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Inner Restlessness

MedGen UID:
858352
•Concept ID:
C3898758
•
Finding

Definition

A feeling of unrest and/or an inability to feel calm or relaxed. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInner Restlessness

Professional guidelines

PubMed

Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects.
Milos G, Antel J, Kaufmann LK, Barth N, Koller A, Tan S, Wiesing U, Hinney A, Libuda L, Wabitsch M, von Känel R, Hebebrand J
Transl Psychiatry 2020 Aug 27;10(1):303. doi: 10.1038/s41398-020-00977-1. PMID: 32855384Free PMC Article
Classification and treatment of tardive syndromes.
Fernandez HH, Friedman JH
Neurologist 2003 Jan;9(1):16-27. doi: 10.1097/01.nrl.0000038585.58012.97. PMID: 12801428

Recent clinical studies

Etiology

Pain Fluctuations in Parkinson's Disease and Their Association with Motor and Non-Motor Fluctuations.
Storch A, Bremer A, Gandor F, Odin P, Ebersbach G, Löhle M
J Parkinsons Dis 2024;14(7):1451-1468. doi: 10.3233/JPD-240026. PMID: 39302380Free PMC Article
Selective serotonin reuptake inhibitor-induced akathisia.
Koliscak LP, Makela EH
J Am Pharm Assoc (2003) 2009 Mar-Apr;49(2):e28-36; quiz e37-8. doi: 10.1331/JAPhA.2009.08083. PMID: 19289334
Classification and treatment of tardive syndromes.
Fernandez HH, Friedman JH
Neurologist 2003 Jan;9(1):16-27. doi: 10.1097/01.nrl.0000038585.58012.97. PMID: 12801428
Managing antipsychotic-induced acute and chronic akathisia.
Miller CH, Fleischhacker WW
Drug Saf 2000 Jan;22(1):73-81. doi: 10.2165/00002018-200022010-00006. PMID: 10647977
Relationship of neuroleptic-induced akathisia to drug-induced parkinsonism.
Sandyk R, Kay SR
Ital J Neurol Sci 1990 Oct;11(5):439-42. doi: 10.1007/BF02336563. PMID: 1980270

Diagnosis

Symptoms of agitated depression and/or akathisia.
Peitl MV, Prološčić J, Blažević-Zelić S, Skarpa-Usmiani I, Peitl V
Psychiatr Danub 2011 Mar;23(1):108-10. PMID: 21448111
Movement disorders induced by gastrointestinal drugs: two paediatric cases.
Elzinga-Huttenga J, Hekster Y, Bijl A, Rotteveel J
Neuropediatrics 2006 Apr;37(2):102-6. doi: 10.1055/s-2006-923981. PMID: 16773510
The causes of underdiagnosing akathisia.
Hirose S
Schizophr Bull 2003;29(3):547-58. doi: 10.1093/oxfordjournals.schbul.a007027. PMID: 14609248
A rating scale for drug-induced akathisia.
Barnes TR
Br J Psychiatry 1989 May;154:672-6. doi: 10.1192/bjp.154.5.672. PMID: 2574607
Identifying akinesia and akathisia: the relationship between patient's self-report and nurse's assessment.
Michaels RA, Mumford K
Arch Psychiatr Nurs 1989 Apr;3(2):97-101. PMID: 2565706

Therapy

Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model.
Bleickardt CJ, Kazdoba TM, Jones NT, Hunter JC, Hodgson RA
Pharmacol Biochem Behav 2014 Mar;118:36-45. Epub 2013 Nov 8 doi: 10.1016/j.pbb.2013.10.030. PMID: 24211858
Symptoms of agitated depression and/or akathisia.
Peitl MV, Prološčić J, Blažević-Zelić S, Skarpa-Usmiani I, Peitl V
Psychiatr Danub 2011 Mar;23(1):108-10. PMID: 21448111
A rating scale for drug-induced akathisia.
Barnes TR
Br J Psychiatry 1989 May;154:672-6. doi: 10.1192/bjp.154.5.672. PMID: 2574607
Effects of alpha 2-receptor blockade in addition to tricyclic antidepressants in therapy-resistant depression.
Schmauss M, Laakmann G, Dieterle D
J Clin Psychopharmacol 1988 Apr;8(2):108-11. PMID: 3372705
A comparative study of the bronchodilatating effects of ipratropium and terbutalin inhaled with Monaghan IPPB-M 515 by 19 patients with chronic obstructive airways disease.
Petersen BN, Weeke E
Scand J Respir Dis Suppl 1979;103:178-82. PMID: 155295

Prognosis

Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review.
Nasyrova RF, Vaiman EE, Repkina VV, Khasanova AK, Asadullin AR, Shipulin GA, Altynbekov KS, Al-Zamil M, Petrova MM, Shnayder NA
Genes (Basel) 2023 Feb 28;14(3) doi: 10.3390/genes14030616. PMID: 36980888Free PMC Article
Physical activity and restlessness correlate with leptin levels in patients with adolescent anorexia nervosa.
Holtkamp K, Herpertz-Dahlmann B, Hebebrand K, Mika C, Kratzsch J, Hebebrand J
Biol Psychiatry 2006 Aug 1;60(3):311-3. Epub 2005 Dec 27 doi: 10.1016/j.biopsych.2005.11.001. PMID: 16376860
Managing antipsychotic-induced acute and chronic akathisia.
Miller CH, Fleischhacker WW
Drug Saf 2000 Jan;22(1):73-81. doi: 10.2165/00002018-200022010-00006. PMID: 10647977
Clinical characteristics and predisposing factors in acute drug-induced akathisia.
Sachdev P, Kruk J
Arch Gen Psychiatry 1994 Dec;51(12):963-74. doi: 10.1001/archpsyc.1994.03950120035007. PMID: 7979885

Clinical prediction guides

Short-term metreleptin treatment of patients with anorexia nervosa: rapid on-set of beneficial cognitive, emotional, and behavioral effects.
Milos G, Antel J, Kaufmann LK, Barth N, Koller A, Tan S, Wiesing U, Hinney A, Libuda L, Wabitsch M, von Känel R, Hebebrand J
Transl Psychiatry 2020 Aug 27;10(1):303. doi: 10.1038/s41398-020-00977-1. PMID: 32855384Free PMC Article
Antagonism of the adenosine A2A receptor attenuates akathisia-like behavior induced with MP-10 or aripiprazole in a novel non-human primate model.
Bleickardt CJ, Kazdoba TM, Jones NT, Hunter JC, Hodgson RA
Pharmacol Biochem Behav 2014 Mar;118:36-45. Epub 2013 Nov 8 doi: 10.1016/j.pbb.2013.10.030. PMID: 24211858
A rating scale for drug-induced akathisia.
Barnes TR
Br J Psychiatry 1989 May;154:672-6. doi: 10.1192/bjp.154.5.672. PMID: 2574607
Effects of alpha 2-receptor blockade in addition to tricyclic antidepressants in therapy-resistant depression.
Schmauss M, Laakmann G, Dieterle D
J Clin Psychopharmacol 1988 Apr;8(2):108-11. PMID: 3372705
A comparative study of the bronchodilatating effects of ipratropium and terbutalin inhaled with Monaghan IPPB-M 515 by 19 patients with chronic obstructive airways disease.
Petersen BN, Weeke E
Scand J Respir Dis Suppl 1979;103:178-82. PMID: 155295

Recent systematic reviews

Single-Nucleotide Polymorphisms as Biomarkers of Antipsychotic-Induced Akathisia: Systematic Review.
Nasyrova RF, Vaiman EE, Repkina VV, Khasanova AK, Asadullin AR, Shipulin GA, Altynbekov KS, Al-Zamil M, Petrova MM, Shnayder NA
Genes (Basel) 2023 Feb 28;14(3) doi: 10.3390/genes14030616. PMID: 36980888Free PMC Article
Medication-Induced Akathisia with Newly Approved Antipsychotics in Patients with a Severe Mental Illness: A Systematic Review and Meta-Analysis.
Demyttenaere K, Detraux J, Racagni G, Vansteelandt K
CNS Drugs 2019 Jun;33(6):549-566. doi: 10.1007/s40263-019-00625-3. PMID: 31065941

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