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t(9;22)

MedGen UID:
856732
•Concept ID:
C3897138
•
Cell or Molecular Dysfunction

Definition

A translocation between chromosome 9 and chromosome 22 that may be associated with Philadelphia chromosome and increased susceptibility to several types of leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(9;22)

Professional guidelines

PubMed

Management of Philadelphia chromosome positive acute lymphoblastic leukemia in the current era.
Badar T, Alkhateeb H, Aljurf M, Kharfan-Dabaja MA
Curr Res Transl Med 2023 Apr-Jun;71(2):103392. Epub 2023 Apr 23 doi: 10.1016/j.retram.2023.103392. PMID: 37121211
Management of chronic myeloid leukaemia: current treatment options, challenges, and future strategies.
Younes S, Ismail MA, Al-Jurf R, Ziyada A, Nasrallah GK, Abdulrouf PV, Nagy M, Zayed H, Farrell T, Sorio C, Morsi H, Qoronfleh MW, Al-Dewik NI
Hematology 2023 Dec;28(1):2196866. doi: 10.1080/16078454.2023.2196866. PMID: 37078896
Chronic Myeloid Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Deininger MW, Shah NP, Altman JK, Berman E, Bhatia R, Bhatnagar B, DeAngelo DJ, Gotlib J, Hobbs G, Maness L, Mead M, Metheny L, Mohan S, Moore JO, Naqvi K, Oehler V, Pallera AM, Patnaik M, Pratz K, Pusic I, Rose MG, Smith BD, Snyder DS, Sweet KL, Talpaz M, Thompson J, Yang DT, Gregory KM, Sundar H
J Natl Compr Canc Netw 2020 Oct 1;18(10):1385-1415. doi: 10.6004/jnccn.2020.0047. PMID: 33022644

Recent clinical studies

Etiology

Cytogenetics and genomics in CML and other myeloproliferative neoplasms.
Kreipe HH, Schlegelberger B
Best Pract Res Clin Haematol 2024 Jun;37(2):101552. Epub 2024 Apr 3 doi: 10.1016/j.beha.2024.101552. PMID: 39098796
Chronic myeloid leukemia: 2025 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2024 Nov;99(11):2191-2212. Epub 2024 Aug 2 doi: 10.1002/ajh.27443. PMID: 39093014
Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions.
Osman AEG, Deininger MW
Blood Rev 2021 Sep;49:100825. Epub 2021 Mar 16 doi: 10.1016/j.blre.2021.100825. PMID: 33773846Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Diagnosis

Cytogenetics and genomics in CML and other myeloproliferative neoplasms.
Kreipe HH, Schlegelberger B
Best Pract Res Clin Haematol 2024 Jun;37(2):101552. Epub 2024 Apr 3 doi: 10.1016/j.beha.2024.101552. PMID: 39098796
Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Molecular processes involved in B cell acute lymphoblastic leukaemia.
Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
Recurrent Cytogenetic Abnormalities in Acute Myeloid Leukemia.
Yang JJ, Park TS, Wan TS
Methods Mol Biol 2017;1541:223-245. doi: 10.1007/978-1-4939-6703-2_19. PMID: 27910027
Genetic events other than BCR-ABL1.
Neviani P
Curr Hematol Malig Rep 2014 Mar;9(1):24-32. doi: 10.1007/s11899-013-0194-x. PMID: 24407376

Therapy

Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Chronic Myeloid Leukemia: Modern therapies, current challenges and future directions.
Osman AEG, Deininger MW
Blood Rev 2021 Sep;49:100825. Epub 2021 Mar 16 doi: 10.1016/j.blre.2021.100825. PMID: 33773846Free PMC Article
Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2020 Jun;95(6):691-709. Epub 2020 Apr 10 doi: 10.1002/ajh.25792. PMID: 32239758
Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2018 Mar;93(3):442-459. doi: 10.1002/ajh.25011. PMID: 29411417

Prognosis

Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2020 Jun;95(6):691-709. Epub 2020 Apr 10 doi: 10.1002/ajh.25792. PMID: 32239758
Chronic myeloid leukemia: 2018 update on diagnosis, therapy and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2018 Mar;93(3):442-459. doi: 10.1002/ajh.25011. PMID: 29411417
The Philadelphia chromosome in leukemogenesis.
Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, Liu B, Feng JX, Pan YJ, Yan JS, Liu Q
Chin J Cancer 2016 May 27;35:48. doi: 10.1186/s40880-016-0108-0. PMID: 27233483Free PMC Article
Jak-2 positive myeloproliferative neoplasms.
Muxí PJ, Oliver AC
Curr Treat Options Oncol 2014 Jun;15(2):147-56. doi: 10.1007/s11864-014-0279-3. PMID: 24627006
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Clinical prediction guides

Exploration of treatment-free remission in CML, based on molecular monitoring.
Zhang Z, Zhou X, Zhou X, Cheng Z, Hu Y
Cancer Med 2024 Jan;13(1):e6849. Epub 2023 Dec 22 doi: 10.1002/cam4.6849. PMID: 38133525Free PMC Article
Treatment and molecular monitoring update in chronic myeloid leukemia management.
Sorel N, Cayssials É, Brizard F, Chomel JC
Ann Biol Clin (Paris) 2017 Apr 1;75(2):129-145. doi: 10.1684/abc.2017.1233. PMID: 28377326
The Philadelphia chromosome in leukemogenesis.
Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, Liu B, Feng JX, Pan YJ, Yan JS, Liu Q
Chin J Cancer 2016 May 27;35:48. doi: 10.1186/s40880-016-0108-0. PMID: 27233483Free PMC Article
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
A classification of acute leukaemia for the 1990s.
Catovsky D, Matutes E, Buccheri V, Shetty V, Hanslip J, Yoshida N, Morilla R
Ann Hematol 1991 Feb;62(1):16-21. doi: 10.1007/BF01714978. PMID: 2031964

Recent systematic reviews

The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases.
Zedan HT, Ali FH, Zayed H
Chromosoma 2022 Sep;131(3):127-146. Epub 2022 Jul 30 doi: 10.1007/s00412-022-00775-2. PMID: 35907041Free PMC Article

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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