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Endophthalmitis

MedGen UID:
8633
Concept ID:
C0014236
Disease or Syndrome
Synonyms: Endophthalmitides; Ophthalmia; Ophthalmias
SNOMED CT: Ophthalmitis (128295000); Ophthalmia (128295000); Inflammatory disorder of the eye (128295000); Endophthalmitis (1847009)
 
Monarch Initiative: MONDO:0016047
Orphanet: ORPHA199323

Definition

A rare ophthalmic disorder characterized by inflammation involving the vitreous and/or aqueous humors, usually due to bacterial or fungal infection. It may arise endogenously from hematogenous spread of the infectious agent, or exogenously after direct inoculation, and can take an acute or chronic course. Clinical signs and symptoms include progressive vitritis, hypopyon, reduced or blurred vision, red eye, pain, and lid swelling. The condition may be complicated by panophthalmitis, corneal infiltration and perforation, affection of orbital structures, and phthisis bulbi. [from ORDO]

Professional guidelines

PubMed

Maseda E, Martín-Loeches I, Zaragoza R, Pemán J, Fortún J, Grau S, Aguilar G, Varela M, Borges M, Giménez MJ, Rodríguez A
Crit Care 2023 Oct 3;27(1):382. doi: 10.1186/s13054-023-04673-6. PMID: 37789338Free PMC Article
Monticelli J, Knezevich A, Luzzati R, Di Bella S
J Infect Chemother 2018 Apr;24(4):237-246. Epub 2018 Feb 1 doi: 10.1016/j.jiac.2018.01.001. PMID: 29396199
David MZ, Daum RS
Curr Top Microbiol Immunol 2017;409:325-383. doi: 10.1007/82_2017_42. PMID: 28900682

Recent clinical studies

Etiology

Panahi P, Mirzakouchaki-Borujeni N, Pourdakan O, Arévalo JF
Ophthalmic Res 2023;66(1):1318-1326. Epub 2023 Oct 19 doi: 10.1159/000534650. PMID: 37857260Free PMC Article
VanDolah H, Tung R
N Engl J Med 2023 Oct 19;389(16):1510. doi: 10.1056/NEJMicm2303731. PMID: 37851877
Fabiani C, Agarwal M, Dogra M, Tosi GM, Davis JL
Ocul Immunol Inflamm 2023 Sep;31(7):1386-1395. Epub 2022 Dec 19 doi: 10.1080/09273948.2022.2152699. PMID: 36534597
Tsirouki T, Steffen J, Dastiridou A, Praidou A, Androudi S
Ocul Immunol Inflamm 2020 Oct 2;28(7):1060-1065. Epub 2020 Jan 16 doi: 10.1080/09273948.2019.1699580. PMID: 31944150
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article

Diagnosis

Panahi P, Mirzakouchaki-Borujeni N, Pourdakan O, Arévalo JF
Ophthalmic Res 2023;66(1):1318-1326. Epub 2023 Oct 19 doi: 10.1159/000534650. PMID: 37857260Free PMC Article
Honavar SG
Indian J Ophthalmol 2022 Feb;70(2):355-356. doi: 10.4103/ijo.IJO_171_22. PMID: 35086194Free PMC Article
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Durand ML
Clin Microbiol Rev 2017 Jul;30(3):597-613. doi: 10.1128/CMR.00113-16. PMID: 28356323Free PMC Article
Montan P
Curr Opin Ophthalmol 2001 Feb;12(1):75-81. doi: 10.1097/00055735-200102000-00013. PMID: 11150085

Therapy

Jaffe GJ, Westby K, Csaky KG, Monés J, Pearlman JA, Patel SS, Joondeph BC, Randolph J, Masonson H, Rezaei KA
Ophthalmology 2021 Apr;128(4):576-586. Epub 2020 Sep 1 doi: 10.1016/j.ophtha.2020.08.027. PMID: 32882310
Das T, Sharma S
Asia Pac J Ophthalmol (Phila) 2018 Mar-Apr;7(2):69-71. doi: 10.22608/APO.201866. PMID: 29558571
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Durand ML
Clin Microbiol Rev 2017 Jul;30(3):597-613. doi: 10.1128/CMR.00113-16. PMID: 28356323Free PMC Article
Arch Ophthalmol 1995 Dec;113(12):1479-96. PMID: 7487614

Prognosis

Furtado JM, Simões M, Vasconcelos-Santos D, Oliver GF, Tyagi M, Nascimento H, Gordon DL, Smith JR
Surv Ophthalmol 2022 Mar-Apr;67(2):440-462. Epub 2021 Jun 18 doi: 10.1016/j.survophthal.2021.06.003. PMID: 34147542
Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Razeghinejad MR, Havens SJ, Katz LJ
Surv Ophthalmol 2017 Sep-Oct;62(5):591-610. Epub 2017 Feb 8 doi: 10.1016/j.survophthal.2017.01.009. PMID: 28188728
Loporchio D, Mukkamala L, Gorukanti K, Zarbin M, Langer P, Bhagat N
Surv Ophthalmol 2016 Sep-Oct;61(5):582-96. Epub 2016 Mar 17 doi: 10.1016/j.survophthal.2016.03.005. PMID: 26994871

Clinical prediction guides

Relhan N, Forster RK, Flynn HW Jr
Am J Ophthalmol 2018 Mar;187:xx-xxvii. Epub 2017 Dec 5 doi: 10.1016/j.ajo.2017.11.021. PMID: 29217351Free PMC Article
Haripriya A, Baam ZR, Chang DF
Asia Pac J Ophthalmol (Phila) 2017 Jul-Aug;6(4):324-329. doi: 10.22608/APO.2017200. PMID: 28780782
Schwartz SG, Flynn HW Jr, Das T, Mieler WF
Dev Ophthalmol 2016;55:176-88. Epub 2015 Oct 26 doi: 10.1159/000431195. PMID: 26501897Free PMC Article
Essex RW, Yi Q, Charles PG, Allen PJ
Ophthalmology 2004 Nov;111(11):2015-22. doi: 10.1016/j.ophtha.2003.09.041. PMID: 15522366
Arch Ophthalmol 1995 Dec;113(12):1479-96. PMID: 7487614

Recent systematic reviews

Reddy A, Liu SH, Brady CJ, Sieving PC, Palestine AG
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD010469. doi: 10.1002/14651858.CD010469.pub4. PMID: 37642198Free PMC Article
Tzoumas N, Riding G, Williams MA, Steel DH
Cochrane Database Syst Rev 2023 Jun 14;6(6):CD009300. doi: 10.1002/14651858.CD009300.pub3. PMID: 37314061Free PMC Article
Aiello F, Gallo Afflitto G, Leviste K, Swaminathan SS, Yoo SH, Findl O, Maurino V, Nucci C
J Cataract Refract Surg 2023 Nov 1;49(11):1168-1179. doi: 10.1097/j.jcrs.0000000000001230. PMID: 37276258
Phongkhun K, Pothikamjorn T, Srisurapanont K, Manothummetha K, Sanguankeo A, Thongkam A, Chuleerarux N, Leksuwankun S, Meejun T, Thanakitcharu J, Walker M, Gopinath S, Torvorapanit P, Langsiri N, Worasilchai N, Moonla C, Plongla R, Kates OS, Nematollahi S, Permpalung N
Clin Infect Dis 2023 May 24;76(10):1738-1749. doi: 10.1093/cid/ciad064. PMID: 36750934Free PMC Article
Kessel L, Flesner P, Andresen J, Erngaard D, Tendal B, Hjortdal J
Acta Ophthalmol 2015 Jun;93(4):303-17. Epub 2015 Mar 16 doi: 10.1111/aos.12684. PMID: 25779209Free PMC Article

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