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Adult embryonal tumor with multilayered rosettes, c19mc-altered

MedGen UID:
83792
•Concept ID:
C0281330
•
Neoplastic Process
Synonyms: Adult Embryonal Tumor with Multilayered Rosettes, C19MC-Altered; adult embryonal tumor with multilayered rosettes, c19mc-altered; adult embryonal tumor with multilayered rosettes, C19MC-altered; adult embryonal tumour with multilayered rosettes, C19MC-altered; Adult Ependymoblastoma; adult ependymoblastoma; ependymoblastoma of adults
 
Monarch Initiative: MONDO:0004310

Definition

An embryonal tumor with multilayered rosettes, C19MC-altered, occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult embryonal tumor with multilayered rosettes, c19mc-altered

Professional guidelines

PubMed

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Advances in Risk Classification and Treatment Strategies for Neuroblastoma.
Pinto NR, Applebaum MA, Volchenboum SL, Matthay KK, London WB, Ambros PF, Nakagawara A, Berthold F, Schleiermacher G, Park JR, Valteau-Couanet D, Pearson AD, Cohn SL
J Clin Oncol 2015 Sep 20;33(27):3008-17. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.4648. PMID: 26304901Free PMC Article

Recent clinical studies

Etiology

Neuroblastoma.
Shah S, Ravindranath Y
Indian J Pediatr 1998 Sep-Oct;65(5):691-705. doi: 10.1007/BF02731044. PMID: 10773924
Neuroblastoma.
Castleberry RP
Eur J Cancer 1997 Aug;33(9):1430-7; discussion 1437-8. doi: 10.1016/s0959-8049(97)00308-0. PMID: 9337686
Esthesioneuroblastoma and neck metastasis.
Davis RE, Weissler MC
Head Neck 1992 Nov-Dec;14(6):477-82. doi: 10.1002/hed.2880140610. PMID: 1468921
Esthesioneuroblastoma.
Shah JP, Feghali J
Am J Surg 1981 Oct;142(4):456-8. doi: 10.1016/0002-9610(81)90374-3. PMID: 7283046
Olfactory esthesioneuroblastoma.
Jensen KJ, Elbrond O, Lund C
J Laryngol Otol 1976 Nov;90(11):1007-13. doi: 10.1017/s0022215100083043. PMID: 1003025

Diagnosis

Primitive neuroectodermal tumor of the kidney in a child.
Citak EC, Oguz A, Karadeniz C, Okur A, Akyurek N
Pediatr Hematol Oncol 2009 Oct-Nov;26(7):481-6. doi: 10.1080/08880010902754792. PMID: 19863203
Esthesioneuroblastoma with intracranial extension.
Meneses MS, Thurel C, Mikol J, Ramina R, Maniglia JJ, Arruda WO, Cophignon J
Neurosurgery 1990 Nov;27(5):813-9; discussion 819-20. doi: 10.1097/00006123-199011000-00023. PMID: 2259415
Medulloepithelioma (diktyoma).
Canning CR, McCartney AC, Hungerford J
Br J Ophthalmol 1988 Oct;72(10):764-7. doi: 10.1136/bjo.72.10.764. PMID: 3056510Free PMC Article
Olfactory esthesioneuroblastoma.
Jensen KJ, Elbrond O, Lund C
J Laryngol Otol 1976 Nov;90(11):1007-13. doi: 10.1017/s0022215100083043. PMID: 1003025
MEDULLO-EPITHELIOMA.
Sayed BA, Sahgal KN, Desai VK
Br J Ophthalmol 1962 Jan;46(1):58-60. doi: 10.1136/bjo.46.1.58. PMID: 18170756Free PMC Article

Therapy

Immunotherapy of Neuroblastoma: Facts and Hopes.
Anderson J, Majzner RG, Sondel PM
Clin Cancer Res 2022 Aug 2;28(15):3196-3206. doi: 10.1158/1078-0432.CCR-21-1356. PMID: 35435953Free PMC Article
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y, Embry L, Hadley J, Kumar R, Michalski J, Hwang E, Gajjar A, Pollack IF, Fouladi M, Northcott PA, Olson JM
JAMA Oncol 2021 Sep 1;7(9):1313-1321. doi: 10.1001/jamaoncol.2021.2224. PMID: 34292305Free PMC Article
Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma.
Morandi F, Frassoni F, Ponzoni M, Brignole C
J Immunol Res 2018;2018:8097398. Epub 2018 Oct 30 doi: 10.1155/2018/8097398. PMID: 30510968Free PMC Article
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066
MEDULLO-EPITHELIOMA.
Sayed BA, Sahgal KN, Desai VK
Br J Ophthalmol 1962 Jan;46(1):58-60. doi: 10.1136/bjo.46.1.58. PMID: 18170756Free PMC Article

Prognosis

Esthesioneuroblastoma: the UCLA experience 1970-1990.
Dulguerov P, Calcaterra T
Laryngoscope 1992 Aug;102(8):843-9. doi: 10.1288/00005537-199208000-00001. PMID: 1495347
Esthesioneuroblastoma and neck metastasis.
Davis RE, Weissler MC
Head Neck 1992 Nov-Dec;14(6):477-82. doi: 10.1002/hed.2880140610. PMID: 1468921
Esthesioneuroblastoma.
Shah JP, Feghali J
CA Cancer J Clin 1983 May-Jun;33(3):154-9. doi: 10.3322/canjclin.33.3.154. PMID: 6404523
Olfactory neuroblastoma.
Baker DC, Perzin KH, Conley J
Otolaryngol Head Neck Surg (1979) 1979 May-Jun;87(3):279-83. doi: 10.1177/019459987908700301. PMID: 492698
Olfactory esthesioneuroblastoma.
Jensen KJ, Elbrond O, Lund C
J Laryngol Otol 1976 Nov;90(11):1007-13. doi: 10.1017/s0022215100083043. PMID: 1003025

Clinical prediction guides

Advancing presurgical non-invasive molecular subgroup prediction in medulloblastoma using artificial intelligence and MRI signatures.
Wang YJ, Wang P, Yan Z, Zhou Q, Gunturkun F, Li P, Hu Y, Wu WE, Zhao K, Zhang M, Lv H, Fu L, Jin J, Du Q, Wang H, Chen K, Qu L, Lin K, Iv M, Wang H, Sun X, Vogel H, Han S, Tian L, Wu F, Gong J
Cancer Cell 2024 Jul 8;42(7):1239-1257.e7. Epub 2024 Jun 27 doi: 10.1016/j.ccell.2024.06.002. PMID: 38942025
The immune cell atlas of human neuroblastoma.
Verhoeven BM, Mei S, Olsen TK, Gustafsson K, Valind A, Lindström A, Gisselsson D, Fard SS, Hagerling C, Kharchenko PV, Kogner P, Johnsen JI, Baryawno N
Cell Rep Med 2022 Jun 21;3(6):100657. Epub 2022 Jun 9 doi: 10.1016/j.xcrm.2022.100657. PMID: 35688160Free PMC Article
New Prognostic Indicators in Pediatric Adrenal Tumors: Neuroblastoma and Adrenal Cortical Tumors, Can We Predict When These Will Behave Badly?
Jarzembowski JA
Surg Pathol Clin 2020 Dec;13(4):625-641. Epub 2020 Oct 9 doi: 10.1016/j.path.2020.08.002. PMID: 33183724
Advances in Risk Classification and Treatment Strategies for Neuroblastoma.
Pinto NR, Applebaum MA, Volchenboum SL, Matthay KK, London WB, Ambros PF, Nakagawara A, Berthold F, Schleiermacher G, Park JR, Valteau-Couanet D, Pearson AD, Cohn SL
J Clin Oncol 2015 Sep 20;33(27):3008-17. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.4648. PMID: 26304901Free PMC Article
Esthesioneuroblastoma: the UCLA experience 1970-1990.
Dulguerov P, Calcaterra T
Laryngoscope 1992 Aug;102(8):843-9. doi: 10.1288/00005537-199208000-00001. PMID: 1495347

Recent systematic reviews

The SH-SY5Y human neuroblastoma cell line, a relevant in vitro cell model for investigating neurotoxicology in human: Focus on organic pollutants.
Lopez-Suarez L, Awabdh SA, Coumoul X, Chauvet C
Neurotoxicology 2022 Sep;92:131-155. Epub 2022 Jul 29 doi: 10.1016/j.neuro.2022.07.008. PMID: 35914637
Patient-Derived Xenotransplant of CNS Neoplasms in Zebrafish: A Systematic Review.
Sarmiento BE, Callegari S, Ghotme KA, Akle V
Cells 2022 Apr 2;11(7) doi: 10.3390/cells11071204. PMID: 35406768Free PMC Article
Chemotherapy for children with medulloblastoma.
Michiels EM, Schouten-Van Meeteren AY, Doz F, Janssens GO, van Dalen EC
Cochrane Database Syst Rev 2015 Jan 1;1(1):CD006678. doi: 10.1002/14651858.CD006678.pub2. PMID: 25879092Free PMC Article
Management of neonatal proptosis: a systematic review.
Erickson BP, Tse DT
Surv Ophthalmol 2014 Jul-Aug;59(4):378-92. Epub 2013 Dec 3 doi: 10.1016/j.survophthal.2013.11.002. PMID: 24929905
Minimally invasive adrenalectomy in children.
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405

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