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t(14;20)

MedGen UID:
856736
•Concept ID:
C3897142
•
Cell or Molecular Dysfunction

Definition

A chromosomal translocation involving chromosome 14 and chromosome 20. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVt(14;20)

Professional guidelines

PubMed

Multiple myeloma: 2024 update on diagnosis, risk-stratification, and management.
Rajkumar SV
Am J Hematol 2024 Sep;99(9):1802-1824. Epub 2024 Jun 28 doi: 10.1002/ajh.27422. PMID: 38943315Free PMC Article
Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.
Rajkumar SV
Am J Hematol 2022 Aug;97(8):1086-1107. Epub 2022 May 23 doi: 10.1002/ajh.26590. PMID: 35560063Free PMC Article
Multiple myeloma with high-risk cytogenetics and its treatment approach.
Hanamura I
Int J Hematol 2022 Jun;115(6):762-777. Epub 2022 May 9 doi: 10.1007/s12185-022-03353-5. PMID: 35534749Free PMC Article

Recent clinical studies

Etiology

Different MAF translocations confer similar prognosis in newly diagnosed multiple myeloma patients.
Goldman-Mazur S, Jurczyszyn A, Castillo JJ, Waszczuk-Gajda A, Grząśko N, Radocha J, Bittrich M, Kortüm KM, Gozzetti A, Usnarska-Zubkiewicz L, Valls JD, Jayabalan DS, Niesvizky R, Kelman J, Coriu D, Rosiñol L, Szukalski Ł, González-Calle V, Mateos MV, Jamroziak K, Hus I, Avivi I, Cohen Y, Mazur P, Suska A, Chappell A, Madduri D, Chhabra S, Kleman A, Hari P, Delforge M, Robak P, Gentile M, Kozłowska I, Goldberg SL, Czepiel J, Długosz-Danecka M, Silbermann R, Olszewski AJ, Barth P, Mikala G, Chim CS, Vesole DH
Leuk Lymphoma 2020 Aug;61(8):1885-1893. Epub 2020 Apr 19 doi: 10.1080/10428194.2020.1749605. PMID: 32306794

Diagnosis

Different MAF translocations confer similar prognosis in newly diagnosed multiple myeloma patients.
Goldman-Mazur S, Jurczyszyn A, Castillo JJ, Waszczuk-Gajda A, Grząśko N, Radocha J, Bittrich M, Kortüm KM, Gozzetti A, Usnarska-Zubkiewicz L, Valls JD, Jayabalan DS, Niesvizky R, Kelman J, Coriu D, Rosiñol L, Szukalski Ł, González-Calle V, Mateos MV, Jamroziak K, Hus I, Avivi I, Cohen Y, Mazur P, Suska A, Chappell A, Madduri D, Chhabra S, Kleman A, Hari P, Delforge M, Robak P, Gentile M, Kozłowska I, Goldberg SL, Czepiel J, Długosz-Danecka M, Silbermann R, Olszewski AJ, Barth P, Mikala G, Chim CS, Vesole DH
Leuk Lymphoma 2020 Aug;61(8):1885-1893. Epub 2020 Apr 19 doi: 10.1080/10428194.2020.1749605. PMID: 32306794

Prognosis

Different MAF translocations confer similar prognosis in newly diagnosed multiple myeloma patients.
Goldman-Mazur S, Jurczyszyn A, Castillo JJ, Waszczuk-Gajda A, Grząśko N, Radocha J, Bittrich M, Kortüm KM, Gozzetti A, Usnarska-Zubkiewicz L, Valls JD, Jayabalan DS, Niesvizky R, Kelman J, Coriu D, Rosiñol L, Szukalski Ł, González-Calle V, Mateos MV, Jamroziak K, Hus I, Avivi I, Cohen Y, Mazur P, Suska A, Chappell A, Madduri D, Chhabra S, Kleman A, Hari P, Delforge M, Robak P, Gentile M, Kozłowska I, Goldberg SL, Czepiel J, Długosz-Danecka M, Silbermann R, Olszewski AJ, Barth P, Mikala G, Chim CS, Vesole DH
Leuk Lymphoma 2020 Aug;61(8):1885-1893. Epub 2020 Apr 19 doi: 10.1080/10428194.2020.1749605. PMID: 32306794

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