U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormality of peripheral nerve conduction

MedGen UID:
866458
Concept ID:
C4020690
Finding
Synonyms: Abnormal peripheral nerve transmission; Sensory and motor nerve conduction abnormalities
 
HPO: HP:0003134

Definition

An abnormality of the conduction of electrical impulses by peripheral (motor or sensory) nerves. This finding is elicited by a nerve conduction study (NCS). [from HPO]

Conditions with this feature

Friedreich ataxia 2
MedGen UID:
356134
Concept ID:
C1865981
Disease or Syndrome
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder characterized by progressive gait and limb ataxia with associated limb muscle weakness, absent lower limb reflexes, extensor plantar responses, dysarthria, and decreased vibratory sense and proprioception. Onset is usually in the first or second decade, before the end of puberty (summary by Delatycki et al., 2000). For a general phenotypic description of Friedreich ataxia (FRDA), see FRDA1 (229300), which is caused by mutation in the FXN gene (606829) on chromosome 9q13.

Professional guidelines

PubMed

Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Sudulagunta SR, Sodalagunta MB, Sepehrar M, Khorram H, Bangalore Raja SK, Kothandapani S, Noroozpour Z, Aheta Sham M, Prasad N, Sunny SP, Mohammed MD, Gangadharappa R, Nidsale Sudarshan R
Ger Med Sci 2015;13:Doc16. Epub 2015 Sep 21 doi: 10.3205/000220. PMID: 26421004Free PMC Article
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237

Recent clinical studies

Etiology

Fearon JA, Barrientos S, Ditthakasem K, Herbert M
Plast Reconstr Surg 2022 Aug 1;150(2):381e-386e. Epub 2022 Jun 8 doi: 10.1097/PRS.0000000000009367. PMID: 35671456
Liang L, Chen T, Wu Y
Neurophysiol Clin 2016 Feb;46(1):27-34. Epub 2016 Mar 2 doi: 10.1016/j.neucli.2015.12.006. PMID: 26947625
Casseb RF, Martinez AR, de Paiva JL, França MC Jr
J Neuroimaging 2015 Sep-Oct;25(5):704-9. Epub 2015 Feb 10 doi: 10.1111/jon.12210. PMID: 25678358
Keller MP, Chance PF
Semin Neurol 1999;19(4):353-62. doi: 10.1055/s-2008-1040850. PMID: 10716658
Feldman RG
Yale J Biol Med 1987 Mar-Apr;60(2):179-86. PMID: 3577214Free PMC Article

Diagnosis

Koike H, Katsuno M
Neurol Sci 2021 Nov;42(11):4489-4501. Epub 2021 Sep 16 doi: 10.1007/s10072-021-05583-7. PMID: 34529193
Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Attarian S, Fatehi F, Rajabally YA, Pareyson D
J Neurol 2020 Aug;267(8):2198-2206. Epub 2019 Apr 15 doi: 10.1007/s00415-019-09319-8. PMID: 30989370
Casseb RF, Martinez AR, de Paiva JL, França MC Jr
J Neuroimaging 2015 Sep-Oct;25(5):704-9. Epub 2015 Feb 10 doi: 10.1111/jon.12210. PMID: 25678358
Eisen A
Neurol Clin 1985 Aug;3(3):495-510. PMID: 2995782

Therapy

Stino AM, Naddaf E, Dyck PJ, Dyck PJB
Muscle Nerve 2021 Feb;63(2):157-169. Epub 2020 Sep 11 doi: 10.1002/mus.27046. PMID: 32914902
Nyunt WWT, Remli R, Abdul Muttlib FA, Leong CF, Masir N, Tumian NR, Abdul Wahid SFS
Malays J Pathol 2017 Dec;39(3):297-303. PMID: 29279594
Pitt M
Curr Opin Pediatr 2013 Dec;25(6):676-81. doi: 10.1097/MOP.0000000000000023. PMID: 24136299
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Prognosis

Sanchez-Sotelo J
Tech Hand Up Extrem Surg 2024 Sep 1;28(3):182-191. doi: 10.1097/BTH.0000000000000484. PMID: 39155676
Chaudhary SK, Kalita J, Misra UK
Neurol India 2023 May-Jun;71(3):458-462. doi: 10.4103/0028-3886.378653. PMID: 37322740
Fearon JA, Barrientos S, Ditthakasem K, Herbert M
Plast Reconstr Surg 2022 Aug 1;150(2):381e-386e. Epub 2022 Jun 8 doi: 10.1097/PRS.0000000000009367. PMID: 35671456
Pareyson D, Marchesi C
Lancet Neurol 2009 Jul;8(7):654-67. doi: 10.1016/S1474-4422(09)70110-3. PMID: 19539237
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Clinical prediction guides

Mouri N, Koike H, Fukami Y, Takahashi M, Yagi S, Furukawa S, Suzuki M, Kishimoto Y, Murate K, Nukui T, Yoshida T, Kudo Y, Tada M, Higashiyama Y, Watanabe H, Nakatsuji Y, Tanaka F, Katsuno M
Eur J Neurol 2024 Jan;31(1):e16091. Epub 2023 Oct 17 doi: 10.1111/ene.16091. PMID: 37847215Free PMC Article
Pang C, Yu H, Cai Y, Song M, Feng F, Gao L, Li K, Chen Y, Xie J, Cheng Y, Lin E, Pan X, Zhang W, Deng B
Diabetes Metab Res Rev 2023 Oct;39(7):e3679. Epub 2023 Jun 20 doi: 10.1002/dmrr.3679. PMID: 37337761
Chaudhary SK, Kalita J, Misra UK
Neurol India 2023 May-Jun;71(3):458-462. doi: 10.4103/0028-3886.378653. PMID: 37322740
Fearon JA, Barrientos S, Ditthakasem K, Herbert M
Plast Reconstr Surg 2022 Aug 1;150(2):381e-386e. Epub 2022 Jun 8 doi: 10.1097/PRS.0000000000009367. PMID: 35671456
Pitt M
Curr Opin Pediatr 2013 Dec;25(6):676-81. doi: 10.1097/MOP.0000000000000023. PMID: 24136299

Recent systematic reviews

Al-Mazidi S, Al-Dakhil L
J Neurophysiol 2023 Jan 1;129(1):191-198. Epub 2022 Dec 7 doi: 10.1152/jn.00386.2022. PMID: 36475865Free PMC Article
Abdelnaby R, Elgenidy A, Sonbol YT, Dardeer KT, Ebrahim MA, Maallem I, Youssef MW, Moawad MHED, Hassan YG, Rabie SA, Mohammed MK, Abdelrhem HAH, Mohamed KA, Walter U
Ultrasound Med Biol 2022 Aug;48(8):1397-1409. Epub 2022 Jun 3 doi: 10.1016/j.ultrasmedbio.2022.04.220. PMID: 35667977
Shabeeb D, Najafi M, Hasanzadeh G, Hadian MR, Musa AE, Shirazi A
Diabetes Metab Syndr 2018 Jul;12(4):591-600. Epub 2018 Mar 28 doi: 10.1016/j.dsx.2018.03.026. PMID: 29610062
Ginanneschi F, Mondelli M, Cioncoloni D, Rossi A
J Electromyogr Kinesiol 2018 Jun;40:32-38. Epub 2018 Mar 20 doi: 10.1016/j.jelekin.2018.03.004. PMID: 29587171
Zis P, Grünewald RA, Chaudhuri RK, Hadjivassiliou M
J Neurol Sci 2017 Jul 15;378:204-209. Epub 2017 May 11 doi: 10.1016/j.jns.2017.05.023. PMID: 28566165

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...