;21(2):129-33. doi: 10.1097/QCO.0b013e3282f44c52. PMID: 18317034

Prognosis

Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Pneumocystis jiroveci.
Fishman JA
Semin Respir Crit Care Med 2020 Feb;41(1):141-157. Epub 2020 Jan 30 doi: 10.1055/s-0039-3399559. PMID: 32000290
The impact of malnutrition on childhood infections.
Walson JL, Berkley JA
Curr Opin Infect Dis 2018 Jun;31(3):231-236. doi: 10.1097/QCO.0000000000000448. PMID: 29570495Free PMC Article
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651
EPIDEMIOLOGY OF PARACOCCIDIOIDOMYCOSIS.
Martinez R
Rev Inst Med Trop Sao Paulo 2015 Sep;57 Suppl 19(Suppl 19):11-20. doi: 10.1590/S0036-46652015000700004. PMID: 26465364Free PMC Article

Clinical prediction guides

Refractory neutrophilic asthma and ciliary genes.
Guntur VP, Manka LA, Moore CM, Wynn E, Vladar EK, Alam R, Pham TH, Fingerlin TE, Martin RJ
J Allergy Clin Immunol 2022 Jun;149(6):1970-1980. Epub 2022 Jan 13 doi: 10.1016/j.jaci.2021.12.761. PMID: 35034774
Vaccines to prevent genital herpes.
Egan K, Hook LM, LaTourette P, Desmond A, Awasthi S, Friedman HM
Transl Res 2020 Jun;220:138-152. Epub 2020 Mar 16 doi: 10.1016/j.trsl.2020.03.004. PMID: 32272093Free PMC Article
Merkel cell polyomavirus and Langerhans cell neoplasm.
Murakami I, Wada N, Nakashima J, Iguchi M, Toi M, Hashida Y, Higuchi T, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Horie Y, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F
Cell Commun Signal 2018 Aug 22;16(1):49. doi: 10.1186/s12964-018-0261-y. PMID: 30134914Free PMC Article
Enteroaggregative Escherichia coli subclinical and clinical infections.
Lima AAM, Medeiros PHQS, Havt A
Curr Opin Infect Dis 2018 Oct;31(5):433-439. doi: 10.1097/QCO.0000000000000477. PMID: 30063473
Neonatal sepsis.
Shane AL, Sánchez PJ, Stoll BJ
Lancet 2017 Oct 14;390(10104):1770-1780. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31002-4. PMID: 28434651

Recent systematic reviews

Immunogenicity and seroefficacy of pneumococcal conjugate vaccines: a systematic review and network meta-analysis.
Feng S, McLellan J, Pidduck N, Roberts N, Higgins JP, Choi Y, Izu A, Jit M, Madhi SA, Mulholland K, Pollard AJ, Procter S, Temple B, Voysey M
Health Technol Assess 2024 Jul;28(34):1-109. doi: 10.3310/YWHA3079. PMID: 39046101Free PMC Article
Asymptomatic Infection and Transmission of Pertussis in Households: A Systematic Review.
Craig R, Kunkel E, Crowcroft NS, Fitzpatrick MC, de Melker H, Althouse BM, Merkel T, Scarpino SV, Koelle K, Friedman L, Arnold C, Bolotin S
Clin Infect Dis 2020 Jan 1;70(1):152-161. doi: 10.1093/cid/ciz531. PMID: 31257450
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2013 Dec 2;2013(12):CD001058. doi: 10.1002/14651858.CD001058.pub3. PMID: 24297389Free PMC Article
Antibiotics for preterm rupture of membranes.
Kenyon S, Boulvain M, Neilson JP
Cochrane Database Syst Rev 2010 Aug 4;(8):CD001058. doi: 10.1002/14651858.CD001058.pub2. PMID: 20687063
Of cattle, sand flies and men: a systematic review of risk factor analyses for South Asian visceral leishmaniasis and implications for elimination.
Bern C, Courtenay O, Alvar J
PLoS Negl Trop Dis 2010 Feb 9;4(2):e599. doi: 10.1371/journal.pntd.0000599. PMID: 20161727Free PMC Article

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