U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Anti-D Hemolytic Disease of the Newborn

MedGen UID:
859621
•Concept ID:
C3900027
•
Disease or Syndrome
Synonym: Isoimmunization of Newborn with Rhesus Anti-D Antibody

Definition

A condition of the newborn characterized by the destruction of red blood cells initiated by the transmission of antibodies from a mother to the child via the placenta against the D antigen, the most common Rhesus factor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-D Hemolytic Disease of the Newborn

Professional guidelines

PubMed

Identification and management of fetal anemia due to hemolytic disease.
van 't Oever RM, Zwiers C, de Winter D, de Haas M, Oepkes D, Lopriore E, Verweij EJJ
Expert Rev Hematol 2022 Nov;15(11):987-998. Epub 2022 Oct 31 doi: 10.1080/17474086.2022.2138853. PMID: 36264850
RhIg for the prevention Rh immunization and IVIg for the treatment of affected neonates.
Legler TJ
Transfus Apher Sci 2020 Oct;59(5):102950. Epub 2020 Sep 25 doi: 10.1016/j.transci.2020.102950. PMID: 33004277
Management of neonatal Rh disease.
Peterec SM
Clin Perinatol 1995 Sep;22(3):561-92. PMID: 8521682

Recent clinical studies

Etiology

Identification and management of fetal anemia due to hemolytic disease.
van 't Oever RM, Zwiers C, de Winter D, de Haas M, Oepkes D, Lopriore E, Verweij EJJ
Expert Rev Hematol 2022 Nov;15(11):987-998. Epub 2022 Oct 31 doi: 10.1080/17474086.2022.2138853. PMID: 36264850
Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature.
Neamţu SD, Novac MB, Neamţu AV, Stanca ID, Boldeanu MV, Gluhovschi A, Stanca L, Dijmărescu AL, Manolea MM, Trăistaru MR, Mateescu GO, Siminel MA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):229-235. doi: 10.47162/RJME.63.1.26. PMID: 36074689Free PMC Article
Hemolytic disease of the fetus and newborn due to Rh(D) incompatibility: A preventable disease that still produces significant morbidity and mortality in children.
Pegoraro V, Urbinati D, Visser GHA, Di Renzo GC, Zipursky A, Stotler BA, Spitalnik SL
PLoS One 2020;15(7):e0235807. Epub 2020 Jul 20 doi: 10.1371/journal.pone.0235807. PMID: 32687543Free PMC Article
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Haemolytic disease of the fetus and newborn.
de Haas M, Thurik FF, Koelewijn JM, van der Schoot CE
Vox Sang 2015 Aug;109(2):99-113. Epub 2015 Apr 20 doi: 10.1111/vox.12265. PMID: 25899660

Diagnosis

Identification and management of fetal anemia due to hemolytic disease.
van 't Oever RM, Zwiers C, de Winter D, de Haas M, Oepkes D, Lopriore E, Verweij EJJ
Expert Rev Hematol 2022 Nov;15(11):987-998. Epub 2022 Oct 31 doi: 10.1080/17474086.2022.2138853. PMID: 36264850
Hemolytic disease of the fetus and newborn in the sensitizing pregnancy where anti-D was incorrectly identified as RhIG.
Walhof ML, Leon J, Greiner AL, Scott JR, Knudson CM
J Clin Lab Anal 2022 Apr;36(4):e24323. Epub 2022 Mar 3 doi: 10.1002/jcla.24323. PMID: 35243688Free PMC Article
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Haemolytic disease of the fetus and newborn.
de Haas M, Thurik FF, Koelewijn JM, van der Schoot CE
Vox Sang 2015 Aug;109(2):99-113. Epub 2015 Apr 20 doi: 10.1111/vox.12265. PMID: 25899660
Haemolytic disease of newborn.
Narang A, Jain N
Indian J Pediatr 2001 Feb;68(2):167-72. doi: 10.1007/BF02722039. PMID: 11284186

Therapy

Hemolytic disease of the fetus and newborn due to Rh(D) incompatibility: A preventable disease that still produces significant morbidity and mortality in children.
Pegoraro V, Urbinati D, Visser GHA, Di Renzo GC, Zipursky A, Stotler BA, Spitalnik SL
PLoS One 2020;15(7):e0235807. Epub 2020 Jul 20 doi: 10.1371/journal.pone.0235807. PMID: 32687543Free PMC Article
Anti-D prophylaxis: past, present and future.
de Haas M, Finning K, Massey E, Roberts DJ
Transfus Med 2014 Feb;24(1):1-7. doi: 10.1111/tme.12099. PMID: 25121157
Detection of fetomaternal hemorrhage.
Kim YA, Makar RS
Am J Hematol 2012 Apr;87(4):417-23. Epub 2012 Jan 9 doi: 10.1002/ajh.22255. PMID: 22231030
Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn.
Brinc D, Lazarus AH
Hematology Am Soc Hematol Educ Program 2009:185-91. doi: 10.1182/asheducation-2009.1.185. PMID: 20008198
Haemolytic disease of newborn.
Narang A, Jain N
Indian J Pediatr 2001 Feb;68(2):167-72. doi: 10.1007/BF02722039. PMID: 11284186

Prognosis

Antenatal RHD screening to guide antenatal anti-D immunoprophylaxis in non-immunized D- pregnant women.
Clausen FB
Immunohematology 2024 Apr 1;40(1):15-27. Epub 2024 May 13 doi: 10.2478/immunohematology-2024-004. PMID: 38739027
Reassessment of Critical Anti-D Antibody Titer in RhD Alloimmunized Antenatal Women.
Singh B, Chaudhary R, Katharia R
Lab Med 2023 Jul 5;54(4):429-433. doi: 10.1093/labmed/lmac149. PMID: 36539334
Tacrolimus treatment saved a rho-incompatible pregnancy.
Nakagawa K, Funaki S, Hisano M, Sugiyama R, Yamaguchi K
J Matern Fetal Neonatal Med 2020 Nov;33(22):3873-3876. Epub 2019 Mar 8 doi: 10.1080/14767058.2019.1587406. PMID: 30821534
Lessons learned from the implementation of non-invasive fetal RHD screening.
Clausen FB
Expert Rev Mol Diagn 2018 May;18(5):423-431. Epub 2018 Apr 19 doi: 10.1080/14737159.2018.1461562. PMID: 29616835
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360

Clinical prediction guides

Reassessment of Critical Anti-D Antibody Titer in RhD Alloimmunized Antenatal Women.
Singh B, Chaudhary R, Katharia R
Lab Med 2023 Jul 5;54(4):429-433. doi: 10.1093/labmed/lmac149. PMID: 36539334
Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature.
Neamţu SD, Novac MB, Neamţu AV, Stanca ID, Boldeanu MV, Gluhovschi A, Stanca L, Dijmărescu AL, Manolea MM, Trăistaru MR, Mateescu GO, Siminel MA
Rom J Morphol Embryol 2022 Jan-Mar;63(1):229-235. doi: 10.47162/RJME.63.1.26. PMID: 36074689Free PMC Article
Lessons learned from the implementation of non-invasive fetal RHD screening.
Clausen FB
Expert Rev Mol Diagn 2018 May;18(5):423-431. Epub 2018 Apr 19 doi: 10.1080/14737159.2018.1461562. PMID: 29616835
Hemolytic disease of the fetus and newborn in the molecular era.
Fasano RM
Semin Fetal Neonatal Med 2016 Feb;21(1):28-34. Epub 2015 Nov 14 doi: 10.1016/j.siny.2015.10.006. PMID: 26589360
Integration of noninvasive prenatal prediction of fetal blood group into clinical prenatal care.
Clausen FB
Prenat Diagn 2014 May;34(5):409-15. Epub 2014 Feb 5 doi: 10.1002/pd.4326. PMID: 24431264

Recent systematic reviews

Does high body mass index (>25 kg/m(2)) or weight (>80 kg) reduce the effectiveness of anti-D prophylaxis in Rh(D)-negative pregnant women? A systematic review and meta-analysis.
Ngan CBM, Kaur R, Jackson DE
Vox Sang 2024 Sep;119(9):902-911. Epub 2024 Jun 18 doi: 10.1111/vox.13693. PMID: 38889996
Anti-D immunization after D positive platelet transfusions in D negative recipients: A systematic review and meta-analysis.
Hubert T, Kerkhoffs JL, Brand A, Schonewille H
Transfusion 2024 May;64(5):933-945. Epub 2024 Apr 18 doi: 10.1111/trf.17833. PMID: 38634345
Misclassification of RhD variants among pregnant women: a systematic review.
Owaidah AY, Yamani LZ
J Med Life 2023 Jul;16(7):981-989. doi: 10.25122/jml-2023-0004. PMID: 37900088Free PMC Article
Non-Invasive Prenatal Fetal Blood Group Genotype and Its Application in the Management of Hemolytic Disease of Fetus and Newborn: Systematic Review and Meta-Analysis.
Alshehri AA, Jackson DE
Transfus Med Rev 2021 Apr;35(2):85-94. Epub 2021 Mar 1 doi: 10.1016/j.tmrv.2021.02.001. PMID: 33781630
Anti-D administration after spontaneous miscarriage for preventing Rhesus alloimmunisation.
Karanth L, Jaafar SH, Kanagasabai S, Nair NS, Barua A
Cochrane Database Syst Rev 2013 Mar 28;2013(3):CD009617. doi: 10.1002/14651858.CD009617.pub2. PMID: 23543581Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...