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Calcineurin Nephrotoxicity

MedGen UID:
859325
Concept ID:
C3899731
Disease or Syndrome
Synonym: Calcineurin Inhibitor Nephrotoxicity

Definition

Kidney injury caused by calcineurin inhibitor immunosuppressive therapy which may lead to diminished kidney function. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCalcineurin Nephrotoxicity

Professional guidelines

PubMed

Madariaga HM, Riella LV
Contrib Nephrol 2017;190:168-180. Epub 2017 May 23 doi: 10.1159/000468963. PMID: 28535528
Pham PT, Pham PC, Wilkinson AH
Curr Opin Organ Transplant 2009 Jun;14(3):231-9. doi: 10.1097/MOT.0b013e32832b34a4. PMID: 19395967

Recent clinical studies

Etiology

Madariaga HM, Riella LV
Contrib Nephrol 2017;190:168-180. Epub 2017 May 23 doi: 10.1159/000468963. PMID: 28535528
Ventura-Aguiar P, Campistol JM, Diekmann F
Expert Opin Drug Saf 2016;15(3):303-19. Epub 2016 Jan 28 doi: 10.1517/14740338.2016.1132698. PMID: 26667069
Matas AJ
Am J Transplant 2011 Apr;11(4):687-92. doi: 10.1111/j.1600-6143.2011.03505.x. PMID: 21446973Free PMC Article
Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR
Transplantation 2004 Aug 15;78(3):461-8. doi: 10.1097/01.tp.0000128612.75163.26. PMID: 15316377
Joosten SA, van Kooten C, Sijpkens YW, de Fijter JW, Paul LC
Kidney Int 2004 May;65(5):1556-9. doi: 10.1111/j.1523-1755.2004.05410.x. PMID: 15086891

Diagnosis

Haq K, Yadav A, Mejia C
Adv Kidney Dis Health 2024 Sep;31(5):416-426. doi: 10.1053/j.akdh.2024.06.002. PMID: 39232612
Gavela E, Pallardó LM, Sancho A, Avilla A, Beltrán S, Roselló E, Pérez ML, García F
Transplant Proc 2009 Jul-Aug;41(6):2099-101. doi: 10.1016/j.transproceed.2009.06.058. PMID: 19715842
Raichlin E, Daly RC, Rosen CB, McGregor CG, Charlton MR, Frantz RP, Clavell AL, Rodeheffer RJ, Pereira NL, Kremers WK, Kushwaha SS, Edwards BS
Transplantation 2009 Jul 27;88(2):219-25. doi: 10.1097/TP.0b013e3181ac60db. PMID: 19623017
Araya CE, Fennell RS, Neiberger RE, Dharnidharka VR
Clin J Am Soc Nephrol 2006 Nov;1(6):1161-6. Epub 2006 Aug 30 doi: 10.2215/CJN.01520506. PMID: 17699342

Therapy

Haq K, Yadav A, Mejia C
Adv Kidney Dis Health 2024 Sep;31(5):416-426. doi: 10.1053/j.akdh.2024.06.002. PMID: 39232612
Ventura-Aguiar P, Campistol JM, Diekmann F
Expert Opin Drug Saf 2016;15(3):303-19. Epub 2016 Jan 28 doi: 10.1517/14740338.2016.1132698. PMID: 26667069
Matas AJ
Am J Transplant 2011 Apr;11(4):687-92. doi: 10.1111/j.1600-6143.2011.03505.x. PMID: 21446973Free PMC Article
Williams D, Haragsim L
Adv Chronic Kidney Dis 2006 Jan;13(1):47-55. doi: 10.1053/j.ackd.2005.11.001. PMID: 16412970
Joosten SA, van Kooten C, Sijpkens YW, de Fijter JW, Paul LC
Kidney Int 2004 May;65(5):1556-9. doi: 10.1111/j.1523-1755.2004.05410.x. PMID: 15086891

Prognosis

Sutherland AI, Akhtar MZ, Zilvetti M, Brockmann J, Ruse S, Fuggle SV, Sinha S, Harden P, Friend PJ
Am J Transplant 2014 Mar;14(3):677-84. doi: 10.1111/ajt.12572. PMID: 24612687
Gavela E, Pallardó LM, Sancho A, Avilla A, Beltrán S, Roselló E, Pérez ML, García F
Transplant Proc 2009 Jul-Aug;41(6):2099-101. doi: 10.1016/j.transproceed.2009.06.058. PMID: 19715842
Raichlin E, Daly RC, Rosen CB, McGregor CG, Charlton MR, Frantz RP, Clavell AL, Rodeheffer RJ, Pereira NL, Kremers WK, Kushwaha SS, Edwards BS
Transplantation 2009 Jul 27;88(2):219-25. doi: 10.1097/TP.0b013e3181ac60db. PMID: 19623017
Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR
Transplantation 2004 Aug 15;78(3):461-8. doi: 10.1097/01.tp.0000128612.75163.26. PMID: 15316377

Clinical prediction guides

Gavela E, Pallardó LM, Sancho A, Avilla A, Beltrán S, Roselló E, Pérez ML, García F
Transplant Proc 2009 Jul-Aug;41(6):2099-101. doi: 10.1016/j.transproceed.2009.06.058. PMID: 19715842
Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR
Transplantation 2004 Aug 15;78(3):461-8. doi: 10.1097/01.tp.0000128612.75163.26. PMID: 15316377

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