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Placental Villous Stromal-Vascular Karyorrhexis

MedGen UID:
857484
•Concept ID:
C3897890
•
Finding
Synonym: Hemorrhagic Placental Endovasculitis

Definition

Three or more foci of two or more placental terminal villi showing karyorrhexis of fetal cells with preservation of the surrounding trophoblast. The villi may also show stromal hypercellularity and mineralization, and can either be hypovascular or only exhibit capillary degenerative changes. Entrapped red blood cells and red blood cell fragments are often seen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlacental Villous Stromal-Vascular Karyorrhexis

Professional guidelines

PubMed

Fetal thrombotic vasculopathy: significance in liveborn children using proposed society for pediatric pathology diagnostic criteria.
Chisholm KM, Heerema-McKenney A
Am J Surg Pathol 2015 Feb;39(2):274-80. doi: 10.1097/PAS.0000000000000334. PMID: 25321333

Recent clinical studies

Etiology

Placental CD34 immunohistochemistry in fetal vascular malperfusion in stillbirth.
Stanek J, Drach A
J Obstet Gynaecol Res 2022 Mar;48(3):719-728. Epub 2022 Jan 29 doi: 10.1111/jog.15169. PMID: 35092332
Association between fetal vascular malperfusion and gestational diabetes.
Goto T, Sato Y, Kodama Y, Tomimori K, Sameshima H, Aman M, Maekawa K, Yamashita A, Asada Y
J Obstet Gynaecol Res 2022 Jan;48(1):80-86. Epub 2021 Nov 2 doi: 10.1111/jog.15046. PMID: 34729872
Temporal heterogeneity of placental segmental fetal vascular malperfusion: timing but not etiopathogenesis.
Stanek J
Virchows Arch 2021 May;478(5):905-914. Epub 2020 Sep 12 doi: 10.1007/s00428-020-02916-3. PMID: 32918597
Segmental villous mineralization: A placental feature of fetal vascular malperfusion.
Stanek J
Placenta 2019 Oct;86:20-27. Epub 2019 Jul 24 doi: 10.1016/j.placenta.2019.07.011. PMID: 31358342
Fetal Vascular Malperfusion.
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954

Diagnosis

Placental CD34 immunohistochemistry in fetal vascular malperfusion in stillbirth.
Stanek J, Drach A
J Obstet Gynaecol Res 2022 Mar;48(3):719-728. Epub 2022 Jan 29 doi: 10.1111/jog.15169. PMID: 35092332
Distal villous lesions are clinically more relevant than proximal large muscular vessel lesions of placental fetal vascular malperfusion.
Stanek J
Histol Histopathol 2022 Apr;37(4):365-372. Epub 2021 Dec 23 doi: 10.14670/HH-18-414. PMID: 34939657
Fetal Vascular Malperfusion.
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954
Fetal thrombotic vasculopathy: significance in liveborn children using proposed society for pediatric pathology diagnostic criteria.
Chisholm KM, Heerema-McKenney A
Am J Surg Pathol 2015 Feb;39(2):274-80. doi: 10.1097/PAS.0000000000000334. PMID: 25321333
Fetal vascular obstructive lesions: nosology and reproducibility of placental reaction patterns.
Redline RW, Ariel I, Baergen RN, Desa DJ, Kraus FT, Roberts DJ, Sander CM
Pediatr Dev Pathol 2004 Sep-Oct;7(5):443-52. Epub 2004 Jul 30 doi: 10.1007/s10024-004-2020-x. PMID: 15547768

Therapy

Segmental villous mineralization: A placental feature of fetal vascular malperfusion.
Stanek J
Placenta 2019 Oct;86:20-27. Epub 2019 Jul 24 doi: 10.1016/j.placenta.2019.07.011. PMID: 31358342

Prognosis

Distal villous lesions are clinically more relevant than proximal large muscular vessel lesions of placental fetal vascular malperfusion.
Stanek J
Histol Histopathol 2022 Apr;37(4):365-372. Epub 2021 Dec 23 doi: 10.14670/HH-18-414. PMID: 34939657

Clinical prediction guides

Placental CD34 immunohistochemistry in fetal vascular malperfusion in stillbirth.
Stanek J, Drach A
J Obstet Gynaecol Res 2022 Mar;48(3):719-728. Epub 2022 Jan 29 doi: 10.1111/jog.15169. PMID: 35092332
Distal villous lesions are clinically more relevant than proximal large muscular vessel lesions of placental fetal vascular malperfusion.
Stanek J
Histol Histopathol 2022 Apr;37(4):365-372. Epub 2021 Dec 23 doi: 10.14670/HH-18-414. PMID: 34939657
Association between fetal vascular malperfusion and gestational diabetes.
Goto T, Sato Y, Kodama Y, Tomimori K, Sameshima H, Aman M, Maekawa K, Yamashita A, Asada Y
J Obstet Gynaecol Res 2022 Jan;48(1):80-86. Epub 2021 Nov 2 doi: 10.1111/jog.15046. PMID: 34729872
Fetal vascular obstructive lesions: nosology and reproducibility of placental reaction patterns.
Redline RW, Ariel I, Baergen RN, Desa DJ, Kraus FT, Roberts DJ, Sander CM
Pediatr Dev Pathol 2004 Sep-Oct;7(5):443-52. Epub 2004 Jul 30 doi: 10.1007/s10024-004-2020-x. PMID: 15547768

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