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Thyroid eye disease

MedGen UID:
83281
Concept ID:
C0339143
Disease or Syndrome
Synonyms: Disease, Graves Eye; Disease, Thyroid Eye; Dysthyroid Ophthalmopathies; Dysthyroid Ophthalmopathy; Eye Disease, Graves; Eye Disease, Thyroid; Graves Eye Disease; Graves Ophthalmopathy; Graves Orbitopathy; Ophthalmopathies, Thyroid-Associated; Ophthalmopathy, Dysthyroid; Ophthalmopathy, Graves; Ophthalmopathy, Thyroid Associated; Ophthalmopathy, Thyroid-Associated; Orbitopathy, Graves; Thyroid Associated Ophthalmopathies; Thyroid Associated Ophthalmopathy; Thyroid Eye Disease; Thyroid Eye Diseases; Thyroid-Associated Ophthalmopathies; Thyroid-Associated Ophthalmopathy
SNOMED CT: Thyroid ophthalmopathy (276177000); Graves' ophthalmopathy (276177000); Graves ophthalmopathy (276177000); Endocrine orbitopathy (276177000); Dysthyroid eye disease (276177000); Graves eye disease (276177000); Graves' eye disease (276177000); Ophthalmic Graves disease (276177000); Thyroid orbitopathy (276177000); Thyroid-associated ophthalmopathy (276177000); Endocrine ophthalmopathy (276177000); Dysthyroid orbitopathy (276177000); Thyroid eye disease (276177000)

Definition

An autoimmune disorder of the EYE, occurring in patients with Graves disease. Subtypes include congestive (inflammation of the orbital connective tissue), myopathic (swelling and dysfunction of the extraocular muscles), and mixed congestive-myopathic ophthalmopathy. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid eye disease

Professional guidelines

PubMed

Hoang TD, Stocker DJ, Chou EL, Burch HB
Endocrinol Metab Clin North Am 2022 Jun;51(2):287-304. Epub 2022 May 11 doi: 10.1016/j.ecl.2021.12.004. PMID: 35662442Free PMC Article
Hall AJH, Topliss DJ
Intern Med J 2022 Jan;52(1):14-20. doi: 10.1111/imj.15067. PMID: 32975863
Taylor PN, Zhang L, Lee RWJ, Muller I, Ezra DG, Dayan CM, Kahaly GJ, Ludgate M
Nat Rev Endocrinol 2020 Feb;16(2):104-116. Epub 2019 Dec 30 doi: 10.1038/s41574-019-0305-4. PMID: 31889140

Recent clinical studies

Etiology

Kahaly GJ, Dolman PJ, Wolf J, Giers BC, Elflein HM, Jain AP, Srinivasan A, Hadjiiski L, Jordan D, Bradley EA, Stan MN, Eckstein A, Pitz S, Vorländer C, Wester ST, Nguyen J, Tucker N, Sales-Sanz M, Feldon SE, Nelson CC, Hardy I, Abia-Serrano M, Tedeschi P, Janes JM, Xu J, Vue P, Macias WL, Douglas RS
J Clin Endocrinol Metab 2023 Nov 17;108(12):3122-3134. doi: 10.1210/clinem/dgad381. PMID: 37390454Free PMC Article
Nie T, Lamb YN
Drugs 2022 Nov;82(17):1663-1670. Epub 2022 Nov 23 doi: 10.1007/s40265-022-01804-1. PMID: 36418673Free PMC Article
Douglas RS, Kahaly GJ, Ugradar S, Elflein H, Ponto KA, Fowler BT, Dailey R, Harris GJ, Schiffman J, Tang R, Wester S, Jain AP, Marcocci C, Marinò M, Antonelli A, Eckstein A, Führer-Sakel D, Salvi M, Sile S, Francis-Sedlak M, Holt RJ, Smith TJ
Ophthalmology 2022 Apr;129(4):438-449. Epub 2021 Oct 21 doi: 10.1016/j.ophtha.2021.10.017. PMID: 34688699
Winther KH, Rayman MP, Bonnema SJ, Hegedüs L
Nat Rev Endocrinol 2020 Mar;16(3):165-176. Epub 2020 Jan 30 doi: 10.1038/s41574-019-0311-6. PMID: 32001830
Douglas RS, Kahaly GJ, Patel A, Sile S, Thompson EHZ, Perdok R, Fleming JC, Fowler BT, Marcocci C, Marinò M, Antonelli A, Dailey R, Harris GJ, Eckstein A, Schiffman J, Tang R, Nelson C, Salvi M, Wester S, Sherman JW, Vescio T, Holt RJ, Smith TJ
N Engl J Med 2020 Jan 23;382(4):341-352. doi: 10.1056/NEJMoa1910434. PMID: 31971679

Diagnosis

Hoang TD, Stocker DJ, Chou EL, Burch HB
Endocrinol Metab Clin North Am 2022 Jun;51(2):287-304. Epub 2022 May 11 doi: 10.1016/j.ecl.2021.12.004. PMID: 35662442Free PMC Article
Bartalena L, Tanda ML
J Intern Med 2022 Nov;292(5):692-716. Epub 2022 Jun 1 doi: 10.1111/joim.13524. PMID: 35604323Free PMC Article
Taylor PN, Zhang L, Lee RWJ, Muller I, Ezra DG, Dayan CM, Kahaly GJ, Ludgate M
Nat Rev Endocrinol 2020 Feb;16(2):104-116. Epub 2019 Dec 30 doi: 10.1038/s41574-019-0305-4. PMID: 31889140
Weiler DL
Clin Exp Optom 2017 Jan;100(1):20-25. Epub 2016 Oct 4 doi: 10.1111/cxo.12472. PMID: 27701774
Bahn RS
N Engl J Med 2010 Feb 25;362(8):726-38. doi: 10.1056/NEJMra0905750. PMID: 20181974Free PMC Article

Therapy

Hoang TD, Stocker DJ, Chou EL, Burch HB
Endocrinol Metab Clin North Am 2022 Jun;51(2):287-304. Epub 2022 May 11 doi: 10.1016/j.ecl.2021.12.004. PMID: 35662442Free PMC Article
Bartalena L, Tanda ML
J Intern Med 2022 Nov;292(5):692-716. Epub 2022 Jun 1 doi: 10.1111/joim.13524. PMID: 35604323Free PMC Article
Hall AJH, Topliss DJ
Intern Med J 2022 Jan;52(1):14-20. doi: 10.1111/imj.15067. PMID: 32975863
Douglas RS, Kahaly GJ, Patel A, Sile S, Thompson EHZ, Perdok R, Fleming JC, Fowler BT, Marcocci C, Marinò M, Antonelli A, Dailey R, Harris GJ, Eckstein A, Schiffman J, Tang R, Nelson C, Salvi M, Wester S, Sherman JW, Vescio T, Holt RJ, Smith TJ
N Engl J Med 2020 Jan 23;382(4):341-352. doi: 10.1056/NEJMoa1910434. PMID: 31971679
Bahn RS
N Engl J Med 2010 Feb 25;362(8):726-38. doi: 10.1056/NEJMra0905750. PMID: 20181974Free PMC Article

Prognosis

Szelog J, Swanson H, Sniegowski MC, Lyon DB
Mo Med 2022 Jul-Aug;119(4):343-350. PMID: 36118816Free PMC Article
Douglas RS, Kahaly GJ, Ugradar S, Elflein H, Ponto KA, Fowler BT, Dailey R, Harris GJ, Schiffman J, Tang R, Wester S, Jain AP, Marcocci C, Marinò M, Antonelli A, Eckstein A, Führer-Sakel D, Salvi M, Sile S, Francis-Sedlak M, Holt RJ, Smith TJ
Ophthalmology 2022 Apr;129(4):438-449. Epub 2021 Oct 21 doi: 10.1016/j.ophtha.2021.10.017. PMID: 34688699
Kahaly GJ, Douglas RS, Holt RJ, Sile S, Smith TJ
Lancet Diabetes Endocrinol 2021 Jun;9(6):360-372. Epub 2021 Apr 15 doi: 10.1016/S2213-8587(21)00056-5. PMID: 33865501
Winther KH, Rayman MP, Bonnema SJ, Hegedüs L
Nat Rev Endocrinol 2020 Mar;16(3):165-176. Epub 2020 Jan 30 doi: 10.1038/s41574-019-0311-6. PMID: 32001830
Burch HB, Cooper DS
JAMA 2015 Dec 15;314(23):2544-54. doi: 10.1001/jama.2015.16535. PMID: 26670972

Clinical prediction guides

Nie T, Lamb YN
Drugs 2022 Nov;82(17):1663-1670. Epub 2022 Nov 23 doi: 10.1007/s40265-022-01804-1. PMID: 36418673Free PMC Article
Barbesino G, Salvi M, Freitag SK
J Clin Endocrinol Metab 2022 Aug 8;107(Suppl_1):S47-S56. doi: 10.1210/clinem/dgac252. PMID: 36346684Free PMC Article
Hall AJH, Topliss DJ
Intern Med J 2022 Jan;52(1):14-20. doi: 10.1111/imj.15067. PMID: 32975863
Douglas RS, Kahaly GJ, Patel A, Sile S, Thompson EHZ, Perdok R, Fleming JC, Fowler BT, Marcocci C, Marinò M, Antonelli A, Dailey R, Harris GJ, Eckstein A, Schiffman J, Tang R, Nelson C, Salvi M, Wester S, Sherman JW, Vescio T, Holt RJ, Smith TJ
N Engl J Med 2020 Jan 23;382(4):341-352. doi: 10.1056/NEJMoa1910434. PMID: 31971679
Burch HB, Cooper DS
JAMA 2015 Dec 15;314(23):2544-54. doi: 10.1001/jama.2015.16535. PMID: 26670972

Recent systematic reviews

Zhang Y, Zhang XJ, Yuan N, Wang YM, Ip P, Chen LJ, Tham CC, Pang CP, Yam JC
Surv Ophthalmol 2023 Nov-Dec;68(6):1166-1207. Epub 2023 Jul 20 doi: 10.1016/j.survophthal.2023.07.001. PMID: 37479063
Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, Chu WK, Chen LJ, Tham CC, Yam JC, Pang CP
Int J Mol Sci 2022 Apr 11;23(8) doi: 10.3390/ijms23084226. PMID: 35457041Free PMC Article
Wolf J, Mitka KI, Hubalewska-Dydejczyk A, Krämer I, Kahaly GJ
Expert Opin Drug Saf 2022 Jul;21(7):881-912. Epub 2022 Aug 15 doi: 10.1080/14740338.2022.2069239. PMID: 35447047
Godfrey KJ, Kazim M
Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4S Suppl 1):S98-S104. doi: 10.1097/IOP.0000000000001074. PMID: 29771752
Jefferis JM, Jones RK, Currie ZI, Tan JH, Salvi SM
Eye (Lond) 2018 Mar;32(3):626-636. Epub 2017 Dec 15 doi: 10.1038/eye.2017.260. PMID: 29243735Free PMC Article

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