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Adult TdT Positive Acute Lymphoblastic Leukemia

MedGen UID:
852477
•Concept ID:
C0279598
•
Neoplastic Process

Definition

TdT positive acute lymphoblastic leukemia that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult TdT Positive Acute Lymphoblastic Leukemia

Professional guidelines

PubMed

DNA methylation as a new tool for the differential diagnosis between T-LBL and lymphocyte-rich thymoma.
Latiri M, Belhocine M, Smith C, Garnier N, Balducci E, Pinton A, Andrieu GP, Bruneau J, Spicuglia S, Jamain S, Latapie V, de Montpreville VT, Chalabreysse L, Marx A, Girard N, Besse B, Plass C, Gibault L, Badoual C, Macintyre E, Asnafi V, Molina TJ, Touzart A
J Pathol 2024 Nov;264(3):284-292. Epub 2024 Sep 27 doi: 10.1002/path.6346. PMID: 39329449
Nasal CD56 positive small round cell tumors. Differential diagnosis of hematological, neurogenic, and myogenic neoplasms.
Liu Q, Ohshima K, Sumie A, Suzushima H, Iwasaki H, Kikuchi M
Virchows Arch 2001 Mar;438(3):271-9. doi: 10.1007/s004280000326. PMID: 11315624
Clinical utility of leukemia cell terminal transferase measurements.
McCaffrey R, Lillquist A, Sallan S, Cohen E, Osband M
Cancer Res 1981 Nov;41(11 Pt 2):4814-20. PMID: 7028251

Recent clinical studies

Etiology

Immunophenotype of Acute Lymphoblastic Leukemia: The Experience of University Hospital Centre Casablanca - Morocco.
Addakiri S, Bencharef H, Jaddaoui S, Ait-Ichou K, Oukkache B
Clin Lab 2023 Sep 1;69(9) doi: 10.7754/Clin.Lab.2023.230307. PMID: 37702695
Prognostic implications of TdT expression in acute myeloid leukemia with an intermediate-risk karyotype.
Saburi M, Ogata M, Satou T, Soga Y, Itani K, Kohno K, Kondo Y, Nakayama T
Int J Hematol 2020 Jul;112(1):17-23. Epub 2020 Apr 6 doi: 10.1007/s12185-020-02871-4. PMID: 32253665
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
The immunophenotype of adult T acute lymphoblastic leukemia in Morocco.
Lahjouji A, Bachir F, Bennani S, Quessar A, Amzazi S
Exp Oncol 2015 Mar;37(1):64-9. PMID: 25804235
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

Immunophenotype of Acute Lymphoblastic Leukemia: The Experience of University Hospital Centre Casablanca - Morocco.
Addakiri S, Bencharef H, Jaddaoui S, Ait-Ichou K, Oukkache B
Clin Lab 2023 Sep 1;69(9) doi: 10.7754/Clin.Lab.2023.230307. PMID: 37702695
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined IGH/BCL2 and MYC rearrangement.
Kelemen K, Holden J, Johnson LJ, Davion S, Robetorye RS
Cytometry B Clin Cytom 2017 Jul;92(4):310-314. Epub 2016 Feb 5 doi: 10.1002/cyto.b.21334. PMID: 26517296
The immunophenotype of adult T acute lymphoblastic leukemia in Morocco.
Lahjouji A, Bachir F, Bennani S, Quessar A, Amzazi S
Exp Oncol 2015 Mar;37(1):64-9. PMID: 25804235
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Therapy

Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Terminal deoxynucleotidyl transferase-negative acute lymphoblastic leukemia.
Faber J, Kantarjian H, Roberts MW, Keating M, Freireich E, Albitar M
Arch Pathol Lab Med 2000 Jan;124(1):92-7. doi: 10.5858/2000-124-0092-TDTNAL. PMID: 10629138
Ph1-positive acute lymphoblastic leukemia associated with an isochromosome 17q.
Kageyama T, Takiuchi H, Hasegawa M, Ohyabu H, Horiike S
Int J Hematol 1991 Jun;54(3):257-61. PMID: 1747460
Terminal deoxynucleotidyl transferase, TdT, as a marker for leukemia and lymphoma cells.
Campagnari F, Bombardieri E, de Braud F, Baldini L, Maiolo AT
Int J Biol Markers 1987 Jan-Apr;2(1):31-42. doi: 10.1177/172460088700200105. PMID: 3323341
Clinical utility of leukemia cell terminal transferase measurements.
McCaffrey R, Lillquist A, Sallan S, Cohen E, Osband M
Cancer Res 1981 Nov;41(11 Pt 2):4814-20. PMID: 7028251

Prognosis

Prognostic implications of TdT expression in acute myeloid leukemia with an intermediate-risk karyotype.
Saburi M, Ogata M, Satou T, Soga Y, Itani K, Kohno K, Kondo Y, Nakayama T
Int J Hematol 2020 Jul;112(1):17-23. Epub 2020 Apr 6 doi: 10.1007/s12185-020-02871-4. PMID: 32253665
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.
Yasuda H, Tsutsui M, Ota Y, Tanaka M, Komatsu N
Histopathology 2018 Apr;72(5):862-866. Epub 2018 Jan 19 doi: 10.1111/his.13433. PMID: 29143359
Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined IGH/BCL2 and MYC rearrangement.
Kelemen K, Holden J, Johnson LJ, Davion S, Robetorye RS
Cytometry B Clin Cytom 2017 Jul;92(4):310-314. Epub 2016 Feb 5 doi: 10.1002/cyto.b.21334. PMID: 26517296
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Clinical prediction guides

Immunophenotype of Acute Lymphoblastic Leukemia: The Experience of University Hospital Centre Casablanca - Morocco.
Addakiri S, Bencharef H, Jaddaoui S, Ait-Ichou K, Oukkache B
Clin Lab 2023 Sep 1;69(9) doi: 10.7754/Clin.Lab.2023.230307. PMID: 37702695
Prognostic implications of TdT expression in acute myeloid leukemia with an intermediate-risk karyotype.
Saburi M, Ogata M, Satou T, Soga Y, Itani K, Kohno K, Kondo Y, Nakayama T
Int J Hematol 2020 Jul;112(1):17-23. Epub 2020 Apr 6 doi: 10.1007/s12185-020-02871-4. PMID: 32253665
A seven-color panel including CD34 and TdT could be applied in >97% patients with T cell lymphoblastic leukemia for minimal residual disease detection independent of the initial phenotype.
Wang YZ, Hao L, Chang Y, Jiang Q, Jiang H, Zhang LP, He LL, Yuan XY, Qin YZ, Huang XJ, Liu YR
Leuk Res 2018 Sep;72:12-19. Epub 2018 Jul 27 doi: 10.1016/j.leukres.2018.07.012. PMID: 30059823
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
Clinical utility of leukemia cell terminal transferase measurements.
McCaffrey R, Lillquist A, Sallan S, Cohen E, Osband M
Cancer Res 1981 Nov;41(11 Pt 2):4814-20. PMID: 7028251

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