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Migrating focal seizure

MedGen UID:
861697
•Concept ID:
C4013260
•
Finding
Synonyms: Migrating focal seizures; Migrating partial seizures
 
HPO: HP:0032786

Definition

A migrating focal seizure is a seizure that involves different body parts, usually without overlap, in a consecutive manner so that the offset of a seizure in one part coincides with its onset in another, even shifting multiple times between the sides of the body. They can be associated with autonomic manifestations. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMigrating focal seizure

Conditions with this feature

Developmental and epileptic encephalopathy, 79
MedGen UID:
1684738
•Concept ID:
C5231410
•
Disease or Syndrome
Developmental and epileptic encephalopathy-79 (DEE79) is a severe neurologic disorder characterized by onset of refractory seizures in the first months of life. Affected individuals have severely impaired psychomotor development and may show hypotonia or spasticity. Brain imaging may show hypomyelination, cerebral atrophy, and thinning of the corpus callosum (summary by Butler et al., 2018 and Hernandez et al., 2019). For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350.
See: Condition Record
Developmental and epileptic encephalopathy, 79

Professional guidelines

PubMed

ILAE classification and definition of epilepsy syndromes with onset in neonates and infants: Position statement by the ILAE Task Force on Nosology and Definitions.
Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshé SL, Nabbout R
Epilepsia 2022 Jun;63(6):1349-1397. Epub 2022 May 3 doi: 10.1111/epi.17239. PMID: 35503712
Epilepsy Syndromes in the First Year of Life and Usefulness of Genetic Testing for Precision Therapy.
Bayat A, Bayat M, Rubboli G, Møller RS
Genes (Basel) 2021 Jul 8;12(7) doi: 10.3390/genes12071051. PMID: 34356067Free PMC Article
Stiripentol in the Management of Epilepsy.
Nickels KC, Wirrell EC
CNS Drugs 2017 May;31(5):405-416. doi: 10.1007/s40263-017-0432-1. PMID: 28434133

Recent clinical studies

Etiology

HCN1 pathogenic variants associated with childhood epilepsy in a cohort of Chinese patients.
Yang Z, Kuang Z, Liao H, Gan S, Peng X, Yang H, Wu L
Epileptic Disord 2024 Feb;26(1):90-97. Epub 2023 Dec 28 doi: 10.1002/epd2.20182. PMID: 38009841
KCNT1 epilepsy with migrating focal seizures shows a temporal sequence with poor outcome, high mortality and SUDEP.
Kuchenbuch M, Barcia G, Chemaly N, Carme E, Roubertie A, Gibaud M, Van Bogaert P, de Saint Martin A, Hirsch E, Dubois F, Sarret C, Nguyen The Tich S, Laroche C, des Portes V, Billette de Villemeur T, Barthez MA, Auvin S, Bahi-Buisson N, Desguerre I, Kaminska A, Benquet P, Nabbout R
Brain 2019 Oct 1;142(10):2996-3008. doi: 10.1093/brain/awz240. PMID: 31532509

Diagnosis

The relationship between the characteristics of burst suppression pattern and different etiologies in epilepsy.
Yang H, Gong P, Jiao X, Zhou Q, Zhang Y, Jiang Y, Yang Z
Sci Rep 2021 Aug 5;11(1):15903. doi: 10.1038/s41598-021-95040-4. PMID: 34354098Free PMC Article
KCNT1 epilepsy with migrating focal seizures shows a temporal sequence with poor outcome, high mortality and SUDEP.
Kuchenbuch M, Barcia G, Chemaly N, Carme E, Roubertie A, Gibaud M, Van Bogaert P, de Saint Martin A, Hirsch E, Dubois F, Sarret C, Nguyen The Tich S, Laroche C, des Portes V, Billette de Villemeur T, Barthez MA, Auvin S, Bahi-Buisson N, Desguerre I, Kaminska A, Benquet P, Nabbout R
Brain 2019 Oct 1;142(10):2996-3008. doi: 10.1093/brain/awz240. PMID: 31532509
SCN2A mutation in an infant presenting with migrating focal seizures and infantile spasm responsive to a ketogenic diet.
Su DJ, Lu JF, Lin LJ, Liang JS, Hung KL
Brain Dev 2018 Sep;40(8):724-727. Epub 2018 Apr 4 doi: 10.1016/j.braindev.2018.03.005. PMID: 29625812

Therapy

HCN1 pathogenic variants associated with childhood epilepsy in a cohort of Chinese patients.
Yang Z, Kuang Z, Liao H, Gan S, Peng X, Yang H, Wu L
Epileptic Disord 2024 Feb;26(1):90-97. Epub 2023 Dec 28 doi: 10.1002/epd2.20182. PMID: 38009841

Prognosis

An intronic variant in BRAT1 creates a cryptic splice site, causing epileptic encephalopathy without prominent rigidity.
Colak FK, Guleray N, Azapagasi E, Yazıcı MU, Aksoy E, Ceylan N
Acta Neurol Belg 2020 Dec;120(6):1425-1432. Epub 2020 Oct 10 doi: 10.1007/s13760-020-01513-0. PMID: 33040300Free PMC Article
KCNT1 epilepsy with migrating focal seizures shows a temporal sequence with poor outcome, high mortality and SUDEP.
Kuchenbuch M, Barcia G, Chemaly N, Carme E, Roubertie A, Gibaud M, Van Bogaert P, de Saint Martin A, Hirsch E, Dubois F, Sarret C, Nguyen The Tich S, Laroche C, des Portes V, Billette de Villemeur T, Barthez MA, Auvin S, Bahi-Buisson N, Desguerre I, Kaminska A, Benquet P, Nabbout R
Brain 2019 Oct 1;142(10):2996-3008. doi: 10.1093/brain/awz240. PMID: 31532509

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