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Adult TdT Positive Acute Lymphoblastic Leukemia

MedGen UID:
852477
•Concept ID:
C0279598
•
Neoplastic Process

Definition

TdT positive acute lymphoblastic leukemia that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult TdT Positive Acute Lymphoblastic Leukemia

Professional guidelines

PubMed

Nasal CD56 positive small round cell tumors. Differential diagnosis of hematological, neurogenic, and myogenic neoplasms.
Liu Q, Ohshima K, Sumie A, Suzushima H, Iwasaki H, Kikuchi M
Virchows Arch 2001 Mar;438(3):271-9. doi: 10.1007/s004280000326. PMID: 11315624
Clinical utility of terminal deoxynucleotidyl transferase and adenosine deaminase determinations in adult leukemia with a lymphoid phenotype.
Brusamolino E, Isernia P, Lazzarino M, Scovassi I, Bertazzoni U, Bernasconi C
J Clin Oncol 1984 Aug;2(8):871-80. doi: 10.1200/JCO.1984.2.8.871. PMID: 6589363
Clinical utility of leukemia cell terminal transferase measurements.
McCaffrey R, Lillquist A, Sallan S, Cohen E, Osband M
Cancer Res 1981 Nov;41(11 Pt 2):4814-20. PMID: 7028251

Recent clinical studies

Etiology

Immunophenotype of Acute Lymphoblastic Leukemia: The Experience of University Hospital Centre Casablanca - Morocco.
Addakiri S, Bencharef H, Jaddaoui S, Ait-Ichou K, Oukkache B
Clin Lab 2023 Sep 1;69(9) doi: 10.7754/Clin.Lab.2023.230307. PMID: 37702695
Prognostic implications of TdT expression in acute myeloid leukemia with an intermediate-risk karyotype.
Saburi M, Ogata M, Satou T, Soga Y, Itani K, Kohno K, Kondo Y, Nakayama T
Int J Hematol 2020 Jul;112(1):17-23. Epub 2020 Apr 6 doi: 10.1007/s12185-020-02871-4. PMID: 32253665
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
The immunophenotype of adult T acute lymphoblastic leukemia in Morocco.
Lahjouji A, Bachir F, Bennani S, Quessar A, Amzazi S
Exp Oncol 2015 Mar;37(1):64-9. PMID: 25804235
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Diagnosis

Immunophenotype of Acute Lymphoblastic Leukemia: The Experience of University Hospital Centre Casablanca - Morocco.
Addakiri S, Bencharef H, Jaddaoui S, Ait-Ichou K, Oukkache B
Clin Lab 2023 Sep 1;69(9) doi: 10.7754/Clin.Lab.2023.230307. PMID: 37702695
LIM domain only 2 (LMO2) expression distinguishes T-lymphoblastic leukemia/lymphoma from indolent T-lymphoblastic proliferations.
Brar N, Butzmann A, Kumar J, Peerani R, Morgan EA, Grigoriadis G, Kumar B, Tatarczuch RM, Warnke RA, Ohgami RS
Histopathology 2020 Dec;77(6):984-988. Epub 2020 Sep 24 doi: 10.1111/his.14176. PMID: 32526041
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
The immunophenotype of adult T acute lymphoblastic leukemia in Morocco.
Lahjouji A, Bachir F, Bennani S, Quessar A, Amzazi S
Exp Oncol 2015 Mar;37(1):64-9. PMID: 25804235
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093

Therapy

Beneficial tyrosine kinase inhibitor therapy in a patient with relapsed BCR-ABL1-like acute lymphoblastic leukemia with CCDC88C-PDGFRB fusion.
Oya S, Morishige S, Ozawa H, Sasaki K, Semba Y, Yamasaki Y, Nakamura T, Aoyama K, Seki R, Mouri F, Osaki K, Miyamoto T, Maeda T, Nagafuji K
Int J Hematol 2021 Feb;113(2):285-289. Epub 2020 Sep 19 doi: 10.1007/s12185-020-03006-5. PMID: 32951102
Early T precursor acute lymphoblastic leukaemia/lymphoma shows differential immunophenotypic characteristics including frequent CD33 expression and in vitro response to targeted CD33 therapy.
Khogeer H, Rahman H, Jain N, Angelova EA, Yang H, Quesada A, Ok CY, Sui D, Wei P, Al Fattani A, Pierce S, Loghavi S, Lamb A, Hu P, Thakral B, Kanagal-Shamanna R, Jorgensen JL, Jabbour EJ, Kantarjian HM, Medeiros LJ, Khoury JD
Br J Haematol 2019 Aug;186(4):538-548. Epub 2019 May 22 doi: 10.1111/bjh.15960. PMID: 31115909
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Acute lymphoblastic leukemia following preleukemic syndromes in adults.
Escudier SM, Albitar M, Robertson LE, Andreeff M, Pierce S, Kantarjian HM
Leukemia 1996 Mar;10(3):473-7. PMID: 8642864
Terminal deoxynucleotidyl transferase, TdT, as a marker for leukemia and lymphoma cells.
Campagnari F, Bombardieri E, de Braud F, Baldini L, Maiolo AT
Int J Biol Markers 1987 Jan-Apr;2(1):31-42. doi: 10.1177/172460088700200105. PMID: 3323341

Prognosis

Prognostic implications of TdT expression in acute myeloid leukemia with an intermediate-risk karyotype.
Saburi M, Ogata M, Satou T, Soga Y, Itani K, Kohno K, Kondo Y, Nakayama T
Int J Hematol 2020 Jul;112(1):17-23. Epub 2020 Apr 6 doi: 10.1007/s12185-020-02871-4. PMID: 32253665
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined IGH/BCL2 and MYC rearrangement.
Kelemen K, Holden J, Johnson LJ, Davion S, Robetorye RS
Cytometry B Clin Cytom 2017 Jul;92(4):310-314. Epub 2016 Feb 5 doi: 10.1002/cyto.b.21334. PMID: 26517296
Lymphoblastic lymphoma.
Cortelazzo S, Ponzoni M, Ferreri AJ, Hoelzer D
Crit Rev Oncol Hematol 2011 Sep;79(3):330-43. Epub 2011 Jan 26 doi: 10.1016/j.critrevonc.2010.12.003. PMID: 21273093
Acute lymphoblastic leukemia following preleukemic syndromes in adults.
Escudier SM, Albitar M, Robertson LE, Andreeff M, Pierce S, Kantarjian HM
Leukemia 1996 Mar;10(3):473-7. PMID: 8642864

Clinical prediction guides

Immunophenotype of Acute Lymphoblastic Leukemia: The Experience of University Hospital Centre Casablanca - Morocco.
Addakiri S, Bencharef H, Jaddaoui S, Ait-Ichou K, Oukkache B
Clin Lab 2023 Sep 1;69(9) doi: 10.7754/Clin.Lab.2023.230307. PMID: 37702695
Prognostic implications of TdT expression in acute myeloid leukemia with an intermediate-risk karyotype.
Saburi M, Ogata M, Satou T, Soga Y, Itani K, Kohno K, Kondo Y, Nakayama T
Int J Hematol 2020 Jul;112(1):17-23. Epub 2020 Apr 6 doi: 10.1007/s12185-020-02871-4. PMID: 32253665
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.
Yasuda H, Tsutsui M, Ota Y, Tanaka M, Komatsu N
Histopathology 2018 Apr;72(5):862-866. Epub 2018 Jan 19 doi: 10.1111/his.13433. PMID: 29143359
Adult precursor-B acute lymphoblastic leukemia with translocations involving chromosome band 19p13 is associated with poor prognosis.
Khalidi HS, O'Donnell MR, Slovak ML, Arber DA
Cancer Genet Cytogenet 1999 Feb;109(1):58-65. doi: 10.1016/s0165-4608(98)00153-8. PMID: 9973961

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