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Endophthalmitis

MedGen UID:
8633
Concept ID:
C0014236
Disease or Syndrome
Synonyms: Endophthalmitides; Ophthalmia; Ophthalmias
SNOMED CT: Ophthalmitis (128295000); Ophthalmia (128295000); Inflammatory disorder of the eye (128295000); Endophthalmitis (1847009)
 
Monarch Initiative: MONDO:0016047
Orphanet: ORPHA199323

Definition

A rare ophthalmic disorder characterized by inflammation involving the vitreous and/or aqueous humors, usually due to bacterial or fungal infection. It may arise endogenously from hematogenous spread of the infectious agent, or exogenously after direct inoculation, and can take an acute or chronic course. Clinical signs and symptoms include progressive vitritis, hypopyon, reduced or blurred vision, red eye, pain, and lid swelling. The condition may be complicated by panophthalmitis, corneal infiltration and perforation, affection of orbital structures, and phthisis bulbi. [from ORDO]

Professional guidelines

PubMed

Brockhaus L, Goldblum D, Eggenschwiler L, Zimmerli S, Marzolini C
Clin Microbiol Infect 2019 Nov;25(11):1364-1369. Epub 2019 Feb 14 doi: 10.1016/j.cmi.2019.01.017. PMID: 30771529
Monticelli J, Knezevich A, Luzzati R, Di Bella S
J Infect Chemother 2018 Apr;24(4):237-246. Epub 2018 Feb 1 doi: 10.1016/j.jiac.2018.01.001. PMID: 29396199
David MZ, Daum RS
Curr Top Microbiol Immunol 2017;409:325-383. doi: 10.1007/82_2017_42. PMID: 28900682

Recent clinical studies

Etiology

Fabiani C, Agarwal M, Dogra M, Tosi GM, Davis JL
Ocul Immunol Inflamm 2023 Sep;31(7):1386-1395. Epub 2022 Dec 19 doi: 10.1080/09273948.2022.2152699. PMID: 36534597
Patel D, Patel SN, Chaudhary V, Garg SJ
Curr Opin Ophthalmol 2022 May 1;33(3):137-146. Epub 2022 Mar 9 doi: 10.1097/ICU.0000000000000850. PMID: 35266893
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Mamalis N, Kearsley L, Brinton E
Curr Opin Ophthalmol 2002 Feb;13(1):14-8. doi: 10.1097/00055735-200202000-00004. PMID: 11807383
Kresloff MS, Castellarin AA, Zarbin MA
Surv Ophthalmol 1998 Nov-Dec;43(3):193-224. doi: 10.1016/s0039-6257(98)00036-8. PMID: 9862309

Diagnosis

Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Durand ML
Clin Microbiol Rev 2017 Jul;30(3):597-613. doi: 10.1128/CMR.00113-16. PMID: 28356323Free PMC Article
Cunningham C, Widder J, Raiji V
Dis Mon 2017 Feb;63(2):45-48. Epub 2016 Nov 15 doi: 10.1016/j.disamonth.2016.09.005. PMID: 27863689
Montan P
Curr Opin Ophthalmol 2001 Feb;12(1):75-81. doi: 10.1097/00055735-200102000-00013. PMID: 11150085
Kresloff MS, Castellarin AA, Zarbin MA
Surv Ophthalmol 1998 Nov-Dec;43(3):193-224. doi: 10.1016/s0039-6257(98)00036-8. PMID: 9862309

Therapy

Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259
Jaffe GJ, Westby K, Csaky KG, Monés J, Pearlman JA, Patel SS, Joondeph BC, Randolph J, Masonson H, Rezaei KA
Ophthalmology 2021 Apr;128(4):576-586. Epub 2020 Sep 1 doi: 10.1016/j.ophtha.2020.08.027. PMID: 32882310
Das T, Sharma S
Asia Pac J Ophthalmol (Phila) 2018 Mar-Apr;7(2):69-71. doi: 10.22608/APO.201866. PMID: 29558571
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Durand ML
Clin Microbiol Rev 2017 Jul;30(3):597-613. doi: 10.1128/CMR.00113-16. PMID: 28356323Free PMC Article

Prognosis

Breazzano MP, Bond JB 3rd, Bearelly S, Kim DH, Donahue SP, Lum F, Olsen TW; American Academy of Ophthalmology
Ophthalmology 2022 Jan;129(1):73-76. Epub 2021 Jul 19 doi: 10.1016/j.ophtha.2021.07.015. PMID: 34293405
Furtado JM, Simões M, Vasconcelos-Santos D, Oliver GF, Tyagi M, Nascimento H, Gordon DL, Smith JR
Surv Ophthalmol 2022 Mar-Apr;67(2):440-462. Epub 2021 Jun 18 doi: 10.1016/j.survophthal.2021.06.003. PMID: 34147542
Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259
Sheu SJ
Korean J Ophthalmol 2017 Aug;31(4):283-289. Epub 2017 Jun 28 doi: 10.3341/kjo.2017.0036. PMID: 28752698Free PMC Article
Razeghinejad MR, Havens SJ, Katz LJ
Surv Ophthalmol 2017 Sep-Oct;62(5):591-610. Epub 2017 Feb 8 doi: 10.1016/j.survophthal.2017.01.009. PMID: 28188728

Clinical prediction guides

Maitray A, Rishi E, Rishi P, Gopal L, Bhende P, Ray R, Therese KL
Indian J Ophthalmol 2019 Jun;67(6):795-800. doi: 10.4103/ijo.IJO_710_18. PMID: 31124489Free PMC Article
Relhan N, Forster RK, Flynn HW Jr
Am J Ophthalmol 2018 Mar;187:xx-xxvii. Epub 2017 Dec 5 doi: 10.1016/j.ajo.2017.11.021. PMID: 29217351Free PMC Article
Schwartz SG, Flynn HW Jr, Das T, Mieler WF
Dev Ophthalmol 2016;55:176-88. Epub 2015 Oct 26 doi: 10.1159/000431195. PMID: 26501897Free PMC Article
Essex RW, Yi Q, Charles PG, Allen PJ
Ophthalmology 2004 Nov;111(11):2015-22. doi: 10.1016/j.ophtha.2003.09.041. PMID: 15522366
Arch Ophthalmol 1995 Dec;113(12):1479-96. PMID: 7487614

Recent systematic reviews

Tzoumas N, Riding G, Williams MA, Steel DH
Cochrane Database Syst Rev 2023 Jun 14;6(6):CD009300. doi: 10.1002/14651858.CD009300.pub3. PMID: 37314061Free PMC Article
Phongkhun K, Pothikamjorn T, Srisurapanont K, Manothummetha K, Sanguankeo A, Thongkam A, Chuleerarux N, Leksuwankun S, Meejun T, Thanakitcharu J, Walker M, Gopinath S, Torvorapanit P, Langsiri N, Worasilchai N, Moonla C, Plongla R, Kates OS, Nematollahi S, Permpalung N
Clin Infect Dis 2023 May 24;76(10):1738-1749. doi: 10.1093/cid/ciad064. PMID: 36750934Free PMC Article
Chersich MF, Takkinen J, Charlier C, Leclercq A, Adams PE, Godbole G, Altmeyer U, Friesema IHM, Labbé Sandelin L, Jenkin L, Fontana L, Aldigeri R, Venter F, Luchters SMF, Lecuit M, Cimino L
Ocul Immunol Inflamm 2018;26(4):508-517. Epub 2017 Feb 1 doi: 10.1080/09273948.2016.1276788. PMID: 28145786
Benoist d'Azy C, Pereira B, Naughton G, Chiambaretta F, Dutheil F
PLoS One 2016;11(6):e0156431. Epub 2016 Jun 3 doi: 10.1371/journal.pone.0156431. PMID: 27257676Free PMC Article
Kessel L, Flesner P, Andresen J, Erngaard D, Tendal B, Hjortdal J
Acta Ophthalmol 2015 Jun;93(4):303-17. Epub 2015 Mar 16 doi: 10.1111/aos.12684. PMID: 25779209Free PMC Article

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