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Cervical Neuroendocrine Carcinoma

MedGen UID:
861862
•Concept ID:
C4013425
•
Neoplastic Process
Synonym: Neuroendocrine cervical carcinoma

Definition

A malignant, high grade neuroendocrine neoplasm that arises from the cervix. This category includes small cell and large cell neuroendocrine carcinoma. [from NCI]

Professional guidelines

PubMed

Influence of clinicopathological characteristics and comprehensive treatment models on the prognosis of small cell carcinoma of the cervix: A systematic review and meta-analysis.
Zhang Q, Xiong Y, Ye J, Zhang L, Li L
PLoS One 2018;13(4):e0192784. Epub 2018 Apr 11 doi: 10.1371/journal.pone.0192784. PMID: 29641578Free PMC Article
Multimodal Management of Locally Advanced Neuroendocrine Cervical Carcinoma: A Single Institution Experience.
Castelnau-Marchand P, Pautier P, Genestie C, Leary A, Bentivegna E, Gouy S, Scoazec JY, Morice P, Haie-Meder C, Chargari C
Int J Gynecol Cancer 2018 Jun;28(5):1013-1019. doi: 10.1097/IGC.0000000000001242. PMID: 29595759
Challenges in the diagnosis and management of cervical neuroendocrine carcinoma.
Burzawa J, Gonzales N, Frumovitz M
Expert Rev Anticancer Ther 2015;15(7):805-10. Epub 2015 May 17 doi: 10.1586/14737140.2015.1047767. PMID: 25980782

Recent clinical studies

Etiology

18F-FDG PET/computed tomography scan in patients with suspicion of recurrent neuroendocrine carcinoma of the cervix.
Jiang Y, Hou G, Huo L, Li F, Zhu Z, Cheng W
Nucl Med Commun 2021 Oct 1;42(10):1151-1156. doi: 10.1097/MNM.0000000000001432. PMID: 33927154Free PMC Article
Expression and clinical significance of a new neuroendocrine marker secretagogin in cervical neuroendocrine carcinoma.
Yu L, Suye S, Huang R, Liang Q, Fu C
J Clin Pathol 2021 Dec;74(12):787-795. Epub 2020 Oct 15 doi: 10.1136/jclinpath-2020-206889. PMID: 33060116
Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix with ovarian metastasis of the former component: a report of 2 cases.
Ramalingam P, Malpica A, Deavers MT
Int J Gynecol Pathol 2012 Sep;31(5):490-6. doi: 10.1097/PGP.0b013e31824735a5. PMID: 22833092
HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand.
Siriaunkgul S, Utaipat U, Settakorn J, Sukpan K, Srisomboon J, Khunamornpong S
Int J Gynaecol Obstet 2011 Nov;115(2):175-9. Epub 2011 Aug 27 doi: 10.1016/j.ijgo.2011.06.010. PMID: 21872245
Expression of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix.
Sukpan K, Settakorn J, Khunamornpong S, Cheewakriangkrai C, Srisomboon J, Siriaunkgul S
Int J Gynecol Cancer 2011 Jul;21(5):911-7. doi: 10.1097/IGC.0b013e31821a2567. PMID: 21633298

Diagnosis

Cervical neuroendocrine carcinoma in the third trimester: a rare case report and literature review.
Chen G, Huang K, Sun J, Yang L
BMC Pregnancy Childbirth 2023 Aug 10;23(1):571. doi: 10.1186/s12884-023-05900-2. PMID: 37563542Free PMC Article
Expression and clinical significance of a new neuroendocrine marker secretagogin in cervical neuroendocrine carcinoma.
Yu L, Suye S, Huang R, Liang Q, Fu C
J Clin Pathol 2021 Dec;74(12):787-795. Epub 2020 Oct 15 doi: 10.1136/jclinpath-2020-206889. PMID: 33060116
Challenges in the diagnosis and management of cervical neuroendocrine carcinoma.
Burzawa J, Gonzales N, Frumovitz M
Expert Rev Anticancer Ther 2015;15(7):805-10. Epub 2015 May 17 doi: 10.1586/14737140.2015.1047767. PMID: 25980782
Expression of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix.
Sukpan K, Settakorn J, Khunamornpong S, Cheewakriangkrai C, Srisomboon J, Siriaunkgul S
Int J Gynecol Cancer 2011 Jul;21(5):911-7. doi: 10.1097/IGC.0b013e31821a2567. PMID: 21633298
Cervical neuroendocrine carcinoma: a clinical and light microscopic study of 14 cases.
Walker AN, Mills SE, Taylor PT
Int J Gynecol Pathol 1988;7(1):64-74. PMID: 2832338

Therapy

HER2 mutations in advanced cervical neuroendocrine carcinoma: implications for trastuzumab deruxtecan therapy.
Chao WR, Lee MY, Sheu GT, Lee YJ, Shen HP, Han CP
Naunyn Schmiedebergs Arch Pharmacol 2024 Oct;397(10):7615-7622. Epub 2024 Apr 30 doi: 10.1007/s00210-024-03066-y. PMID: 38689071
Challenges in the diagnosis and management of cervical neuroendocrine carcinoma.
Burzawa J, Gonzales N, Frumovitz M
Expert Rev Anticancer Ther 2015;15(7):805-10. Epub 2015 May 17 doi: 10.1586/14737140.2015.1047767. PMID: 25980782

Prognosis

Cervical neuroendocrine carcinoma in the third trimester: a rare case report and literature review.
Chen G, Huang K, Sun J, Yang L
BMC Pregnancy Childbirth 2023 Aug 10;23(1):571. doi: 10.1186/s12884-023-05900-2. PMID: 37563542Free PMC Article
18F-FDG PET/computed tomography scan in patients with suspicion of recurrent neuroendocrine carcinoma of the cervix.
Jiang Y, Hou G, Huo L, Li F, Zhu Z, Cheng W
Nucl Med Commun 2021 Oct 1;42(10):1151-1156. doi: 10.1097/MNM.0000000000001432. PMID: 33927154Free PMC Article
Expression and clinical significance of a new neuroendocrine marker secretagogin in cervical neuroendocrine carcinoma.
Yu L, Suye S, Huang R, Liang Q, Fu C
J Clin Pathol 2021 Dec;74(12):787-795. Epub 2020 Oct 15 doi: 10.1136/jclinpath-2020-206889. PMID: 33060116
Challenges in the diagnosis and management of cervical neuroendocrine carcinoma.
Burzawa J, Gonzales N, Frumovitz M
Expert Rev Anticancer Ther 2015;15(7):805-10. Epub 2015 May 17 doi: 10.1586/14737140.2015.1047767. PMID: 25980782
Expression of survivin, CD117, and C-erbB-2 in neuroendocrine carcinoma of the uterine cervix.
Sukpan K, Settakorn J, Khunamornpong S, Cheewakriangkrai C, Srisomboon J, Siriaunkgul S
Int J Gynecol Cancer 2011 Jul;21(5):911-7. doi: 10.1097/IGC.0b013e31821a2567. PMID: 21633298

Clinical prediction guides

18F-FDG PET/computed tomography scan in patients with suspicion of recurrent neuroendocrine carcinoma of the cervix.
Jiang Y, Hou G, Huo L, Li F, Zhu Z, Cheng W
Nucl Med Commun 2021 Oct 1;42(10):1151-1156. doi: 10.1097/MNM.0000000000001432. PMID: 33927154Free PMC Article
Expression and clinical significance of a new neuroendocrine marker secretagogin in cervical neuroendocrine carcinoma.
Yu L, Suye S, Huang R, Liang Q, Fu C
J Clin Pathol 2021 Dec;74(12):787-795. Epub 2020 Oct 15 doi: 10.1136/jclinpath-2020-206889. PMID: 33060116
Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix.
Siriaunkgul S, Utaipat U, Suwiwat S, Settakorn J, Sukpan K, Srisomboon J, Khunamornpong S
Asian Pac J Cancer Prev 2012;13(7):3281-5. doi: 10.7314/apjcp.2012.13.7.3281. PMID: 22994748
Downregulation of BRG-1 repressed expression of CD44s in cervical neuroendocrine carcinoma and adenocarcinoma.
Kuo KT, Liang CW, Hsiao CH, Lin CH, Chen CA, Sheu BC, Lin MC
Mod Pathol 2006 Dec;19(12):1570-7. Epub 2006 Sep 22 doi: 10.1038/modpathol.3800687. PMID: 16998464

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