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Ovarian mixed germ cell neoplasm

MedGen UID:
83602
Concept ID:
C0280135
Neoplastic Process
Synonyms: Mixed Germ Cell Neoplasm of Ovary; mixed germ cell neoplasm of ovary; Mixed Germ Cell Neoplasm of the Ovary; mixed germ cell neoplasm of the ovary; mixed germ cell tumor; Mixed Germ Cell Tumor of Ovary; mixed germ cell tumor of ovary; Mixed Germ Cell Tumor of the Ovary; mixed germ cell tumor of the ovary; mixed germ cell tumour; mixed germ cell tumour of ovary; mixed germ cell tumour of the ovary; Ovarian Mixed Germ Cell Neoplasm; ovarian mixed germ cell neoplasm; Ovarian Mixed Germ Cell Tumor; ovarian mixed germ cell tumor; ovarian mixed germ cell tumour; ovary mixed germ cell tumor; ovary mixed germ cell tumour
 
Monarch Initiative: MONDO:0003710

Definition

An ovarian malignant germ cell tumor characterized by the presence of at least two different germ cell tumor components. The most common combination of germ cell tumors is dysgerminoma and yolk sac tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian mixed germ cell neoplasm

Professional guidelines

PubMed

Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Zalel Y, Piura B, Elchalal U, Czernobilsky B, Antebi S, Dgani R
Int J Gynaecol Obstet 1996 Oct;55(1):1-10. doi: 10.1016/0020-7292(96)02719-1. PMID: 8910077
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594

Recent clinical studies

Etiology

Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Saini T, Kundu R, Rastogi P, Rohilla M, Gupta P, Gupta N, Srinivasan R, Dey P
Cytopathology 2022 Jul;33(4):493-498. Epub 2022 Apr 9 doi: 10.1111/cyt.13122. PMID: 35347771
Heremans R, Valentin L, Sladkevicius P, Timmerman S, Moro F, Van Holsbeke C, Epstein E, Testa AC, Timmerman D, Froyman W
Ultrasound Obstet Gynecol 2022 Oct;60(4):549-558. Epub 2022 Sep 15 doi: 10.1002/uog.24904. PMID: 35316568
Graham R, MacDonald ND, Lockley M, Miller R, Butler J, Murali K, Sarker SJ, Banerjee S, Stoneham S, Shamash J, Liberale V, Berney DM, Newton C
Eur J Obstet Gynecol Reprod Biol 2022 Apr;271:138-144. Epub 2022 Feb 16 doi: 10.1016/j.ejogrb.2022.02.013. PMID: 35192975
Berney DM, Stoneham S, Arora R, Shamash J, Lockley M
Histopathology 2020 Jan;76(1):25-36. doi: 10.1111/his.14016. PMID: 31846529

Diagnosis

Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Heremans R, Valentin L, Sladkevicius P, Timmerman S, Moro F, Van Holsbeke C, Epstein E, Testa AC, Timmerman D, Froyman W
Ultrasound Obstet Gynecol 2022 Oct;60(4):549-558. Epub 2022 Sep 15 doi: 10.1002/uog.24904. PMID: 35316568
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795

Therapy

Billmire D, Dicken B, Rescorla F, Ross J, Piao J, Huang L, Krailo M, Pashankar F, Frazier L; Children's Oncology Group
J Pediatr Adolesc Gynecol 2021 Jun;34(3):383-386. Epub 2020 Dec 13 doi: 10.1016/j.jpag.2020.11.014. PMID: 33316416Free PMC Article
Hu T, Fang Y, Sun Q, Zhao H, Ma D, Zhu T, Wang C
Surg Oncol 2019 Dec;31:8-13. Epub 2019 Aug 20 doi: 10.1016/j.suronc.2019.08.006. PMID: 31446304
Sigismondi C, Scollo P, Ferrandina G, Candiani M, Angioli R, Viganò R, Scarfone G, Mangili G
Int J Gynecol Cancer 2015 Feb;25(2):203-7. doi: 10.1097/IGC.0000000000000358. PMID: 25569816
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Zalel Y, Piura B, Elchalal U, Czernobilsky B, Antebi S, Dgani R
Int J Gynaecol Obstet 1996 Oct;55(1):1-10. doi: 10.1016/0020-7292(96)02719-1. PMID: 8910077

Prognosis

Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Zhang R, Sun YC, Zhang GY, Wu LY, Zuo J
Eur J Gynaecol Oncol 2012;33(5):489-92. PMID: 23185794

Clinical prediction guides

Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Bossart M, Plett H, Krämer B, Braicu E, Czogalla B, Klar M, Singer S, Mayr D, Staebler A, du Bois A, Kommoss S, Link T, Burges A, Heitz F, Grube M, Trillsch F, Harter P, Wimberger P, Buderath P, Hasenburg A
Arch Gynecol Obstet 2023 Apr;307(4):1155-1162. Epub 2022 Sep 21 doi: 10.1007/s00404-022-06781-0. PMID: 36127525Free PMC Article
Heremans R, Valentin L, Sladkevicius P, Timmerman S, Moro F, Van Holsbeke C, Epstein E, Testa AC, Timmerman D, Froyman W
Ultrasound Obstet Gynecol 2022 Oct;60(4):549-558. Epub 2022 Sep 15 doi: 10.1002/uog.24904. PMID: 35316568
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Iacobelli JF, Charles AK, Crook M, Stewart CJ
Pathology 2015 Feb;47(2):118-22. doi: 10.1097/PAT.0000000000000208. PMID: 25551299

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