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Extracorporeal Circuit Clot

MedGen UID:
853099
•Concept ID:
C0949072
•
Finding

Definition

Thrombus formation within an apparatus that carries blood outside of the body, such as pheresis, dialysis or extracorporeal membrane oxygenation (ECMO). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtracorporeal Circuit Clot

Professional guidelines

PubMed

Management of Bivalirudin Dosing and Replacement Fluid During Therapeutic Plasma Exchange in Children on Extracorporeal Membrane Oxygenation.
Chomat MR, Swanson K, Barton K, Douds M, Said AS
ASAIO J 2024 Mar 1;70(3):e31-e37. Epub 2023 Nov 29 doi: 10.1097/MAT.0000000000002094. PMID: 38029748
Aggressive management of massive hemothorax in patients on extracorporeal membrane oxygenation.
Huang PM, Ko WJ, Tsai PR, Kuo SW, Hsu HH, Chen JS, Lee JM, Lee YC
Asian J Surg 2012 Jan;35(1):16-22. Epub 2012 May 31 doi: 10.1016/j.asjsur.2012.04.003. PMID: 22726559
Monitoring and management of anticoagulation in children requiring extracorporeal circulation.
Malviya S
Semin Thromb Hemost 1997;23(6):563-7. doi: 10.1055/s-2007-996137. PMID: 9469631

Recent clinical studies

Etiology

Anticoagulation for people receiving long-term haemodialysis.
Natale P, Palmer SC, Ruospo M, Longmuir H, Dodds B, Prasad R, Batt TJ, Jose MD, Strippoli GF
Cochrane Database Syst Rev 2024 Jan 8;1(1):CD011858. doi: 10.1002/14651858.CD011858.pub2. PMID: 38189593Free PMC Article
Early Blood Clot Detection Using Forward Scattering Light Measurements Is Not Superior to Delta Pressure Measurements.
Fischbach A, Lamberti M, Simons JA, Wrede E, Theißen A, Winnersbach P, Rossaint R, Stollenwerk A, Bleilevens C
Biosensors (Basel) 2023 Dec 4;13(12) doi: 10.3390/bios13121012. PMID: 38131772Free PMC Article
Anticoagulation options for continuous renal replacement therapy in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials.
Zhou Z, Liu C, Yang Y, Wang F, Zhang L, Fu P
Crit Care 2023 Jun 7;27(1):222. doi: 10.1186/s13054-023-04519-1. PMID: 37287084Free PMC Article
Platelet count reduction during in vitro membrane oxygenation affects platelet activation, neutrophil extracellular trap formation and clot stability, but does not prevent clotting.
Winnersbach P, Rossaint J, Buhl EM, Singh S, Lölsberg J, Wessling M, Rossaint R, Bleilevens C
Perfusion 2022 Mar;37(2):134-143. Epub 2021 Jan 21 doi: 10.1177/0267659121989231. PMID: 33475044Free PMC Article
Introducing the Loop for Circuit Access during Extracorporeal Membrane Oxygenation: Feasibility and Safety.
Broman LM, Eriksson C, Frenckner B, Palmér K
J Extra Corpor Technol 2019 Sep;51(3):175-178. PMID: 31548742Free PMC Article

Diagnosis

Detecting Oxygenator Thrombosis in ECMO: A Review of Current Techniques and an Exploration of Future Directions.
Leerson J, Tulloh A, Lopez FT, Gregory S, Buscher H, Rosengarten G
Semin Thromb Hemost 2024 Mar;50(2):253-270. Epub 2023 Aug 28 doi: 10.1055/s-0043-1772843. PMID: 37640048
Early Blood Clot Detection Using Forward Scattering Light Measurements Is Not Superior to Delta Pressure Measurements.
Fischbach A, Lamberti M, Simons JA, Wrede E, Theißen A, Winnersbach P, Rossaint R, Stollenwerk A, Bleilevens C
Biosensors (Basel) 2023 Dec 4;13(12) doi: 10.3390/bios13121012. PMID: 38131772Free PMC Article
Soluble fibrin is a useful marker for predicting extracorporeal membrane oxygenation circuit exchange because of circuit clots.
Hoshino K, Muranishi K, Kawano Y, Hatomoto H, Yamasaki S, Nakamura Y, Ishikura H
J Artif Organs 2018 Jun;21(2):196-200. Epub 2018 Jan 30 doi: 10.1007/s10047-018-1021-x. PMID: 29383543
Detection of Thrombosis in the Extracorporeal Membrane Oxygenation Circuit by Infrasound: Proof of Concept.
Fuchs G, Berg N, Eriksson A, Prahl Wittberg L
Artif Organs 2017 Jun;41(6):573-579. Epub 2016 Sep 22 doi: 10.1111/aor.12782. PMID: 27654663Free PMC Article
Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.
Wand S, Schneider S, Meybohm P, Zacharowski K, Weber CF
Clin Lab 2015;61(3-4):379-87. doi: 10.7754/clin.lab.2014.140931. PMID: 25975006

Therapy

Anticoagulation for people receiving long-term haemodialysis.
Natale P, Palmer SC, Ruospo M, Longmuir H, Dodds B, Prasad R, Batt TJ, Jose MD, Strippoli GF
Cochrane Database Syst Rev 2024 Jan 8;1(1):CD011858. doi: 10.1002/14651858.CD011858.pub2. PMID: 38189593Free PMC Article
The History of Extracorporeal Membrane Oxygenation and the Development of Extracorporeal Membrane Oxygenation Anticoagulation.
Bartlett R, Arachichilage DJ, Chitlur M, Hui SR, Neunert C, Doyle A, Retter A, Hunt BJ, Lim HS, Saini A, Renné T, Kostousov V, Teruya J
Semin Thromb Hemost 2024 Feb;50(1):81-90. Epub 2023 Feb 7 doi: 10.1055/s-0043-1761488. PMID: 36750217
Early Blood Clot Detection Using Forward Scattering Light Measurements Is Not Superior to Delta Pressure Measurements.
Fischbach A, Lamberti M, Simons JA, Wrede E, Theißen A, Winnersbach P, Rossaint R, Stollenwerk A, Bleilevens C
Biosensors (Basel) 2023 Dec 4;13(12) doi: 10.3390/bios13121012. PMID: 38131772Free PMC Article
Anticoagulation options for continuous renal replacement therapy in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials.
Zhou Z, Liu C, Yang Y, Wang F, Zhang L, Fu P
Crit Care 2023 Jun 7;27(1):222. doi: 10.1186/s13054-023-04519-1. PMID: 37287084Free PMC Article
Flow Monitoring of ECMO Circuit for Detecting Oxygenator Obstructions.
Sarathy S, Turek JW, Chu J, Badheka A, Nino MA, Raghavan ML
Ann Biomed Eng 2021 Dec;49(12):3636-3646. Epub 2021 Oct 27 doi: 10.1007/s10439-021-02878-w. PMID: 34705123

Prognosis

Anticoagulation for people receiving long-term haemodialysis.
Natale P, Palmer SC, Ruospo M, Longmuir H, Dodds B, Prasad R, Batt TJ, Jose MD, Strippoli GF
Cochrane Database Syst Rev 2024 Jan 8;1(1):CD011858. doi: 10.1002/14651858.CD011858.pub2. PMID: 38189593Free PMC Article
In vitro and in vivo assessment of oxygenator blood volume for the prediction of clot formation in an ECMO circuit (theory and validation).
Krivitski N, Galyanov G, Cooper D, Said MM, Rivera O, Mikesell GT, Rais-Bahrami K
Perfusion 2018 May;33(1_suppl):51-56. doi: 10.1177/0267659118765883. PMID: 29788838
Soluble fibrin is a useful marker for predicting extracorporeal membrane oxygenation circuit exchange because of circuit clots.
Hoshino K, Muranishi K, Kawano Y, Hatomoto H, Yamasaki S, Nakamura Y, Ishikura H
J Artif Organs 2018 Jun;21(2):196-200. Epub 2018 Jan 30 doi: 10.1007/s10047-018-1021-x. PMID: 29383543
Assessment of hemostatic changes after initiation of continuous venovenous hemodialysis.
Wand S, Schneider S, Meybohm P, Zacharowski K, Weber CF
Clin Lab 2015;61(3-4):379-87. doi: 10.7754/clin.lab.2014.140931. PMID: 25975006
Pharmacokinetics of dalteparin during haemodialysis.
Nigten J, de Groot KA, Grootendorst DC, Koolen SL, Herruer MH, Schut NH
Nephron Clin Pract 2013;124(3-4):179-83. Epub 2013 Dec 24 doi: 10.1159/000356384. PMID: 24401673

Clinical prediction guides

Anticoagulation for people receiving long-term haemodialysis.
Natale P, Palmer SC, Ruospo M, Longmuir H, Dodds B, Prasad R, Batt TJ, Jose MD, Strippoli GF
Cochrane Database Syst Rev 2024 Jan 8;1(1):CD011858. doi: 10.1002/14651858.CD011858.pub2. PMID: 38189593Free PMC Article
Anticoagulation options for continuous renal replacement therapy in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials.
Zhou Z, Liu C, Yang Y, Wang F, Zhang L, Fu P
Crit Care 2023 Jun 7;27(1):222. doi: 10.1186/s13054-023-04519-1. PMID: 37287084Free PMC Article
Non-anticoagulant factors affecting coagulation in the extracorporeal circulation circuit and the development of an individualized regional citrate anticoagulation protocol for hemodialysis: A real-world retrospective study.
Hu Z, Xu J, Gong Y, Gan C, Jiang T, Wu X, Jiang Y, Xiong T, Deng J, Zhong Y, Zou M, Luo L
Int J Artif Organs 2023 Jun;46(6):329-336. doi: 10.1177/03913988231168162. PMID: 37278534
In vitro and in vivo assessment of oxygenator blood volume for the prediction of clot formation in an ECMO circuit (theory and validation).
Krivitski N, Galyanov G, Cooper D, Said MM, Rivera O, Mikesell GT, Rais-Bahrami K
Perfusion 2018 May;33(1_suppl):51-56. doi: 10.1177/0267659118765883. PMID: 29788838
Soluble fibrin is a useful marker for predicting extracorporeal membrane oxygenation circuit exchange because of circuit clots.
Hoshino K, Muranishi K, Kawano Y, Hatomoto H, Yamasaki S, Nakamura Y, Ishikura H
J Artif Organs 2018 Jun;21(2):196-200. Epub 2018 Jan 30 doi: 10.1007/s10047-018-1021-x. PMID: 29383543

Recent systematic reviews

Anticoagulation for people receiving long-term haemodialysis.
Natale P, Palmer SC, Ruospo M, Longmuir H, Dodds B, Prasad R, Batt TJ, Jose MD, Strippoli GF
Cochrane Database Syst Rev 2024 Jan 8;1(1):CD011858. doi: 10.1002/14651858.CD011858.pub2. PMID: 38189593Free PMC Article
Anticoagulation options for continuous renal replacement therapy in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials.
Zhou Z, Liu C, Yang Y, Wang F, Zhang L, Fu P
Crit Care 2023 Jun 7;27(1):222. doi: 10.1186/s13054-023-04519-1. PMID: 37287084Free PMC Article
Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.
Tsujimoto H, Tsujimoto Y, Nakata Y, Fujii T, Takahashi S, Akazawa M, Kataoka Y
Cochrane Database Syst Rev 2020 Dec 14;12(12):CD012467. doi: 10.1002/14651858.CD012467.pub3. PMID: 33314078Free PMC Article
Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.
Tsujimoto H, Tsujimoto Y, Nakata Y, Fujii T, Takahashi S, Akazawa M, Kataoka Y
Cochrane Database Syst Rev 2020 Mar 13;3(3):CD012467. doi: 10.1002/14651858.CD012467.pub2. PMID: 32164041Free PMC Article

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