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t(8;21)

MedGen UID:
856733
•Concept ID:
C3897139
•
Cell or Molecular Dysfunction

Definition

A cytogenetic abnormality that involves a translocation between chromosomes 8 and 21. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(8;21)

Professional guidelines

PubMed

The core concepts of core binding factor acute myeloid leukemia: Current considerations for prognosis and treatment.
Darwish C, Farina K, Tremblay D
Blood Rev 2023 Nov;62:101117. Epub 2023 Jul 25 doi: 10.1016/j.blre.2023.101117. PMID: 37524647
Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Biomarkers of Gemtuzumab Ozogamicin Response for Acute Myeloid Leukemia Treatment.
Fenwarth L, Fournier E, Cheok M, Boyer T, Gonzales F, Castaigne S, Boissel N, Lambert J, Dombret H, Preudhomme C, Duployez N
Int J Mol Sci 2020 Aug 6;21(16) doi: 10.3390/ijms21165626. PMID: 32781546Free PMC Article

Recent clinical studies

Etiology

A multicenter retrospective comparison between systemic mastocytosis with t(8;21) AML and KIT mutant t(8;21) AML.
Zhang Z, Yin J, Lian G, Bao X, Hu M, Liu Z, Yu Y, Mi R, Zuo Y, Shi P, Zheng W, Jiang Q, Chao H, Xiao P, Yu W, Han Y, Wu Y, Zeng Y, Wu D, Yang X, Chen S
Blood Adv 2024 Feb 27;8(4):889-894. doi: 10.1182/bloodadvances.2023012006. PMID: 38170739Free PMC Article
Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia.
Lo MY, Tsai XC, Lin CC, Tien FM, Kuo YY, Lee WH, Peng YL, Liu MC, Tseng MH, Hsu CA, Chen JC, Lin LI, Sun HI, Chuang YK, Ko BS, Tang JL, Yao M, Chou WC, Hou HA, Tien HF
Am J Hematol 2023 May;98(5):760-769. Epub 2023 Mar 13 doi: 10.1002/ajh.26892. PMID: 36861732
Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
Core-binding factor acute myeloid leukemia.
Sangle NA, Perkins SL
Arch Pathol Lab Med 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. PMID: 22032582
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Diagnosis

A multicenter retrospective comparison between systemic mastocytosis with t(8;21) AML and KIT mutant t(8;21) AML.
Zhang Z, Yin J, Lian G, Bao X, Hu M, Liu Z, Yu Y, Mi R, Zuo Y, Shi P, Zheng W, Jiang Q, Chao H, Xiao P, Yu W, Han Y, Wu Y, Zeng Y, Wu D, Yang X, Chen S
Blood Adv 2024 Feb 27;8(4):889-894. doi: 10.1182/bloodadvances.2023012006. PMID: 38170739Free PMC Article
Morphological and Immunophenotypic Clues to the WHO Categories of Acute Myeloid Leukaemia.
Bain BJ, Béné MC
Acta Haematol 2019;141(4):232-244. Epub 2019 Apr 9 doi: 10.1159/000496097. PMID: 30965338
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Therapy-Related Myeloid Neoplasms.
Bueso-Ramos CE, Kanagal-Shamanna R, Routbort MJ, Hanson CA
Am J Clin Pathol 2015 Aug;144(2):207-18. doi: 10.1309/AJCPU1JO2LYTWUAV. PMID: 26185306
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Therapy

Combination of eriocalyxin B and homoharringtonine exerts synergistic anti-tumor effects against t(8;21) AML.
Lei YC, Chen XJ, Dai YT, Dai B, Wang JY, Li MH, Liu P, Liu H, Wang KK, Jiang L, Chen B
Acta Pharmacol Sin 2024 Mar;45(3):633-645. Epub 2023 Nov 28 doi: 10.1038/s41401-023-01196-2. PMID: 38017299Free PMC Article
Core binding factor acute myelogenous leukemia-2021 treatment algorithm.
Borthakur G, Kantarjian H
Blood Cancer J 2021 Jun 16;11(6):114. doi: 10.1038/s41408-021-00503-6. PMID: 34135311Free PMC Article
RUNX1 Dosage in Development and Cancer.
Lie-A-Ling M, Mevel R, Patel R, Blyth K, Baena E, Kouskoff V, Lacaud G
Mol Cells 2020 Feb 29;43(2):126-138. doi: 10.14348/molcells.2019.0301. PMID: 31991535Free PMC Article
Myeloid Sarcoma.
Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M
Oncol Res Treat 2019;42(4):224-229. Epub 2019 Mar 6 doi: 10.1159/000497210. PMID: 30840960
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Prognosis

Nomogram models predicting prognosis for patients with t(8;21) acute myeloid leukemia: a SEER-based study.
Yang J, Zhu X, Zhang H, Fu Y, Li Z, Xing Z, Yu Y, Cao P, Le J, Jiang J, Li J, Wang H, Qian M, Zhai X
Hematology 2024 Dec;29(1):2381169. Epub 2024 Jul 24 doi: 10.1080/16078454.2024.2381169. PMID: 39046131
HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m(6)A-dependent stabilization of KDM4B mRNA.
Shao YL, Li YQ, Li MY, Wang LL, Zhou HS, Liu DH, Yu L, Lin J, Gao XN
Leukemia 2023 Jun;37(6):1254-1267. Epub 2023 Apr 22 doi: 10.1038/s41375-023-01904-1. PMID: 37087529
Prognosis and monitoring of core-binding factor acute myeloid leukemia: current and emerging factors.
Duployez N, Willekens C, Marceau-Renaut A, Boudry-Labis E, Preudhomme C
Expert Rev Hematol 2015 Feb;8(1):43-56. Epub 2014 Oct 28 doi: 10.1586/17474086.2014.976551. PMID: 25348871
Core-binding factor acute myeloid leukemia.
Sangle NA, Perkins SL
Arch Pathol Lab Med 2011 Nov;135(11):1504-9. doi: 10.5858/arpa.2010-0482-RS. PMID: 22032582
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Clinical prediction guides

Reversal of MYB-dependent suppression of MAFB expression overrides leukaemia phenotype in MLL-rearranged AML.
Negri A, Ward C, Bucci A, D'Angelo G, Cauchy P, Radesco A, Ventura AB, Walton DS, Clarke M, Mandriani B, Pappagallo SA, Mondelli P, Liao K, Gargano G, Zaccaria GM, Viggiano L, Lasorsa FM, Ahmed A, Di Molfetta D, Fiermonte G, Cives M, Guarini A, Vegliante MC, Ciavarella S, Frampton J, Volpe G
Cell Death Dis 2023 Nov 23;14(11):763. doi: 10.1038/s41419-023-06276-z. PMID: 37996430Free PMC Article
Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.
Li XP, Dai Y, Zhang WN, Pan MM, Mao J, Zhao B, Jiang L, Gao Y
Int Immunopharmacol 2023 Dec;125(Pt B):111178. Epub 2023 Nov 9 doi: 10.1016/j.intimp.2023.111178. PMID: 37951201
HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m(6)A-dependent stabilization of KDM4B mRNA.
Shao YL, Li YQ, Li MY, Wang LL, Zhou HS, Liu DH, Yu L, Lin J, Gao XN
Leukemia 2023 Jun;37(6):1254-1267. Epub 2023 Apr 22 doi: 10.1038/s41375-023-01904-1. PMID: 37087529
Validation of the prognostic significance of the 2022 European LeukemiaNet risk stratification system in intensive chemotherapy treated aged 18 to 65 years patients with de novo acute myeloid leukemia.
Lo MY, Tsai XC, Lin CC, Tien FM, Kuo YY, Lee WH, Peng YL, Liu MC, Tseng MH, Hsu CA, Chen JC, Lin LI, Sun HI, Chuang YK, Ko BS, Tang JL, Yao M, Chou WC, Hou HA, Tien HF
Am J Hematol 2023 May;98(5):760-769. Epub 2023 Mar 13 doi: 10.1002/ajh.26892. PMID: 36861732
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.
Grimwade D, Hills RK, Moorman AV, Walker H, Chatters S, Goldstone AH, Wheatley K, Harrison CJ, Burnett AK; National Cancer Research Institute Adult Leukaemia Working Group
Blood 2010 Jul 22;116(3):354-65. Epub 2010 Apr 12 doi: 10.1182/blood-2009-11-254441. PMID: 20385793

Recent systematic reviews

Prevalence and Clinical Outcome of FMS-Like Tyrosine Kinase Mutations Among Patients With Core Binding Factor-Acute Myeloid Leukemia: Systematic Review and Meta-Analysis.
Srinivasan S, Kumar S, Vijayasekharan K, Agrawal AK
Clin Lymphoma Myeloma Leuk 2022 Apr;22(4):e221-e232. Epub 2021 Oct 2 doi: 10.1016/j.clml.2021.09.020. PMID: 34750085
Prognostic Importance of C-KIT Mutations in Core Binding Factor Acute Myeloid Leukemia: A Systematic Review.
Ayatollahi H, Shajiei A, Sadeghian MH, Sheikhi M, Yazdandoust E, Ghazanfarpour M, Shams SF, Shakeri S
Hematol Oncol Stem Cell Ther 2017 Mar;10(1):1-7. Epub 2016 Sep 3 doi: 10.1016/j.hemonc.2016.08.005. PMID: 27613372
Prognostic Significance of KIT Mutations in Core-Binding Factor Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis.
Chen W, Xie H, Wang H, Chen L, Sun Y, Chen Z, Li Q
PLoS One 2016;11(1):e0146614. Epub 2016 Jan 15 doi: 10.1371/journal.pone.0146614. PMID: 26771376Free PMC Article

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