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Differentiated Retinoblastoma

MedGen UID:
83171
•Concept ID:
C0334600
•
Neoplastic Process
Synonyms: Retinoblastoma - differentiated; Retinoblastoma, differentiated
SNOMED CT: Retinoblastoma - differentiated (26019009); Retinoblastoma, differentiated (26019009)

Definition

A retinoblastoma with well differentiated features. It often produces Flexner-Wintersteiner rosettes or Homer-Wright rosettes. In some cases the tumor cells form fleurettes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDifferentiated Retinoblastoma

Professional guidelines

PubMed

Causes of chemoreduction failure in retinoblastoma and analysis of associated factors leading to eventual treatment with external beam radiotherapy and enucleation.
Gündüz K, Günalp I, Yalçindağ N, Unal E, Taçyildiz N, Erden E, Geyik PO
Ophthalmology 2004 Oct;111(10):1917-24. doi: 10.1016/j.ophtha.2004.04.016. PMID: 15465557

Recent clinical studies

Etiology

UBE2T/STAT3 Signaling Promotes the Proliferation and Tumorigenesis in Retinoblastoma.
Xu N, Cui Y, Shi H, Guo G, Sun F, Jian T, Rao H
Invest Ophthalmol Vis Sci 2022 Aug 2;63(9):20. doi: 10.1167/iovs.63.9.20. PMID: 35980647Free PMC Article
Secondary enucleated retinoblastoma with MYCN amplification.
Moulin AP, Stathopoulos C, Marcelli F, Schoumans Pouw J, Beck-Popovic M, Munier FL
Ophthalmic Genet 2021 Jun;42(3):354-359. Epub 2021 Apr 19 doi: 10.1080/13816810.2021.1897847. PMID: 33870828
Retinoblastoma Cell Culturing and Evaluation of Their Drug Resistance.
Saakyan SV, Tsygankov АY, Moiseeva NI, Karamysheva АF, Zhil'tsova MG, Tadevosyan SS
Bull Exp Biol Med 2018 May;165(1):148-153. Epub 2018 May 24 doi: 10.1007/s10517-018-4117-7. PMID: 29796815
A new rosette in retinoblastoma.
Das D, Bhattacharjee K, Barthakur SS, Tahiliani PS, Deka P, Bhattacharjee H, Deka A, Paul R
Indian J Ophthalmol 2014 May;62(5):638-41. doi: 10.4103/0301-4738.129786. PMID: 24881618Free PMC Article
Phthisis bulbi in retinoblastoma.
Kashyap S, Meel R, Pushker N, Sen S, Bakhshi S, Bajaj MS, Chawla B, Sethi S, Ghose S, Chandra M
Clin Exp Ophthalmol 2011 Mar;39(2):105-10. Epub 2011 Feb 22 doi: 10.1111/j.1442-9071.2010.02426.x. PMID: 21040312

Diagnosis

Coexistence of persistent fetal vasculature and retinoblastoma in the same eye.
Castillo-Trejo B, Pérez-Pérez JF, Aguilar-Morales K, Castelo-Huerta M, Pérez-Giráldez A, Corredor-Casas S
Bol Med Hosp Infant Mex 2023;80(Supl 1):53-57. doi: 10.24875/BMHIM.22000104. PMID: 37490692
Secondary enucleated retinoblastoma with MYCN amplification.
Moulin AP, Stathopoulos C, Marcelli F, Schoumans Pouw J, Beck-Popovic M, Munier FL
Ophthalmic Genet 2021 Jun;42(3):354-359. Epub 2021 Apr 19 doi: 10.1080/13816810.2021.1897847. PMID: 33870828
Retinoblastoma Cell Culturing and Evaluation of Their Drug Resistance.
Saakyan SV, Tsygankov АY, Moiseeva NI, Karamysheva АF, Zhil'tsova MG, Tadevosyan SS
Bull Exp Biol Med 2018 May;165(1):148-153. Epub 2018 May 24 doi: 10.1007/s10517-018-4117-7. PMID: 29796815
A new rosette in retinoblastoma.
Das D, Bhattacharjee K, Barthakur SS, Tahiliani PS, Deka P, Bhattacharjee H, Deka A, Paul R
Indian J Ophthalmol 2014 May;62(5):638-41. doi: 10.4103/0301-4738.129786. PMID: 24881618Free PMC Article
Phthisis bulbi in retinoblastoma.
Kashyap S, Meel R, Pushker N, Sen S, Bakhshi S, Bajaj MS, Chawla B, Sethi S, Ghose S, Chandra M
Clin Exp Ophthalmol 2011 Mar;39(2):105-10. Epub 2011 Feb 22 doi: 10.1111/j.1442-9071.2010.02426.x. PMID: 21040312

Therapy

L1 increases adhesion-mediated proliferation and chemoresistance of retinoblastoma.
Jo DH, Lee K, Kim JH, Jun HO, Kim Y, Cho YL, Yu YS, Min JK, Kim JH
Oncotarget 2017 Feb 28;8(9):15441-15452. doi: 10.18632/oncotarget.14487. PMID: 28061460Free PMC Article
Failure of globe conservation in a case of adult onset retinoblastoma.
Khetan V, Bindu A, Kamat P, Kumar SK
Middle East Afr J Ophthalmol 2014 Oct-Dec;21(4):358-60. doi: 10.4103/0974-9233.142280. PMID: 25371646Free PMC Article
Phthisis bulbi in retinoblastoma.
Kashyap S, Meel R, Pushker N, Sen S, Bakhshi S, Bajaj MS, Chawla B, Sethi S, Ghose S, Chandra M
Clin Exp Ophthalmol 2011 Mar;39(2):105-10. Epub 2011 Feb 22 doi: 10.1111/j.1442-9071.2010.02426.x. PMID: 21040312
Intravenously administered gold nanoparticles pass through the blood-retinal barrier depending on the particle size, and induce no retinal toxicity.
Kim JH, Kim JH, Kim KW, Kim MH, Yu YS
Nanotechnology 2009 Dec 16;20(50):505101. Epub 2009 Nov 19 doi: 10.1088/0957-4484/20/50/505101. PMID: 19923650
Causes of chemoreduction failure in retinoblastoma and analysis of associated factors leading to eventual treatment with external beam radiotherapy and enucleation.
Gündüz K, Günalp I, Yalçindağ N, Unal E, Taçyildiz N, Erden E, Geyik PO
Ophthalmology 2004 Oct;111(10):1917-24. doi: 10.1016/j.ophtha.2004.04.016. PMID: 15465557

Prognosis

Coexistence of persistent fetal vasculature and retinoblastoma in the same eye.
Castillo-Trejo B, Pérez-Pérez JF, Aguilar-Morales K, Castelo-Huerta M, Pérez-Giráldez A, Corredor-Casas S
Bol Med Hosp Infant Mex 2023;80(Supl 1):53-57. doi: 10.24875/BMHIM.22000104. PMID: 37490692
Phthisis bulbi in retinoblastoma.
Kashyap S, Meel R, Pushker N, Sen S, Bakhshi S, Bajaj MS, Chawla B, Sethi S, Ghose S, Chandra M
Clin Exp Ophthalmol 2011 Mar;39(2):105-10. Epub 2011 Feb 22 doi: 10.1111/j.1442-9071.2010.02426.x. PMID: 21040312
Ca(v)3.1 splice variant expression during neuronal differentiation of Y-79 retinoblastoma cells.
Bertolesi GE, Walia Da Silva R, Jollimore CA, Shi C, Barnes S, Kelly ME
Neuroscience 2006 Aug 11;141(1):259-68. Epub 2006 May 6 doi: 10.1016/j.neuroscience.2006.03.067. PMID: 16678971
Optic nerve invasion of retinoblastoma. Metastatic potential and clinical risk factors.
Shields CL, Shields JA, Baez K, Cater JR, De Potter P
Cancer 1994 Feb 1;73(3):692-8. doi: 10.1002/1097-0142(19940201)73:3<692::aid-cncr2820730331>3.0.co;2-8. PMID: 8299091
Choroidal invasion of retinoblastoma: metastatic potential and clinical risk factors.
Shields CL, Shields JA, Baez KA, Cater J, De Potter PV
Br J Ophthalmol 1993 Sep;77(9):544-8. doi: 10.1136/bjo.77.9.544. PMID: 8218048Free PMC Article

Clinical prediction guides

UBE2T/STAT3 Signaling Promotes the Proliferation and Tumorigenesis in Retinoblastoma.
Xu N, Cui Y, Shi H, Guo G, Sun F, Jian T, Rao H
Invest Ophthalmol Vis Sci 2022 Aug 2;63(9):20. doi: 10.1167/iovs.63.9.20. PMID: 35980647Free PMC Article
Retinoblastoma Cell Culturing and Evaluation of Their Drug Resistance.
Saakyan SV, Tsygankov АY, Moiseeva NI, Karamysheva АF, Zhil'tsova MG, Tadevosyan SS
Bull Exp Biol Med 2018 May;165(1):148-153. Epub 2018 May 24 doi: 10.1007/s10517-018-4117-7. PMID: 29796815
Expression of SIRT2 and SIRT6 in retinoblastoma.
Orellana ME, Quezada C, Maloney SC, Antecka E, Balazsi M, Burnier MN Jr
Ophthalmic Res 2015;53(2):100-8. Epub 2015 Feb 5 doi: 10.1159/000368718. PMID: 25660418
A new rosette in retinoblastoma.
Das D, Bhattacharjee K, Barthakur SS, Tahiliani PS, Deka P, Bhattacharjee H, Deka A, Paul R
Indian J Ophthalmol 2014 May;62(5):638-41. doi: 10.4103/0301-4738.129786. PMID: 24881618Free PMC Article
Choroidal invasion of retinoblastoma: metastatic potential and clinical risk factors.
Shields CL, Shields JA, Baez KA, Cater J, De Potter PV
Br J Ophthalmol 1993 Sep;77(9):544-8. doi: 10.1136/bjo.77.9.544. PMID: 8218048Free PMC Article

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