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Endophthalmitis

MedGen UID:
8633
Concept ID:
C0014236
Disease or Syndrome
Synonyms: Endophthalmitides; Ophthalmia; Ophthalmias
SNOMED CT: Ophthalmitis (128295000); Ophthalmia (128295000); Inflammatory disorder of the eye (128295000); Endophthalmitis (1847009)
 
Monarch Initiative: MONDO:0016047
Orphanet: ORPHA199323

Definition

A rare ophthalmic disorder characterized by inflammation involving the vitreous and/or aqueous humors, usually due to bacterial or fungal infection. It may arise endogenously from hematogenous spread of the infectious agent, or exogenously after direct inoculation, and can take an acute or chronic course. Clinical signs and symptoms include progressive vitritis, hypopyon, reduced or blurred vision, red eye, pain, and lid swelling. The condition may be complicated by panophthalmitis, corneal infiltration and perforation, affection of orbital structures, and phthisis bulbi. [from ORDO]

Professional guidelines

PubMed

Maseda E, Martín-Loeches I, Zaragoza R, Pemán J, Fortún J, Grau S, Aguilar G, Varela M, Borges M, Giménez MJ, Rodríguez A
Crit Care 2023 Oct 3;27(1):382. doi: 10.1186/s13054-023-04673-6. PMID: 37789338Free PMC Article
Monticelli J, Knezevich A, Luzzati R, Di Bella S
J Infect Chemother 2018 Apr;24(4):237-246. Epub 2018 Feb 1 doi: 10.1016/j.jiac.2018.01.001. PMID: 29396199
David MZ, Daum RS
Curr Top Microbiol Immunol 2017;409:325-383. doi: 10.1007/82_2017_42. PMID: 28900682

Recent clinical studies

Etiology

Panahi P, Mirzakouchaki-Borujeni N, Pourdakan O, Arévalo JF
Ophthalmic Res 2023;66(1):1318-1326. Epub 2023 Oct 19 doi: 10.1159/000534650. PMID: 37857260Free PMC Article
VanDolah H, Tung R
N Engl J Med 2023 Oct 19;389(16):1510. doi: 10.1056/NEJMicm2303731. PMID: 37851877
Fabiani C, Agarwal M, Dogra M, Tosi GM, Davis JL
Ocul Immunol Inflamm 2023 Sep;31(7):1386-1395. Epub 2022 Dec 19 doi: 10.1080/09273948.2022.2152699. PMID: 36534597
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Montan P
Curr Opin Ophthalmol 2001 Feb;12(1):75-81. doi: 10.1097/00055735-200102000-00013. PMID: 11150085

Diagnosis

Fan J, Flynn HW Jr
Ophthalmol Retina 2023 Dec;7(12):1125. Epub 2023 Sep 14 doi: 10.1016/j.oret.2023.08.010. PMID: 37702641
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Durand ML
Clin Microbiol Rev 2017 Jul;30(3):597-613. doi: 10.1128/CMR.00113-16. PMID: 28356323Free PMC Article
Cunningham C, Widder J, Raiji V
Dis Mon 2017 Feb;63(2):45-48. Epub 2016 Nov 15 doi: 10.1016/j.disamonth.2016.09.005. PMID: 27863689
Chee SP, Jap A
Curr Opin Ophthalmol 2001 Dec;12(6):464-70. doi: 10.1097/00055735-200112000-00012. PMID: 11734687

Therapy

VanDolah H, Tung R
N Engl J Med 2023 Oct 19;389(16):1510. doi: 10.1056/NEJMicm2303731. PMID: 37851877
Fan J, Flynn HW Jr
Ophthalmol Retina 2023 Dec;7(12):1125. Epub 2023 Sep 14 doi: 10.1016/j.oret.2023.08.010. PMID: 37702641
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Durand ML
Clin Microbiol Rev 2017 Jul;30(3):597-613. doi: 10.1128/CMR.00113-16. PMID: 28356323Free PMC Article
Lo JS, Lo JO, Hunter AJ
J Hosp Med 2008 May;3(3):272-3. doi: 10.1002/jhm.305. PMID: 18571810

Prognosis

Breazzano MP, Bond JB 3rd, Bearelly S, Kim DH, Donahue SP, Lum F, Olsen TW; American Academy of Ophthalmology
Ophthalmology 2022 Jan;129(1):73-76. Epub 2021 Jul 19 doi: 10.1016/j.ophtha.2021.07.015. PMID: 34293405
Furtado JM, Simões M, Vasconcelos-Santos D, Oliver GF, Tyagi M, Nascimento H, Gordon DL, Smith JR
Surv Ophthalmol 2022 Mar-Apr;67(2):440-462. Epub 2021 Jun 18 doi: 10.1016/j.survophthal.2021.06.003. PMID: 34147542
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Razeghinejad MR, Havens SJ, Katz LJ
Surv Ophthalmol 2017 Sep-Oct;62(5):591-610. Epub 2017 Feb 8 doi: 10.1016/j.survophthal.2017.01.009. PMID: 28188728
Quinn CJ
Optom Clin 1996;5(1):111-30. PMID: 8963073

Clinical prediction guides

Kato A, Horita N, Namkoong H, Nomura E, Masuhara N, Kaneko T, Mizuki N, Takeuchi M
Sci Rep 2022 Oct 18;12(1):17416. doi: 10.1038/s41598-022-21423-w. PMID: 36258003Free PMC Article
Relhan N, Forster RK, Flynn HW Jr
Am J Ophthalmol 2018 Mar;187:xx-xxvii. Epub 2017 Dec 5 doi: 10.1016/j.ajo.2017.11.021. PMID: 29217351Free PMC Article
Durand ML, Heier JS
Curr Clin Top Infect Dis 2000;20:271-97. PMID: 10943529
Arch Ophthalmol 1995 Dec;113(12):1479-96. PMID: 7487614
Chan CC, Nussenblatt RB, Fujikawa LS, Palestine AG, Stevens G Jr, Parver LM, Luckenbach MW, Kuwabara T
Ophthalmology 1986 May;93(5):690-5. doi: 10.1016/s0161-6420(86)33694-7. PMID: 3523359

Recent systematic reviews

Sunaga T, Maeda M, Saulle R, Ng SM, Sato MT, Hasegawa T, Mason AN, Noma H, Ota E
Cochrane Database Syst Rev 2024 Jun 3;6(6):CD015804. doi: 10.1002/14651858.CD015804.pub2. PMID: 38829176Free PMC Article
Phongkhun K, Pothikamjorn T, Srisurapanont K, Manothummetha K, Sanguankeo A, Thongkam A, Chuleerarux N, Leksuwankun S, Meejun T, Thanakitcharu J, Walker M, Gopinath S, Torvorapanit P, Langsiri N, Worasilchai N, Moonla C, Plongla R, Kates OS, Nematollahi S, Permpalung N
Clin Infect Dis 2023 May 24;76(10):1738-1749. doi: 10.1093/cid/ciad064. PMID: 36750934Free PMC Article
Wadhwani M, Mishra SK, Manika M, Bhartiya S
Rom J Ophthalmol 2020 Apr-Jun;64(2):105-115. PMID: 32685775Free PMC Article
Parke DW 3rd, Flynn HW Jr, Fisher YL
Can J Ophthalmol 2013 Feb;48(1):8-12. doi: 10.1016/j.jcjo.2012.11.005. PMID: 23419293
Tuon FF, de Almeida GM, Costa SF
Med Mycol 2007 Aug;45(5):441-7. doi: 10.1080/13693780701381289. PMID: 17654271

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