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t(9;22)

MedGen UID:
856732
Concept ID:
C3897138
Cell or Molecular Dysfunction

Definition

A translocation between chromosome 9 and chromosome 22 that may be associated with Philadelphia chromosome and increased susceptibility to several types of leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(9;22)

Professional guidelines

PubMed

Badar T, Alkhateeb H, Aljurf M, Kharfan-Dabaja MA
Curr Res Transl Med 2023 Apr-Jun;71(2):103392. Epub 2023 Apr 23 doi: 10.1016/j.retram.2023.103392. PMID: 37121211
Younes S, Ismail MA, Al-Jurf R, Ziyada A, Nasrallah GK, Abdulrouf PV, Nagy M, Zayed H, Farrell T, Sorio C, Morsi H, Qoronfleh MW, Al-Dewik NI
Hematology 2023 Dec;28(1):2196866. doi: 10.1080/16078454.2023.2196866. PMID: 37078896
Deininger MW, Shah NP, Altman JK, Berman E, Bhatia R, Bhatnagar B, DeAngelo DJ, Gotlib J, Hobbs G, Maness L, Mead M, Metheny L, Mohan S, Moore JO, Naqvi K, Oehler V, Pallera AM, Patnaik M, Pratz K, Pusic I, Rose MG, Smith BD, Snyder DS, Sweet KL, Talpaz M, Thompson J, Yang DT, Gregory KM, Sundar H
J Natl Compr Canc Netw 2020 Oct 1;18(10):1385-1415. doi: 10.6004/jnccn.2020.0047. PMID: 33022644

Recent clinical studies

Etiology

Jabbour E, Kantarjian H
Am J Hematol 2024 Nov;99(11):2191-2212. Epub 2024 Aug 2 doi: 10.1002/ajh.27443. PMID: 39093014
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Osman AEG, Deininger MW
Blood Rev 2021 Sep;49:100825. Epub 2021 Mar 16 doi: 10.1016/j.blre.2021.100825. PMID: 33773846Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
van Dongen JJ, Macintyre EA, Gabert JA, Delabesse E, Rossi V, Saglio G, Gottardi E, Rambaldi A, Dotti G, Griesinger F, Parreira A, Gameiro P, Diáz MG, Malec M, Langerak AW, San Miguel JF, Biondi A
Leukemia 1999 Dec;13(12):1901-28. doi: 10.1038/sj.leu.2401592. PMID: 10602411

Diagnosis

Kreipe HH, Schlegelberger B
Best Pract Res Clin Haematol 2024 Jun;37(2):101552. Epub 2024 Apr 3 doi: 10.1016/j.beha.2024.101552. PMID: 39098796
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Malouf C, Ottersbach K
Cell Mol Life Sci 2018 Feb;75(3):417-446. Epub 2017 Aug 17 doi: 10.1007/s00018-017-2620-z. PMID: 28819864Free PMC Article
Yang JJ, Park TS, Wan TS
Methods Mol Biol 2017;1541:223-245. doi: 10.1007/978-1-4939-6703-2_19. PMID: 27910027
Neviani P
Curr Hematol Malig Rep 2014 Mar;9(1):24-32. doi: 10.1007/s11899-013-0194-x. PMID: 24407376

Therapy

Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Osman AEG, Deininger MW
Blood Rev 2021 Sep;49:100825. Epub 2021 Mar 16 doi: 10.1016/j.blre.2021.100825. PMID: 33773846Free PMC Article
Jabbour E, Kantarjian H
Am J Hematol 2020 Jun;95(6):691-709. Epub 2020 Apr 10 doi: 10.1002/ajh.25792. PMID: 32239758
Jabbour E, Kantarjian H
Am J Hematol 2018 Mar;93(3):442-459. doi: 10.1002/ajh.25011. PMID: 29411417

Prognosis

Jabbour E, Kantarjian H
Am J Hematol 2020 Jun;95(6):691-709. Epub 2020 Apr 10 doi: 10.1002/ajh.25792. PMID: 32239758
Jabbour E, Kantarjian H
Am J Hematol 2018 Mar;93(3):442-459. doi: 10.1002/ajh.25011. PMID: 29411417
Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, Liu B, Feng JX, Pan YJ, Yan JS, Liu Q
Chin J Cancer 2016 May 27;35:48. doi: 10.1186/s40880-016-0108-0. PMID: 27233483Free PMC Article
Muxí PJ, Oliver AC
Curr Treat Options Oncol 2014 Jun;15(2):147-56. doi: 10.1007/s11864-014-0279-3. PMID: 24627006
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Clinical prediction guides

Zhang Z, Zhou X, Zhou X, Cheng Z, Hu Y
Cancer Med 2024 Jan;13(1):e6849. Epub 2023 Dec 22 doi: 10.1002/cam4.6849. PMID: 38133525Free PMC Article
Sorel N, Cayssials É, Brizard F, Chomel JC
Ann Biol Clin (Paris) 2017 Apr 1;75(2):129-145. doi: 10.1684/abc.2017.1233. PMID: 28377326
Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, Liu B, Feng JX, Pan YJ, Yan JS, Liu Q
Chin J Cancer 2016 May 27;35:48. doi: 10.1186/s40880-016-0108-0. PMID: 27233483Free PMC Article
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793
Catovsky D, Matutes E, Buccheri V, Shetty V, Hanslip J, Yoshida N, Morilla R
Ann Hematol 1991 Feb;62(1):16-21. doi: 10.1007/BF01714978. PMID: 2031964

Recent systematic reviews

Zedan HT, Ali FH, Zayed H
Chromosoma 2022 Sep;131(3):127-146. Epub 2022 Jul 30 doi: 10.1007/s00412-022-00775-2. PMID: 35907041Free PMC Article

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