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Abnormal peripheral action potential amplitude

MedGen UID:: 868204
•Concept ID:: C4022596
•: Finding

HPO:	HP:0030179

Definition

An anomaly in the magnitude of the action potential along a peripheral nerve, that is, of the rapid rise and fall of the electrical membrane potential of the nerve. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal peripheral action potential amplitude

Congenital Systemic Disorder
- Abnormality of the nervous system
  - Abnormality of the peripheral nervous system
    - Abnormal peripheral nervous system physiology
      - Abnormality of peripheral nervous system electrophysiology
        Abnormality of peripheral nerve conduction
        Abnormal peripheral action potential amplitude
        Compound muscle action potential amplitude facilitation
        Decreased amplitude of sensory action potentials
        Decreased distal sensory nerve action potential
        Decreased compound muscle action potential amplitude
        Reduced F-wave amplitude

Professional guidelines

PubMed

Assessment of diagnostic criteria for multifocal motor neuropathy in patients included in the Italian database.

Doneddu PE, Gentile L, Cocito D, Fazio R, Luigetti M, Briani C, Filosto M, Siciliano G, Benedetti L, Antonini G, Matà S, Marfia GA, Inghilleri M, Manganelli F, Cosentino G, Brighina F, Carpo M, Carta F, Mazzeo A, Peci E, Strano C, Romano A, Campagnolo M, Cotti-Piccinelli S, Viola DV, Germano F, Leonardi L, Sperti M, Mataluni G, Ceccanti M, Spina E, Vegezzi E, Di Stefano V, Nobile-Orazio E
Eur J Neurol 2024 May;31(5):e16248. Epub 2024 Feb 20 doi: 10.1111/ene.16248. PMID: 38376074

Clinical utility of sensory nerve conduction of medial femoral cutaneous nerve.

Oh SJ, Hatanaka Y, Ohira M, Kurokawa K, Claussen GC
Muscle Nerve 2012 Feb;45(2):195-9. doi: 10.1002/mus.22287. PMID: 22246874

MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2.

Verhoeven K, Claeys KG, Züchner S, Schröder JM, Weis J, Ceuterick C, Jordanova A, Nelis E, De Vriendt E, Van Hul M, Seeman P, Mazanec R, Saifi GM, Szigeti K, Mancias P, Butler IJ, Kochanski A, Ryniewicz B, De Bleecker J, Van den Bergh P, Verellen C, Van Coster R, Goemans N, Auer-Grumbach M, Robberecht W, Milic Rasic V, Nevo Y, Tournev I, Guergueltcheva V, Roelens F, Vieregge P, Vinci P, Moreno MT, Christen HJ, Shy ME, Lupski JR, Vance JM, De Jonghe P, Timmerman V
Brain 2006 Aug;129(Pt 8):2093-102. Epub 2006 May 19 doi: 10.1093/brain/awl126. PMID: 16714318

See all (6)

Recent clinical studies

Etiology

Electroneurological changes in peripheral nerves in patients post-COVID.

Stępień J, Pastuszak Ż
J Neurophysiol 2023 Feb 1;129(2):392-398. Epub 2022 Dec 14 doi: 10.1152/jn.00396.2022. PMID: 36515426 Free PMC Article

Electrophysiological characteristics of patients with nitrous oxide abuse.

Li Y, Zhang X, Zhao C
Neurol Res 2021 Oct;43(10):793-801. Epub 2021 Jun 8 doi: 10.1080/01616412.2021.1935101. PMID: 34101535

Vibratory testing with the 64 Hz Rydel-Seiffer tuning fork and its relation to the sural nerve action potential.

Xirou S, Kokotis P, Zambelis T, Anagnostou E
J Peripher Nerv Syst 2020 Dec;25(4):395-400. Epub 2020 Oct 31 doi: 10.1111/jns.12418. PMID: 33107143

Progressive length-dependent polyneuropathy in xeroderma pigmentosum group A.

Tsuji Y, Ueda T, Sekiguchi K, Nishiyama M, Kanda F, Nishigori C, Toda T, Matsumoto R
Muscle Nerve 2020 Oct;62(4):534-540. Epub 2020 Aug 10 doi: 10.1002/mus.27028. PMID: 32696477

Clinical Characteristics and Electrodiagnostic Features of Guillain-Barré Syndrome Among the Pediatric Population.

Ashrafi MR, Mohammadalipoor A, Naeini AR, Amanat M, Tavasoli AR, Heidari M, Badv RS, Mohammadi M, Zamani GR, Rahimi-Dehgolan S, Rahimi R, Akbari MG
J Child Neurol 2020 Jun;35(7):448-455. Epub 2020 Mar 10 doi: 10.1177/0883073820905157. PMID: 32156188

See all (119)

Diagnosis

Diagnostic accuracy of nerve ultrasonography for the detection of peripheral neuropathy in type 2 diabetes.

Dhanapalaratnam R, Issar T, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Eur J Neurol 2022 Dec;29(12):3571-3579. Epub 2022 Sep 14 doi: 10.1111/ene.15534. PMID: 36039540 Free PMC Article

Clinical Characteristics and Electrodiagnostic Features of Guillain-Barré Syndrome Among the Pediatric Population.

Electrophysiological demyelinating features in hereditary ATTR amyloidosis.

Ohashi N, Kodaira M, Morita H, Sekijima Y
Amyloid 2019 Mar;26(1):15-23. Epub 2019 Jan 26 doi: 10.1080/13506129.2018.1564903. PMID: 30688105

F-waves--physiology and clinical uses.

Fisher MA
ScientificWorldJournal 2007 Feb 2;7:144-60. doi: 10.1100/tsw.2007.49. PMID: 17334607 Free PMC Article

Electrodiagnosis of radiculopathies.

Eisen A
Neurol Clin 1985 Aug;3(3):495-510. PMID: 2995782

See all (127)

Therapy

Lenalidomide long-term neurotoxicity: Clinical and neurophysiologic prospective study.

Dalla Torre C, Zambello R, Cacciavillani M, Campagnolo M, Berno T, Salvalaggio A, De March E, Barilà G, Lico A, Lucchetta M, Ermani M, Briani C
Neurology 2016 Sep 13;87(11):1161-6. Epub 2016 Aug 17 doi: 10.1212/WNL.0000000000003093. PMID: 27534712

Peripheral Nerve Dysfunction in Middle-Aged Subjects Born with Thalidomide Embryopathy.

Nicotra A, Newman C, Johnson M, Eremin O, Friede T, Malik O, Nicholas R
PLoS One 2016;11(4):e0152902. Epub 2016 Apr 21 doi: 10.1371/journal.pone.0152902. PMID: 27100829 Free PMC Article

Long- and short-term health effects of pesticide exposure: a cohort study from China.

Hu R, Huang X, Huang J, Li Y, Zhang C, Yin Y, Chen Z, Jin Y, Cai J, Cui F
PLoS One 2015;10(6):e0128766. Epub 2015 Jun 4 doi: 10.1371/journal.pone.0128766. PMID: 26042669 Free PMC Article

Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapy.

Vinik AI, Bril V, Litchy WJ, Price KL, Bastyr EJ 3rd; MBBQ Study Group
Muscle Nerve 2005 Nov;32(5):619-25. doi: 10.1002/mus.20423. PMID: 16116628

Peripheral and autonomic nerve function in 259 diabetic patients with peripheral neuropathy treated with ponalrestat (an aldose reductase inhibitor) or placebo for 18 months. United Kingdom/Scandinavian Ponalrestat Trial.

Sundkvist G, Armstrong FM, Bradbury JE, Chaplin C, Ellis SH, Owens DR, Rosén I, Sönksen P
J Diabetes Complications 1992 Apr-Jun;6(2):123-30. doi: 10.1016/1056-8727(92)90023-e. PMID: 1611136

See all (49)

Prognosis

Papantoniou M, Rentzos M, Zampelis T, Tzavellas E, Paparrigopoulos T, Kokotis P
Alcohol 2024 Jun;117:65-71. Epub 2024 Apr 3 doi: 10.1016/j.alcohol.2024.04.001. PMID: 38580031

Diagnostic accuracy of nerve ultrasonography for the detection of peripheral neuropathy in type 2 diabetes.

Dhanapalaratnam R, Issar T, Poynten AM, Milner KL, Kwai NCG, Krishnan AV
Eur J Neurol 2022 Dec;29(12):3571-3579. Epub 2022 Sep 14 doi: 10.1111/ene.15534. PMID: 36039540 Free PMC Article

Vibratory testing with the 64 Hz Rydel-Seiffer tuning fork and its relation to the sural nerve action potential.

Xirou S, Kokotis P, Zambelis T, Anagnostou E
J Peripher Nerv Syst 2020 Dec;25(4):395-400. Epub 2020 Oct 31 doi: 10.1111/jns.12418. PMID: 33107143

Lenalidomide long-term neurotoxicity: Clinical and neurophysiologic prospective study.

"Benign" early repolarization versus malignant early abnormalities: clinical-electrocardiographic distinction and genetic basis.

Pérez-Riera AR, Abreu LC, Yanowitz F, Barros RB, Femenía F, McIntyre WF, Baranchuk A
Cardiol J 2012;19(4):337-46. doi: 10.5603/cj.2012.0063. PMID: 22825893

See all (42)

Clinical prediction guides

Electroneurological changes in peripheral nerves in patients post-COVID.

Stępień J, Pastuszak Ż
J Neurophysiol 2023 Feb 1;129(2):392-398. Epub 2022 Dec 14 doi: 10.1152/jn.00396.2022. PMID: 36515426 Free PMC Article

Progressive length-dependent polyneuropathy in xeroderma pigmentosum group A.

Tsuji Y, Ueda T, Sekiguchi K, Nishiyama M, Kanda F, Nishigori C, Toda T, Matsumoto R
Muscle Nerve 2020 Oct;62(4):534-540. Epub 2020 Aug 10 doi: 10.1002/mus.27028. PMID: 32696477

Clinical Characteristics and Electrodiagnostic Features of Guillain-Barré Syndrome Among the Pediatric Population.

Electrophysiological demyelinating features in hereditary ATTR amyloidosis.

Ohashi N, Kodaira M, Morita H, Sekijima Y
Amyloid 2019 Mar;26(1):15-23. Epub 2019 Jan 26 doi: 10.1080/13506129.2018.1564903. PMID: 30688105

"Benign" early repolarization versus malignant early abnormalities: clinical-electrocardiographic distinction and genetic basis.

Pérez-Riera AR, Abreu LC, Yanowitz F, Barros RB, Femenía F, McIntyre WF, Baranchuk A
Cardiol J 2012;19(4):337-46. doi: 10.5603/cj.2012.0063. PMID: 22825893

See all (69)

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Abnormal peripheral action potential amplitude

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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