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Ovarian mixed germ cell neoplasm

MedGen UID:
83602
•Concept ID:
C0280135
•
Neoplastic Process
Synonyms: Mixed Germ Cell Neoplasm of Ovary; mixed germ cell neoplasm of ovary; Mixed Germ Cell Neoplasm of the Ovary; mixed germ cell neoplasm of the ovary; mixed germ cell tumor; Mixed Germ Cell Tumor of Ovary; mixed germ cell tumor of ovary; Mixed Germ Cell Tumor of the Ovary; mixed germ cell tumor of the ovary; mixed germ cell tumour; mixed germ cell tumour of ovary; mixed germ cell tumour of the ovary; Ovarian Mixed Germ Cell Neoplasm; ovarian mixed germ cell neoplasm; Ovarian Mixed Germ Cell Tumor; ovarian mixed germ cell tumor; ovarian mixed germ cell tumour; ovary mixed germ cell tumor; ovary mixed germ cell tumour
 
Monarch Initiative: MONDO:0003710

Definition

An ovarian malignant germ cell tumor characterized by the presence of at least two different germ cell tumor components. The most common combination of germ cell tumors is dysgerminoma and yolk sac tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian mixed germ cell neoplasm

Professional guidelines

PubMed

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Diagnosis and management of malignant germ cell ovarian tumors in young females.
Zalel Y, Piura B, Elchalal U, Czernobilsky B, Antebi S, Dgani R
Int J Gynaecol Obstet 1996 Oct;55(1):1-10. doi: 10.1016/0020-7292(96)02719-1. PMID: 8910077

Recent clinical studies

Etiology

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Metastatic germ cell tumour in effusion cytology.
Saini T, Kundu R, Rastogi P, Rohilla M, Gupta P, Gupta N, Srinivasan R, Dey P
Cytopathology 2022 Jul;33(4):493-498. Epub 2022 Apr 9 doi: 10.1111/cyt.13122. PMID: 35347771
Imaging in gynecological disease (24): clinical and ultrasound characteristics of ovarian mature cystic teratomas.
Heremans R, Valentin L, Sladkevicius P, Timmerman S, Moro F, Van Holsbeke C, Epstein E, Testa AC, Timmerman D, Froyman W
Ultrasound Obstet Gynecol 2022 Oct;60(4):549-558. Epub 2022 Sep 15 doi: 10.1002/uog.24904. PMID: 35316568
Ovarian germ cell tumour classification: views from the testis.
Berney DM, Stoneham S, Arora R, Shamash J, Lockley M
Histopathology 2020 Jan;76(1):25-36. doi: 10.1111/his.14016. PMID: 31846529
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Diagnosis

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Imaging in gynecological disease (24): clinical and ultrasound characteristics of ovarian mature cystic teratomas.
Heremans R, Valentin L, Sladkevicius P, Timmerman S, Moro F, Van Holsbeke C, Epstein E, Testa AC, Timmerman D, Froyman W
Ultrasound Obstet Gynecol 2022 Oct;60(4):549-558. Epub 2022 Sep 15 doi: 10.1002/uog.24904. PMID: 35316568
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Therapy

Imaging Appearance of Nongerminoma Pediatric Ovarian Germ Cell Tumors Does Not Discriminate Benign from Malignant Histology.
Billmire D, Dicken B, Rescorla F, Ross J, Piao J, Huang L, Krailo M, Pashankar F, Frazier L; Children's Oncology Group
J Pediatr Adolesc Gynecol 2021 Jun;34(3):383-386. Epub 2020 Dec 13 doi: 10.1016/j.jpag.2020.11.014. PMID: 33316416Free PMC Article
A case series of patients with gonadal dysgenesis-associated mixed malignant ovarian germ cell tumor.
Yang W, Wu L, He Q, Zhang Y, Zhang Y, Tian Y
Gynecol Endocrinol 2020 Oct;36(10):934-937. Epub 2020 Jun 9 doi: 10.1080/09513590.2020.1775194. PMID: 32516003
Clinical management of malignant ovarian germ cell tumors: A 26-year experience in a tertiary care institution.
Hu T, Fang Y, Sun Q, Zhao H, Ma D, Zhu T, Wang C
Surg Oncol 2019 Dec;31:8-13. Epub 2019 Aug 20 doi: 10.1016/j.suronc.2019.08.006. PMID: 31446304
Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Diagnosis and management of malignant germ cell ovarian tumors in young females.
Zalel Y, Piura B, Elchalal U, Czernobilsky B, Antebi S, Dgani R
Int J Gynaecol Obstet 1996 Oct;55(1):1-10. doi: 10.1016/0020-7292(96)02719-1. PMID: 8910077

Prognosis

Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma.
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Diagnosis and management of malignant germ cell ovarian tumors in young females.
Zalel Y, Piura B, Elchalal U, Czernobilsky B, Antebi S, Dgani R
Int J Gynaecol Obstet 1996 Oct;55(1):1-10. doi: 10.1016/0020-7292(96)02719-1. PMID: 8910077

Clinical prediction guides

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Imaging in gynecological disease (24): clinical and ultrasound characteristics of ovarian mature cystic teratomas.
Heremans R, Valentin L, Sladkevicius P, Timmerman S, Moro F, Van Holsbeke C, Epstein E, Testa AC, Timmerman D, Froyman W
Ultrasound Obstet Gynecol 2022 Oct;60(4):549-558. Epub 2022 Sep 15 doi: 10.1002/uog.24904. PMID: 35316568
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
NUT protein immunoreactivity in ovarian germ cell tumours.
Iacobelli JF, Charles AK, Crook M, Stewart CJ
Pathology 2015 Feb;47(2):118-22. doi: 10.1097/PAT.0000000000000208. PMID: 25551299
Gonadal teratomas: a review and speculation.
Ulbright TM
Adv Anat Pathol 2004 Jan;11(1):10-23. doi: 10.1097/00125480-200401000-00002. PMID: 14676637

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