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Abnormal erythroid lineage cell morphology

MedGen UID:
866550
•Concept ID:
C4020862
•
Finding
Synonym: Abnormality of cells of the erythroid lineage
 
HPO: HP:0012130

Definition

An anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes. [from HPO]

Professional guidelines

PubMed

Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - "2021 update on diagnosis, risk-stratification, and management".
Patnaik MM, Tefferi A
Am J Hematol 2021 Mar 1;96(3):379-394. Epub 2021 Jan 28 doi: 10.1002/ajh.26090. PMID: 33428785
Diagnosis and management of congenital dyserythropoietic anemias.
Gambale A, Iolascon A, Andolfo I, Russo R
Expert Rev Hematol 2016 Mar;9(3):283-96. Epub 2016 Jan 6 doi: 10.1586/17474086.2016.1131608. PMID: 26653117
Clinical and morphological criteria for the diagnosis of prefibrotic idiopathic (primary) myelofibrosis.
Thiele J, Kvasnicka HM, Zankovich R, Diehl V
Ann Hematol 2001 Mar;80(3):160-5. doi: 10.1007/s002770000278. PMID: 11320901

Recent clinical studies

Etiology

Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - "2021 update on diagnosis, risk-stratification, and management".
Patnaik MM, Tefferi A
Am J Hematol 2021 Mar 1;96(3):379-394. Epub 2021 Jan 28 doi: 10.1002/ajh.26090. PMID: 33428785
Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera.
Brusson M, De Grandis M, Cochet S, Bigot S, Marin M, Leduc M, Guillonneau F, Mayeux P, Peyrard T, Chomienne C, Le Van Kim C, Cassinat B, Kiladjian JJ, El Nemer W
Haematologica 2018 Jun;103(6):972-981. Epub 2018 Mar 29 doi: 10.3324/haematol.2017.182303. PMID: 29599206Free PMC Article
Abnormal adhesion of red blood cells in polycythemia vera: a prothrombotic effect?
El Nemer W, De Grandis M, Brusson M
Thromb Res 2014 May;133 Suppl 2:S107-11. doi: 10.1016/S0049-3848(14)50018-7. PMID: 24862129
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165

Diagnosis

Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - "2021 update on diagnosis, risk-stratification, and management".
Patnaik MM, Tefferi A
Am J Hematol 2021 Mar 1;96(3):379-394. Epub 2021 Jan 28 doi: 10.1002/ajh.26090. PMID: 33428785
Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera.
Brusson M, De Grandis M, Cochet S, Bigot S, Marin M, Leduc M, Guillonneau F, Mayeux P, Peyrard T, Chomienne C, Le Van Kim C, Cassinat B, Kiladjian JJ, El Nemer W
Haematologica 2018 Jun;103(6):972-981. Epub 2018 Mar 29 doi: 10.3324/haematol.2017.182303. PMID: 29599206Free PMC Article
Diagnosis and management of congenital dyserythropoietic anemias.
Gambale A, Iolascon A, Andolfo I, Russo R
Expert Rev Hematol 2016 Mar;9(3):283-96. Epub 2016 Jan 6 doi: 10.1586/17474086.2016.1131608. PMID: 26653117
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Myelodysplastic syndromes: pathogenesis, functional abnormalities, and clinical implications.
Jacobs A
J Clin Pathol 1985 Nov;38(11):1201-17. doi: 10.1136/jcp.38.11.1201. PMID: 2999194Free PMC Article

Therapy

Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - "2021 update on diagnosis, risk-stratification, and management".
Patnaik MM, Tefferi A
Am J Hematol 2021 Mar 1;96(3):379-394. Epub 2021 Jan 28 doi: 10.1002/ajh.26090. PMID: 33428785
ENDOCRINE REGULATION OF ERYTHROID LINEAGE OF HEMATOPOIESIS IN CHILDREN LIVING UNDER A LOW-DOSE RADIATION EXPOSURE AFTER THE CHORNOBYL NPP ACCIDENT.
Bebeshko VG, Bruslova KM, Boyarska OY, Lyashenko LO, Tsvyetkova NM, Gonchar LO, Chernysh TO, Trychlib IV, Pismenniy VD, Yaroshenko ZS, Vasylenko VV
Probl Radiac Med Radiobiol 2020 Dec;25:374-389. doi: 10.33145/2304-8336-2020-25-374-389. PMID: 33361848
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Myeloid and erythroid lineage expression of haemopoietic progenitors derived from an abnormal clone in erythroleukaemia.
Suda T, Sato Y, Furukawa Y, Suda J, Eguchi M, Saito M, Miura Y
Br J Haematol 1986 Dec;64(4):647-56. doi: 10.1111/j.1365-2141.1986.tb02226.x. PMID: 3467787
Myelodysplastic syndromes: pathogenesis, functional abnormalities, and clinical implications.
Jacobs A
J Clin Pathol 1985 Nov;38(11):1201-17. doi: 10.1136/jcp.38.11.1201. PMID: 2999194Free PMC Article

Prognosis

Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - "2021 update on diagnosis, risk-stratification, and management".
Patnaik MM, Tefferi A
Am J Hematol 2021 Mar 1;96(3):379-394. Epub 2021 Jan 28 doi: 10.1002/ajh.26090. PMID: 33428785
ENDOCRINE REGULATION OF ERYTHROID LINEAGE OF HEMATOPOIESIS IN CHILDREN LIVING UNDER A LOW-DOSE RADIATION EXPOSURE AFTER THE CHORNOBYL NPP ACCIDENT.
Bebeshko VG, Bruslova KM, Boyarska OY, Lyashenko LO, Tsvyetkova NM, Gonchar LO, Chernysh TO, Trychlib IV, Pismenniy VD, Yaroshenko ZS, Vasylenko VV
Probl Radiac Med Radiobiol 2020 Dec;25:374-389. doi: 10.33145/2304-8336-2020-25-374-389. PMID: 33361848
Genetic-pathologic characterization of myeloproliferative neoplasms.
Kim Y, Park J, Jo I, Lee GD, Kim J, Kwon A, Choi H, Jang W, Chae H, Han K, Eom KS, Cho BS, Lee SE, Yang J, Shin SH, Kim H, Ko YH, Park H, Jin JY, Lee S, Jekarl DW, Yahng SA, Kim M
Exp Mol Med 2016 Jul 22;48(7):e247. doi: 10.1038/emm.2016.55. PMID: 27444979Free PMC Article
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Clinical and morphological features of paediatric myelodysplastic syndromes: a review of 34 cases.
Polychronopoulou S, Panagiotou JP, Kossiva L, Mavrou A, Anagnostou D, Haidas S
Acta Paediatr 2004 Aug;93(8):1015-23. doi: 10.1111/j.1651-2227.2004.tb02708.x. PMID: 15456186

Clinical prediction guides

Heterozygous mutation SLFN14 K208N in mice mediates species-specific differences in platelet and erythroid lineage commitment.
Stapley RJ, Smith CW, Haining EJ, Bacon A, Lax S, Pisareva VP, Pisarev AV, Watson SP, Khan AO, Morgan NV
Blood Adv 2021 Jan 26;5(2):377-390. doi: 10.1182/bloodadvances.2020002404. PMID: 33496736Free PMC Article
Exploring blast composition in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms: CD45RA and CD371 improve diagnostic value of flow cytometry through assessment of myeloblast heterogeneity and stem cell aberrancy.
Shameli A, Dharmani-Khan P, Luider J, Auer I, Shabani-Rad MT
Cytometry B Clin Cytom 2021 Sep;100(5):574-589. Epub 2020 Dec 24 doi: 10.1002/cyto.b.21983. PMID: 33369070Free PMC Article
Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo.
Woods B, Chen W, Chiu S, Marinaccio C, Fu C, Gu L, Bulic M, Yang Q, Zouak A, Jia S, Suraneni PK, Xu K, Levine RL, Crispino JD, Wen QJ
Clin Cancer Res 2019 Oct 1;25(19):5901-5912. Epub 2019 Jun 19 doi: 10.1158/1078-0432.CCR-18-4089. PMID: 31217200Free PMC Article
The lower risk MDS patient at risk of rapid progression.
Mittelman M, Oster HS, Hoffman M, Neumann D
Leuk Res 2010 Dec;34(12):1551-5. Epub 2010 Jun 22 doi: 10.1016/j.leukres.2010.05.023. PMID: 20573398
Acute erythroid neoplastic proliferations. A biological study based on 62 patients.
Domingo-Claros A, Larriba I, Rozman M, Irriguible D, Vallespí T, Aventin A, Ayats R, Millá F, Solé F, Florensa L, Gallart M, Tuset E, Lopez C, Woessner S
Haematologica 2002 Feb;87(2):148-53. PMID: 11836165

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