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Metastatic Malignant Neoplasm in the Pancreas

MedGen UID:
83434
•Concept ID:
C0346976
•
Neoplastic Process
Synonyms: Cancer metastatic to pancreas; Metastasis to pancreas; Metastatic Cancer to the Pancreas; Metastatic malignant neoplasm of pancreas; Metastatic malignant neoplasm to pancreas; Metastatic Malignant Neoplasm to the Pancreas; Metastatic Neoplasm to the Pancreas; Metastatic Tumor to the Pancreas; Pancreatic metastasis; Secondary Cancer to the Pancreas; Secondary malignant deposit in pancreas; Secondary malignant neoplasm of pancreas; Secondary Malignant Neoplasm to the Pancreas; Secondary Malignant Tumor to the Pancreas
SNOMED CT: Metastasis to pancreas (94459006); Secondary malignant deposit in pancreas (94459006); Pancreatic metastasis (94459006); Secondary malignant neoplasm of pancreas (94459006); Metastatic malignant neoplasm to pancreas (94459006); Cancer metastatic to pancreas (94459006); Metastatic malignant neoplasm of pancreas (94459006)

Definition

A malignant neoplasm that has spread to the pancreas from another anatomic site. Representative examples include metastatic carcinomas from the gastrointestinal tract, metastatic melanomas, and renal cell carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Pancreas

Professional guidelines

PubMed

Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056
The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Management of Metastatic and/or Unresectable Pheochromocytoma and Paraganglioma.
Fishbein L, Del Rivero J, Else T, Howe JR, Asa SL, Cohen DL, Dahia PLM, Fraker DL, Goodman KA, Hope TA, Kunz PL, Perez K, Perrier ND, Pryma DA, Ryder M, Sasson AR, Soulen MC, Jimenez C
Pancreas 2021 Apr 1;50(4):469-493. doi: 10.1097/MPA.0000000000001792. PMID: 33939658
Ductal pancreatic adenocarcinoma.
Seufferlein T, Porzner M, Heinemann V, Tannapfel A, Stuschke M, Uhl W
Dtsch Arztebl Int 2014 May 30;111(22):396-402. doi: 10.3238/arztebl.2014.0396. PMID: 24980565Free PMC Article

Recent clinical studies

Etiology

The role of resection for melanoma metastases to the pancreas.
Guerra F, Coletta D, Deutsch GB, Giuliani G, Patriti A, Fischer TD, Coratti A; Collaborators
HPB (Oxford) 2022 Dec;24(12):2045-2052. Epub 2022 Sep 5 doi: 10.1016/j.hpb.2022.08.012. PMID: 36167766
The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.
Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Blackford AL, Rustgi AK, Dudley B, Lee LS, Chhoda A, Kwon R, Ginsberg GG, Klein AP, Kamel I, Hruban RH, He J, Shin EJ, Lennon AM, Canto MI, Goggins M
J Clin Oncol 2022 Oct 1;40(28):3257-3266. Epub 2022 Jun 15 doi: 10.1200/JCO.22.00298. PMID: 35704792Free PMC Article
Fibrocalculous pancreatic diabetes.
Kumaran S, Unnikrishnan AG
J Diabetes Complications 2021 Jan;35(1):107627. Epub 2020 May 22 doi: 10.1016/j.jdiacomp.2020.107627. PMID: 32553576
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Diagnosis

The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival.
Dbouk M, Katona BW, Brand RE, Chak A, Syngal S, Farrell JJ, Kastrinos F, Stoffel EM, Blackford AL, Rustgi AK, Dudley B, Lee LS, Chhoda A, Kwon R, Ginsberg GG, Klein AP, Kamel I, Hruban RH, He J, Shin EJ, Lennon AM, Canto MI, Goggins M
J Clin Oncol 2022 Oct 1;40(28):3257-3266. Epub 2022 Jun 15 doi: 10.1200/JCO.22.00298. PMID: 35704792Free PMC Article
Imaging of Pancreatic Tumors.
Morse B, Klapman J
Monogr Clin Cytol 2020;26:21-33. Epub 2020 Sep 28 doi: 10.1159/000455731. PMID: 32987388
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Organoid models of human and mouse ductal pancreatic cancer.
Boj SF, Hwang CI, Baker LA, Chio II, Engle DD, Corbo V, Jager M, Ponz-Sarvise M, Tiriac H, Spector MS, Gracanin A, Oni T, Yu KH, van Boxtel R, Huch M, Rivera KD, Wilson JP, Feigin ME, Öhlund D, Handly-Santana A, Ardito-Abraham CM, Ludwig M, Elyada E, Alagesan B, Biffi G, Yordanov GN, Delcuze B, Creighton B, Wright K, Park Y, Morsink FH, Molenaar IQ, Borel Rinkes IH, Cuppen E, Hao Y, Jin Y, Nijman IJ, Iacobuzio-Donahue C, Leach SD, Pappin DJ, Hammell M, Klimstra DS, Basturk O, Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA
Cell 2015 Jan 15;160(1-2):324-38. Epub 2014 Dec 31 doi: 10.1016/j.cell.2014.12.021. PMID: 25557080Free PMC Article
Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA
Nature 2010 Oct 28;467(7319):1114-7. doi: 10.1038/nature09515. PMID: 20981102Free PMC Article

Therapy

Exercise for cancer cachexia in adults.
Grande AJ, Silva V, Sawaris Neto L, Teixeira Basmage JP, Peccin MS, Maddocks M
Cochrane Database Syst Rev 2021 Mar 18;3(3):CD010804. doi: 10.1002/14651858.CD010804.pub3. PMID: 33735441Free PMC Article
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Chemotherapy for pancreatic cancer.
Springfeld C, Jäger D, Büchler MW, Strobel O, Hackert T, Palmer DH, Neoptolemos JP
Presse Med 2019 Mar;48(3 Pt 2):e159-e174. Epub 2019 Mar 15 doi: 10.1016/j.lpm.2019.02.025. PMID: 30879894
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Autoimmune pancreatitis.
Pickartz T, Mayerle J, Lerch MM
Nat Clin Pract Gastroenterol Hepatol 2007 Jun;4(6):314-23. doi: 10.1038/ncpgasthep0837. PMID: 17541445

Prognosis

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Cancers Metastatic to the Liver.
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Pancreatic endocrine tumors.
Asa SL
Mod Pathol 2011 Apr;24 Suppl 2:S66-77. doi: 10.1038/modpathol.2010.127. PMID: 21455203
Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA
Nature 2010 Oct 28;467(7319):1114-7. doi: 10.1038/nature09515. PMID: 20981102Free PMC Article
Autoimmune pancreatitis.
Pickartz T, Mayerle J, Lerch MM
Nat Clin Pract Gastroenterol Hepatol 2007 Jun;4(6):314-23. doi: 10.1038/ncpgasthep0837. PMID: 17541445

Clinical prediction guides

The role of resection for melanoma metastases to the pancreas.
Guerra F, Coletta D, Deutsch GB, Giuliani G, Patriti A, Fischer TD, Coratti A; Collaborators
HPB (Oxford) 2022 Dec;24(12):2045-2052. Epub 2022 Sep 5 doi: 10.1016/j.hpb.2022.08.012. PMID: 36167766
Clinical and Histological Basis of Adenosquamous Carcinoma of the Pancreas: A 30-year Experience.
Moslim MA, Lefton MD, Ross EA, Mackrides N, Reddy SS
J Surg Res 2021 Mar;259:350-356. Epub 2020 Nov 13 doi: 10.1016/j.jss.2020.09.024. PMID: 33190924Free PMC Article
Non-functional neuroendocrine tumors of the pancreas: Advances in diagnosis and management.
Cloyd JM, Poultsides GA
World J Gastroenterol 2015 Aug 28;21(32):9512-25. doi: 10.3748/wjg.v21.i32.9512. PMID: 26327759Free PMC Article
Role of Radiotherapy and Newer Techniques in the Treatment of GI Cancers.
Hajj C, Goodman KA
J Clin Oncol 2015 Jun 1;33(16):1737-44. Epub 2015 Apr 27 doi: 10.1200/JCO.2014.59.9787. PMID: 25918298
Pancreatic endocrine tumors.
Asa SL
Mod Pathol 2011 Apr;24 Suppl 2:S66-77. doi: 10.1038/modpathol.2010.127. PMID: 21455203

Recent systematic reviews

The role of hepatic and pancreatic metastatectomy in the management of metastatic renal cell carcinoma: A systematic review.
Rodger FE, Brennan PT, Nair R, Holroyd DJ
Surg Oncol 2022 Sep;44:101819. Epub 2022 Jul 20 doi: 10.1016/j.suronc.2022.101819. PMID: 35940030
Exercise for cancer cachexia in adults.
Grande AJ, Silva V, Sawaris Neto L, Teixeira Basmage JP, Peccin MS, Maddocks M
Cochrane Database Syst Rev 2021 Mar 18;3(3):CD010804. doi: 10.1002/14651858.CD010804.pub3. PMID: 33735441Free PMC Article
Metastatic tumors to the pancreas: a systematic review and meta-analysis.
Sperti C, Pozza G, Brazzale AR, Buratin A, Moletta L, Beltrame V, Valmasoni M
Minerva Chir 2016 Oct;71(5):337-44. Epub 2016 Jul 14 PMID: 27412234
Systematic review and meta-analysis of liver resection for metastatic melanoma.
Aubin JM, Rekman J, Vandenbroucke-Menu F, Lapointe R, Fairfull-Smith RJ, Mimeault R, Balaa FK, Martel G
Br J Surg 2013 Aug;100(9):1138-47. Epub 2013 Jun 17 doi: 10.1002/bjs.9189. PMID: 23775340
Molecularly targeted therapies in metastatic pancreatic cancer: a systematic review.
Zagouri F, Sergentanis TN, Chrysikos D, Zografos CG, Papadimitriou CA, Dimopoulos MA, Filipits M, Bartsch R
Pancreas 2013 Jul;42(5):760-73. doi: 10.1097/MPA.0b013e31827aedef. PMID: 23774698

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