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Giant Cell and Spindle Cell Carcinoma

MedGen UID:
83111
•Concept ID:
C0334234
•
Neoplastic Process
Synonym: Giant cell and spindle cell carcinoma
SNOMED CT: Giant cell and spindle cell carcinoma (72969003)

Definition

A malignant epithelial neoplasm composed of giant, pleomorphic cells and spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGiant Cell and Spindle Cell Carcinoma

Professional guidelines

PubMed

Primary sarcomas of the lung.
Suster S
Semin Diagn Pathol 1995 May;12(2):140-57. PMID: 7638447
Treatment of locally advanced thyroid carcinoma with combination doxorubicin and radiation therapy.
Kim JH, Leeper RD
Cancer 1987 Nov 15;60(10):2372-5. doi: 10.1002/1097-0142(19871115)60:10<2372::aid-cncr2820601004>3.0.co;2-1. PMID: 3664425
Undifferentiated giant and spindle cell carcinoma of the thyroid. Report on two combined treatment modalities.
Tennvall J, Andersson T, Aspegren K, Biörklund A, Ingemansson S, Landberg T, Akerman M
Acta Radiol Oncol Radiat Phys Biol 1979;18(5):408-16. doi: 10.3109/02841867909128226. PMID: 532692

Recent clinical studies

Etiology

Incidental findings on FDG-PET/CT in large vessel vasculitis.
Hans V, Abele J, Yacyshyn E
Clin Rheumatol 2023 Aug;42(8):2163-2171. Epub 2023 Apr 22 doi: 10.1007/s10067-023-06558-z. PMID: 37086310
Japanese Oncology Group 0802: Another giant leap.
D'Amico TA
J Thorac Cardiovasc Surg 2023 Mar;165(3):873-875. Epub 2022 Oct 14 doi: 10.1016/j.jtcvs.2022.09.060. PMID: 36376119
HPV-Related Papillary Lesions of the Oral Mucosa: A Review.
Betz SJ
Head Neck Pathol 2019 Mar;13(1):80-90. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01003-7. PMID: 30693456Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE
Eur Urol 2016 Jul;70(1):106-119. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.02.028. PMID: 26996659

Diagnosis

Is pancreatic giant cell tumor resistant to standard chemotherapy?
Çağlayan D, Karakurt Eryilmaz M, Korkmaz M, Karaağaç M, Hendem E, Artaç M
Anticancer Drugs 2022 Sep 1;33(8):758-760. Epub 2022 Aug 10 doi: 10.1097/CAD.0000000000001331. PMID: 35946539
Pancreatic Ductal Adenocarcinoma.
Dhillon J, Betancourt M
Monogr Clin Cytol 2020;26:74-91. Epub 2020 Sep 28 doi: 10.1159/000455736. PMID: 32987385
Atypical giant trichoblastoma: An unusual presentation.
Nguyen LV, Masouminia M, Choy JO, Peng SK, Ji P, French SW
Exp Mol Pathol 2017 Feb;102(1):22-24. Epub 2016 Nov 9 doi: 10.1016/j.yexmp.2016.10.007. PMID: 27836679
Xanthogranulomatous pyelonephritis.
Li L, Parwani AV
Arch Pathol Lab Med 2011 May;135(5):671-4. doi: 10.5858/2009-0769-RSR.1. PMID: 21526966
Post-irradiation cytology of cervical cancer patients.
Shield PW, Daunter B, Wright RG
Cytopathology 1992;3(3):167-82. doi: 10.1111/j.1365-2303.1992.tb00043.x. PMID: 1511122

Therapy

Giant cell arteritis associated with PD-1 inhibition.
Couette N, Paul J
BMJ Case Rep 2021 Nov 29;14(11) doi: 10.1136/bcr-2021-246443. PMID: 34844970Free PMC Article
Lung cancer in 2017: Giant steps and stumbling blocks.
Heigener DF, Reck M
Nat Rev Clin Oncol 2018 Feb;15(2):71-72. Epub 2017 Nov 21 doi: 10.1038/nrclinonc.2017.178. PMID: 29158589
Lipoid pneumonia.
Wright BA, Jeffrey PH
Semin Respir Infect 1990 Dec;5(4):314-21. PMID: 2093976
Oral lesions.
Hinds EC, Kent JN
Am J Gastroenterol 1971 Mar;55(3):225-36. PMID: 4931041
Plasminogen-activator-producing tumour.
Davidson JF, McNicol GP, Frank GL, Anderson TJ, Douglas AS
Br Med J 1969 Jan 11;1(5636):88-91. doi: 10.1136/bmj.1.5636.88. PMID: 5761832Free PMC Article

Prognosis

Is pancreatic giant cell tumor resistant to standard chemotherapy?
Çağlayan D, Karakurt Eryilmaz M, Korkmaz M, Karaağaç M, Hendem E, Artaç M
Anticancer Drugs 2022 Sep 1;33(8):758-760. Epub 2022 Aug 10 doi: 10.1097/CAD.0000000000001331. PMID: 35946539
Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells.
Wang X, Miao J, Wang S, Shen R, Zhang S, Tian Y, Li M, Zhu D, Yao A, Bao W, Zhang Q, Tang X, Wang X, Li J
Mol Cancer 2022 Jun 22;21(1):133. doi: 10.1186/s12943-022-01596-8. PMID: 35733218Free PMC Article
Grading of renal cell carcinoma.
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310
Endometrial adenocarcinoma with trophoblastic differentiation.
Bradley CS, Benjamin I, Wheeler JE, Rubin SC
Gynecol Oncol 1998 Apr;69(1):74-7. doi: 10.1006/gyno.1998.4969. PMID: 9571002
Xanthoma of bone.
Bertoni F, Unni KK, McLeod RA, Sim FH
Am J Clin Pathol 1988 Oct;90(4):377-84. doi: 10.1093/ajcp/90.4.377. PMID: 3140652

Clinical prediction guides

Case report: Buschke-Lowenstein tumor, a giant anal condyloma acuminata.
Saldivar-Reyes DA, Muñoz-Maldonado GE, Fernández-Treviño JR, Vidal-Torres Ó, Medina-Muñoz DE
Cir Cir 2023;91(6):835-838. doi: 10.24875/CIRU.22000302. PMID: 38096879
Incidental findings on FDG-PET/CT in large vessel vasculitis.
Hans V, Abele J, Yacyshyn E
Clin Rheumatol 2023 Aug;42(8):2163-2171. Epub 2023 Apr 22 doi: 10.1007/s10067-023-06558-z. PMID: 37086310
Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus-Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial.
Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, Michel LS, Ley J, Oppelt P, Dunn GP, Barnell EK, Spies NC, Lin T, Li T, Mulder DT, Hanna Y, Cirlan I, Pugh TJ, Mudianto T, Riley R, Zhou L, Jo VY, Stachler MD, Hanna GJ, Kass J, Haddad R, Schoenfeld JD, Gjini E, Lako A, Thorstad W, Gay HA, Daly M, Rodig SJ, Hagemann IS, Kallogjeri D, Piccirillo JF, Chernock RD, Griffith M, Griffith OL, Adkins DR
Clin Cancer Res 2020 Oct 1;26(19):5140-5152. Epub 2020 Jul 14 doi: 10.1158/1078-0432.CCR-20-1695. PMID: 32665297Free PMC Article
Grading of renal cell carcinoma.
Delahunt B, Eble JN, Egevad L, Samaratunga H
Histopathology 2019 Jan;74(1):4-17. doi: 10.1111/his.13735. PMID: 30565310
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE
Eur Urol 2016 Jul;70(1):106-119. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.02.028. PMID: 26996659

Recent systematic reviews

The "Forgotten" Subtypes of Breast Carcinoma: A Systematic Review of Selected Histological Variants Not Included or Not Recognized as Distinct Entities in the Current World Health Organization Classification of Breast Tumors.
Koufopoulos NI, Boutas I, Pouliakis A, Samaras MG, Kotanidis C, Kontogeorgi A, Dimas DT, Ieronimaki AI, Leventakou D, Spathis A, Zanelli M, Palicelli A, Zizzo M, Goutas D, Pateras IS, Panayiotides IG
Int J Mol Sci 2024 Aug 1;25(15) doi: 10.3390/ijms25158382. PMID: 39125951Free PMC Article
The Molecular Mechanisms of Actions, Effects, and Clinical Implications of PARP Inhibitors in Epithelial Ovarian Cancers: A Systematic Review.
Lau CH, Seow KM, Chen KH
Int J Mol Sci 2022 Jul 23;23(15) doi: 10.3390/ijms23158125. PMID: 35897700Free PMC Article
Squamous Cell Carcinoma Arising from Perianal Buschke-Lowenstein Tumor (Giant Condyloma Acuminatum): Comprehensive Literature Review.
Ates M, Akbulut S, Tuncer A, Sahin E, Karabulut E, Sarici KB
J Gastrointest Cancer 2022 Dec;53(4):1083-1092. Epub 2021 Oct 25 doi: 10.1007/s12029-021-00713-y. PMID: 34694593
Is early detection of basal cell carcinoma worthwhile? Systematic review based on the WHO criteria for screening.
Hoorens I, Vossaert K, Ongenae K, Brochez L
Br J Dermatol 2016 Jun;174(6):1258-65. Epub 2016 May 24 doi: 10.1111/bjd.14477. PMID: 26872563
Rash to the mTOR inhibitor everolimus: systematic review and meta-analysis.
Ramirez-Fort MK, Case EC, Rosen AC, Cerci FB, Wu S, Lacouture ME
Am J Clin Oncol 2014 Jun;37(3):266-71. doi: 10.1097/COC.0b013e318277d62f. PMID: 23241507

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