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Adult Nasal Type Extranodal NK/T-Cell Lymphoma

MedGen UID:
853495
•Concept ID:
C1879279
•
Neoplastic Process

Definition

Nasal type extranodal NK/T-cell lymphoma that occurs in adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Nasal Type Extranodal NK/T-Cell Lymphoma

Professional guidelines

PubMed

Evidence of cure for extranodal nasal-type natural killer/T-cell lymphoma with current treatment: an analysis of the CLCG database.
Liu X, Zhang LL, Qu BL, Zhong QZ, Qian LT, Yang Y, Hou XR, Qiao XY, Wang H, Zhu Y, Cao JZ, Wu JX, Wu T, Zhu SY, Shi M, Zhang HL, Zhang XM, Su H, Song YQ, Zhu J, Zhang YJ, Huang HQ, Wang Y, Chen F, Yin L, He X, Cai S, Li YX, Qi SN
Haematologica 2023 Sep 1;108(9):2467-2475. doi: 10.3324/haematol.2022.281847. PMID: 36951150Free PMC Article
Diagnosis and management of natural killer-cell malignancies.
Ishida F, Kwong YL
Expert Rev Hematol 2010 Oct;3(5):593-602. doi: 10.1586/ehm.10.51. PMID: 21083476
Treatment of T-cell non-Hodgkin's lymphoma.
Evens AM, Gartenhaus RB
Curr Treat Options Oncol 2004 Aug;5(4):289-303. doi: 10.1007/s11864-004-0020-8. PMID: 15233906

Recent clinical studies

Etiology

Evidence of cure for extranodal nasal-type natural killer/T-cell lymphoma with current treatment: an analysis of the CLCG database.
Liu X, Zhang LL, Qu BL, Zhong QZ, Qian LT, Yang Y, Hou XR, Qiao XY, Wang H, Zhu Y, Cao JZ, Wu JX, Wu T, Zhu SY, Shi M, Zhang HL, Zhang XM, Su H, Song YQ, Zhu J, Zhang YJ, Huang HQ, Wang Y, Chen F, Yin L, He X, Cai S, Li YX, Qi SN
Haematologica 2023 Sep 1;108(9):2467-2475. doi: 10.3324/haematol.2022.281847. PMID: 36951150Free PMC Article
Mature T/NK-Cell lymphomas of the oral and maxillofacial region: A multi-institutional collaborative study.
de Arruda JAA, Abrantes TC, Cunha JLS, Roza ALOC, Agostini M, Abrahão AC, Canedo NHS, Ramos DD, Milito CB, Pontes FSC, Pontes HAR, Barra MB, Zanella VG, Martins MAT, Martins MD, Israel MS, Freire NA, Barreto MEZ, Sánchez-Romero C, Carlos R, Abreu LG, Vargas PA, de Almeida OP, Fonseca FP, Romañach MJ, Mesquita RA, de Andrade BAB
J Oral Pathol Med 2021 Jul;50(6):548-557. Epub 2021 Jun 29 doi: 10.1111/jop.13205. PMID: 34091947
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis.
Stoll JR, Willner J, Oh Y, Pulitzer M, Moskowitz A, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1073-1090. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.080. PMID: 33940098
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393

Diagnosis

Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis.
Stoll JR, Willner J, Oh Y, Pulitzer M, Moskowitz A, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1073-1090. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.080. PMID: 33940098
Extranodal NK/T-cell lymphoma, nasal type: Clinical features, outcome, and prognostic factors in 101 cases.
Su YJ, Wang PN, Chang H, Shih LY, Lin TL, Kuo MC, Chuang WY, Wu JH, Tang TC, Hung YS, Dunn P, Kao HW
Eur J Haematol 2018 Sep;101(3):379-388. Epub 2018 Jul 27 doi: 10.1111/ejh.13126. PMID: 29908084
Natural killer/T-cell lymphomas in pediatric and adolescent patients.
Termuhlen AM
Clin Adv Hematol Oncol 2017 Mar;15(3):200-209. PMID: 28398275
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393

Therapy

Prognostic Value of (18)F-FDG PET/CT Radiomics in Extranodal Nasal-Type NK/T Cell Lymphoma.
Luo Y, Huang Z, Gao Z, Wang B, Zhang Y, Bai Y, Wu Q, Wang M
Korean J Radiol 2024 Feb;25(2):189-198. doi: 10.3348/kjr.2023.0618. PMID: 38288898Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
Extranodal NK/T-cell lymphoma, nasal type: Clinical features, outcome, and prognostic factors in 101 cases.
Su YJ, Wang PN, Chang H, Shih LY, Lin TL, Kuo MC, Chuang WY, Wu JH, Tang TC, Hung YS, Dunn P, Kao HW
Eur J Haematol 2018 Sep;101(3):379-388. Epub 2018 Jul 27 doi: 10.1111/ejh.13126. PMID: 29908084
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393

Prognosis

Evidence of cure for extranodal nasal-type natural killer/T-cell lymphoma with current treatment: an analysis of the CLCG database.
Liu X, Zhang LL, Qu BL, Zhong QZ, Qian LT, Yang Y, Hou XR, Qiao XY, Wang H, Zhu Y, Cao JZ, Wu JX, Wu T, Zhu SY, Shi M, Zhang HL, Zhang XM, Su H, Song YQ, Zhu J, Zhang YJ, Huang HQ, Wang Y, Chen F, Yin L, He X, Cai S, Li YX, Qi SN
Haematologica 2023 Sep 1;108(9):2467-2475. doi: 10.3324/haematol.2022.281847. PMID: 36951150Free PMC Article
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis.
Stoll JR, Willner J, Oh Y, Pulitzer M, Moskowitz A, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1073-1090. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.080. PMID: 33940098
Extranodal NK/T-cell lymphoma, nasal type: Clinical features, outcome, and prognostic factors in 101 cases.
Su YJ, Wang PN, Chang H, Shih LY, Lin TL, Kuo MC, Chuang WY, Wu JH, Tang TC, Hung YS, Dunn P, Kao HW
Eur J Haematol 2018 Sep;101(3):379-388. Epub 2018 Jul 27 doi: 10.1111/ejh.13126. PMID: 29908084
EBV in T-/NK-Cell Tumorigenesis.
Kimura H
Adv Exp Med Biol 2018;1045:459-475. doi: 10.1007/978-981-10-7230-7_21. PMID: 29896680
Natural killer/T-cell lymphomas in pediatric and adolescent patients.
Termuhlen AM
Clin Adv Hematol Oncol 2017 Mar;15(3):200-209. PMID: 28398275

Clinical prediction guides

First-line sintilimab with pegaspargase, gemcitabine, and oxaliplatin in advanced extranodal natural killer/T cell lymphoma (SPIRIT): a multicentre, single-arm, phase 2 trial.
Tian XP, Cai J, Xia Y, Zhang YC, Wang L, Liu PP, Huang HQ, Li YJ, Zhou H, Li ZM, Yang J, Wei LQ, Zou QH, Huang Y, Li J, Ling L, Zhong WL, Cai QQ
Lancet Haematol 2024 May;11(5):e336-e344. Epub 2024 Mar 27 doi: 10.1016/S2352-3026(24)00066-8. PMID: 38554717
Prognostic Value of (18)F-FDG PET/CT Radiomics in Extranodal Nasal-Type NK/T Cell Lymphoma.
Luo Y, Huang Z, Gao Z, Wang B, Zhang Y, Bai Y, Wu Q, Wang M
Korean J Radiol 2024 Feb;25(2):189-198. doi: 10.3348/kjr.2023.0618. PMID: 38288898Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
Nasopharyngeal/nasal type NK/T lymphoma: analysis of 23 cases and current review of the literature.
Youssef YB, Bougmiza I, Bouabid Z, Achour B, Regaieg H, Sriha B, Belkadhi M, Omri HE, Khelif A
Kulak Burun Bogaz Ihtis Derg 2012 Sep-Oct;22(5):275-83. doi: 10.5606/kbbihtisas.2012.053. PMID: 22991988
Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.
Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393

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