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Adult Intracranial Germ Cell Tumor

MedGen UID:
853226
Concept ID:
C1370508
Neoplastic Process

Definition

A germ cell tumor that arises within the cranium and occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Intracranial Germ Cell Tumor

Professional guidelines

PubMed

Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Müller HL
Neuroendocrinology 2020;110(9-10):753-766. Epub 2019 Nov 4 doi: 10.1159/000504512. PMID: 31678973
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article

Recent clinical studies

Etiology

Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Gerstner ER, Pajtler KW
Semin Neurol 2018 Feb;38(1):104-111. Epub 2018 Mar 16 doi: 10.1055/s-0038-1636503. PMID: 29548057
Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS
Neuro Oncol 2014 Jul;16(7):896-913. doi: 10.1093/neuonc/nou087. PMID: 24842956Free PMC Article
Chen H, Zhou R, Liu J, Tang J
J Clin Neurosci 2012 Jun;19(6):849-53. Epub 2012 Apr 25 doi: 10.1016/j.jocn.2011.06.038. PMID: 22537657

Diagnosis

Träger M, Schweizer L, Pérez E, Schmid S, Hain EG, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann DF, Dorostkar MM, Feyer P, May SA, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
Neuro Oncol 2023 Jul 6;25(7):1286-1298. doi: 10.1093/neuonc/noad030. PMID: 36734226Free PMC Article
Rudà R, Bruno F, Pellerino A, Soffietti R
Curr Oncol Rep 2022 Aug;24(8):985-993. Epub 2022 Apr 6 doi: 10.1007/s11912-022-01260-w. PMID: 35384591Free PMC Article
Nabors LB, Portnow J, Ahluwalia M, Baehring J, Brem H, Brem S, Butowski N, Campian JL, Clark SW, Fabiano AJ, Forsyth P, Hattangadi-Gluth J, Holdhoff M, Horbinski C, Junck L, Kaley T, Kumthekar P, Loeffler JS, Mrugala MM, Nagpal S, Pandey M, Parney I, Peters K, Puduvalli VK, Robins I, Rockhill J, Rusthoven C, Shonka N, Shrieve DC, Swinnen LJ, Weiss S, Wen PY, Willmarth NE, Bergman MA, Darlow SD
J Natl Compr Canc Netw 2020 Nov 2;18(11):1537-1570. doi: 10.6004/jnccn.2020.0052. PMID: 33152694
Gerstner ER, Pajtler KW
Semin Neurol 2018 Feb;38(1):104-111. Epub 2018 Mar 16 doi: 10.1055/s-0038-1636503. PMID: 29548057
Chen H, Zhou R, Liu J, Tang J
J Clin Neurosci 2012 Jun;19(6):849-53. Epub 2012 Apr 25 doi: 10.1016/j.jocn.2011.06.038. PMID: 22537657

Therapy

Merchant TE, Bendel AE, Sabin ND, Burger PC, Shaw DW, Chang E, Wu S, Zhou T, Eisenstat DD, Foreman NK, Fuller CE, Anderson ET, Hukin J, Lau CC, Pollack IF, Laningham FH, Lustig RH, Armstrong FD, Handler MH, Williams-Hughes C, Kessel S, Kocak M, Ellison DW, Ramaswamy V
J Clin Oncol 2019 Apr 20;37(12):974-983. Epub 2019 Feb 27 doi: 10.1200/JCO.18.01765. PMID: 30811284Free PMC Article
Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, Richman AR, Kowalczyk MS, Abdelrahman S, Geduldig JE, Charbonneau S, Pelton K, Iorgulescu JB, Elagina L, Zhang W, Olive O, McCluskey C, Olsen LR, Stevens J, Lane WJ, Salazar AM, Daley H, Wen PY, Chiocca EA, Harden M, Lennon NJ, Gabriel S, Getz G, Lander ES, Regev A, Ritz J, Neuberg D, Rodig SJ, Ligon KL, Suvà ML, Wucherpfennig KW, Hacohen N, Fritsch EF, Livak KJ, Ott PA, Wu CJ, Reardon DA
Nature 2019 Jan;565(7738):234-239. Epub 2018 Dec 19 doi: 10.1038/s41586-018-0792-9. PMID: 30568305Free PMC Article
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066
Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WK, Paleologos N, Nicholas MK, Jensen R, Vredenburgh J, Huang J, Zheng M, Cloughesy T
J Clin Oncol 2009 Oct 1;27(28):4733-40. Epub 2009 Aug 31 doi: 10.1200/JCO.2008.19.8721. PMID: 19720927

Prognosis

Tawbi HA, Forsyth PA, Hodi FS, Algazi AP, Hamid O, Lao CD, Moschos SJ, Atkins MB, Lewis K, Postow MA, Thomas RP, Glaspy J, Jang S, Khushalani NI, Pavlick AC, Ernstoff MS, Reardon DA, Kudchadkar R, Tarhini A, Chung C, Ritchings C, Durani P, Askelson M, Puzanov I, Margolin KA
Lancet Oncol 2021 Dec;22(12):1692-1704. Epub 2021 Nov 10 doi: 10.1016/S1470-2045(21)00545-3. PMID: 34774225Free PMC Article
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626
Reyes-Botero G, Mokhtari K, Martin-Duverneuil N, Delattre JY, Laigle-Donadey F
Oncologist 2012;17(3):388-97. Epub 2012 Mar 1 doi: 10.1634/theoncologist.2011-0335. PMID: 22382458Free PMC Article
Jorsal T, Rørth M
Acta Oncol 2012 Jan;51(1):3-9. doi: 10.3109/0284186X.2011.586000. PMID: 22150165

Clinical prediction guides

Rousseau J, Bennett J, Lim-Fat MJ
Semin Neurol 2023 Dec;43(6):909-928. Epub 2023 Nov 10 doi: 10.1055/s-0043-1776775. PMID: 37949116
Träger M, Schweizer L, Pérez E, Schmid S, Hain EG, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann DF, Dorostkar MM, Feyer P, May SA, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
Neuro Oncol 2023 Jul 6;25(7):1286-1298. doi: 10.1093/neuonc/noad030. PMID: 36734226Free PMC Article
Zhao F, Wu T, Wang LM, Zhang J, Zhang H, Li SW, Zhang S, Li P, Wang B, Luo L, Liu PN
Am J Surg Pathol 2021 Jul 1;45(7):979-987. doi: 10.1097/PAS.0000000000001669. PMID: 33739788
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Pfister S, Witt O
Recent Results Cancer Res 2009;171:67-81. doi: 10.1007/978-3-540-31206-2_4. PMID: 19322538

Recent systematic reviews

Brown NJ, Gendreau J, Kuo CC, Nguyen O, Yang C, Catapano JS, Lawton MT
J Neurooncol 2023 Oct;165(1):41-51. Epub 2023 Oct 25 doi: 10.1007/s11060-023-04477-2. PMID: 37880419
Yang R, Isaacs AM, Cadieux M, Hirmer TJ, CreveCoeur TS, Lapointe AP, Opoku-Darko M, Premji Z, Riva-Cambrin J, Gallagher CN
Childs Nerv Syst 2021 Jun;37(6):1849-1858. Epub 2021 Mar 6 doi: 10.1007/s00381-021-05098-8. PMID: 33675391
Totten DJ, Manzoor NF, Perkins EL, Labadie RF, Bennett ML, Haynes DS
Laryngoscope 2021 Sep;131(9):2081-2087. Epub 2021 Feb 10 doi: 10.1002/lary.29434. PMID: 33567134
Hart MG, Grant GR, Solyom EF, Grant R
Cochrane Database Syst Rev 2019 Jun 6;6(6):CD002034. doi: 10.1002/14651858.CD002034.pub2. PMID: 31169915Free PMC Article
Yamaki VN, Solla DJF, Ribeiro RR, da Silva SA, Teixeira MJ, Figueiredo EG
Neurosurgery 2019 Sep 1;85(3):E420-E429. doi: 10.1093/neuros/nyz062. PMID: 30989225

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